Ribosome Structure and Translation Mechanisms

Displaying 1 - 35 of 35CSV
Thomas, H. B., Demain, L. A. M., Cabrera-Orefice, A., Schrauwen, I., Shamseldin, H. E., Rea, A., Bharadwaj, T., Smith, T. B., Oláhová, M., Thompson, K., He, L., Kaur, N., Shukla, A., Abukhalid, M., Ansar, M., Rehman, S., Riazuddin, S., Abdulwahab, F., Smith, J. M., … Newman, W. G. (2025). Bi-allelic variants in MRPL49 cause variable clinical presentations, including sensorineural hearing loss, leukodystrophy, and ovarian insufficiency. The American Journal of Human Genetics. https://doi.org/10.1016/j.ajhg.2025.02.005
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Borck, P. C., Boyle, I., Jankovic, K., Bick, N., Foster, K., Lau, A. C., Parker-Burns, L. I., Lubicki, D. A., Li, T., Borah, A. A., Lofaso, N. J., Das Sharma, S., Chan, T., Kishen, R. V., Adeagbo, A., Raghavan, S., Aquilanti, E., Prensner, J. R., Krill-Burger, J. M., … Vazquez, F. (2025). SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO. Nature, 638(8052), 1104–1111. https://doi.org/10.1038/s41586-024-08509-3
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Wang, Z., Liu, Z., Fang, Y., Zhang, H. H., Sun, X., Hao, N., Que, J., & Ding, H. (2025). Training data diversity enhances the basecalling of novel RNA modification-induced nanopore sequencing readouts. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-55974-z
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Lessel, I., Baresic, A., Chinn, I. K., May, J., Goenka, A., Chandler, K. E., Posey, J. E., Afenjar, A., Averdunk, L., Bedeschi, M. F., Besnard, T., Brager, R., Brick, L., Brugger, M., Brunet, T., Byrne, S., Calle-Martín, O. de la, Capra, V., Cardenas, P., … Lessel, D. (2025). DNA-binding affinity and specificity determine the phenotypic diversity in BCL11B-related disorders. The American Journal of Human Genetics. https://doi.org/10.1016/j.ajhg.2024.12.012
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Xie, S. C., Tai, C.-W., Morton, C. J., Ma, L., Huang, S.-C., Wittlin, S., Du, Y., Hu, Y., Dogovski, C., Salimimarand, M., Griffin, R., England, D., de la Cruz, E., Deni, I., Yeo, T., Burkhard, A. Y., Striepen, J., Schindler, K. A., Crespo, B., … Tilley, L. (2024). A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo. PLOS Pathogens, 20(12), e1012429. https://doi.org/10.1371/journal.ppat.1012429
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del Rivero Morfin, P. J., Chavez, D. S., Jayaraman, S., Yang, L., Geisler, S. M., Kochiss, A. L., Tuluc, P., Colecraft, H. M., Marx, S. O., Liu, X. S., Rajadhyaksha, A. M., & Ben-Johny, M. (2024). A genetically encoded actuator boosts L-type calcium channel function in diverse physiological settings. Science Advances, 10(44). https://doi.org/10.1126/sciadv.adq3374
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Jeon, Y., Lu, Y., Ferrari, M. M., Channagiri, T., Xu, P., Meers, C., Zhang, Y., Balachander, S., Park, V. S., Marsili, S., Pursell, Z. F., Jonoska, N., & Storici, F. (2024). RNA-mediated double-strand break repair by end-joining mechanisms. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-51457-9
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Elvira-Blázquez, D., Fernández-Justel, J. M., Arcas, A., Statello, L., Goñi, E., González, J., Ricci, B., Zaccara, S., Raimondi, I., & Huarte, M. (2024). YTHDC1 m6A-dependent and m6A-independent functions converge to preserve the DNA damage response. The EMBO Journal, 43(16), 3494–3522. https://doi.org/10.1038/s44318-024-00153-x
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Kim, J., Kratz, A. F., Chen, S., Sheng, J., Kim, H. K., Zhang, L., Singh, B. K., & Chavez, A. (2024). High-throughput tagging of endogenous loci for rapid characterization of protein function. Science Advances, 10(18). https://doi.org/10.1126/sciadv.adg8771
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Small-Saunders, J. L., Sinha, A., Bloxham, T. S., Hagenah, L. M., Sun, G., Preiser, P. R., Dedon, P. C., & Fidock, D. A. (2024). tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum. Nature Microbiology, 9(6), 1483–1498. https://doi.org/10.1038/s41564-024-01664-3
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El Sayyed, H., Pambos, O. J., Stracy, M., Gottesman, M. E., & Kapanidis, A. N. (2024). Single-molecule tracking reveals the functional allocation, in vivo interactions, and spatial organization of universal transcription factor NusG. Molecular Cell, 84(5), 926-937.e4. https://doi.org/10.1016/j.molcel.2024.01.025
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Xie, S. C., Wang, Y., Morton, C. J., Metcalfe, R. D., Dogovski, C., Pasaje, C. F. A., Dunn, E., Luth, M. R., Kumpornsin, K., Istvan, E. S., Park, J. S., Fairhurst, K. J., Ketprasit, N., Yeo, T., Yildirim, O., Bhebhe, M. N., Klug, D. M., Rutledge, P. J., Godoy, L. C., … Tilley, L. (2024). Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-45224-z
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Bartosch, A. M. W., Youth, E. H. H., Hansen, S., Wu, Y., Buchanan, H. M., Kaufman, M. E., Xiao, H., Koo, S. Y., Ashok, A., Sivakumar, S., Soni, R. K., Dumitrescu, L. C., Lam, T. G., Ropri, A. S., Lee, A. J., Klein, H.-U., Vardarajan, B. N., Bennett, D. A., Young-Pearse, T. L., … Teich, A. F. (2023). ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer’s disease. The Journal of Neuroscience, JN-RM-2324-22. https://doi.org/10.1523/jneurosci.2324-22.2023
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Li, D., Wang, Q., Bayat, A., Battig, M. R., Zhou, Y., Bosch, D. G. M., van Haaften, G., Granger, L., Petersen, A. K., Pérez-Jurado, L. A., Aznar-Laín, G., Aneja, A., Hancarova, M., Bendova, S., Schwarz, M., Kremlikova Pourova, R., Sedlacek, Z., Keena, B. A., March, M. E., … Hakonarson, H. (2024). Spliceosome malfunction causes neurodevelopmental disorders with overlapping features. Journal of Clinical Investigation, 134(1). https://doi.org/10.1172/jci171235
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Nygaard, R., Graham, C. L. B., Belcher Dufrisne, M., Colburn, J. D., Pepe, J., Hydorn, M. A., Corradi, S., Brown, C. M., Ashraf, K. U., Vickery, O. N., Briggs, N. S., Deering, J. J., Kloss, B., Botta, B., Clarke, O. B., Columbus, L., Dworkin, J., Stansfeld, P. J., Roper, D. I., & Mancia, F. (2023). Structural basis of peptidoglycan synthesis by E. coli RodA-PBP2 complex. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-40483-8
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Shamanskiy, V., Mikhailova, A. A., Tretiakov, E. O., Ushakova, K., Mikhailova, A. G., Oreshkov, S., Knorre, D. A., Ree, N., Overdevest, J. B., Lukowski, S. W., Gostimskaya, I., Yurov, V., Liou, C.-W., Lin, T.-K., Kunz, W. S., Reymond, A., Mazunin, I., Bazykin, G. A., Fellay, J., … Popadin, K. (2023). Secondary structure of the human mitochondrial genome affects formation of deletions. BMC Biology, 21(1). https://doi.org/10.1186/s12915-023-01606-1
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Blomquist, V. G., Niu, J., Choudhury, P., Al Saneh, A., Colecraft, H. M., & Ahern, C. A. (2023). Transfer RNA-mediated restoration of potassium current and electrical correction in premature termination long-QT syndrome hERG mutants. Molecular Therapy - Nucleic Acids, 34, 102032. https://doi.org/10.1016/j.omtn.2023.102032
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Myers, S. J., Yuan, H., Perszyk, R. E., Zhang, J., Kim, S., Nocilla, K. A., Allen, J. P., Bain, J. M., Lemke, J. R., Lal, D., Benke, T. A., & Traynelis, S. F. (2023). Classification of missense variants in the N-methyl-d-aspartate receptor GRIN gene family as gain- or loss-of-function. Human Molecular Genetics, 32(19), 2857–2871. https://doi.org/10.1093/hmg/ddad104
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FitzPatrick, V. D., Leemans, C., van Arensbergen, J., van Steensel, B., & Bussemaker, H. J. (2023). Defining the fine structure of promoter activity on a genome-wide scale with CISSECTOR. Nucleic Acids Research, 51(11), 5499–5511. https://doi.org/10.1093/nar/gkad232
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Botta, S., de Prisco, N., Chemiakine, A., Brandt, V., Cabaj, M., Patel, P., Doron‐Mandel, E., Treadway, C. J., Jovanovic, M., Brown, N. G., Soni, R. K., & Gennarino, V. A. (2023). Dosage sensitivity to Pumilio1 variants in the mouse brain reflects distinct molecular mechanisms. The EMBO Journal, 42(11). Portico. https://doi.org/10.15252/embj.2022112721
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Istvan, E. S., Guerra, F., Abraham, M., Huang, K.-S., Rocamora, F., Zhao, H., Xu, L., Pasaje, C., Kumpornsin, K., Luth, M. R., Cui, H., Yang, T., Palomo Diaz, S., Gomez-Lorenzo, M. G., Qahash, T., Mittal, N., Ottilie, S., Niles, J., Lee, M. C. S., … Winzeler, E. A. (2023). Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Science Translational Medicine, 15(686). https://doi.org/10.1126/scitranslmed.adc9249
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Jin, D., Zhu, Y., Schubert, H. L., Goff, S. P., & Musier-Forsyth, K. (2023). HIV-1 Gag Binds the Multi-Aminoacyl-tRNA Synthetase Complex via the EPRS Subunit. Viruses, 15(2), 474. https://doi.org/10.3390/v15020474
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Ford, L., Asok, A., Tripp, A. D., Parro, C., Fitzpatrick, M., de Solis, C. A., Chen, P.-T. Y., Shafiian, N., Fioriti, L., Soni, R. K., & Kandel, E. R. (2023). CPEB3 low-complexity motif regulates local protein synthesis via protein–protein interactions in neuronal ribonucleoprotein granules. Proceedings of the National Academy of Sciences, 120(6). https://doi.org/10.1073/pnas.2114747120
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Hsu, D. J., Gao, J., Yamaguchi, N., Pinzaru, A., Wu, Q., Mandayam, N., Liberti, M., Heissel, S., Alwaseem, H., Tavazoie, S., & Tavazoie, S. F. (2023). Arginine limitation drives a directed codon-dependent DNA sequence evolution response in colorectal cancer cells. Science Advances, 9(1). https://doi.org/10.1126/sciadv.ade9120
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Ressler, A. K., Sampaio, G. L. A., Dugger, S. A., Sapir, T., Krizay, D., Boland, M. J., Reiner, O., & Goldstein, D. B. (2023). Evidence of shared transcriptomic dysregulation of HNRNPU-related disorder between human organoids and embryonic mice. IScience, 26(1), 105797. https://doi.org/10.1016/j.isci.2022.105797
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Metz, J. B., Hornstein, N. J., Sharma, S. D., Worley, J., Gonzalez, C., & Sims, P. A. (2022). High-throughput translational profiling with riboPLATE-seq. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-09638-3
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Masuda, I., Yamaki, Y., Detroja, R., Tagore, S., Moore, H., Maharjan, S., Nakano, Y., Christian, T., Matsubara, R., Lowe, T. M., Frenkel-Morgenstern, M., & Hou, Y.-M. (2022). tRNA methylation resolves codon usage bias at the limit of cell viability. Cell Reports, 41(4), 111539. https://doi.org/10.1016/j.celrep.2022.111539
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Glazer, A. M., Davogustto, G., Shaffer, C. M., Vanoye, C. G., Desai, R. R., Farber-Eger, E. H., Dikilitas, O., Shang, N., Pacheco, J. A., Yang, T., Muhammad, A., Mosley, J. D., Van Driest, S. L., Wells, Q. S., Shaffer, L. L., Kalash, O. R., Wada, Y., Bland, H. T., Yoneda, Z. T., … Roden, D. M. (2022). Arrhythmia Variant Associations and Reclassifications in the eMERGE-III Sequencing Study. Circulation, 145(12), 877–891. https://doi.org/10.1161/circulationaha.121.055562
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Blomquist, V. G., Niu, J., Colecraft, H. M., & Ahern, C. A. (2022). Suppressor TRNA-mediated rescue of hERG LQTS2 nonsense mutations. Biophysical Journal, 121(3), 177a. https://doi.org/10.1016/j.bpj.2021.11.1853
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Ma, Y., Dammer, E. B., Felsky, D., Duong, D. M., Klein, H.-U., White, C. C., Zhou, M., Logsdon, B. A., McCabe, C., Xu, J., Wang, M., Wingo, T. S., Lah, J. J., Zhang, B., Schneider, J., Allen, M., Wang, X., Ertekin-Taner, N., Seyfried, N. T., … De Jager, P. L. (2021). Atlas of RNA editing events affecting protein expression in aged and Alzheimer’s disease human brain tissue. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-27204-9
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