UM1AI068614

NIH – National Institute of Allergy and Infectious Diseases

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Safety, tolerability, pharmacokinetics, and neutralisation activities of the anti-HIV-1 monoclonal antibody PGT121.414.LS administered alone and in combination with VRC07-523LS in adults without HIV in the USA (HVTN 136/HPTN 092): a first-in-human, open-label, randomised controlled phase 1 trial

Edupuganti, S., Hurt, C. B., Stephenson, K. E., Huang, Y., Paez, C. A., Yu, C., Yen, C., Hanscom, B., He, Z., Miner, M. D., Gamble, T., Heptinstall, J., Seaton, K. E., Domin, E., Lin, B. C., McKee, K., Doria-Rose, N., Regenold, S., Spiegel, H., … Afemata, S. (2024). Safety, tolerability, pharmacokinetics, and neutralisation activities of the anti-HIV-1 monoclonal antibody PGT121.414.LS administered alone and in combination with VRC07-523LS in adults without HIV in the USA (HVTN 136/HPTN 092): a first-in-human, open-label, randomised controlled phase 1 trial. The Lancet HIV. https://doi.org/10.1016/s2352-3018(24)00247-9
Authors:
Srilatha Edupuganti
Christopher B Hurt
Kathryn E Stephenson
Yunda Huang
Carmen A Paez
Chenchen Yu
Catherine Yen
Brett Hanscom
Zonglin He
Maurine D Miner
Theresa Gamble
Jack Heptinstall
Kelly E Seaton
Elizabeth Domin
Bob C Lin
Krisha McKee
Nicole Doria-Rose
Stephanie Regenold
Hans Spiegel
Maija Anderson
Nadia McClosky
Lily Zhang
Estelle Piwowar-Manning
Margaret E Ackerman
Michael Pensiero
Bonnie J Dye
Raphael J Landovitz
Kenneth Mayer
Marc Siegel
Magdalena Sobieszczyk
Stephen R Walsh
Lucio Gama
Dan H Barouch
David C Montefiori
Georgia D Tomaras
Affiliated Authors:
Magdalena Sobieszczyk
Columbia Affiliation:
Author Keywords:
alanine aminotransferase
creatinine
paracetamol
antibodies, monoclonal
antibodies, monoclonal, humanized
antibodies, neutralizing
broadly neutralizing antibodies
hiv antibodies
monolix 2020r1
r version 4.0.4
sas version 9.4m7
anti hiv 1 monoclonal antibody pgt121.414.ls
anti hiv 1 monoclonal antibody vrc07 523ls
human immunodeficiency virus vaccine
unclassified drug
broadly neutralizing antibody
human immunodeficiency virus antibody
monoclonal antibody
neutralizing antibody
adult
arthralgia
article
controlled study
cytotoxicity
diaphoresis
drug dose escalation
drug efficacy
drug safety
drug tolerability
dyspnea
erythema
fatigue
female
fever
follow up
headache
human
human immunodeficiency virus 1
human immunodeficiency virus infection
ic50
immunogenicity
immunosuppressive treatment
major clinical study
malaise
male
myalgia
nausea
patient safety
pharmacokinetics
phase 1 clinical trial
physical examination
pruritus
randomized controlled trial
tachycardia
urticaria
vaccination
clinical trial
drug effect
drug therapy
immunology
middle aged
multicenter study
united states
young adult
hiv infections
hiv-1
humans
Grants:
UM1AI068614 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068619 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1016/s2352-3018(24)00247-9
PMID:
39667379
DOI:
10.1016/s2352-3018(24)00247-9
Journal:
Lancet HIV
Publication Date:
Data Source:
PubMed
Source Link:
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Potent neutralization by a RBD antibody with broad specificity for SARS-CoV-2 JN.1 and other variants

Piepenbrink, M. S., Khalil, A. M., Chang, A., Mostafa, A., Basu, M., Sarkar, S., Panjwani, S., Ha, Y. H., Ma, Y., Ye, C., Wang, Q., Green, T. J., Kizziah, J. L., Erdmann, N. B., Goepfert, P. A., Liu, L., Ho, D. D., Martinez-Sobrido, L., Walter, M. R., & Kobie, J. J. (2024). Potent neutralization by a RBD antibody with broad specificity for SARS-CoV-2 JN.1 and other variants. Npj Viruses, 2(1). https://doi.org/10.1038/s44298-024-00063-z
Authors:
Michael S Piepenbrink
Ahmed Magdy Khalil
Ana Chang
Ahmed Mostafa
Madhubanti Basu
Sanghita Sarkar
Simran Panjwani
Yaelyn H Ha
Yao Ma
Chengjin Ye
Qian Wang
Todd J Green
James L Kizziah
Nathaniel B Erdmann
Paul A Goepfert
Lihong Liu
David D Ho
Luis Martinez-Sobrido
Mark R Walter
James J Kobie
Affiliated Authors:
Qian Wang
Lihong Liu
David D Ho
Columbia Affiliation:
Author Keywords:
antibodies
sars-cov-2
Grants:
P30CA013148 (NIH – National Cancer Institute)
R01AI161175 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068614 (NIH – National Institute of Allergy and Infectious Diseases)
S10OD024978 (NIH – Office of the Director, National Institutes of Health)
Publication Type:
Article
Unique ID:
10.1038/s44298-024-00063-z
PMID:
39553825
DOI:
10.1038/s44298-024-00063-z
Journal:
NPJ Viruses
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record

Record Created:

Association Between SARS-CoV-2 Viral Load and COVID-19 Vaccination in 4 Phase 3 Trials

