Signal Transduction

Displaying 1 - 45 of 45CSV
Bertulfo, K., Perez-Duran, P., Miller, H., Ma, C., Ambesi-Impiombato, A., Samon, J., Mackey, A., Lin, W.-H. W., Ferrando, A. A., & Palomero, T. (2025). Therapeutic targeting of the NOTCH1 and neddylation pathways in T cell acute lymphoblastic leukemia. Proceedings of the National Academy of Sciences, 122(14). https://doi.org/10.1073/pnas.2426742122
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Gaspar, R. C., Macêdo, A. P. A., Nakandakari, S. C. B. R., Muñoz, V. R., Abud, G. F., Vieira, R. F. L., de Sousa Neto, I. V., Pavan, I. C. B., da Silva, L. G. S., Simabuco, F. M., da Silva, A. S. R., Junior, W. S., Marchini, J. S., Nonino, C. B., Cintra, D. E., Ropelle, E. R., Pajvani, U. B., de Freitas, E. C., & Pauli, J. R. (2025). Notch1 Signalling Is Downregulated by Aerobic Exercise, Leading to Improvement of Hepatic Metabolism in Obese Mice. Liver International, 45(4). Portico. https://doi.org/10.1111/liv.70068
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Loffredo, L. F., Kustagi, A., Ringham, O. R., Li, F., de los Santos-Alexis, K., Saqi, A., & Arpaia, N. (2025). Heparan sulfate regulates amphiregulin programming of tissue reparative lung mesenchymal cells during influenza A virus infection in mice. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-57362-z
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Park, J. Y., Ha, E. S., Lee, J., Brun, P.-J., Kim, Y., Chung, S. S., Hwang, D., Lee, S.-A., & Park, K. S. (2025). The brown fat-specific overexpression of RBP4 improves thermoregulation and systemic metabolism by activating the canonical adrenergic signaling pathway. Experimental & Molecular Medicine, 57(3), 554–566. https://doi.org/10.1038/s12276-025-01411-6
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Hahn, H., Daly, C., Little, J., Perry-Hauser, N. A., Flores-Espinoza, E., Inoue, A., Plouffe, B., & Thomsen, A. R. (2025). Endosomal chemokine receptor signalosomes regulate central mechanisms underlying cell migration. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.99373
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Vasou, A., Nightingale, K., Cetkovská, V., Scheler, J., Bamford, C. G. G., Andrejeva, J., Rowe, J. C., Swatek, K. N., Schwarz‐Linek, U., Randall, R. E., McLauchlan, J., Weekes, M. P., Bogunovic, D., & Hughes, D. J. (2025). ISG15‐Dependent Stabilisation of USP18 Is Necessary but Not Sufficient to Regulate Type I Interferon Signalling in Humans. European Journal of Immunology, 55(2). Portico. https://doi.org/10.1002/eji.202451651
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Shin, A. E., Sugiura, K., Kariuki, S. W., Cohen, D. A., Flashner, S. P., Klein-Szanto, A. J., Nishiwaki, N., De, D., Vasan, N., Gabre, J. T., Lengner, C. J., Sims, P. A., & Rustgi, A. K. (2025). LIN28B-mediated PI3K/AKT pathway activation promotes metastasis in colorectal cancer models. Journal of Clinical Investigation. https://doi.org/10.1172/jci186035
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Wang, B. Z., Morsink, M. A. J., Kim, S. W., Luo, L. J., Zhang, X., Soni, R. K., Lock, R. I., Rao, J., Kim, Y., Zhang, A., Neyazi, M., Gorham, J. M., Kim, Y., Brown, K., DeLaughter, D. M., Zhang, Q., McDonough, B., Watkins, J. M., Cunningham, K. M., … Vunjak-Novakovic, G. (2025). Cardiac fibroblast BAG3 regulates TGFBR2 signaling and fibrosis in dilated cardiomyopathy. Journal of Clinical Investigation, 135(1). https://doi.org/10.1172/jci181630
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De Felice, D., Alaimo, A., Bressan, D., Genovesi, S., Marmocchi, E., Annesi, N., Beccaceci, G., Dalfovo, D., Cutrupi, F., Medaglia, S., Foletto, V., Lorenzoni, M., Gandolfi, F., Kannan, S., Verma, C. S., Vasciaveo, A., Shen, M. M., Romanel, A., Chiacchiera, F., … Lunardi, A. (2024). Rarγ-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer. EMBO Reports. https://doi.org/10.1038/s44319-024-00335-y
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Powers, A. S., Khan, A., Paggi, J. M., Latorraca, N. R., Souza, S., Di Salvo, J., Lu, J., Soisson, S. M., Johnston, J. M., Weinglass, A. B., & Dror, R. O. (2024). A non-canonical mechanism of GPCR activation. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-54103-6
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Prasad, K., Bhattacharya, D., Shams, S. G. E., Izarraras, K., Hart, T., Mayfield, B., Blaszczyk, M. B., Zhou, Z., Pajvani, U. B., Friedman, S. L., & Bhattacharya, M. (2024). Kisspeptin Alleviates Human Hepatic Fibrogenesis by Inhibiting TGFβ Signaling in Hepatic Stellate Cells. Cells, 13(19), 1651. https://doi.org/10.3390/cells13191651
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McKimpson, W. M., Spiegel, S., Mukhanova, M., Kraakman, M., Du, W., Kitamoto, T., Yu, J., Deng, Z., Pajvani, U., & Accili, D. (2024). Calorie restriction activates a gastric Notch-FOXO1 pathway to expand ghrelin cells. Journal of Cell Biology, 223(10). https://doi.org/10.1083/jcb.202305093
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Lumish, H. S., Sherrid, M. V., Janssen, P. M. L., Ferrari, G., Hasegawa, K., Castillero, E., Adlestein, E., Swistel, D. G., Topkara, V. K., Maurer, M. S., Reilly, M. P., & Shimada, Y. J. (2024). Comprehensive Proteomic Profiling of Human Myocardium Reveals Signaling Pathways Dysregulated in Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology, 84(20), 1999–2011. https://doi.org/10.1016/j.jacc.2024.07.043
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Wu, Y., Foollee, A., Chan, A. Y., Hille, S., Hauke, J., Challis, M. P., Johnson, J. L., Yaron, T. M., Mynard, V., Aung, O. H., Cleofe, M. A. S., Huang, C., Lim Kam Sian, T. C. C., Rahbari, M., Gallage, S., Heikenwalder, M., Cantley, L. C., Schittenhelm, R. B., Formosa, L. E., … Rose, A. J. (2024). Phosphoproteomics-directed manipulation reveals SEC22B as a hepatocellular signaling node governing metabolic actions of glucagon. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-52703-w
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Lopez-Bujanda, Z. A., Hadavi, S. H., Ruiz De Porras, V., Martínez-Balibrea, E., & Dallos, M. C. (2024). Chemotactic signaling pathways in prostate cancer: Implications in the tumor microenvironment and as potential therapeutic targets. Chemokine Receptors in Health and Disease, 162–205. https://doi.org/10.1016/bs.ircmb.2024.03.008
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Tayran, H., Yilmaz, E., Bhattarai, P., Min, Y., Wang, X., Ma, Y., Wang, N., Jeong, I., Nelson, N., Kassara, N., Cosacak, M. I., Dogru, R. M., Reyes-Dumeyer, D., Stenersen, J. M., Reddy, J. S., Qiao, M., Flaherty, D., Gunasekaran, T. I., Yang, Z., … Kizil, C. (2024). ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer’s disease through BDNF/NGFR signaling. Cell Genomics, 4(9), 100642. https://doi.org/10.1016/j.xgen.2024.100642
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Qin, L., Deng, Y., Zhang, X., Tang, L., Zhang, C., Xu, S., Wang, K., Wang, M., Zhang, X., Su, M., Xie, Q., Hendrickson, W. A., & Chen, Y. (2024). Mechanistic insights into phosphoactivation of SLAC1 in guard cell signaling. Proceedings of the National Academy of Sciences, 121(29). https://doi.org/10.1073/pnas.2323040121
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Wojnacki, J., Quassollo, G., Bordenave, M. D., Unsain, N., Martínez, G. F., Szalai, A. M., Pertz, O., Gundersen, G. G., Bartolini, F., Stefani, F. D., Cáceres, A., & Bisbal, M. (2024). Dual spatio-temporal regulation of axon growth and microtubule dynamics by RhoA signaling pathways. Journal of Cell Science, 137(14). https://doi.org/10.1242/jcs.261970
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Liu, J., Cao, S., Imbach, K. J., Gritsenko, M. A., Lih, T.-S. M., Kyle, J. E., Yaron-Barir, T. M., Binder, Z. A., Li, Y., Strunilin, I., Wang, Y.-T., Tsai, C.-F., Ma, W., Chen, L., Clark, N. M., Shinkle, A., Naser Al Deen, N., Caravan, W., Houston, A., … Ding, L. (2024). Multi-scale signaling and tumor evolution in high-grade gliomas. Cancer Cell, 42(7), 1217-1238.e19. https://doi.org/10.1016/j.ccell.2024.06.004
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Heath, H., Yoo, J. Y., Akter, S., Jain, A., Sharma, V., McGee, H., Soliman, A., Mahmoud, A. M., Matthews, A. K., Winn, R. A., Madak-Erdogan, Z., & Kim, S. J. (2024). The Effect of Exposure to Neighborhood Violence on Glucocorticoid Receptor Signaling in Lung Tumors. Cancer Research Communications, 4(7), 1643–1654. https://doi.org/10.1158/2767-9764.crc-24-0032
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Columbia Affiliation
Ding, J., Nguyen, A. T., Lohman, K., Hensley, M. T., Parker, D., Hou, L., Taylor, J., Voora, D., Sawyer, J. K., Boudyguina, E., Bancks, M. P., Bertoni, A., Pankow, J. S., Rotter, J. I., Goodarzi, M. O., Tracy, R. P., Murdoch, D. M., Rich, S. S., Psaty, B. M., … Liu, Y. (2024). LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes. Journal of Clinical Investigation, 134(10). https://doi.org/10.1172/jci173278
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Rosenberger, G., Li, W., Turunen, M., He, J., Subramaniam, P. S., Pampou, S., Griffin, A. T., Karan, C., Kerwin, P., Murray, D., Honig, B., Liu, Y., & Califano, A. (2024). Network-based elucidation of colon cancer drug resistance mechanisms by phosphoproteomic time-series analysis. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-47957-3
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Zhang, F., Sahu, V., Peng, K., Wang, Y., Li, T., Bala, P., Aitymbayev, D., Sahgal, P., Schaefer, A., Der, C. J., Ryeom, S., Yoon, S., Sethi, N., Bass, A. J., & Zhang, H. (2024). Recurrent RhoGAP gene fusion CLDN18-ARHGAP26 promotes RHOA activation and focal adhesion kinase and YAP-TEAD signalling in diffuse gastric cancer. Gut, 73(8), 1280–1291. https://doi.org/10.1136/gutjnl-2023-329686
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Bobba, S., Chauhan, K. S., Akter, S., Das, S., Mittal, E., Mathema, B., Philips, J. A., & Khader, S. A. (2024). A protective role for type I interferon signaling following infection with Mycobacterium tuberculosis carrying the rifampicin drug resistance-conferring RpoB mutation H445Y. PLOS Pathogens, 20(4), e1012137. https://doi.org/10.1371/journal.ppat.1012137
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Biswas, S., Shahriar, S., Bachay, G., Arvanitis, P., Jamoul, D., Brunken, W. J., & Agalliu, D. (2024). Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin/β-catenin signaling. Neuron, 112(12), 1978-1996.e6. https://doi.org/10.1016/j.neuron.2024.03.011
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Li, D., Wang, X., Chen, K., Shan, D., Cui, G., Yuan, W., Lin, Q., Gimple, R. C., Dixit, D., Lu, C., Gu, D., You, H., Gao, J., Li, Y., Kang, T., Yang, J., Yu, H., Song, K., Shi, Z., … Wang, X. (2024). IFI35 regulates non-canonical NF-κB signaling to maintain glioblastoma stem cells and recruit tumor-associated macrophages. Cell Death & Differentiation, 31(6), 738–752. https://doi.org/10.1038/s41418-024-01292-8
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Wu, C., Cai, X., Wang, Y., Rodriguez, C. D., Zoaldi, G., Herrmann, L., Huang, C.-Y., Wang, X., Sanghvi, V. R., Lu, R. O., & Meng, Z. (2024). Interplay of RAP2 GTPase and the cytoskeleton in Hippo pathway regulation. Journal of Biological Chemistry, 300(5), 107257. https://doi.org/10.1016/j.jbc.2024.107257
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Shih, B. B., Ma, C., Cortes, J. R., Reglero, C., Miller, H., Quinn, S. A., Albero, R., Laurent, A. P., Mackey, A., Ferrando, A. A., Geskin, L., & Palomero, T. (2024). Romidepsin and Afatinib Abrogate Jak–Signal Transducer and Activator of Transcription Signaling and Elicit Synergistic Antitumor Effects in Cutaneous T-Cell Lymphoma. Journal of Investigative Dermatology, 144(7), 1579-1589.e8. https://doi.org/10.1016/j.jid.2023.12.010
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Kitsak, M., Ganin, A., Elmokashfi, A., Cui, H., Eisenberg, D. A., Alderson, D. L., Korkin, D., & Linkov, I. (2023). Finding shortest and nearly shortest path nodes in large substantially incomplete networks by hyperbolic mapping. Nature Communications, 14(1). https://doi.org/10.1038/s41467-022-35181-w
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Columbia Affiliation
Mehta, V., Dwivedi, A. R., Ludhiadch, A., Rana, V., Goel, K. K., Uniyal, P., Joshi, G., Kumar, A., & Kumar, B. (2024). A decade of USFDA-approved small molecules as anti-inflammatory agents: Recent trends and Commentaries on the “industrial” perspective. European Journal of Medicinal Chemistry, 263, 115942. https://doi.org/10.1016/j.ejmech.2023.115942
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Gu, H. J., Ahn, J. S., Ahn, G. J., Shin, S. H., & Ryu, B.-Y. (2023). Restoration of PM2.5-induced spermatogonia GC-1 cellular damage by parthenolide via suppression of autophagy and inflammation: An in vitro study. Toxicology, 499, 153651. https://doi.org/10.1016/j.tox.2023.153651
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Lee, K. H., Manning, J. J., Javitch, J., & Shi, L. (2023). A Novel “Activation Switch” Motif Common to All Aminergic Receptors. Journal of Chemical Information and Modeling, 63(16), 5001–5017. https://doi.org/10.1021/acs.jcim.3c00732
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DeBlasi, J. M., Falzone, A., Caldwell, S., Prieto-Farigua, N., Prigge, J. R., Schmidt, E. E., Chio, I. I. C., Karreth, F. A., & DeNicola, G. M. (2023). Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression. Cancer Research, 83(12), 1953–1967. https://doi.org/10.1158/0008-5472.can-22-3848
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Chen, L., Fu, L., Sun, J., Huang, Z., Fang, M., Zinkle, A., Liu, X., Lu, J., Pan, Z., Wang, Y., Liang, G., Li, X., Chen, G., & Mohammadi, M. (2023). Structural basis for FGF hormone signalling. Nature, 618(7966), 862–870. https://doi.org/10.1038/s41586-023-06155-9
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Ong, H. W., Liang, Y., Richardson, W., Lowry, E. R., Wells, C. I., Chen, X., Silvestre, M., Dempster, K., Silvaroli, J. A., Smith, J. L., Wichterle, H., Pabla, N. S., Ultanir, S. K., Bullock, A. N., Drewry, D. H., & Axtman, A. D. (2023). Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS Chemical Neuroscience, 14(9), 1672–1685. https://doi.org/10.1021/acschemneuro.3c00135
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Patterson, V., Ullah, F., Bryant, L., Li, D., Griffin, J. N., Sidhu, A., Saliganan, S., Blaile, M., Saenz, M. S., Smith, R., Ellingwood, S., Grange, D. K., Hu, X., Mireguli, M., Luo, Y., Shen, Y., Mulhern, M., Zackai, E., Ritter, A., … Bhoj, E. (2023). Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish. Science Advances, 9(17). https://doi.org/10.1126/sciadv.ade0631
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Perry-Hauser, N. A., VanDyck, M. W., Lee, K. H., Shi, L., & Javitch, J. A. (2022). Disentangling autoproteolytic cleavage from tethered agonist–dependent activation of the adhesion receptor ADGRL3. Journal of Biological Chemistry, 298(12), 102594. https://doi.org/10.1016/j.jbc.2022.102594
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Su, H., Yang, F., Fu, R., Trinh, B., Sun, N., Liu, J., Kumar, A., Baglieri, J., Siruno, J., Le, M., Li, Y., Dozier, S., Nair, A., Filliol, A., Sinchai, N., Rosenthal, S. B., Santini, J., Metallo, C. M., Molina, A., … Karin, M. (2022). Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature, 610(7931), 366–372. https://doi.org/10.1038/s41586-022-05169-z
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Zhou, D., Wu, Z., Park, J.-G., Fiches, G. N., Li, T.-W., Ma, Q., Huang, H., Biswas, A., Martinez-Sobrido, L., Santoso, N. G., & Zhu, J. (2022). FACT subunit SUPT16H associates with BRD4 and contributes to silencing of interferon signaling. Nucleic Acids Research, 50(15), 8700–8718. https://doi.org/10.1093/nar/gkac645
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Broustas, C. G., Mukherjee, S., Pannkuk, E. L., Laiakis, E. C., Fornace, A. J., & Amundson, S. A. (2022). Effect of the p38 Mitogen-Activated Protein Kinase Signaling Cascade on Radiation Biodosimetry. Radiation Research, 198(1). https://doi.org/10.1667/rade-21-00240.1
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Han, H., Wang, Y., Curto, J., Gurrapu, S., Laudato, S., Rumandla, A., Chakraborty, G., Wang, X., Chen, H., Jiang, Y., Kumar, D., Caggiano, E. G., Capogiri, M., Zhang, B., Ji, Y., Maity, S. N., Hu, M., Bai, S., Aparicio, A. M., … Giancotti, F. G. (2022). Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasis. Cell Reports, 39(1), 110595. https://doi.org/10.1016/j.celrep.2022.110595
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Bhat, N., Narayanan, A., Fathzadeh, M., Kahn, M., Zhang, D., Goedeke, L., Neogi, A., Cardone, R. L., Kibbey, R. G., Fernandez-Hernando, C., Ginsberg, H. N., Jain, D., Shulman, G. I., & Mani, A. (2022). Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice. Journal of Clinical Investigation, 132(3). https://doi.org/10.1172/jci153724
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