Department of Genetics and Development

Displaying 51 - 100 of 413CSV
Wang, W., Williams, D. J., Teoh, J. J., Soundararajan, D., Zuberi, A., Lutz, C. M., Frankel, W. N., & Makinson, C. D. (2024). Impaired axon initial segment structure and function in a model of ARHGEF9 developmental and epileptic encephalopathy. Proceedings of the National Academy of Sciences, 121(42). https://doi.org/10.1073/pnas.2400709121
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Baghel, M., Shi, S. L., Patel, H., Velagapudi, V., Ali, A. M., & Yadav, V. K. (2024). Taurine/chenodeoxycholic acid ratio as a potential serum biomarker for low vitamin B12 levels in humans. British Journal of Nutrition, 132(6), 712–724. https://doi.org/10.1017/s0007114524002022
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Triplett, M. K., Johnson, M. J., & Symington, L. S. (2024). Induction of homologous recombination by site-specific replication stress. DNA Repair, 142, 103753. https://doi.org/10.1016/j.dnarep.2024.103753
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Hwang, Y., Shimamura, Y., Tanaka, J., Miura, A., Sawada, A., Sarmah, H., Shimizu, D., Kondo, Y., Lee, H., Martini, F., Ninish, Z., Yan, K. S., Yamada, K., & Mori, M. (2024). FGF2 promotes the expansion of parietal mesothelial progenitor pools and inhibits BMP4-mediated smooth muscle cell differentiation. Frontiers in Cell and Developmental Biology, 12. https://doi.org/10.3389/fcell.2024.1387237
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Ho, J., Puoplo, N., Pokharel, N., Hirdaramani, A., Hanyaloglu, A. C., & Cheng, C.-W. (2024). Nutrigenomic underpinnings of intestinal stem cells in inflammatory bowel disease and colorectal cancer development. Frontiers in Genetics, 15. https://doi.org/10.3389/fgene.2024.1349717
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Mackay, H. L., Stone, H. R., Ronson, G. E., Ellis, K., Lanz, A., Aghabi, Y., Walker, A. K., Starowicz, K., Garvin, A. J., Van Eijk, P., Koestler, S. A., Anthony, E. J., Piberger, A. L., Chauhan, A. S., Conway-Thomas, P., Vaitsiankova, A., Vijayendran, S., Beesley, J. F., Petermann, E., … Morris, J. R. (2024). USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-52250-4
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Chen, Y., Su, Y., Cao, X., Siavelis, I., Leo, I. R., Zeng, J., Tsagkozis, P., Hesla, A. C., Papakonstantinou, A., Liu, X., Huang, W., Zhao, B., Haglund, C., Ehnman, M., Johansson, H., Lin, Y., Lehtiö, J., Zhang, Y., Larsson, O., … de Flon, F. H. (2024). Molecular Profiling Defines Three Subtypes of Synovial Sarcoma. Advanced Science, 11(41). Portico. https://doi.org/10.1002/advs.202404510
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Engreitz, J. M., Lawson, H. A., Singh, H., Starita, L. M., Hon, G. C., Carter, H., Sahni, N., Reddy, T. E., Lin, X., Li, Y., Munshi, N. V., Chahrour, M. H., Boyle, A. P., Hitz, B. C., Mortazavi, A., Craven, M., Mohlke, K. L., … Samer, E. K. (2024). Deciphering the impact of genomic variation on function. Nature, 633(8028), 47–57. https://doi.org/10.1038/s41586-024-07510-0
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Imada, S., Khawaled, S., Shin, H., Meckelmann, S. W., Whittaker, C. A., Corrêa, R. O., Alquati, C., Lu, Y., Tie, G., Pradhan, D., Calibasi-Kocal, G., Nascentes Melo, L. M., Allies, G., Rösler, J., Wittenhofer, P., Krystkiewicz, J., Schmitz, O. J., Roper, J., Vinolo, M. A. R., … Yilmaz, Ö. H. (2024). Short-term post-fast refeeding enhances intestinal stemness via polyamines. Nature, 633(8031), 895–904. https://doi.org/10.1038/s41586-024-07840-z
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Gretarsson, K. H., Abini-Agbomson, S., Gloor, S. L., Weinberg, D. N., McCuiston, J. L., Kumary, V. U. S., Hickman, A. R., Sahu, V., Lee, R., Xu, X., Lipieta, N., Flashner, S., Adeleke, O. A., Popova, I. K., Taylor, H. F., Noll, K., Windham, C. L., Maryanski, D. N., Venters, B. J., … Lu, C. (2024). Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch. Science Advances, 10(35). https://doi.org/10.1126/sciadv.adp0975
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Bashore, A. C., Xue, C., Kim, E., Yan, H., Zhu, L. Y., Pan, H., Kissner, M., Ross, L. S., Zhang, H., Li, M., & Reilly, M. P. (2024). Monocyte Single-Cell Multimodal Profiling in Cardiovascular Disease Risk States. Circulation Research, 135(6), 685–700. https://doi.org/10.1161/circresaha.124.324457
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Jones, D. J., Soundararajan, D., Taylor, N. K., Aimiuwu, O. V., Mathkar, P., Shore, A., Teoh, J. J., Wang, W., Sands, T. T., Weston, M. C., Harper, S. Q., & Frankel, W. N. (2024). Effective knockdown-replace gene therapy in a novel mouse model of DNM1 developmental and epileptic encephalopathy. Molecular Therapy. https://doi.org/10.1016/j.ymthe.2024.08.009
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Jehangir, I. A., Jan, B., Al-Tawaha, A. R. M., Hussain, A., Nazir, A., Bhat, T. A., Bhat, M. A., & Ali, I. (2024). Assessing the impact of nutrient omissions on growth, yield, and nutrient use efficiency in winter rape (Brassica napus L.) under rainfed ecology. Journal of Plant Nutrition, 47(13), 2122–2133. https://doi.org/10.1080/01904167.2024.2330527
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Tang, S., Conte, V., Zhang, D. J., Žedaveinytė, R., Lampe, G. D., Wiegand, T., Tang, L. C., Wang, M., Walker, M. W. G., George, J. T., Berchowitz, L. E., Jovanovic, M., & Sternberg, S. H. (2024). De novo gene synthesis by an antiviral reverse transcriptase. Science, 386(6717). https://doi.org/10.1126/science.adq0876
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Scuoppo, C., Cai, B., Ofori, K., Scholze, H., Kumar, R., D’Alessandro, A., Basso, K., Pasqualucci, L., & Dalla-Favera, R. (2024). Repurposing NAMPT Inhibitors for Germinal Center B Cell–Like Diffuse Large B-Cell Lymphoma. Blood Cancer Discovery, 5(6), 417–427. https://doi.org/10.1158/2643-3230.bcd-24-0020
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Plumber, S. A., Tate, T., Al-Ahmadie, H., Chen, X., Choi, W., Basar, M., Lu, C., Viny, A., Batourina, E., Li, J., Gretarsson, K., Alija, B., Molotkov, A., Wiessner, G., Lee, B. H. L., McKiernan, J., McConkey, D. J., Dinney, C., Czerniak, B., & Mendelsohn, C. L. (2024). Rosiglitazone and trametinib exhibit potent anti-tumor activity in a mouse model of muscle invasive bladder cancer. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-50678-2
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Adilbay, D., Gonzales, J., Zazhytska, M., Demetrio de Souza Franca, P., Roberts, S., Viray, T. D., Artschwager, R., Patel, S., Kodra, A., Overdevest, J. B., Chow, C. Y., King, G. F., Jain, S. K., Ordonez, A. A., Carroll, L. S., Lomvardas, S., Reiner, T., & Pillarsetty, N. (2024). Noninvasive Diagnostic Method to Objectively Measure Olfaction and Diagnose Smell Disorders by a Molecularly Targeted Fluorescence Imaging Agent. Journal of Nuclear Medicine, 65(8), 1293–1300. https://doi.org/10.2967/jnumed.123.266123
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Perrier, S., Macintosh, J., Misiaszek, A. D., Lambert, G., Guerrero, K., Tran, L. T., Müller, C. W., Pastinen, T., Maegawa, G. H. B., Thiffault, I., & Bernard, G. (2024). Novel Pathogenic Variants in POLR3K Cause POLR3‐Related Leukodystrophy. Human Mutation, 2024(1). Portico. https://doi.org/10.1155/2024/8807171
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Yu, J., Zhang, Y., Fang, Y., Paulo, J. A., Yaghoubi, D., Hua, X., Shipkovenska, G., Toda, T., Zhang, Z., Gygi, S. P., Jia, S., Li, Q., & Moazed, D. (2024). A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance. Cell. https://doi.org/10.1016/j.cell.2024.07.006
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Toda, T., Fang, Y., Shan, C.-M., Hua, X., Kim, J.-K., Tang, L. C., Jovanovic, M., Tong, L., Qiao, F., Zhang, Z., & Jia, S. (2024). Mrc1 regulates parental histone segregation and heterochromatin inheritance. Molecular Cell. https://doi.org/10.1016/j.molcel.2024.07.002
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Žedaveinytė, R., Meers, C., Le, H. C., Mortman, E. E., Tang, S., Lampe, G. D., Pesari, S. R., Gelsinger, D. R., Wiegand, T., & Sternberg, S. H. (2024). Antagonistic conflict between transposon-encoded introns and guide RNAs. Science, 385(6705). https://doi.org/10.1126/science.adm8189
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Kodra, A. L., Singh, A. S., de la Cova, C., Ziosi, M., & Johnston, L. A. (2024). The Drosophila tumor necrosis factor Eiger promotes Myc supercompetition independent of canonical Jun N-terminal kinase signaling. GENETICS. https://doi.org/10.1093/genetics/iyae107
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Singhal, A., Styers, H. C., Rub, J., Li, Z., Torborg, S. R., Kim, J. Y., Grbovic-Huezo, O., Feng, H., Tarcan, Z. Cagla., Sahin Ozkan, H., Hallin, J., Basturk, O., Yaeger, R., Christensen, J. G., Betel, D., Yan, Y., Chio, I. I. C., de Stanchina, E., & Tammela, T. (2024). A classical epithelial state drives acute resistance to KRAS inhibition in pancreas cancer. Cancer Discovery. https://doi.org/10.1158/2159-8290.cd-24-0740
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Portela-Lomba, M., Simón, D., Callejo-Móstoles, M., de la Fuente, G., Fernández de Sevilla, D., García-Escudero, V., Moreno-Flores, M. T., & Sierra, J. (2024). Generation of functional neurons from adult human mucosal olfactory ensheathing glia by direct lineage conversion. Cell Death & Disease, 15(7). https://doi.org/10.1038/s41419-024-06862-9
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Ahmed, A., Kato, N., & Gautier, J. (2024). Replication-Independent ICL Repair: From Chemotherapy to Cell Homeostasis. Journal of Molecular Biology, 436(13), 168618. https://doi.org/10.1016/j.jmb.2024.168618
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Connors, C. Q., Mauro, M. S., Wiles, J. T., Countryman, A. D., Martin, S. L., Lacroix, B., Shirasu-Hiza, M., Dumont, J., Kasza, K. E., Davies, T. R., & Canman, J. C. (2024). Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane. Molecular Biology of the Cell, 35(7). https://doi.org/10.1091/mbc.e24-02-0096-t
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Martin, B. E., Sands, T., Bier, L., Bergner, A., Boehme, A. K., & Lippa, N. (2024). Comparing the frequency of variants of uncertain significance (VUS) between ancestry groups in a paediatric epilepsy cohort. Journal of Medical Genetics, 61(7), 645–651. https://doi.org/10.1136/jmg-2023-109450
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Gallitto, M., De Santos, G. L., Wei, H.-J., Zhang, X., Zhang, Z., & Wu, C.-C. (2024). DIPG-41. CONVECTION ENHANCED DELIVERY-MEDIATED RADIOSENSITIZATION FOR DIFFUSE MIDLINE GLIOMA. Neuro-Oncology, 26(Supplement_4), 0–0. https://doi.org/10.1093/neuonc/noae064.094
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Lu, Z., Wang, Y., Assumpção, A. L. F. V., Liu, P., Kopp, A., Saka, S., Mcilwain, S. J., Viny, A. D., Brand, M., & Pan, X. (2024). Yin Yang 1 regulates cohesin complex protein SMC3 in mouse hematopoietic stem cells. Blood Advances, 8(12), 3076–3091. https://doi.org/10.1182/bloodadvances.2023011411
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Morcillo, P., Kabra, K., Velasco, K., Cordero, H., Jennings, S., Yun, T. D., Larrea, D., Akman, H. O., & Schon, E. A. (2024). Aberrant ER-mitochondria communication is a common pathomechanism in mitochondrial disease. Cell Death & Disease, 15(6). https://doi.org/10.1038/s41419-024-06781-9
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Serra-Cardona, A., Hua, X., McNutt, S. W., Zhou, H., Toda, T., Jia, S., Chu, F., & Zhang, Z. (2024). The PCNA–Pol δ complex couples lagging strand DNA synthesis to parental histone transfer for epigenetic inheritance. Science Advances, 10(23). https://doi.org/10.1126/sciadv.adn5175
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Bravo, J. I., Mizrahi, C. R., Kim, S., Zhang, L., Suh, Y., & Benayoun, B. A. (2024). An eQTL-based approach reveals candidate regulators of LINE-1 RNA levels in lymphoblastoid cells. PLOS Genetics, 20(6), e1011311. https://doi.org/10.1371/journal.pgen.1011311
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Malagola, E., Vasciaveo, A., Ochiai, Y., Kim, W., Zheng, B., Zanella, L., Wang, A. L. E., Middelhoff, M., Nienhüser, H., Deng, L., Wu, F., Waterbury, Q. T., Belin, B., LaBella, J., Zamechek, L. B., Wong, M. H., Li, L., Guha, C., Cheng, C.-W., … Wang, T. C. (2024). Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury. Cell, 187(12), 3056-3071.e17. https://doi.org/10.1016/j.cell.2024.05.004
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Carmichael, J., Figueiredo, I., Gurel, B., Beije, N., Yuan, W., Rekowski, J., Seed, G., Carreira, S., Bertan, C., Fenor de la Maza, M. de L. D., Chandran, K., Neeb, A., Welti, J., Gallagher, L., Bogdan, D., Crespo, M., Riisnaes, R., Ferreira, A., Miranda, S., … de Bono, J. (2024). RNASEH2B loss and PARP inhibition in advanced prostate cancer. Journal of Clinical Investigation. https://doi.org/10.1172/jci178278
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Suryadevara, V., Hudgins, A. D., Rajesh, A., Pappalardo, A., Karpova, A., Dey, A. K., Hertzel, A., Agudelo, A., Rocha, A., Soygur, B., Schilling, B., Carver, C. M., Aguayo-Mazzucato, C., Baker, D. J., Bernlohr, D. A., Jurk, D., Mangarova, D. B., Quardokus, E. M., Enninga, E. A. L., … Neretti, N. (2024). SenNet recommendations for detecting senescent cells in different tissues. Nature Reviews Molecular Cell Biology. https://doi.org/10.1038/s41580-024-00738-8
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Tanaka, J., Miura, A., Shimamura, Y., Hwang, Y., Shimizu, D., Kondo, Y., Sawada, A., Sarmah, H., Ninish, Z., Mishima, K., & Mori, M. (2024). Generation of salivary glands derived from pluripotent stem cells via conditional blastocyst complementation. Cell Reports, 43(6), 114340. https://doi.org/10.1016/j.celrep.2024.114340
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Walsh, Z. H., Shah, P., Kothapalli, N., Shah, S. B., Nikolenyi, G., Brodtman, D. Z., Leuzzi, G., Rogava, M., Mu, M., Ho, P., Abuzaid, S., Vasan, N., AlQuraishi, M., Milner, J. D., Ciccia, A., Melms, J. C., & Izar, B. (2024). Mapping variant effects on anti-tumor hallmarks of primary human T cells with base-editing screens. Nature Biotechnology. https://doi.org/10.1038/s41587-024-02235-x
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Watanabe, J., Clutter, M. R., Gullette, M. J., Sasaki, T., Uchida, E., Kaur, S., Mo, Y., Abe, K., Ishi, Y., Takata, N., Natsumeda, M., Gadd, S., Zhang, Z., Becher, O. J., & Hashizume, R. (2024). BET bromodomain inhibition potentiates radiosensitivity in models of H3K27-altered diffuse midline glioma. Journal of Clinical Investigation, 134(13). https://doi.org/10.1172/jci174794
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Zhang, X., Duan, S., Apostolou, P. E., Wu, X., Watanabe, J., Gallitto, M., Barron, T., Taylor, K. R., Woo, P. J., Hua, X., Zhou, H., Wei, H.-J., McQuillan, N., Kang, K.-D., Friedman, G. K., Canoll, P. D., Chang, K., Wu, C.-C., Hashizume, R., … Zhang, Z. (2024). CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma. Cancer Discovery, OF1–OF23. https://doi.org/10.1158/2159-8290.cd-23-0012
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Ahamed, F. M. M., Padusha, M. S. A., Banu, A. M., Maitra, S., Alharbi, H. M., Kumarasamy, V., Uti, D. E., Mohite, P., Alexiou, A., & Ali, I. (2024). Evaluation of diethyl 4-(5-bromo-1H-indol-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate: synthesis, anti-corrosion potential, and biomedical applications. BMC Chemistry, 18(1). https://doi.org/10.1186/s13065-024-01123-4
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Lee, J., Lee, J., Sohn, E. J., Taglialatela, A., O’Sullivan, R. J., Ciccia, A., & Min, J. (2024). Extrachromosomal telomere DNA derived from excessive strand displacements. Proceedings of the National Academy of Sciences, 121(19). https://doi.org/10.1073/pnas.2318438121
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Patel, B., Zhou, Y., Babcock, R. L., Ma, F., Zal, M. A., Kumar, D., Medik, Y. B., Kahn, L. M., Pineda, J. E., Park, E. M., Schneider, S. M., Tang, X., Raso, M. G., Jeter, C. R., Zal, T., Clise-Dwyer, K., Keyomarsi, K., Giancotti, F. G., Colla, S., & Watowich, S. S. (2024). STAT3 protects hematopoietic stem cells by preventing activation of a deleterious autocrine type-I interferon response. Leukemia, 38(5), 1143–1155. https://doi.org/10.1038/s41375-024-02218-6
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Nakagawa, S., Carnevali, D., Tan, X., Alvarez, M. J., Parfitt, D.-E., Di Vicino, U., Arumugam, K., Shin, W., Aranda, S., Normanno, D., Sebastian-Perez, R., Cannatá, C., Cortes, P., Neguembor, M. V., Shen, M. M., Califano, A., & Cosma, M. P. (2024). The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development. Stem Cell Reports, 19(5), 689–709. https://doi.org/10.1016/j.stemcr.2024.04.004
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Acharya, A., Bret, H., Huang, J.-W., Mütze, M., Göse, M., Kissling, V. M., Seidel, R., Ciccia, A., Guérois, R., & Cejka, P. (2024). Mechanism of DNA unwinding by MCM8-9 in complex with HROB. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-47936-8
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