A genomic mutational constraint map using variation in 76,156 human genomes

Chen, S., Francioli, L. C., Goodrich, J. K., Collins, R. L., Kanai, M., Wang, Q., Alföldi, J., Watts, N. A., Vittal, C., Gauthier, L. D., Poterba, T., Wilson, M. W., Tarasova, Y., Phu, W., Grant, R., Yohannes, M. T., Koenig, Z., Farjoun, Y., … Banks, E. (2023). A genomic mutational constraint map using variation in 76,156 human genomes. Nature, 625(7993), 92–100. https://doi.org/10.1038/s41586-023-06045-0
Authors:
Siwei Chen
Laurent C. Francioli
Julia K. Goodrich
Ryan L. Collins
Masahiro Kanai
Qingbo Wang
Jessica Alföldi
Nicholas A. Watts
Christopher Vittal
Laura D. Gauthier
Timothy Poterba
Michael W. Wilson
Yekaterina Tarasova
William Phu
Riley Grant
Mary T. Yohannes
Zan Koenig
Yossi Farjoun
Eric Banks
Stacey Donnelly
Stacey Gabriel
Namrata Gupta
Steven Ferriera
Charlotte Tolonen
Sam Novod
Louis Bergelson
David Roazen
Valentin Ruano-Rubio
Miguel Covarrubias
Christopher Llanwarne
Nikelle Petrillo
Gordon Wade
Thibault Jeandet
Ruchi Munshi
Kathleen Tibbetts
Maria Abreu
Carlos A. Aguilar Salinas
Tariq Ahmad
Christine M. Albert
Diego Ardissino
Irina M. Armean
Elizabeth G. Atkinson
Gil Atzmon
John Barnard
Samantha M. Baxter
Laurent Beaugerie
Emelia J. Benjamin
David Benjamin
Michael Boehnke
Lori L. Bonnycastle
Erwin P. Bottinger
Donald W. Bowden
Matthew J. Bown
Harrison Brand
Steven Brant
Ted Brookings
Sam Bryant
Sarah E. Calvo
Hannia Campos
John C. Chambers
Juliana C. Chan
Katherine R. Chao
Sinéad Chapman
Daniel I. Chasman
Rex Chisholm
Judy Cho
Rajiv Chowdhury
Mina K. Chung
Wendy K. Chung
Kristian Cibulskis
Bruce Cohen
Kristen M. Connolly
Adolfo Correa
Beryl B. Cummings
Dana Dabelea
John Danesh
Dawood Darbar
Phil Darnowsky
Joshua Denny
Ravindranath Duggirala
Josée Dupuis
Patrick T. Ellinor
Roberto Elosua
James Emery
Eleina England
Jeanette Erdmann
Tõnu Esko
Emily Evangelista
Diane Fatkin
Jose Florez
Andre Franke
Jack Fu
Martti Färkkilä
Kiran Garimella
Jeff Gentry
Gad Getz
David C. Glahn
Benjamin Glaser
Stephen J. Glatt
David Goldstein
Clicerio Gonzalez
Leif Groop
Sanna Gudmundsson
Andrea Haessly
Christopher Haiman
Ira Hall
Craig L. Hanis
Matthew Harms
Mikko Hiltunen
Matti M. Holi
Christina M. Hultman
Chaim Jalas
Mikko Kallela
Diane Kaplan
Jaakko Kaprio
Sekar Kathiresan
Eimear E. Kenny
Bong-Jo Kim
Young Jin Kim
Daniel King
George Kirov
Jaspal Kooner
Seppo Koskinen
Harlan M. Krumholz
Subra Kugathasan
Soo Heon Kwak
Markku Laakso
Nicole Lake
Trevyn Langsford
Kristen M. Laricchia
Terho Lehtimäki
Monkol Lek
Emily Lipscomb
Ruth J. F. Loos
Wenhan Lu
Steven A. Lubitz
Teresa Tusie Luna
Ronald C. W. Ma
Gregory M. Marcus
Jaume Marrugat
Kari M. Mattila
Steven McCarroll
Mark I. McCarthy
Jacob L. McCauley
Dermot McGovern
Ruth McPherson
James B. Meigs
Olle Melander
Andres Metspalu
Deborah Meyers
Eric V. Minikel
Braxton D. Mitchell
Vamsi K. Mootha
Aliya Naheed
Saman Nazarian
Peter M. Nilsson
Michael C. O’Donovan
Yukinori Okada
Dost Ongur
Lorena Orozco
Michael J. Owen
Colin Palmer
Nicholette D. Palmer
Aarno Palotie
Kyong Soo Park
Carlos Pato
Ann E. Pulver
Dan Rader
Nazneen Rahman
Alex Reiner
Anne M. Remes
Dan Rhodes
Stephen Rich
John D. Rioux
Samuli Ripatti
Dan M. Roden
Jerome I. Rotter
Nareh Sahakian
Danish Saleheen
Veikko Salomaa
Andrea Saltzman
Nilesh J. Samani
Kaitlin E. Samocha
Alba Sanchis-Juan
Jeremiah Scharf
Molly Schleicher
Heribert Schunkert
Sebastian Schönherr
Eleanor G. Seaby
Svati H. Shah
Megan Shand
Ted Sharpe
Moore B. Shoemaker
Tai Shyong
Edwin K. Silverman
Moriel Singer-Berk
Pamela Sklar
Jonathan T. Smith
J. Gustav Smith
Hilkka Soininen
Harry Sokol
Rachel G. Son
Jose Soto
Tim Spector
Christine Stevens
Nathan O. Stitziel
Patrick F. Sullivan
Jaana Suvisaari
E. Shyong Tai
Kent D. Taylor
Yik Ying Teo
Ming Tsuang
Tiinamaija Tuomi
Dan Turner
Teresa Tusie-Luna
Erkki Vartiainen
Marquis Vawter
Lily Wang
Arcturus Wang
James S. Ware
Hugh Watkins
Rinse K. Weersma
Ben Weisburd
Maija Wessman
Nicola Whiffin
James G. Wilson
Ramnik J. Xavier
Anne O’Donnell-Luria
Matthew Solomonson
Cotton Seed
Alicia R. Martin
Michael E. Talkowski
Heidi L. Rehm
Mark J. Daly
Grace Tiao
Benjamin M. Neale
Daniel G. MacArthur
Konrad J. Karczewski
Affiliated Authors:
Wendy K. Chung
David Goldstein
Matthew Harms
Columbia Affiliation:
elink
Publication Type:
Article
Unique ID:
10.1038/s41586-023-06045-0
PMID:
38057664
DOI:
10.1038/s41586-023-06045-0
Journal:
Nature
Publication Date:
Data Source:
Scopus
Source Link:
View Scopus Record
View Web of Science Record

Record Created: