Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection

Yang, L., Han, Y., Zhang, T., Dong, X., Ge, J., Roy, A., Zhu, J., Lu, T., Jeya Vandana, J., de Silva, N., Robertson, C. C., Xiang, J. Z., Pan, C., Sun, Y., Que, J., Evans, T., Liu, C., Wang, W., Naji, A., … Chen, S. (2024). Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection. Cell Stem Cell. https://doi.org/10.1016/j.stem.2024.08.007
Authors:
Liuliu Yang
Yuling Han
Tuo Zhang
Xue Dong
Jian Ge
Aadita Roy
Jiajun Zhu
Tiankun Lu
J Jeya Vandana
Neranjan de Silva
Catherine C Robertson
Jenny Z Xiang
Chendong Pan
Yanjie Sun
Jianwen Que
Todd Evans
Chengyang Liu
Wei Wang
Ali Naji
Stephen C J Parker
Robert E Schwartz
Shuibing Chen
Affiliated Authors:
Jian Ge
Jianwen Que
Columbia Affiliation:
Subjects:
Pancreatic Islet Dysfunction and Regeneration (OpenAlex Topic)
Genetics and Pathogenesis of Type 1 Diabetes (OpenAlex Topic)
Mechanisms of Apoptotic Cell Clearance and Immune Regulation (OpenAlex Topic)
Author Keywords:
coxsackievirus b4
diabetes
human pluripotent stem cells
proinflammatory macrophages
sars-cov-2
endothelial cells
organoids
pancreatic endocrine cells
pyroptosis
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Publication Type:
Article
Unique ID:
10.1016/j.stem.2024.08.007
PMID:
39232561
DOI:
10.1016/j.stem.2024.08.007
Journal:
Cell Stem Cell
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created: