eLife

Displaying 1 - 49 of 49
Barber, A. G., Quintero, C. M., Hamilton, M., Rajbhandari, N., Sasik, R., Zhang, Y., Kim, C., Husain, H., Sun, X., & Reya, T. (2025). Regulation of lung cancer initiation and progression by the stem cell determinant Musashi. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.97021
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Hahn, H., Daly, C., Little, J., Perry-Hauser, N. A., Flores-Espinoza, E., Inoue, A., Plouffe, B., & Thomsen, A. R. (2025). Endosomal chemokine receptor signalosomes regulate central mechanisms underlying cell migration. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.99373
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Perkins, S. M., Amematsro, E. A., Cunningham, J., Wang, Q., & Churchland, M. M. (2025). An emerging view of neural geometry in motor cortex supports high-performance decoding. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.89421
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Hui, D., Dudek, S., Kiryluk, K., Walunas, T. L., Kullo, I. J., Wei, W.-Q., Tiwari, H., Peterson, J. F., Chung, W. K., Davis, B. H., Khan, A., Kottyan, L. C., Limdi, N. A., Feng, Q., Puckelwartz, M. J., Weng, C., Smith, J. L., Karlson, E. W., … Ritchie, M. D. (2025). Risk factors affecting polygenic score performance across diverse cohorts. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.88149
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Balasubramanian, R., Kizhatil, K., Li, T., Tolman, N., Bhandari, A., Clark, G., Bupp-Chickering, V., Kelly, R. A., Zhou, S., Peregrin, J., Simón, M., Montgomery, C., Stamer, W. D., Qian, J., & John, S. W. (2024). Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.96459.3
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Shore, A. N., Li, K., Safari, M., Qunies, A. M., Spitznagel, B. D., Weaver, C. D., Emmitte, K., Frankel, W., & Weston, M. C. (2024). Heterozygous expression of a Kcnt1 gain-of-function variant has differential effects on somatostatin- and parvalbumin-expressing cortical GABAergic neurons. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.92915
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Raudales, R., Kim, G., Kelly, S. M., Hatfield, J., Guan, W., Zhao, S., Paul, A., Qian, Y., Li, B., & Huang, Z. J. (2024). Specific and comprehensive genetic targeting reveals brain-wide distribution and synaptic input patterns of GABAergic axo-axonic interneurons. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.93481
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Jellinger, A. L., Suthard, R. L., Yuan, B., Surets, M., Ruesch, E. A., Caban, A. J., Liu, S., Shpokayte, M., & Ramirez, S. (2024). Chronic activation of a negative engram induces behavioral and cellular abnormalities. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.96281
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Yu, H., Nishio, H., Barbi, J., Mitchell-Flack, M., Vignali, P. D., Zheng, Y., Lebid, A., Chang, K.-Y., Fu, J., Higgins, M., Huang, C.-T., Zhang, X., Li, Z., Blosser, L., Tam, A., Drake, C., & Pardoll, D. (2024). Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.96812
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Balasubramanian, R., Kizhatil, K., Li, T., Tolman, N., Bhandari, A., Clark, G., Bupp-Chickering, V., Kelly, R. A., Zhou, S., Peregrin, J., Simón, M., Montgomery, C., Stamer, W. D., Qian, J., & John, S. W. (2024). Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states. ELife, 13. CLOCKSS. https://doi.org/10.7554/elife.96459
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Oevel, K., Hohensee, S., Kumar, A., Rosas-Brugada, I., Bartolini, F., Soykan, T., & Haucke, V. (2024). Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.92755.3
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Bashkirova, E. V., Klimpert, N., Monahan, K., Campbell, C. E., Osinski, J., Tan, L., Schieren, I., Pourmorady, A., Stecky, B., Barnea, G., Xie, X. S., Abdus-Saboor, I., Shykind, B. M., Marlin, B. J., Gronostajski, R. M., Fleischmann, A., & Lomvardas, S. (2023). Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.87445
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Miura, A., Sarmah, H., Tanaka, J., Hwang, Y., Sawada, A., Shimamura, Y., Otoshi, T., Kondo, Y., Fang, Y., Shimizu, D., Ninish, Z., Suer, J. L., Dubois, N. C., Davis, J., Toyooka, S., Wu, J., Que, J., Hawkins, F. J., Lin, C.-S., & Mori, M. (2023). Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes the generation of the whole lung. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.86105
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Nagaraj, G., Vinayak, S., Khaki, A. R., Sun, T., Kuderer, N. M., Aboulafia, D. M., Acoba, J. D., Awosika, J., Bakouny, Z., Balmaceda, N. B., Bao, T., Bashir, B., Berg, S., Bilen, M. A., Bindal, P., Blau, S., Bodin, B. E., Borno, H. T., … Castellano, C. (2023). Clinical characteristics, racial inequities, and outcomes in patients with breast cancer and COVID-19: A COVID-19 and cancer consortium (CCC19) cohort study. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.82618
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Zou, X., Shanmugam, S. K., Kanner, S. A., Sampson, K. J., Kass, R. S., & Colecraft, H. M. (2023). Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.83466
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Kimble, M. T., Johnson, M. J., Nester, M. R., & Symington, L. S. (2023). Long-range DNA end resection supports homologous recombination by checkpoint activation rather than extensive homology generation. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.84322
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Zhao, J., Fan, B., Huang, J., Cowling, B. J., Au Yeung, S. L. R., Baccarelli, A., Leung, G. M., & Schooling, C. M. (2023). Environment- and epigenome-wide association study of obesity in ‘Children of 1997’ birth cohort. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.82377
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Padavannil, A., Murari, A., Rhooms, S.-K., Owusu-Ansah, E., & Letts, J. A. (2023). Resting mitochondrial complex I from Drosophila melanogaster adopts a helix-locked state. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.84415
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Pederick, D. T., Perry-Hauser, N. A., Meng, H., He, Z., Javitch, J. A., & Luo, L. (2023). Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.83529
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Macaisne, N., Bellutti, L., Laband, K., Edwards, F., Pitayu-Nugroho, L., Gervais, A., Ganeswaran, T., Geoffroy, H., Maton, G., Canman, J. C., Lacroix, B., & Dumont, J. (2023). Synergistic stabilization of microtubules by BUB-1, HCP-1, and CLS-2 controls microtubule pausing and meiotic spindle assembly. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.82579
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Canetta, S. E., Holt, E. S., Benoit, L. J., Teboul, E., Sahyoun, G. M., Ogden, R. T., Harris, A. Z., & Kellendonk, C. (2022). Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.80324
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Oppong, R. F., Terracciano, A., Picard, M., Qian, Y., Butler, T. J., Tanaka, T., Moore, A. Z., Simonsick, E. M., Opsahl-Ong, K., Coletta, C., Sutin, A. R., Gorospe, M., Resnick, S. M., Cucca, F., Scholz, S. W., Traynor, B. J., Schlessinger, D., Ferrucci, L., & Ding, J. (2022). Personality traits are consistently associated with blood mitochondrial DNA copy number estimated from genome sequences in two genetic cohort studies. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.77806
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Li, Y., Wu, Y., Federzoni, E. A., Wang, X., Dharmawan, A., Hu, X., Wang, H., Hawley, R. J., Stevens, S., Sykes, M., & Yang, Y.-G. (2022). CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.73677
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Feng, Y., Neme, R., Beh, L. Y., Chen, X., Braun, J., Lu, M. W., & Landweber, L. F. (2022). Comparative genomics reveals insight into the evolutionary origin of massively scrambled genomes. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.82979
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Li, J., Wu, J., Hall, C., Bai, X., & Choi, E. (2022). Molecular basis for the role of disulfide-linked αCTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.81286
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Hay, J. A., Kissler, S. M., Fauver, J. R., Mack, C., Tai, C. G., Samant, R. M., Connolly, S., Anderson, D. J., Khullar, G., MacKay, M., Patel, M., Kelly, S., Manhertz, A., Eiter, I., Salgado, D., Baker, T., Howard, B., Dudley, J. T., Mason, C. E., … Grad, Y. H. (2022). Quantifying the impact of immune history and variant on SARS-CoV-2 viral kinetics and infection rebound: A retrospective cohort study. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.81849
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Huang, H., Fang, Y., Jiang, M., Zhang, Y., Biermann, J., Melms, J. C., Danielsson, J. A., Yang, Y., Qiang, L., Liu, J., Zhou, Y., Wang, M., Hu, Z., Wang, T. C., Saqi, A., Sun, J., Matsumoto, I., Cardoso, W. V., Emala, C. W., … Que, J. (2022). Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.78217
