Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective

Ong, H. W., Liang, Y., Richardson, W., Lowry, E. R., Wells, C. I., Chen, X., Silvestre, M., Dempster, K., Silvaroli, J. A., Smith, J. L., Wichterle, H., Pabla, N. S., Ultanir, S. K., Bullock, A. N., Drewry, D. H., & Axtman, A. D. (2023). Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS Chemical Neuroscience, 14(9), 1672–1685. https://doi.org/10.1021/acschemneuro.3c00135
Authors:
Han Wee Ong
Yi Liang
William Richardson
Emily R Lowry
Carrow I Wells
Xiangrong Chen
Margaux Silvestre
Kelvin Dempster
Josie A Silvaroli
Jeffery L Smith
Hynek Wichterle
Navjot S Pabla
Sila K Ultanir
Alex N Bullock
David H Drewry
Alison D Axtman
Affiliated Authors:
Emily R Lowry
Hynek Wichterle
Author Keywords:
cdkl5
chemical probe
crystal structure
gsk3α
gsk3β
kinase
neuroprotective
Publication Type:
Article
Unique ID:
10.1021/acschemneuro.3c00135
PMID:
Publication Date:
Data Source:
PubMed

Record Created: