Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma

Li, K., Tolman, N., Segrè, A. V., Stuart, K. V., Zeleznik, O. A., Vallabh, N. A., Hu, K., Zebardast, N., Hanyuda, A., Raita, Y., Montgomery, C., Zhang, C., Hysi, P. G., Do, R., Khawaja, A. P., Wiggs, J. L., Kang, J. H., John, S. W., & Pasquale, L. R. (2025). Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma. ELife, 14. CLOCKSS. https://doi.org/10.7554/elife.105576
Authors:
Keva Li
Nicholas Tolman
Ayellet V Segrè
Kelsey V Stuart
Oana A Zeleznik
Neeru A Vallabh
Kuang Hu
Nazlee Zebardast
Akiko Hanyuda
Yoshihiko Raita
Christa Montgomery
Chi Zhang
Pirro G Hysi
Ron Do
Anthony P Khawaja
Janey L Wiggs
Jae H Kang
Simon W M John
Louis R Pasquale
Affiliated Authors:
Nicholas Tolman
Christa Montgomery
Chi Zhang
Simon W M John
Columbia Affiliation:
Subjects:
Glaucoma (MeSH)
Pyruvic Acid (MeSH)
Genetic Predisposition to Disease (MeSH)
Author Keywords:
cell biology
genetics
genomics
glaucoma
glaucoma resilience
metabolomics
mouse
pyruvate
tricarboxylic acid cycle
elink
Publication Type:
Article
Unique ID:
10.7554/elife.105576
PMID:
40272416
DOI:
10.7554/elife.105576
Journal:
eLife
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record

Record Created: