eLife
Displaying 1 - 49 of 49
Barber, A. G., Quintero, C. M., Hamilton, M., Rajbhandari, N., Sasik, R., Zhang, Y., Kim, C., Husain, H., Sun, X., & Reya, T. (2025). Regulation of lung cancer initiation and progression by the stem cell determinant Musashi. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.97021
Publication Date
Columbia Affiliation
Hahn, H., Daly, C., Little, J., Perry-Hauser, N. A., Flores-Espinoza, E., Inoue, A., Plouffe, B., & Thomsen, A. R. (2025). Endosomal chemokine receptor signalosomes regulate central mechanisms underlying cell migration. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.99373
Publication Date
Columbia Affiliation
Perkins, S. M., Amematsro, E. A., Cunningham, J., Wang, Q., & Churchland, M. M. (2025). An emerging view of neural geometry in motor cortex supports high-performance decoding. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.89421
Publication Date
Columbia Affiliation
Hui, D., Dudek, S., Kiryluk, K., Walunas, T. L., Kullo, I. J., Wei, W.-Q., Tiwari, H., Peterson, J. F., Chung, W. K., Davis, B. H., Khan, A., Kottyan, L. C., Limdi, N. A., Feng, Q., Puckelwartz, M. J., Weng, C., Smith, J. L., Karlson, E. W., … Ritchie, M. D. (2025). Risk factors affecting polygenic score performance across diverse cohorts. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.88149
Publication Date
Columbia Affiliation
Balasubramanian, R., Kizhatil, K., Li, T., Tolman, N., Bhandari, A., Clark, G., Bupp-Chickering, V., Kelly, R. A., Zhou, S., Peregrin, J., Simón, M., Montgomery, C., Stamer, W. D., Qian, J., & John, S. W. (2024). Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.96459.3
Publication Date
Columbia Affiliation
View
Shore, A. N., Li, K., Safari, M., Qunies, A. M., Spitznagel, B. D., Weaver, C. D., Emmitte, K., Frankel, W., & Weston, M. C. (2024). Heterozygous expression of a Kcnt1 gain-of-function variant has differential effects on somatostatin- and parvalbumin-expressing cortical GABAergic neurons. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.92915
Publication Date
Columbia Affiliation
Raudales, R., Kim, G., Kelly, S. M., Hatfield, J., Guan, W., Zhao, S., Paul, A., Qian, Y., Li, B., & Huang, Z. J. (2024). Specific and comprehensive genetic targeting reveals brain-wide distribution and synaptic input patterns of GABAergic axo-axonic interneurons. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.93481
Publication Date
Columbia Affiliation
Jellinger, A. L., Suthard, R. L., Yuan, B., Surets, M., Ruesch, E. A., Caban, A. J., Liu, S., Shpokayte, M., & Ramirez, S. (2024). Chronic activation of a negative engram induces behavioral and cellular abnormalities. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.96281
Publication Date
Columbia Affiliation
Yu, H., Nishio, H., Barbi, J., Mitchell-Flack, M., Vignali, P. D., Zheng, Y., Lebid, A., Chang, K.-Y., Fu, J., Higgins, M., Huang, C.-T., Zhang, X., Li, Z., Blosser, L., Tam, A., Drake, C., & Pardoll, D. (2024). Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.96812
Publication Date
Columbia Affiliation
View
Balasubramanian, R., Kizhatil, K., Li, T., Tolman, N., Bhandari, A., Clark, G., Bupp-Chickering, V., Kelly, R. A., Zhou, S., Peregrin, J., Simón, M., Montgomery, C., Stamer, W. D., Qian, J., & John, S. W. (2024). Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.96459
Publication Date
Columbia Affiliation
Oevel, K., Hohensee, S., Kumar, A., Rosas-Brugada, I., Bartolini, F., Soykan, T., & Haucke, V. (2024). Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.92755.3
Publication Date
Columbia Affiliation
Cullen, E. R., Safari, M., Mittelstadt, I., & Weston, M. C. (2024). Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.91323
Publication Date
Bashkirova, E. V., Klimpert, N., Monahan, K., Campbell, C. E., Osinski, J., Tan, L., Schieren, I., Pourmorady, A., Stecky, B., Barnea, G., Xie, X. S., Abdus-Saboor, I., Shykind, B. M., Marlin, B. J., Gronostajski, R. M., Fleischmann, A., & Lomvardas, S. (2023). Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.87445
Publication Date
Columbia Affiliation
Löffler, A., Zylberberg, A., Shadlen, M. N., & Wolpert, D. M. (2023). Judging the difficulty of perceptual decisions. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.86892
Publication Date
Columbia Affiliation
View
Miura, A., Sarmah, H., Tanaka, J., Hwang, Y., Sawada, A., Shimamura, Y., Otoshi, T., Kondo, Y., Fang, Y., Shimizu, D., Ninish, Z., Suer, J. L., Dubois, N. C., Davis, J., Toyooka, S., Wu, J., Que, J., Hawkins, F. J., Lin, C.-S., & Mori, M. (2023). Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes the generation of the whole lung. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.86105
Publication Date
Columbia Affiliation
Center for Stem Cell Therapies; Center for Human Development; Vagelos College of Physicians and Surgeons; Department of Genetics and Development; Department of Medicine; Division of Pulmonary, Allergy, and Critical Care Medicine; Division of Digestive and Liver Diseases; Department of Pathology and Cell Biology
Nagaraj, G., Vinayak, S., Khaki, A. R., Sun, T., Kuderer, N. M., Aboulafia, D. M., Acoba, J. D., Awosika, J., Bakouny, Z., Balmaceda, N. B., Bao, T., Bashir, B., Berg, S., Bilen, M. A., Bindal, P., Blau, S., Bodin, B. E., Borno, H. T., … Castellano, C. (2023). Clinical characteristics, racial inequities, and outcomes in patients with breast cancer and COVID-19: A COVID-19 and cancer consortium (CCC19) cohort study. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.82618
Publication Date
Columbia Affiliation
View
Zou, X., Shanmugam, S. K., Kanner, S. A., Sampson, K. J., Kass, R. S., & Colecraft, H. M. (2023). Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.83466
Publication Date
Columbia Affiliation
View
Kimble, M. T., Johnson, M. J., Nester, M. R., & Symington, L. S. (2023). Long-range DNA end resection supports homologous recombination by checkpoint activation rather than extensive homology generation. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.84322
Publication Date
Columbia Affiliation
Zhao, J., Fan, B., Huang, J., Cowling, B. J., Au Yeung, S. L. R., Baccarelli, A., Leung, G. M., & Schooling, C. M. (2023). Environment- and epigenome-wide association study of obesity in ‘Children of 1997’ birth cohort. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.82377
Publication Date
Columbia Affiliation
Padavannil, A., Murari, A., Rhooms, S.-K., Owusu-Ansah, E., & Letts, J. A. (2023). Resting mitochondrial complex I from Drosophila melanogaster adopts a helix-locked state. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.84415
Publication Date
Columbia Affiliation
Sherif, Z. A., Gomez, C. R., Connors, T. J., Henrich, T. J., & Reeves, W. B. (2023). Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC). ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.86002
Publication Date
Columbia Affiliation
View
Pederick, D. T., Perry-Hauser, N. A., Meng, H., He, Z., Javitch, J. A., & Luo, L. (2023). Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.83529
Publication Date
Columbia Affiliation
View
Macaisne, N., Bellutti, L., Laband, K., Edwards, F., Pitayu-Nugroho, L., Gervais, A., Ganeswaran, T., Geoffroy, H., Maton, G., Canman, J. C., Lacroix, B., & Dumont, J. (2023). Synergistic stabilization of microtubules by BUB-1, HCP-1, and CLS-2 controls microtubule pausing and meiotic spindle assembly. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.82579
Publication Date
Columbia Affiliation
View
Agarwal, I., Fuller, Z. L., Myers, S. R., & Przeworski, M. (2023). Relating pathogenic loss-of-function mutations in humans to their evolutionary fitness costs. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.83172
Publication Date
Columbia Affiliation
Canetta, S. E., Holt, E. S., Benoit, L. J., Teboul, E., Sahyoun, G. M., Ogden, R. T., Harris, A. Z., & Kellendonk, C. (2022). Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.80324
Publication Date
Columbia Affiliation
Oppong, R. F., Terracciano, A., Picard, M., Qian, Y., Butler, T. J., Tanaka, T., Moore, A. Z., Simonsick, E. M., Opsahl-Ong, K., Coletta, C., Sutin, A. R., Gorospe, M., Resnick, S. M., Cucca, F., Scholz, S. W., Traynor, B. J., Schlessinger, D., Ferrucci, L., & Ding, J. (2022). Personality traits are consistently associated with blood mitochondrial DNA copy number estimated from genome sequences in two genetic cohort studies. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.77806
Publication Date
Columbia Affiliation
Li, Y., Wu, Y., Federzoni, E. A., Wang, X., Dharmawan, A., Hu, X., Wang, H., Hawley, R. J., Stevens, S., Sykes, M., & Yang, Y.-G. (2022). CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.73677
Publication Date
Columbia Affiliation
Feng, Y., Neme, R., Beh, L. Y., Chen, X., Braun, J., Lu, M. W., & Landweber, L. F. (2022). Comparative genomics reveals insight into the evolutionary origin of massively scrambled genomes. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.82979
Publication Date
Columbia Affiliation
View
Li, J., Wu, J., Hall, C., Bai, X., & Choi, E. (2022). Molecular basis for the role of disulfide-linked αCTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.81286
Publication Date
Columbia Affiliation
Hay, J. A., Kissler, S. M., Fauver, J. R., Mack, C., Tai, C. G., Samant, R. M., Connolly, S., Anderson, D. J., Khullar, G., MacKay, M., Patel, M., Kelly, S., Manhertz, A., Eiter, I., Salgado, D., Baker, T., Howard, B., Dudley, J. T., Mason, C. E., … Grad, Y. H. (2022). Quantifying the impact of immune history and variant on SARS-CoV-2 viral kinetics and infection rebound: A retrospective cohort study. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.81849
Publication Date
Columbia Affiliation
Xu, X., Hua, X., Brown, K., Ren, X., & Zhang, Z. (2022). Mcm2 promotes stem cell differentiation via its ability to bind H3-H4. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.80917
Publication Date
Columbia Affiliation
Zhou, Y., Yang, Y., Guo, L., Qian, J., Ge, J., Sinner, D., Ding, H., Califano, A., & Cardoso, W. V. (2022). Airway basal cells show regionally distinct potential to undergo metaplastic differentiation. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.80083
Publication Date
Columbia Affiliation
Department of Medicine; Vagelos College of Physicians and Surgeons; Department of Pediatrics; Division of Pediatric Gastroenterology, Hepatology, and Nutrition; Department of Systems Biology; Department of Biochemistry and Molecular Biophysics; Department of Biomedical Informatics; Division of Hematology/Oncology; Center for Human Development; Department of Genetics and Development; Herbert Irving Comprehensive Cancer Center; Division of Pulmonary, Allergy, and Critical Care Medicine
Huang, H., Fang, Y., Jiang, M., Zhang, Y., Biermann, J., Melms, J. C., Danielsson, J. A., Yang, Y., Qiang, L., Liu, J., Zhou, Y., Wang, M., Hu, Z., Wang, T. C., Saqi, A., Sun, J., Matsumoto, I., Cardoso, W. V., Emala, C. W., … Que, J. (2022). Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.78217
Publication Date
Columbia Affiliation
Department of Medicine; Vagelos College of Physicians and Surgeons; Department of Anesthesiology; Division of Preventive Medicine and Nutrition; Department of Pathology and Cell Biology; Division of Hematology/Oncology; Department of Systems Biology; Division of Digestive and Liver Diseases; Center for Human Development; Center for Translational Immunology; Division of Pulmonary, Allergy, and Critical Care Medicine
Trolle, J., McBee, R. M., Kaufman, A., Pinglay, S., Berger, H., German, S., Liu, L., Shen, M. J., Guo, X., Martin, J. A., Pacold, M. E., Jones, D. R., Boeke, J. D., & Wang, H. H. (2022). Resurrecting essential amino acid biosynthesis in mammalian cells. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.72847
Publication Date
Columbia Affiliation
Yang, W., & Shaman, J. L. (2022). COVID-19 pandemic dynamics in South Africa and epidemiological characteristics of three variants of concern (Beta, Delta, and Omicron). ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.78933
Publication Date
Columbia Affiliation
de Manuel, M., Wu, F. L., & Przeworski, M. (2022). A paternal bias in germline mutation is widespread in amniotes and can arise independently of cell division numbers. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.80008
Publication Date
Columbia Affiliation
Akalu, Y. T., Mercau, M. E., Ansems, M., Hughes, L. D., Nevin, J., Alberto, E. J., Liu, X. N., He, L.-Z., Alvarado, D., Keler, T., Kong, Y., Philbrick, W. M., Bosenberg, M., Finnemann, S. C., Iavarone, A., Lasorella, A., Rothlin, C. V., & Ghosh, S. (2022). Tissue-specific modifier alleles determine Mertk loss-of-function traits. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.80530
Publication Date
Columbia Affiliation
Martyniuk, K. M., Torres-Herraez, A., Lowes, D. C., Rubinstein, M., Labouesse, M. A., & Kellendonk, C. (2022). Dopamine D2Rs coordinate cue-evoked changes in striatal acetylcholine levels. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.76111
Publication Date
Columbia Affiliation
Rane, S., Hogan, T., Lee, E., Seddon, B., & Yates, A. J. (2022). Towards a unified model of naive T cell dynamics across the lifespan. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.78168
Publication Date
Columbia Affiliation
Das, A., Myers, J., Mathura, R., Shofty, B., Metzger, B. A., Bijanki, K., Wu, C., Jacobs, J., & Sheth, S. A. (2022). Spontaneous neuronal oscillations in the human insula are hierarchically organized traveling waves. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.76702
Publication Date
Columbia Affiliation
Trambaiolli, L. R., Peng, X., Lehman, J. F., Linn, G., Russ, B. E., Schroeder, C. E., Liu, H., & Haber, S. N. (2022). Anatomical and functional connectivity support the existence of a salience network node within the caudal ventrolateral prefrontal cortex. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.76334
Publication Date
Columbia Affiliation
Goodman, K. M., Katsamba, P. S., Rubinstein, R., Ahlsén, G., Bahna, F., Mannepalli, S., Dan, H., Sampogna, R. V., Shapiro, L., & Honig, B. (2022). How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.72416
Publication Date
Columbia Affiliation
Francois, M., Canal Delgado, I., Shargorodsky, N., Leu, C.-S., & Zeltser, L. (2022). Assessing the effects of stress on feeding behaviors in laboratory mice. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.70271
Publication Date
Columbia Affiliation
Hobson, B. D., Choi, S. J., Mosharov, E. V., Soni, R. K., Sulzer, D., & Sims, P. A. (2022). Subcellular proteomics of dopamine neurons in the mouse brain. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.70921
Publication Date
Columbia Affiliation
Department of Systems Biology; Vagelos College of Physicians and Surgeons; Department of Biochemistry and Molecular Biophysics; Department of Psychiatry; Herbert Irving Comprehensive Cancer Center; Department of Neurology; Department of Molecular Pharmacology and Therapeutics; JP Sulzberger Columbia Genome Center
Smith, E. H., Liou, J., Merricks, E. M., Davis, T., Thomson, K., Greger, B., House, P., Emerson, R. G., Goodman, R., McKhann, G. M., Sheth, S., Schevon, C., & Rolston, J. D. (2022). Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.73541
Publication Date
Columbia Affiliation
Belsky, D. W., Caspi, A., Corcoran, D. L., Sugden, K., Poulton, R., Arseneault, L., Baccarelli, A., Chamarti, K., Gao, X., Hannon, E., Harrington, H. L., Houts, R., Kothari, M., Kwon, D., Mill, J., Schwartz, J., Vokonas, P., Wang, C., Williams, B. S., & Moffitt, T. E. (2022). DunedinPACE, a DNA methylation biomarker of the pace of aging. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.73420
Publication Date
Columbia Affiliation
Kimura, H., Paranal, R. M., Nanda, N., Wood, L. D., Eshleman, J. R., Hruban, R. H., Goggins, M. G., Klein, A. P., & Roberts, N. J. (2022). Functional CDKN2A assay identifies frequent deleterious alleles misclassified as variants of uncertain significance. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.71137
Publication Date
Columbia Affiliation
View
Rousová, D., Nivsarkar, V., Altmannova, V., Raina, V. B., Funk, S. K., Liedtke, D., Janning, P., Müller, F., Reichle, H., Vader, G., & Weir, J. R. (2021). Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation. ELife, 10. CLOCKSS. https://doi.org/10.7554/elife.72330
Publication Date
Columbia Affiliation
Loureiro-Campos, E., Mateus-Pinheiro, A., Patrício, P., Soares-Cunha, C., Silva, J., Sardinha, V. M., Mendes-Pinheiro, B., Silveira-Rosa, T., Domingues, A. V., Rodrigues, A. J., Oliveira, J., Sousa, N., Alves, N. D., & Pinto, L. (2021). Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods. ELife, 10. CLOCKSS. https://doi.org/10.7554/elife.70685
Publication Date
Columbia Affiliation