Janes, H., Fisher, L. H., Kee, J. J., Parameswaran, L., Goepfert, P. A., Falsey, A. R., Ludwig, J., Magaret, C. A., Gilbert, P. B., Kublin, J. G., Rouphael, N., Sobieszczyk, M. E., El Sahly, H. M., Baden, L. R., Grinsztejn, B., Walsh, S. R., Gray, G. E., Kotloff, K. L., Gay, C. L., … Huang, Y. (2024). Association Between SARS-CoV-2 Viral Load and COVID-19 Vaccination in 4 Phase 3 Trials. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiae400
Authors:
Holly Janes
Leigh H. Fisher
Jia Jin Kee
Lalitha Parameswaran
Paul A. Goepfert
Ann R. Falsey
James P. Ludwig
Craig A. Magaret
Peter B. Gilbert
James G. Kublin
Nadine Rouphael
Magdalena E. Sobieszczyk
Hana M. El Sahly
Lindsey R. Baden
Beatriz Grinsztejn
Stephen R. Walsh
Glenda Gray
Karen L. Kotloff
Cynthia L. Gay
Alexander L. Greninger
Milagritos D. Tapia
E. Adrianne Hammershaimb
Frances Priddy
Justin A Green
Frank Struyf
Lisa M. Dunkle
Kathleen M. Neuzil
Lawrence Corey
Yunda Huang
Affiliated Authors:
Magdalena E. Sobieszczyk
Columbia Affiliation:
Subjects:
Coronavirus Disease 2019 Research (OpenAlex Topic)
Factors Affecting Vaccine Hesitancy and Acceptance (OpenAlex Topic)
Coronavirus Disease 2019 (OpenAlex Topic)
Author Keywords:
covid-19 transmission
covid-19 vaccine
infectiousness
randomized trial
sars-cov-2 viral load
Grants:
U01AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI148450 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068614 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068635 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI148689 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI148574 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1093/infdis/jiae400
PMID:
39225478
DOI:
10.1093/infdis/jiae400
Journal:
Journal of Infectious Diseases
Publication Date:
Data Source:
OpenAlex
Source Link:
View OpenAlex Record
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Record Created:

SARS-CoV-2 Viral Load in the Nasopharynx at Time of First Infection Among Unvaccinated Individuals

Fisher, L. H., Kee, J. J., Liu, A., Espinosa, C. M., Randhawa, A. K., Ludwig, J., Magaret, C. A., Robinson, S. T., Gilbert, P. B., Hyrien, O., Kublin, J. G., Rouphael, N., Falsey, A. R., Sobieszczyk, M. E., El Sahly, H. M., Grinsztejn, B., Gray, G. E., Kotloff, K. L., Gay, C. L., … Leathers, V. (2024). SARS-CoV-2 Viral Load in the Nasopharynx at Time of First Infection Among Unvaccinated Individuals. JAMA Network Open, 7(5), e2412835. https://doi.org/10.1001/jamanetworkopen.2024.12835
Authors:
Leigh H. Fisher
Jia Jin Kee
Albert Liu
Claudia Espinosa
April K. Randhawa
James P. Ludwig
Craig A. Magaret
Samuel T. Robinson
Peter B. Gilbert
Ollivier Hyrien
James G. Kublin
Nadine Rouphael
Ann R. Falsey
Magdalena E. Sobieszczyk
Hana M. El Sahly
Beatriz Grinsztejn
Glenda Gray
Karen L. Kotloff
Cynthia L. Gay
Brett Leav
Ian Hirsch
Frank Struyf
Lisa M. Dunkle
Kathleen M. Neuzil
Lawrence Corey
Yunda Huang
Paul Goepfert
Stephen R. Walsh
Lindsey R. Baden
Holly Janes
Atoya Adams
Eric N. Miller
Bruce Rankin
Steven Shinn
Dean Follmann
Jacqueline M. Miller
Jerald Sadoff
Marshall Nash
S Green
Christian Jacobsen
Jayasree Krishnankutty
Sikhongi Phungwayo
Richard Glover
Stacy Slechta
Troy Holdeman
Robyn Hartvickson
Amber Grant
Terry L. Poling
Terry D. Klein
Thomas Klein
Tracy Klein
William Smith
Richard Gibson
Jennifer Winbigler
Elizabeth Parker
Priyantha N. Wijewardane
Eric Bravo
Jeffrey Thessing
Michelle Maxwell
Amanda Horn
Catherine Healy
Christine Akamine
Laurence Chu
R. Michelle Chouteau
Michael Cotugno
George H. Bauer
Greg Hachigian
Masaru Oshita
Michael Cancilla
Kristen Kiersey
William Seger
Mohammed Antwi
Allison Green
Anthony Kim
Michaël Desjardins
Jennifer Johnson
Amy C Sherman
Judith Borger
Nafisa Saleem
Joel Solis
Martha Medina
Westly Keating
Edgar García
Cynthia Bueno
Nathan Segall
Douglas Denham
Thomas Weiss
Ayoade Avworo
Parke Hedges
Cynthia Strout
Raimundo Santiago
Yvonne Davis
Patty Howenstine
Alison Bondell
Kristin J. Marks
Tina Wang
Timothy Wilkin
Mary Vogler
Carrie D. Johnston
Michele P. Andrasik
Affiliated Authors:
Magdalena E. Sobieszczyk
Columbia Affiliation:
Subjects:
COVID-19 (MeSH)
Nasopharynx (MeSH)
Viral Load (MeSH)
SARS-CoV-2 (MeSH)
Coronavirus Disease 2019 Research (OpenAlex Topic)
Diagnostic Methods for COVID-19 Detection (OpenAlex Topic)
Epidemiology and Pathogenesis of Respiratory Viral Infections (OpenAlex Topic)
Grants:
UM1AI069476 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068617 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI148450 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068618 (NIH – National Institute of Allergy and Infectious Diseases)
U01AI069496 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI148689 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069534 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068614 (NIH – National Institute of Allergy and Infectious Diseases)
U01AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069496 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068635 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI148576 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069423 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1001/jamanetworkopen.2024.12835
PMID:
38780941
DOI:
10.1001/jamanetworkopen.2024.12835
Journal:
JAMA Network Open
Publication Date:
Data Source:
OpenAlex
Source Link:
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Record Created:

Impact of LS Mutation on Pharmacokinetics of Preventive HIV Broadly Neutralizing Monoclonal Antibodies: A Cross-Protocol Analysis of 16 Clinical Trials in People without HIV

Mayer, B. T., Zhang, L., deCamp, A. C., Yu, C., Sato, A., Angier, H., Seaton, K. E., Yates, N., Ledgerwood, J. E., Mayer, K., Caskey, M., Nussenzweig, M., Stephenson, K., Julg, B., Barouch, D. H., Sobieszczyk, M. E., Edupuganti, S., Kelley, C. F., McElrath, M. J., … Huang, Y. (2024). Impact of LS Mutation on Pharmacokinetics of Preventive HIV Broadly Neutralizing Monoclonal Antibodies: A Cross-Protocol Analysis of 16 Clinical Trials in People without HIV. Pharmaceutics, 16(5), 594. https://doi.org/10.3390/pharmaceutics16050594
Authors:
Bryan T. Mayer
Lily Zhang
Allan C. deCamp
Chenchen Yu
Alicia Sato
Heather Angier
Kelly E. Seaton
Nicole L. Yates
Julie E. Ledgerwood
Kenneth H. Mayer
Marina Caskey
Michel C. Nussenzweig
Kathryn E. Stephenson
Boris Jülg
Dan H. Barouch
Magdalena E. Sobieszczyk
Srilatha Edupuganti
Colleen F. Kelley
M. Juliana McElrath
Huub C. Gelderblom
Michael Pensiero
Adrian B. McDermott
Lúcio Gama
Richard A. Koup
Peter B. Gilbert
Myron S. Cohen
Lawrence Corey
Ollivier Hyrien
Georgia D. Tomaras
Yunda Huang
Affiliated Authors:
Magdalena E. Sobieszczyk
Columbia Affiliation:
Subjects:
Therapeutic Antibodies: Development, Engineering, and Applications (OpenAlex Topic)
Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (OpenAlex Topic)
Role of Complement System in Immune Response (OpenAlex Topic)
Author Keywords:
hiv prevention
ls mutation
monoclonal antibodies
population pharmacokinetics modeling
targeted maximum likelihood estimation (tmle)
two-compartment model
Grants:
UM1AI069412 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068619 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068618 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068635 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068617 (NIH – National Institute of Allergy and Infectious Diseases)
U01AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068613 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068614 (NIH – National Institute of Allergy and Infectious Diseases)
U01AI068635 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.3390/pharmaceutics16050594
PMID:
38794258
DOI:
10.3390/pharmaceutics16050594
Journal:
Pharmaceutics
Publication Date:
Data Source:
OpenAlex
Source Link:
View OpenAlex Record
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Record Created:

COVID-19 vaccine efficacy in participants with weakened immune systems from four randomized-controlled trials

Sherman, A. C., Tuan, J., Cantos, V. D., Adeyiga, O., Mahoney, S., Ortega-Villa, A. M., Tillman, A., Whitaker, J., Woodward Davis, A. S., Leav, B., Hirsch, I., Sadoff, J., Dunkle, L. M., Gilbert, P. B., Janes, H. E., Kublin, J. G., Goepfert, P. A., Kotloff, K., Rouphael, N., … Gay, C. L. (2024). Coronavirus Disease 2019 Vaccine Efficacy in Participants With Weakened Immune Systems From 4 Randomized controlled Trials. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciae192
Authors:
Amy Sherman
Jessica Tuan
Valeria D Cantos
Oladunni Adeyiga
Scott Mahoney
Ana M Ortega-Villa
Amy Tillman
Jennifer Whitaker
Amanda S Woodward Davis
Brett Leav
Ian Hirsch
Jerald Sadoff
Lisa M Dunkle
Peter B Gilbert
Holly E Janes
James G Kublin
Paul A Goepfert
Karen Kotloff
Nadine Rouphael
Ann R Falsey
Hana M El Sahly
Magdalena E Sobieszczyk
Yunda Huang
Kathleen M Neuzil
Lawrence Corey
Beatriz Grinsztejn
Glenda Gray
Martha Nason
Lindsey R Baden
Cynthia L Gay
Affiliated Authors:
Magdalena E Sobieszczyk
Columbia Affiliation:
Author Keywords:
covid-19
hiv
immunocompromised
vaccine
vaccine efficacy
Grants:
UM1AI148689 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068614 (NIH – National Institute of Allergy and Infectious Diseases)
U01AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068635 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069476 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069412 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI148576 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069423 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI148450 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1093/cid/ciae192
PMID:
38598658
DOI:
10.1093/cid/ciae192
Journal:
Clinical Infectious Diseases
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created:

Polytopic fractional delivery of an HIV vaccine alters cellular responses and results in increased epitope breadth in a phase 1 randomized trial

Miner, M. D., deCamp, A., Grunenberg, N., De Rosa, S. C., Fiore-Gartland, A., Bar, K., Spearman, P., Allen, M., Yu, P.-C., Manso, B., Frahm, N., Kalams, S., Baden, L., Keefer, M. C., Scott, H. M., Novak, R., Van Tieu, H., Tomaras, G. D., Kublin, J. G., … Luke-Kilolam, A. (2024). Polytopic fractional delivery of an HIV vaccine alters cellular responses and results in increased epitope breadth in a phase 1 randomized trial. EBioMedicine, 100, 104987. https://doi.org/10.1016/j.ebiom.2024.104987
Authors:
Maurine D. Miner
Allan C. deCamp
Nicole Grunenberg
Stephen C. De Rosa
Andrew Fioré-Gartland
Katharine J. Bar
Paul Spearman
Mary Allen
Pei-Chun Yu
Bryce A. Manso
Nicole Frahm
Spyros A. Kalams
Lindsey R. Baden
Michael T. Yin
Hyman Scott
Richard M. Novak
Hong‐Van Tieu
Georgia D. Tomaras
James G. Kublin
M. Juliana McElrath
Lawrence Corey
Ian Frank
Artur Olhovetchi Kalichman
Paul T. Edlefsen
Mary E. Enama
John Hural
Renée Holt
Debora Dunbar
David T. Crawford
Ian Maki
Jan N. Johannessen
Scharla Estep
Yevgeny Grigoriev
Tamra Madenwald
Marianne Hansen
Drienna Holman
Ramey Fair
Geneviève Meyer
Anya Luke-Kilolam
Affiliated Authors:
Hong‐Van Tieu
Columbia Affiliation:
Subjects:
AIDS Vaccines (MeSH)
HIV Infections (MeSH)
Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (OpenAlex Topic)
Immunobiology of Dendritic Cells (OpenAlex Topic)
Prediction of Peptide-MHC Binding Affinity (OpenAlex Topic)
Author Keywords:
hiv
fractionated delivery
polytopic vaccination
ad5
epitope breadth
Grants:
UM1AI068635 (NIH – National Institute of Allergy and Infectious Diseases)
P30AI027757 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069534 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068618 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069554 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069412 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069439 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068614 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069511 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069496 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1016/j.ebiom.2024.104987
PMID:
38306894
DOI:
10.1016/j.ebiom.2024.104987
Journal:
EBioMedicine
Publication Date:
Data Source:
OpenAlex
Source Link:
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Record Created:

High monoclonal neutralization titers reduced breakthrough HIV-1 viral loads in the Antibody Mediated Prevention trials

Reeves, D. B., Mayer, B. T., deCamp, A. C., Huang, Y., Zhang, B., Carpp, L. N., Magaret, C. A., Juraska, M., Gilbert, P. B., Montefiori, D. C., Bar, K. J., Cardozo-Ojeda, E. F., Schiffer, J. T., Rossenkhan, R., Edlefsen, P., Morris, L., Mkhize, N. N., Williamson, C., Mullins, J. I., … Edupuganti, S. (2023). High monoclonal neutralization titers reduced breakthrough HIV-1 viral loads in the Antibody Mediated Prevention trials. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-43384-y
Authors:
Daniel B Reeves
Bryan T Mayer
Allan C deCamp
Yunda Huang
Bo Zhang
Lindsay N Carpp
Craig A Magaret
Michal Juraska
Peter B Gilbert
David C Montefiori
Katharine J Bar
E Fabian Cardozo-Ojeda
Joshua T Schiffer
Raabya Rossenkhan
Paul Edlefsen
Lynn Morris
Nonhlanhla N Mkhize
Carolyn Williamson
James I Mullins
Kelly E Seaton
Georgia D Tomaras
Philip Andrew
Nyaradzo Mgodi
Julie E Ledgerwood
Myron S Cohen
Lawrence Corey
Logashvari Naidoo
Catherine Orrell
Paul A Goepfert
Martin Casapia
Magdalena E Sobieszczyk
Shelly T Karuna
Srilatha Edupuganti
Affiliated Authors:
Magdalena E Sobieszczyk
Columbia Affiliation:
Subjects:
HIV Infections (MeSH)
HIV-1 (MeSH)
Grants:
R01AI150500 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068614 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068635 (NIH – National Institute of Allergy and Infectious Diseases)
R37AI054165 (NIH – National Institute of Allergy and Infectious Diseases)
K25AI155224 (NIH – National Institute of Allergy and Infectious Diseases)
P30AI027757 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068613 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068617 (NIH – National Institute of Allergy and Infectious Diseases)
P30AI064518 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068618 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068619 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1038/s41467-023-43384-y
PMID:
38097552
DOI:
10.1038/s41467-023-43384-y
Journal:
Nature Communications
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Scopus Record

Record Created:

Safety, tolerability, pharmacokinetics, and immunological activity of dual-combinations and triple-combinations of anti-HIV monoclonal antibodies PGT121, PGDM1400, 10-1074, and VRC07-523LS administered intravenously to HIV-uninfected adults: a phase 1 randomised trial

Sobieszczyk, M. E., Mannheimer, S., Paez, C. A., Yu, C., Gamble, T., Theodore, D. A., Chege, W., Yacovone, M., Hanscom, B., Heptinstall, J., Seaton, K. E., Zhang, L., Miner, M. D., Eaton, A., Weiner, J. A., Mayer, K., Kalams, S., Stephenson, K., Julg, B., … Montefiori, D. (2023). Safety, tolerability, pharmacokinetics, and immunological activity of dual-combinations and triple-combinations of anti-HIV monoclonal antibodies PGT121, PGDM1400, 10-1074, and VRC07-523LS administered intravenously to HIV-uninfected adults: a phase 1 randomised trial. The Lancet HIV, 10(10), e653–e662. https://doi.org/10.1016/s2352-3018(23)00140-6
Authors:
Magdalena E Sobieszczyk
Sharon Mannheimer
Carmen A Paez
Chenchen Yu
Theresa Gamble
Deborah A Theodore
Wairimu Chege
Margaret Yacovone
Brett Hanscom
Jack Heptinstall
Kelly E Seaton
Lily Zhang
Maurine D Miner
Amanda Eaton
Joshua A Weiner
Kenneth Mayer
Spyros Kalams
Kathryn Stephenson
Boris Julg
Marina Caskey
Michel Nussenzweig
Lucio Gama
Dan H Barouch
Margaret E Ackerman
Georgia D Tomaras
Yunda Huang
David Montefiori
Affiliated Authors:
Magdalena E Sobieszczyk
Sharon Mannheimer
Deborah A Theodore
Columbia Affiliation:
Subjects:
HIV Infections (MeSH)
HIV-1 (MeSH)
Grants:
UM1AI068635 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068614 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068613 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068619 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068618 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068617 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069412 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069439 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1016/s2352-3018(23)00140-6
PMID:
37802566
DOI:
10.1016/s2352-3018(23)00140-6
Journal:
Lancet HIV
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Scopus Record

Record Created:

Post-COVID symptom profiles and duration in a global convalescent COVID-19 observational cohort: Correlations with demographics, medical history, acute COVID-19 severity and global region

Karuna, S., Gallardo-Cartagena, J. A., Theodore, D., Hunidzarira, P., Montenegro-Idrogo, J., Hu, J., Jones, M., Kim, V., De La Grecca, R., Trahey, M., Karg, C., Takalani, A., Polakowski, L., Hutter, J., Miner, M. D., Erdmann, N., Goepfert, P., Maboa, R., … Corey, L. (2023). Post-COVID symptom profiles and duration in a global convalescent COVID-19 observational cohort: Correlations with demographics, medical history, acute COVID-19 severity and global region. Journal of Global Health, 13. https://doi.org/10.7189/jogh.13.06020
Authors:
Shelly Karuna
Jorge A Gallardo-Cartagena
Deborah Theodore
Portia Hunidzarira
Juan Montenegro-Idrogo
Jiani Hu
Megan Jones
Vicky Kim
Robert De La Grecca
Meg Trahey
Carissa Karg
Azwi Takalani
Laura Polakowski
Julia Hutter
Maurine D Miner
Nathan Erdmann
Paul Goepfert
Rebone Maboa
Lawrence Corey
Katherine Gill
Shuying Sue Li
Affiliated Authors:
Deborah Theodore
Columbia Affiliation:
Subjects:
COVID-19 (MeSH)
Grants:
UM1AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068614 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068617 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069423 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068635 (NIH – National Institute of Allergy and Infectious Diseases)
U01AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.7189/jogh.13.06020
PMID:
37352144
DOI:
10.7189/jogh.13.06020
Journal:
Journal of Global Health
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record

Record Created:

Rapid Development of an Integrated Network Infrastructure to Conduct Phase 3 COVID-19 Vaccine Trials

Mena Lora, A. J., Long, J. E., Huang, Y., Baden, L. R., El Sahly, H. M., Follmann, D., Goepfert, P., Gray, G., Grinsztejn, B., Kotloff, K., Rouphael, N., Sobieszczyk, M., Walsh, S. R., Andriesen, J., Shah, K. A., Zhang, Y., Gilbert, P., Janes, H., Gay, C. L., … Wallace, S. E. (2023). Rapid Development of an Integrated Network Infrastructure to Conduct Phase 3 COVID-19 Vaccine Trials. JAMA Network Open, 6(1), e2251974. https://doi.org/10.1001/jamanetworkopen.2022.51974
Authors:
Alfredo J Mena Lora
Jessica E. Long
Yunda Huang
Lindsey R. Baden
Hana M. El Sahly
Dean Follmann
Paul Goepfert
Glenda Gray
Beatriz Grinsztejn
Karen L. Kotloff
Nadine Rouphael
Magdelena Sobieszczyk
Stephen R. Walsh
Jessica Andriesen
Karan A. Shah
Yuanyuan Zhang
Peter B. Gilbert
Holly Janes
Cynthia L. Gay
Ann R. Falsey
Rebecca L. Tripp
Richard L. Gorman
Tina Tong
Mary Marovich
Kathleen M. Neuzil
Lawrence Corey
James G. Kublin
Daniel Reirden
Lilly Cheng Immergluck
Colleen F. Kelley
Anna P. Durbin
Milagritos Tapia
Megan Deming
Karen L. Kotloff
Jorge Pinto
Paul Goepfert
Zaheer Hoosain
Johan Lombaard
Kathryn E. Stephenson
Lindsey R. Baden
Stephen R. Walsh
Ken Mayer
Pedro Cahn
Marcelo Losso
Isabel Cassetti
Steven Innes
Linda‐Gail Bekker
Sheetal Kassim
Catherine Orrel
Graeme Meintjes
Amy Ward
Andreas Diacon
David A. Wohl
Cindy M. Gray
Chrinstine Turley
Temitope Oyedele
Babafemi Taiwo
Karen Krueger
Rick Novak
Beverly E. Sha
Laura Hammit
Carl J. Fichtenbaum
David I. Bernstein
Jeffrey M. Jacobson
Dima Dandachi
Hasan Raja Naqvi
Susan L. Koletar
Nadine Rouphael
Sri Edupuganti
Thomas Campbell
Elizabeth Secord
Samantha Siva
Nitesha Jeenarain
Logashvari Naidoo
Nigel Garrett
Nivashnee Naicker
Vimla Naicker
Jayganthie Naidoo
Anamikah Premrajh
Emmanuel B. Walter
Jeff Henderson
Hugo A. Tempelman
Abraham Siika
Evan J. Anderson
Brenda Okech
Richard Rupp
Hana M. El Sahly
Catherine M. Healy
Robert Arduino
Patricia Winokur
Martín Casapía
Gailen D. Marshall
Bhagyashri Navalkele
Sharla Badel-Faeson
Ian Sanne
Lee Fairlie
Adeodata Kekitiinwa
Patricia Ntege
Peter Elyanu
Cissy K. Mutuluuza
Affiliated Authors:
Magdelena Sobieszczyk
Columbia Affiliation:
Subjects:
COVID-19 (MeSH)
Vaccines (MeSH)
Coronavirus Disease 2019 Research (OpenAlex Topic)
Immunogenicity of Biosimilar Therapeutics in Drug Development (OpenAlex Topic)
Diagnostic Methods for COVID-19 Detection (OpenAlex Topic)
Grants:
UM1AI148576 (NIH – National Institute of Allergy and Infectious Diseases)
P30AI045008 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068635 (NIH – National Institute of Allergy and Infectious Diseases)
U01AI069424 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI148685 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068614 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI148689 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI148684 (NIH – National Institute of Allergy and Infectious Diseases)
U01AI068614 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1001/jamanetworkopen.2022.51974
PMID:
36689221
DOI:
10.1001/jamanetworkopen.2022.51974
Journal:
JAMA Network Open
Publication Date:
Data Source:
OpenAlex
Source Link:
View OpenAlex Record
View PubMed Record
View Scopus Record
View Web of Science Record

Record Created:

Neutralization titer biomarker for antibody-mediated prevention of HIV-1 acquisition

Gilbert, P. B., Huang, Y., deCamp, A. C., Karuna, S., Zhang, Y., Magaret, C. A., Giorgi, E. E., Korber, B., Edlefsen, P. T., Rossenkhan, R., Juraska, M., Rudnicki, E., Kochar, N., Huang, Y., Carpp, L. N., Barouch, D. H., Mkhize, N. N., Hermanus, T., Kgagudi, P., … Morris, L. (2022). Neutralization titer biomarker for antibody-mediated prevention of HIV-1 acquisition. Nature Medicine, 28(9), 1924–1932. https://doi.org/10.1038/s41591-022-01953-6
Authors:
Peter B Gilbert
Yunda Huang
Allan C deCamp
Shelly Karuna
Yuanyuan Zhang
Craig A Magaret
Elena E Giorgi
Bette Korber
Paul T Edlefsen
Raabya Rossenkhan
Michal Juraska
Erika Rudnicki
Nidhi Kochar
Ying Huang
Lindsay N Carpp
Dan H Barouch
Nonhlanhla N Mkhize
Tandile Hermanus
Prudence Kgagudi
Valerie Bekker
Haajira Kaldine
Rutendo E Mapengo
Amanda Eaton
Elize Domin
Carley West
Wenhong Feng
Haili Tang
Kelly E Seaton
Jack Heptinstall
Caroline Brackett
Kelvin Chiong
Georgia D Tomaras
Philip Andrew
Bryan T Mayer
Daniel B Reeves
Magdalena E Sobieszczyk
Nigel Garrett
Jorge Sanchez
Cynthia Gay
Joseph Makhema
Carolyn Williamson
James I Mullins
John Hural
Myron S Cohen
Lawrence Corey
David C Montefiori
Lynn Morris
Affiliated Authors:
Magdalena E Sobieszczyk
Columbia Affiliation:
Subjects:
Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (OpenAlex Topic)
Regulatory T Cell Development and Function (OpenAlex Topic)
Natural Killer Cells in Immunity (OpenAlex Topic)
HIV Infections (MeSH)
HIV-1 (MeSH)
Grants:
P30AI064518 (NIH – National Institute of Allergy and Infectious Diseases)
P01AI131251 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068613 (NIH – National Institute of Allergy and Infectious Diseases)
P30AI027757 (NIH – National Institute of Allergy and Infectious Diseases)
R01AI152115 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068617 (NIH – National Institute of Allergy and Infectious Diseases)
R37AI054165 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068614 (NIH – National Institute of Allergy and Infectious Diseases)
U01AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068619 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068618 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068635 (NIH – National Institute of Allergy and Infectious Diseases)
K25AI155224 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1038/s41591-022-01953-6
PMID:
35995954
DOI:
10.1038/s41591-022-01953-6
Journal:
Nature Medicine
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Scopus Record
View OpenAlex Record
View Web of Science Record

Record Created:

Phase 3 Safety and Efficacy of AZD1222 (CHADOX1 NCoV-19) Covid-19 Vaccine

Falsey, A. R., Sobieszczyk, M. E., Hirsch, I., Sproule, S., Robb, M. L., Corey, L., Neuzil, K. M., Hahn, W., Hunt, J., Mulligan, M. J., McEvoy, C., DeJesus, E., Hassman, M., Little, S. J., Pahud, B. A., Durbin, A., Pickrell, P., Daar, E. S., Bush, L., … Gonzalez-Lopez, A. (2021). Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine. New England Journal of Medicine, 385(25), 2348–2360. https://doi.org/10.1056/nejmoa2105290
Authors:
Ann R. Falsey
Magdalena E. Sobieszczyk
Ian Hirsch
Stephanie Sproule
Merlin L. Robb
Lawrence Corey
Kathleen M. Neuzil
William Hahn
Julie Hunt
Mark J. Mulligan
Charlene McEvoy
Edwin DeJesus
Michael Hassman
Susan J. Little
Barbara A. Pahud
Anna Durbin
Paul Pickrell
Eric S. Daar
Larry Bush
Joel Solis
Quito Osuna Carr
Temitope Oyedele
Susan Buchbinder
Jessica Cowden
Sergio L. Vargas
Alfredo Guerreros Benavides
Robert Call
Michael C. Keefer
Beth D. Kirkpatrick
John Pullman
Tina Tong
Margaret Brewinski Isaacs
David Benkeser
Holly E. Janes
Martha C. Nason
Justin A. Green
Elizabeth J. Kelly
Jill Maaske
Nancy Mueller
Kathryn Shoemaker
Therese Takas
Richard P. Marshall
Menelas N. Pangalos
Tonya Villafana
Antonio Gonzalez-Lopez
Affiliated Authors:
Magdalena E. Sobieszczyk
Columbia Affiliation:
Subjects:
COVID-19 (MeSH)
ChAdOx1 nCoV-19 (MeSH)
Vaccine Efficacy (MeSH)
Grants:
UM1AI148574 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI148450 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068635 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068614 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068618 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI148684 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068636 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI148372 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068619 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1056/NEJMoa2105290
PMID:
34587382
DOI:
10.1056/NEJMoa2105290
Journal:
New England Journal of Medicine
Publication Date:
Data Source:
Scopus
Source Link:
View Scopus Record
View PubMed Record
View Web of Science Record

Record Created:

Rectal tissue and vaginal tissue from intravenous VRC01 recipients show protection against ex vivo HIV-1 challenge

Astronomo, R. D., Lemos, M. P., Narpala, S. R., Czartoski, J., Fleming, L. B., Seaton, K. E., Prabhakaran, M., Huang, Y., Lu, Y., Westerberg, K., Zhang, L., Gross, M. K., Hural, J., Tieu, H.-V., Baden, L. R., Hammer, S., Frank, I., Ochsenbauer, C., Grunenberg, N., … McElrath, M. J. (2021). Rectal tissue and vaginal tissue from intravenous VRC01 recipients show protection against ex vivo HIV-1 challenge. Journal of Clinical Investigation, 131(16). https://doi.org/10.1172/jci146975
Authors:
Rena D. Astronomo
Maria P. Lemos
Sandeep R. Narpala
Julie Czartoski
Lamar Ballweber Fleming
Kelly E. Seaton
Madhu Prabhakaran
Yunda Huang
Yiwen Lu
Katharine Westerberg
Lily Zhang
Mary K. Gross
John Hural
Hong-Van Tieu
Lindsey R. Baden
Scott Hammer
Ian Frank
Christina Ochsenbauer
Nicole Grunenberg
Julie E. Ledgerwood
Kenneth Mayer
Georgia Tomaras
Adrian B. McDermott
M. Juliana McElrath
Affiliated Authors:
Scott Hammer
Columbia Affiliation:
Subjects:
Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (OpenAlex Topic)
Vaginal Microbiome and Sexually Transmitted Infections (OpenAlex Topic)
Diseases Related to Blood Group Variants (OpenAlex Topic)
Antibodies, Monoclonal (MeSH)
Broadly Neutralizing Antibodies (MeSH)
HIV Antibodies (MeSH)
HIV Infections (MeSH)
HIV-1 (MeSH)
Rectum (MeSH)
Vagina (MeSH)
Author Keywords:
aids vaccine
aids/hiv
drug therapy
Grants:
UM1AI069481 (NIH – National Institute of Allergy and Infectious Diseases)
P30AI064518 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068635 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068618 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069412 (NIH – National Institute of Allergy and Infectious Diseases)
P30AI045008 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005048 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068614 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1172/JCI146975
PMID:
34166231
DOI:
10.1172/JCI146975
Journal:
Journal of Clinical Investigation
Publication Date:
Data Source:
Scopus
Source Link:
View Scopus Record
View Web of Science Record
View PubMed Record
View OpenAlex Record

Record Created:

AIDSVAX protein boost improves breadth and magnitude of vaccine-induced HIV-1 envelope-specific responses after a 7-year rest period

Huang, Y., Seaton, K. E., Casapia, M., Polakowski, L., De Rosa, S. C., Cohen, K., Yu, C., Elizaga, M., Paez, C., Miner, M. D., Kelley, C. F., Maenza, J., Keefer, M., Lama, J. R., Sobieszczyk, M., Buchbinder, S., Baden, L. R., Lee, C., Gulati, V., … Goepfert, P. (2021). AIDSVAX protein boost improves breadth and magnitude of vaccine-induced HIV-1 envelope-specific responses after a 7-year rest period. Vaccine, 39(33), 4641–4650. https://doi.org/10.1016/j.vaccine.2021.06.066
Authors:
Yunda Huang
Kelly E Seaton
Martin Casapia
Laura Polakowski
Stephen C De Rosa
Kristen Cohen
Chenchen Yu
Marnie Elizaga
Carmen Paez
Maurine D Miner
Colleen F Kelley
Janine Maenza
Michael Keefer
Javier R Lama
Magdalena Sobieszczyk
Susan Buchbinder
Lindsey R Baden
Carter Lee
Vineeta Gulati
Faruk Sinangil
David Montefiori
M Juliana McElrath
Georgia D Tomaras
Harriet L Robinson
Paul Goepfert
Affiliated Authors:
Magdalena Sobieszczyk
Columbia Affiliation:
Subjects:
AIDS Vaccines (MeSH)
HIV Infections (MeSH)
HIV-1 (MeSH)
Vaccines, DNA (MeSH)
Author Keywords:
hiv vaccine
dna vaccine
mva vaccine
late boost
aidsvax
v1v2 antibody
Grants:
UM1AI068614 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
P30AI064518 (NIH – National Institute of Allergy and Infectious Diseases)
U01AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068635 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068618 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1016/j.vaccine.2021.06.066
PMID:
34229888
DOI:
10.1016/j.vaccine.2021.06.066
Journal:
Vaccine
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Scopus Record
View Web of Science Record

Record Created:

Feasibility and Successful Enrollment in a Proof-of-Concept HIV Prevention Trial of VRC01, a Broadly Neutralizing HIV-1 Monoclonal Antibody

Edupuganti, S., Mgodi, N., Karuna, S. T., Andrew, P., Rudnicki, E., Kochar, N., deCamp, A., De La Grecca, R., Anderson, M., Karg, C., Tindale, I., Greene, E., Broder, G. B., Lucas, J., Hural, J., Gallardo-Cartagena, J. A., Gonzales, P., Frank, I., … Sobieszczyk, M. (2021). Feasibility and Successful Enrollment in a Proof-of-Concept HIV Prevention Trial of VRC01, a Broadly Neutralizing HIV-1 Monoclonal Antibody. JAIDS Journal of Acquired Immune Deficiency Syndromes, 87(1), 671–679. https://doi.org/10.1097/qai.0000000000002639
Authors:
Srilatha Edupuganti
Nyaradzo Mgodi
Shelly T. Karuna
Erika Rudnicki
Nidhi Kochar
Allan DeCamp
Robert De la Grecca
Maija Anderson
Carissa Karg
India Tindale
Gail B. Broder
John Hural
Maurine D. Miner
Peter B. Gilbert
Lawrence Corey
Philip Andrew
Elizabeth Greene
Jonathan Lucas
Myron S. Cohen
Jorge A. Gallardo-Cartagena
Pedro Gonzales
Ian Frank
Magdalena Sobieszczyk
Margarita M. Gomez Lorenzo
David Burns
Peter L. Anderson
Julie Ledgerwood
John R. Mascola
Affiliated Authors:
Magdalena Sobieszczyk
Columbia Affiliation:
Subjects:
Antibodies, Monoclonal (MeSH)
Antibodies, Neutralizing (MeSH)
Broadly Neutralizing Antibodies (MeSH)
HIV Antibodies (MeSH)
HIV Infections (MeSH)
Author Keywords:
vrc01
bnab
hiv
passive immunization
amp studies
hvtn 704
hptn 085
Grants:
P30AI045008 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069534 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068614 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068619 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068635 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005048 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068618 (NIH – National Institute of Allergy and Infectious Diseases)
U01AI068618 (NIH – National Institute of Allergy and Infectious Diseases)
U01AI068635 (NIH – National Institute of Allergy and Infectious Diseases)
U01AI068614 (NIH – National Institute of Allergy and Infectious Diseases)
U01AI068619 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1097/QAI.0000000000002639
PMID:
33587505
DOI:
10.1097/QAI.0000000000002639
Journal:
Journal of Acquired Immune Deficiency Syndromes
Publication Date:
Data Source:
Web of Science
Source Link:
View Web of Science Record
View PubMed Record

Record Created:

Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition

Corey, L., Gilbert, P. B., Juraska, M., Montefiori, D. C., Morris, L., Karuna, S. T., Edupuganti, S., Mgodi, N. M., deCamp, A. C., Rudnicki, E., Huang, Y., Gonzales, P., Cabello, R., Orrell, C., Lama, J. R., Laher, F., Lazarus, E. M., Sanchez, J., Frank, I., … Cohen, M. S. (2021). Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition. New England Journal of Medicine, 384(11), 1003–1014. https://doi.org/10.1056/nejmoa2031738
Authors:
Lawrence Corey
Peter B Gilbert
Michal Juraska
David C Montefiori
Lynn Morris
Shelly T Karuna
Srilatha Edupuganti
Nyaradzo M Mgodi
Allan C deCamp
Erika Rudnicki
Yunda Huang
Pedro Gonzales
Robinson Cabello
Catherine Orrell
Javier R Lama
Fatima Laher
Erica M Lazarus
Jorge Sanchez
Ian Frank
Juan Hinojosa
Magdalena E Sobieszczyk
Kyle E Marshall
Pamela G Mukwekwerere
Joseph Makhema
Lindsey R Baden
James I Mullins
Carolyn Williamson
John Hural
M Juliana McElrath
Carter Bentley
Simbarashe Takuva
Margarita M Gomez Lorenzo
David N Burns
Nicole Espy
April K Randhawa
Nidhi Kochar
Estelle Piwowar-Manning
Deborah J Donnell
Nirupama Sista
Philip Andrew
James G Kublin
Glenda Gray
Julie E Ledgerwood
John R Mascola
Myron S Cohen
Affiliated Authors:
Lawrence Corey
Peter B Gilbert
Michal Juraska
David C Montefiori
Lynn Morris
Shelly T Karuna
Srilatha Edupuganti
Nyaradzo M Mgodi
Allan C deCamp
Erika Rudnicki
Yunda Huang
Pedro Gonzales
Robinson Cabello
Catherine Orrell
Javier R Lama
Fatima Laher
Erica M Lazarus
Jorge Sanchez
Ian Frank
Juan Hinojosa
Magdalena E Sobieszczyk
Kyle E Marshall
Pamela G Mukwekwerere
Joseph Makhema
Lindsey R Baden
James I Mullins
Carolyn Williamson
John Hural
M Juliana McElrath
Carter Bentley
Simbarashe Takuva
Margarita M Gomez Lorenzo
David N Burns
Nicole Espy
April K Randhawa
Nidhi Kochar
Estelle Piwowar-Manning
Deborah J Donnell
Nirupama Sista
Philip Andrew
James G Kublin
Glenda Gray
Julie E Ledgerwood
John R Mascola
Myron S Cohen
Columbia Affiliation:
Subjects:
Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (OpenAlex Topic)
Efficacy and Safety of Antiretroviral Therapy for HIV (OpenAlex Topic)
Prevention and Treatment of HIV/AIDS Infection (OpenAlex Topic)
Antibodies, Monoclonal (MeSH)
Broadly Neutralizing Antibodies (MeSH)
HIV Antibodies (MeSH)
HIV Infections (MeSH)
HIV-1 (MeSH)
Grants:
UM1AI068635 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI154468 (NIH – National Institute of Allergy and Infectious Diseases)
P30AI027757 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068618 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068619 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069481 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069470 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005048 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068617 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069412 (NIH – National Institute of Allergy and Infectious Diseases)
P30AI045008 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069463 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069424 (NIH – National Institute of Allergy and Infectious Diseases)
U01AI069476 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069436 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069469 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068613 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI068614 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI108568 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069496 (NIH – National Institute of Allergy and Infectious Diseases)
U01AI069436 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069476 (NIH – National Institute of Allergy and Infectious Diseases)
UM1AI069453 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1056/nejmoa2031738
PMID:
33730454
DOI:
10.1056/nejmoa2031738
Journal:
New England Journal of Medicine
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created:

CSV