p53 mutation biases squamocolumnar junction progenitor cells towards dysplasia rather than metaplasia in Barrett's oesophagus

Lian, G., Malagola, E., Wei, C., Shi, Q., Zhao, J., Hata, M., Kobayashi, H., Ochiai, Y., Zheng, B., Zhi, X., Wu, F., Tu, R., Nápoles, O. C., Su, W., Li, L., Jing, C., Chen, M., Zamechek, L., Friedman, R., … Wang, T. C. (2024). p53 mutation biases squamocolumnar junction progenitor cells towards dysplasia rather than metaplasia in Barrett’s oesophagus. Gut, gutjnl-2024-332095. https://doi.org/10.1136/gutjnl-2024-332095
Authors:
Guodong Lian
Ermanno Malagola
Chengguo Wei
Qiongyu Shi
Junfei Zhao
Masahiro Hata
Hiroki Kobayashi
Yosuke Ochiai
Biyun Zheng
Xiaofei Zhi
Feijing Wu
Ruhong Tu
Osmel Companioni Nápoles
Wenjing Su
Leping Li
Changqing Jing
Man Chen
Leah Zamechek
Richard Friedman
Karol Nowicki-Osuch
Michael Quante
Jianwen Que
Timothy C Wang
Affiliated Authors:
Guodong Lian
Ermanno Malagola
Qiongyu Shi
Junfei Zhao
Masahiro Hata
Hiroki Kobayashi
Yosuke Ochiai
Biyun Zheng
Xiaofei Zhi
Feijing Wu
Ruhong Tu
Osmel Companioni Nápoles
Leah Zamechek
Richard Friedman
Karol Nowicki-Osuch
Jianwen Que
Timothy C Wang
Columbia Affiliation:
Author Keywords:
barrett's metaplasia
barrett's oesophagus
dysplasia
oesophageal cancer
stem cells
tamoxifen
trp53 protein, mouse
tumor suppressor protein p53
histone h2ax
interleukin 1beta
ki 67 antigen
reactive oxygen metabolite
protein p53
aneuploidy
animal experiment
animal model
animal tissue
article
babam1 gene
barrett esophagus
birc5 gene
cancer growth
cck2r gene
ccna2 gene
cell differentiation
cell proliferation
computer analysis
controlled study
copy number variation
differential gene expression
dna damage
dna repair
esophageal adenocarcinoma
flow cytometry
fluorescence activated cell sorting
gene
gene expression
gene mutation
gene overexpression
gene set enrichment analysis
genomic instability
histopathology
immunofluorescence
in situ hybridization
lgr5 gene
metaplasia
mki67 gene
mouse
muc6 gene
nonhuman
notch signaling
notch2 gene
olfm4 gene
orthotopic transplantation
p53 gene
pi3k/akt signaling
progenitor cell line
prom1 gene
single cell rna seq
squamocolumnar junction progenitor cells
stmn1 gene
tgf beta signaling
whole genome sequencing
wnt signaling
adenocarcinoma
animal
cardia
disease exacerbation
disease model
esophagus tumor
genetics
metabolism
mutation
pathology
stem cell
adenocarcinoma of esophagus
animals
disease models, animal
disease progression
esophageal neoplasms
mice
Grants:
R01CA272901 (NIH – National Cancer Institute)
R01DK132251 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
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Publication Type:
Article
Unique ID:
10.1136/gutjnl-2024-332095
PMID:
39353725
DOI:
10.1136/gutjnl-2024-332095
Journal:
Gut
Publication Date:
Data Source:
PubMed
Source Link:
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