Relating pathogenic loss-of-function mutations in humans to their evolutionary fitness costs

Agarwal, I., Fuller, Z. L., Myers, S. R., & Przeworski, M. (2023). Relating pathogenic loss-of-function mutations in humans to their evolutionary fitness costs. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.83172
Authors:
Ipsita Agarwal
Zachary L. Fuller
Molly Przeworski
Simon R. Myers
Affiliated Authors:
Ipsita Agarwal
Zachary L. Fuller
Molly Przeworski
Columbia Affiliation:
Author Keywords:
loss-of-function mutations
early-onset disease
human genetics
natural selection
distribution of fitness effects
x chromosome
human
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Publication Type:
Article
Unique ID:
10.7554/eLife.83172
PMID:
36648429
DOI:
10.7554/eLife.83172
Journal:
eLife
Publication Date:
Data Source:
Web of Science
Source Link:
View Web of Science Record

Record Created: