Efficacy and Safety of Antiretroviral Therapy for HIV

Displaying 1 - 21 of 21CSV
Hagenah, L. M., Yeo, T., Schindler, K. A., Jeon, J. H., Bloxham, T. S., Small-Saunders, J. L., Mok, S., & Fidock, D. A. (2024). Plasmodium falciparum African PfCRT Mutant Isoforms Conducive to Piperaquine Resistance Are Infrequent and Impart a Major Fitness Cost. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiae617
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Awalt, J. K., Su, W., Nguyen, W., Loi, K., Jarman, K. E., Penington, J. S., Ramesh, S., Fairhurst, K. J., Yeo, T., Park, H., Uhlemann, A.-C., Chandra Maity, B., De, N., Mukherjee, P., Chakraborty, A., Churchyard, A., Famodimu, M. T., Delves, M. J., Baum, J., … Sleebs, B. E. (2024). Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b. European Journal of Medicinal Chemistry, 280, 116921. https://doi.org/10.1016/j.ejmech.2024.116921
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Calic, P. P. S., Ashton, T. D., Mansouri, M., Loi, K., Jarman, K. E., Qiu, D., Lehane, A. M., Roy, S., Rao, G. P., Maity, B., Wittlin, S., Crespo, B., Gamo, F.-J., Deni, I., Fidock, D. A., Chowdury, M., de Koning-Ward, T. F., Cowman, A. F., Jackson, P. F., … Sleebs, B. E. (2024). Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3. European Journal of Medicinal Chemistry, 276, 116677. https://doi.org/10.1016/j.ejmech.2024.116677
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Xie, S. C., Wang, Y., Morton, C. J., Metcalfe, R. D., Dogovski, C., Pasaje, C. F. A., Dunn, E., Luth, M. R., Kumpornsin, K., Istvan, E. S., Park, J. S., Fairhurst, K. J., Ketprasit, N., Yeo, T., Yildirim, O., Bhebhe, M. N., Klug, D. M., Rutledge, P. J., Godoy, L. C., … Tilley, L. (2024). Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-45224-z
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Ross, J., Perumal, R., Wolf, A., Zulu, M., Guzman, K., Seepamore, B., Reis, K., Nyilana, H., Hlathi, S., Narasimmulu, R., Cheung, Y. K. K., Amico, K. R., Friedland, G., Daftary, A., Zelnick, J. R., Naidoo, K., & O’Donnell, M. R. (2023). Adaptive evaluation of mHealth and conventional adherence support interventions to optimize outcomes with new treatment regimens for drug-resistant tuberculosis and HIV in South Africa (ADAP-TIV): study protocol for an adaptive randomized controlled trial. Trials, 24(1). https://doi.org/10.1186/s13063-023-07520-9
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Cicero, K. I., Dlamini, X., Mavengere, Y., Justman, J., Nuwagaba-Biribonwoha, H., Dlamini, M., Ngwenyama, S., Ngcamphalala, C., Low, A., Philip, N. M., El-Sadr, W. M., Sahabo, R., Abreha, T., Temesgen, S., Dlamini, S., Mahlalela, N., Chiuzan, C., Chen, Y., Pan, S. S., … Neugut, A. I. (2023). Prevalence of Monoclonal Gammopathy of Undetermined Significance in Eswatini: A Study of an African Population. Blood, 142(Supplement 1), 4767–4767. https://doi.org/10.1182/blood-2023-172435
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Benner, S. E., Zhu, X., Hussain, S., Florman, S., Eby, Y., Fernandez, R. E., Ostrander, D., Rana, M., Ottmann, S., Hand, J., Price, J. C., Pereira, M. R., Wojciechowski, D., Simkins, J., Stosor, V., Mehta, S. A., Aslam, S., Malinis, M., Haidar, G., … Tobian, A. A. R. (2023). HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV. The Journal of Infectious Diseases, 228(9), 1274–1279. https://doi.org/10.1093/infdis/jiad241
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Dhodapkar, M., Bumma, N., Richter, J., Lee, H., Hoffman, J., Suvannasankha, A., Lentzsch, S., Shah, M., Zonder, J., Baz, R., Wu, K. L., Pianko, M., Silbermann, R., Min, C.-K., Vekemans, M.-C. M., Munder, M., Byun, J. M., Lopez, J. M., DeVeaux, M., … Jagannath, S. (2023). P-247 Efficacy and safety of linvoseltamab 200 mg in patients with relapsed/refractory multiple myeloma (RRMM): analysis of the LINKER-MM1 study. Clinical Lymphoma Myeloma and Leukemia, 23, S172. https://doi.org/10.1016/s2152-2650(23)01865-7
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Deni, I., Stokes, B. H., Ward, K. E., Fairhurst, K. J., Pasaje, C. F. A., Yeo, T., Akbar, S., Park, H., Muir, R., Bick, D. S., Zhan, W., Zhang, H., Liu, Y. J., Ng, C. L., Kirkman, L. A., Almaliti, J., Gould, A. E., Duffey, M., O’Donoghue, A. J., … Fidock, D. A. (2023). Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome. Cell Chemical Biology, 30(5), 470-485.e6. https://doi.org/10.1016/j.chembiol.2023.03.002
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Winans, S., Yu, H. J., de los Santos, K., Wang, G. Z., KewalRamani, V. N., & Goff, S. P. (2022). A point mutation in HIV-1 integrase redirects proviral integration into centromeric repeats. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-29097-8
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Laleu, B., Rubiano, K., Yeo, T., Hallyburton, I., Anderson, M., Crespo‐Fernandez, B., Gamo, F., Antonova‐Koch, Y., Orjuela‐Sanchez, P., Wittlin, S., Jana, G. P., Maity, B. C., Chenu, E., Duffy, J., Sjö, P., Waterson, D., Winzeler, E., Guantai, E., Fidock, D. A., & Hansson, T. G. (2022). Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2. ChemMedChem, 17(22). Portico. https://doi.org/10.1002/cmdc.202200393
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Benner, S. E., Eby, Y., Zhu, X., Fernandez, R. E., Patel, E. U., Ruff, J. E., Habtehyimer, F., Schmidt, H. A., Kirby, C. S., Hussain, S., Ostrander, D., Desai, N. M., Florman, S., Rana, M. M., Friedman-Moraco, R., Pereira, M. R., Mehta, S., Stock, P., Gilbert, A., … Tobian, A. A. R. (2022). The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir. JCI Insight, 7(21). https://doi.org/10.1172/jci.insight.162968
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Okombo, J., Mok, S., Qahash, T., Yeo, T., Bath, J., Orchard, L. M., Owens, E., Koo, I., Albert, I., Llinás, M., & Fidock, D. A. (2022). Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages. PLOS Pathogens, 18(10), e1010926. https://doi.org/10.1371/journal.ppat.1010926
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Batal, I., Hasni, S., & Serur, D. (2022). A 65-year-old kidney transplant recipient with elevated serum creatinine without significant proteinuria. American Journal of Transplantation, 22(10), 2475–2477. https://doi.org/10.1111/ajt.17152
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Qiu, D., Pei, J. V., Rosling, J. E. O., Thathy, V., Li, D., Xue, Y., Tanner, J. D., Penington, J. S., Aw, Y. T. V., Aw, J. Y. H., Xu, G., Tripathi, A. K., Gnadig, N. F., Yeo, T., Fairhurst, K. J., Stokes, B. H., Murithi, J. M., Kümpornsin, K., Hasemer, H., … Lehane, A. M. (2022). A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-33403-9
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Morris, S. E., Strehlau, R., Shiau, S., Abrams, E. J., Tiemessen, C. T., Kuhn, L., & Yates, A. J. (2022). Healthy dynamics of CD4 T cells may drive HIV resurgence in perinatally-infected infants on antiretroviral therapy. PLOS Pathogens, 18(8), e1010751. https://doi.org/10.1371/journal.ppat.1010751
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Jennings, L., Robbins, R. N., Nguyen, N., Ferraris, C., Leu, C.-S., Dolezal, C., Hsiao, N., Mgbako, O., Joska, J., Castillo-Mancilla, J. R., Myer, L., Anderson, P. L., Remien, R. H., & Orrell, C. (2022). Tenofovir diphosphate in dried blood spots predicts future viremia in persons with HIV taking antiretroviral therapy in South Africa. AIDS, 36(7), 933–940. https://doi.org/10.1097/qad.0000000000003185
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Prockop, S., Beitinjaneh, A., Choquet, S., Dahiya, S., Dinavahi, R., Farah, R., Gamelin, L., Ghobadi, A., Mehta, A., Nayak, P., Reshef, R., Satyanarayana, G., Stiff, P., Ye, W., & Mahadeo, K. M. (2022). S256: TABELECLEUCEL FOR EBV-DRIVEN POST-TRANSPLANT LYMPHOPROLIFERATIVE DISEASE FOLLOWING ALLOGENEIC HEMATOPOIETIC CELL OR SOLID ORGAN TRANSPLANT AFTER FAILURE OF RITUXIMAB ± CHEMOTHERAPY (ALLELE). HemaSphere, 6, 157–158. https://doi.org/10.1097/01.hs9.0000843916.04522.0a
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Kashyap, A., Abramov, D., Bharadwaj, A., Rabkin, M., & Rabkin, D. G. (2022). Coronary artery aneurysm, ectasia and stenosis in a 53-year-old man with HIV infection. Journal of Surgical Case Reports, 2022(3). https://doi.org/10.1093/jscr/rjac056
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Columbia Affiliation
Small-Saunders, J. L., Hagenah, L. M., Wicht, K. J., Dhingra, S. K., Deni, I., Kim, J., Vendome, J., Gil-Iturbe, E., Roepe, P. D., Mehta, M., Mancia, F., Quick, M., Eppstein, M. J., & Fidock, D. A. (2022). Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance. PLOS Pathogens, 18(2), e1010278. https://doi.org/10.1371/journal.ppat.1010278
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