Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice

Bhat, N., Narayanan, A., Fathzadeh, M., Kahn, M., Zhang, D., Goedeke, L., Neogi, A., Cardone, R. L., Kibbey, R. G., Fernandez-Hernando, C., Ginsberg, H. N., Jain, D., Shulman, G. I., & Mani, A. (2022). Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice. Journal of Clinical Investigation, 132(3). https://doi.org/10.1172/jci153724

Authors:

Neha Bhat

Anand Narayanan

Mohsen Fathzadeh

Mario Kahn

Dongyan Zhang

Leigh Goedeke

Arpita Neogi

Rebecca L. Cardone

Richard G. Kibbey

Carlos Fernandez-Hernando

Henry N. Ginsberg