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Trolle, J., McBee, R. M., Kaufman, A., Pinglay, S., Berger, H., German, S., Liu, L., Shen, M. J., Guo, X., Martin, J. A., Pacold, M. E., Jones, D. R., Boeke, J. D., & Wang, H. H. (2022). Resurrecting essential amino acid biosynthesis in mammalian cells. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.72847
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Yang, W., & Shaman, J. L. (2022). COVID-19 pandemic dynamics in South Africa and epidemiological characteristics of three variants of concern (Beta, Delta, and Omicron). ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.78933
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de Manuel, M., Wu, F. L., & Przeworski, M. (2022). A paternal bias in germline mutation is widespread in amniotes and can arise independently of cell division numbers. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.80008
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Akalu, Y. T., Mercau, M. E., Ansems, M., Hughes, L. D., Nevin, J., Alberto, E. J., Liu, X. N., He, L.-Z., Alvarado, D., Keler, T., Kong, Y., Philbrick, W. M., Bosenberg, M., Finnemann, S. C., Iavarone, A., Lasorella, A., Rothlin, C. V., & Ghosh, S. (2022). Tissue-specific modifier alleles determine Mertk loss-of-function traits. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.80530
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Martyniuk, K. M., Torres-Herraez, A., Lowes, D. C., Rubinstein, M., Labouesse, M. A., & Kellendonk, C. (2022). Dopamine D2Rs coordinate cue-evoked changes in striatal acetylcholine levels. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.76111
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Rane, S., Hogan, T., Lee, E., Seddon, B., & Yates, A. J. (2022). Towards a unified model of naive T cell dynamics across the lifespan. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.78168
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Das, A., Myers, J., Mathura, R., Shofty, B., Metzger, B. A., Bijanki, K., Wu, C., Jacobs, J., & Sheth, S. A. (2022). Spontaneous neuronal oscillations in the human insula are hierarchically organized traveling waves. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.76702
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Trambaiolli, L. R., Peng, X., Lehman, J. F., Linn, G., Russ, B. E., Schroeder, C. E., Liu, H., & Haber, S. N. (2022). Anatomical and functional connectivity support the existence of a salience network node within the caudal ventrolateral prefrontal cortex. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.76334
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Goodman, K. M., Katsamba, P. S., Rubinstein, R., Ahlsén, G., Bahna, F., Mannepalli, S., Dan, H., Sampogna, R. V., Shapiro, L., & Honig, B. (2022). How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.72416
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Smith, E. H., Liou, J., Merricks, E. M., Davis, T., Thomson, K., Greger, B., House, P., Emerson, R. G., Goodman, R., McKhann, G. M., Sheth, S., Schevon, C., & Rolston, J. D. (2022). Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.73541
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Belsky, D. W., Caspi, A., Corcoran, D. L., Sugden, K., Poulton, R., Arseneault, L., Baccarelli, A., Chamarti, K., Gao, X., Hannon, E., Harrington, H. L., Houts, R., Kothari, M., Kwon, D., Mill, J., Schwartz, J., Vokonas, P., Wang, C., Williams, B. S., & Moffitt, T. E. (2022). DunedinPACE, a DNA methylation biomarker of the pace of aging. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.73420
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Kimura, H., Paranal, R. M., Nanda, N., Wood, L. D., Eshleman, J. R., Hruban, R. H., Goggins, M. G., Klein, A. P., & Roberts, N. J. (2022). Functional CDKN2A assay identifies frequent deleterious alleles misclassified as variants of uncertain significance. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.71137
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Rousová, D., Nivsarkar, V., Altmannova, V., Raina, V. B., Funk, S. K., Liedtke, D., Janning, P., Müller, F., Reichle, H., Vader, G., & Weir, J. R. (2021). Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation. ELife, 10. CLOCKSS. https://doi.org/10.7554/elife.72330
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Loureiro-Campos, E., Mateus-Pinheiro, A., Patrício, P., Soares-Cunha, C., Silva, J., Sardinha, V. M., Mendes-Pinheiro, B., Silveira-Rosa, T., Domingues, A. V., Rodrigues, A. J., Oliveira, J., Sousa, N., Alves, N. D., & Pinto, L. (2021). Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods. ELife, 10. CLOCKSS. https://doi.org/10.7554/elife.70685
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