Therapeutic Antibodies: Development, Engineering, and Applications

Displaying 1 - 33 of 33CSV
Saha, N., Lee, S. G., Brockmann, E.-C., de la Cruz, M. J., Goldgur, Y., Mendoza, R. P., Stanchina, E. de, Love, T. M., Marvald, J., Xu, Y., Xu, K., Himanen, J. P., Lamminmäki, U., Veach, D., & Nikolov, D. B. (2024). Fully human monoclonal antibody targeting the cysteine-rich substrate-interacting region of ADAM17 on cancer cells. Biomedicine & Pharmacotherapy, 180, 117605. https://doi.org/10.1016/j.biopha.2024.117605
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Zhong, J., Lerrer, S., & Mor, A. (2024). An Imaging-Based Assay to Measure the Location of PD-1 at the Immune Synapse for Testing the Binding Efficacy of Anti-PD-1 and Anti-PD-L1 Antibodies. BIO-PROTOCOL, 14(1352). https://doi.org/10.21769/bioprotoc.5057
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Fleischer, S., Nash, T. R., Tamargo, M. A., Lock, R. I., Venturini, G., Morsink, M., Graney, P. L., Li, V., Lamberti, M. J., Liberman, M., Kim, Y., Tavakol, D. N., Zhuang, R. Z., Whitehead, J., Friedman, R. A., Soni, R. K., Seidman, J. G., Seidman, C. E., Geraldino-Pardilla, L., … Vunjak-Novakovic, G. (2024). An engineered human cardiac tissue model reveals contributions of systemic lupus erythematosus autoantibodies to myocardial injury. Nature Cardiovascular Research, 3(9), 1123–1139. https://doi.org/10.1038/s44161-024-00525-w
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Bumma, N., Richter, J., Jagannath, S., Lee, H. C., Hoffman, J. E., Suvannasankha, A., Zonder, J. A., Shah, M. R., Lentzsch, S., Baz, R., Maly, J. J., Namburi, S., Pianko, M. J., Ye, J. C., Wu, K. L., Silbermann, R., Min, C.-K., Vekemans, M.-C., Munder, M., … Dhodapkar, M. V. (2024). Linvoseltamab for Treatment of Relapsed/Refractory Multiple Myeloma. Journal of Clinical Oncology, 42(22), 2702–2712. https://doi.org/10.1200/jco.24.01008
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Askanase, A. D., Furie, R. A., Dall’Era, M., Bomback, A. S., Schwarting, A., Zhao, M.-H., Bruce, I. N., Khamashta, M., Rubin, B., Carroll, A., Daniels, M., Levy, R. A., van Vollenhoven, R., & Urowitz, M. B. (2024). Disease-modifying therapies in systemic lupus erythematosus for extrarenal manifestations. Lupus Science & Medicine, 11(1), e001124. https://doi.org/10.1136/lupus-2023-001124
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Mayer, B. T., Zhang, L., deCamp, A. C., Yu, C., Sato, A., Angier, H., Seaton, K. E., Yates, N., Ledgerwood, J. E., Mayer, K., Caskey, M., Nussenzweig, M., Stephenson, K., Julg, B., Barouch, D. H., Sobieszczyk, M. E., Edupuganti, S., Kelley, C. F., McElrath, M. J., … Huang, Y. (2024). Impact of LS Mutation on Pharmacokinetics of Preventive HIV Broadly Neutralizing Monoclonal Antibodies: A Cross-Protocol Analysis of 16 Clinical Trials in People without HIV. Pharmaceutics, 16(5), 594. https://doi.org/10.3390/pharmaceutics16050594
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Krustev, E., Hanly, J. G., Chin, R., Buhler, K. A., Urowitz, M. B., Gordon, C., Bae, S.-C., Romero-Diaz, J., Sánchez-Guerrero, J., Bernatsky, S., Wallace, D. J., Isenberg, D., Rahman, A., Merrill, J. T., Fortin, P. R., Gladman, D. D., Bruce, I. N., Petri, M. A., Ginzler, E. M., … Choi, M. Y. (2024). Anti-KIF20B autoantibodies are associated with cranial neuropathy in systemic lupus erythematosus. Lupus Science & Medicine, 11(1), e001139. https://doi.org/10.1136/lupus-2023-001139
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Cherng, H.-J. J., & Herrera, A. (2024). Now You “CD20,” Now You Don’t: A Vanishing Act in B-cell Lymphomas After Bispecific Antibody Treatment. The Hematologist, 21(2). https://doi.org/10.1182/hem.v21.2.202425
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Winter, H., Baldassano, R. N., Pfeffkorn, M. D., Wali, P., Verstraete, S. G., Picoraro, J. A., Washek, M. A., Kumar, N., Mortan, W., Havard- Jr, M., Blystone, L., Trombler, B., Pursley, C., Lin, X., Dillon, S. T., Gu, X., Otu, H. H., Ngo, L., & Libermann, T. A. (2024). P192 Personalizing treatment for predicting response to infliximab in children with Crohn’s disease using proteomic biomarkers. Journal of Crohn’s and Colitis, 18(Supplement_1), i506–i506. https://doi.org/10.1093/ecco-jcc/jjad212.0322
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Mohan, M., Shah, N., Luan, D., Monge, J., Forsberg, M., Bhatlapenumarthi, V., Balev, M., Patwari, A., Cheruvalath, H., Bhutani, D., Thanendrarajan, S., Dhakal, B., Zangari, M., Al Hadidi, S., Cooper, D. L., Lentzsch, S., van Rhee, F., D’Souza, A., Szabo, A., … Chakraborty, R. (2023). Teclistamab in Relapsed Refractory Multiple Myeloma: Multi-Institutional Real-World Study. Blood, 142(Supplement 1), 545–545. https://doi.org/10.1182/blood-2023-174875
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Diefenbach, C. S., Jegede, O., Ansell, S. M., Steidl, C., Natkunam, Y., Scott, D. W., Mehta-Shah, N., Amengual, J. E., Forlenza, C. J., Cole, P. D., Bartlett, N. L., David, K. A., Advani, R. H., Ambinder, R. F., Thomas, S., Ibrahimi, S., & Kahl, B. S. (2023). Results from an Intergroup Randomized Phase II Study of the Combinations of Ipilimumab, Nivolumab and Brentuximab Vedotin in Patients with Relapsed/Refractory Classic Hodgkin Lymphoma: A Trial of the ECOG-ACRIN Research Group (E4412). Blood, 142(Supplement 1), 607–607. https://doi.org/10.1182/blood-2023-184531
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Jagannath, S., Richter, J., Dhodapkar, M. V., Hoffman, J. E., Lee, H. C., Suvannasankha, A., Shah, M. R., Lentzsch, S., Zonder, J. A., Baz, R., Maly, J. J., Namburi, S., Wu, K. L., Pianko, M., Ye, J. C., Silbermann, R., Min, C.-K., Vekemans, M.-C., Munder, M., … Bumma, N. (2023). Patterns of Response to 200 Mg Linvoseltamab in Patients with Relapsed/Refractory Multiple Myeloma: Longer Follow-Up of the Linker-MM1 Study. Blood, 142(Supplement 1), 4746–4746. https://doi.org/10.1182/blood-2023-177968
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Liu, J., O’Malley, D., Nieuwenhuysen, E. V., Moore, K., Hamilton, E., Yeku, O., Bouberhan, S., Hou, J., Schröder, D., Wang, B., Yoo, S.-Y., Govindraj, S., Brouwer-Visser, J., Peterman, M., Schmidt, T., Barnes, B., Lowy, I., Uldrick, T., Miller, E., & O’Cearbhaill, R. (2023). PO011LBA/#1512  Ubamatamab (MUC16XCD3 bispecific antibody) with or without cemiplimab (Anti-PD-1 antibody) in recurrent ovarian cancer: phase 1 clinical and biomarker results. Plenary 03: Oral Abstract Presentations – Ovarian Cancer. https://doi.org/10.1136/ijgc-2023-igcs.11
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O’Cearbhaill, R. E., Moore, K. N., Yeku, O., Liu, J. F., Bouberhan, S., Hamilton, E. P., Hou, J. Y., Van Nieuwenhuysen, E., Papadimitriou, K., Yoo, S.-Y., Govindraj, S., Brouwer-Visser, J., Peterman, M., Schmidt, T., Barnes, B., Madia, P., Zhu, M., Uldrick, T. S., Miller, E. A., & O’Malley, D. (2023). 754P Ubamatamab (MUC16xCD3 bispecific antibody) with cemiplimab (anti-PD-1 antibody) in recurrent ovarian cancer: Phase I dose-escalation study. Annals of Oncology, 34, S516–S517. https://doi.org/10.1016/j.annonc.2023.09.1933
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Schreidah, C. M., Reynolds, G. B., Fahmy, L. M., Carvajal, R. D., Vermeer, M. H., Whittaker, S., Pe’er, I., & Geskin, L. J. (2023). Scoping review of genetic databases for rare dermatologic diseases: Opportunity for artificial intelligence and machine learning. JAAD International, 12, 24–31. https://doi.org/10.1016/j.jdin.2023.02.017
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Sergeeva, A. P., Katsamba, P. S., Liao, J., Sampson, J. M., Bahna, F., Mannepalli, S., Morano, N. C., Shapiro, L., Friesner, R. A., & Honig, B. (2023). Free Energy Perturbation Calculations of Mutation Effects on SARS-CoV-2 RBD::ACE2 Binding Affinity. Journal of Molecular Biology, 435(15), 168187. https://doi.org/10.1016/j.jmb.2023.168187
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Di Meo, F., Iyer, A., Akama, K., Cheng, R., Yu, C., Cesarano, A., Kurihara, N., Tenshin, H., Aljoufi, A., Marino, S., Soni, R. K., Roda, J., Sissons, J., Vu, L. P., Guzman, M., Huang, K., Laskowski, T., Broxmeyer, H. E., Roodman, D. G., & Perna, F. (2023). A target discovery pipeline identified ILT3 as a target for immunotherapy of multiple myeloma. Cell Reports Medicine, 4(7), 101110. https://doi.org/10.1016/j.xcrm.2023.101110
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Askanase, A., Stach, C., Brittain, C., Stojan, G., & Furie, R. (2023). POS0115 DAPIROLIZUMAB PEGOL EFFICACY BY SUBGROUPS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: A POST HOC ANALYSIS OF PHASE 2 CLINICAL TRIAL DATA. Scientific Abstracts. https://doi.org/10.1136/annrheumdis-2023-eular.1991
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Askanase, A., Furie, R., Dall’era, M., Bomback, A., Schwarting, A., Zhao, M. H., Bruce, I. N., Khamashta, M., Rubin, B., Carroll, A., Daniels, M., Levy, R., Van Vollenhoven, R., & Urowitz, M. B. (2023). POS1153 APPLYING THE WORKING DEFINITION OF THE DISEASE MODIFICATION CRITERIA TO SYSTEMIC LUPUS ERYTHEMATOSUS TREATMENTS FROM THE PUBLISHED LITERATURE. Scientific Abstracts. https://doi.org/10.1136/annrheumdis-2023-eular.3052
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Askanase, A., Furie, R., Dall’era, M., Bomback, A., Schwarting, A., Zhao, M. H., Bruce, I. N., Khamashta, M., Rubin, B., Carroll, A., Daniels, M., Levy, R., Van Vollenhoven, R., & Urowitz, M. B. (2023). AB0531 APPLYING THE WORKING DEFINITION OF THE DISEASE MODIFICATION CRITERIA TO LUPUS NEPHRITIS TREATMENTS FROM THE PUBLISHED LITERATURE. Scientific Abstracts. https://doi.org/10.1136/annrheumdis-2023-eular.3897
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Hamid, O., Lewis, K., Weise, A., McKean, M., Papadopoulos, K. P., Crown, J., Kim, T. M., Lakhani, N. J., Kaczmar, J., Kudchadkar, R., Spira, A., Rabinowits, G., Kim, K., Carvajal, R., Williamson, S., Ioffe, E., Chen, S., Mani, J., Jankovic, V., … Gullo, G. (2023). Phase 1 study of fianlimab, a human lymphocyte activation gene-3 monoclonal antibody, in combination with cemiplimab in advanced melanoma: Expansion cohort analysis. SKIN The Journal of Cutaneous Medicine, 7(2), s179. https://doi.org/10.25251/skin.7.supp.179
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Askanase, A., Furie, R., DallEra, M., Bomback, A., Schwarting, A., Zhao, M.-H., Bruce, I., Khamashta, M., Rubin, B., Carroll, A., Daniels, M., Levy, R. A., Vollenhoven, R. van, Urowitz, M., & David, N. (2023). APPLYING THE WORKING DEFINITION OF THE DISEASE MODIFICATION CRITERIA TO SYSTEMIC LUPUS ERYTHEMATOSUS TREATMENTS FROM THE PUBLISHED LITERATURE. Congresso Brasileiro de Reumatologia, 1. https://doi.org/10.47660/cbr.2023.2501
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Strazza, M., Moore, E. K., Adam, K., Azoulay-Alfaguter, I., & Mor, A. (2022). Neutralization of the adaptor protein PAG by monoclonal antibody limits murine tumor growth. Molecular Therapy - Methods & Clinical Development, 27, 380–390. https://doi.org/10.1016/j.omtm.2022.10.012
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Bumma, N., Richter, J., Brayer, J., Zonder, J. A., Dhodapkar, M., Shah, M. R., Hoffman, J. E., Mawad, R., Maly, J. J., Lentzsch, S., Suvannasankha, A., Roy, P., Dey, J., Chokshi, D., Boyapati, A., Visich, J., Houvras, Y., Rodriguez Lorenc, K., Kroog, G. S., & Jagannath, S. (2022). Updated Safety and Efficacy of REGN5458, a BCMAxCD3 Bispecific Antibody, Treatment for Relapsed/Refractory Multiple Myeloma: A Phase 1/2 First-in-Human Study. Blood, 140(Supplement 1), 10140–10141. https://doi.org/10.1182/blood-2022-159969
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Sharma, M., Lathers, D., Johnson, M., Luke, J., Puzanov, I., Curti, B., Chen, C., El-Khoueiry, A., Henick, B., Callahan, M., Sznol, M., Patel, S., Wilson, D., Ricker, M., Cao, L., Jayaraman, P., Che, J., Peng, L., Feltquate, D., … Tolcher, A. (2022). 772 A phase 1/2 dose escalation/expansion study evaluating the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of E-602, a bi-sialidase fusion protein, in advanced cancer (GLIMMER-01). Regular and Young Investigator Award Abstracts, A803–A803. https://doi.org/10.1136/jitc-2022-sitc2022.0772
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Friedman, C., Carvajal, R., Davar, D., Castanon, E., Ascierto, P., Calvo, E., O’Hara, M., Powell, S., Shapira-Frommer, R., Garralda, E., Renouf, D. J., Perets, R., Yunan, M., Ravindran, P., Hammell, A., O’Brien, S., Xu, K., Wilson, N., Jhatakia, A., … Gutierrez, M. (2022). 592 Phase 1/2a study of the novel nonfucosylated anti–CTLA-4 monoclonal antibody BMS-986218 ± nivolumab in advanced solid tumors: part 1 results. Regular and Young Investigator Award Abstracts, A620–A621. https://doi.org/10.1136/jitc-2022-sitc2022.0592
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Qiu, A., Miller, A., Zotti, F. D., Santhanakrishnan, M., Hendrickson, J. E., Tredicine, M., Stowell, S. R., Luckey, C. J., Zimring, J. C., & Hudson, K. E. (2022). FcγRIV is required for IgG2c mediated enhancement of RBC alloimmunization. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.972723
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Van Nieuwenhuysen, E., O’Malley, D., O’Cearbhaill, R. E., Moore, K. N., Hamilton, E. P., Yeku, O., Bouberhan, S., Hou, J. Y., Yoo, S.-Y., Brouwer-Visser, J., Cheung, H. K., Peterman, M., Goncalves, P., Schmidt, T., Zhu, M., Lowy, I., Rowlands, T., Uldrick, T. S., Miller, E. A., & Liu, J. F. (2022). 523MO Ubamatamab (REGN4018, MUC16xCD3 bispecific antibody) monotherapy in patients with recurrent ovarian cancer (OC): Phase I dose-escalation analysis. Annals of Oncology, 33, S784. https://doi.org/10.1016/j.annonc.2022.07.651
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Hamid, O., Sato, T., Davar, D., Callahan, M. K., Thistlethwaite, F., Aljumaily, R., Johnson, M. L., Arkenau, H.-T., Ileana Dumbrava, E. E., Izar, B., Chen, H. A., Marshall, S., Yuan, Y., Deo, M., Stanhope, S., Collins, L., Mundy, R., Abdullah, S. E., & Lopez, J. S. (2022). 728O Results from phase I dose escalation of IMC-F106C, the first PRAME × CD3 ImmTAC bispecific protein in solid tumors. Annals of Oncology, 33, S875. https://doi.org/10.1016/j.annonc.2022.07.854
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Kyi, C. K., Spira, A., Carbone, D. P., Johnson, M. L., Henick, B. S., Johnson, B., Borghaei, H., Mahipal, A., Hecht, J. R., Catenacci, D., Liao, C.-Y., Shergill, A., Memmott, R., Presley, C., Jaroslavsky, J., Schenk, D., Jooss, K., Ferguson, A. R., & Goldman, J. W. (2022). 736MO Personalized, off-the-shelf KRAS neoantigen-specific immunotherapy for the treatment of advanced solid tumors: Clinical benefit associated with decreases in ctDNA (SLATE-KRAS). Annals of Oncology, 33, S880. https://doi.org/10.1016/j.annonc.2022.07.862
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Zonder, J. A., Richter, J., Bumma, N., Brayer, J., Hoffman, J. E., Bensinger, W. I., Wu, K. L., Xu, L., Chokshi, D., Boyapati, A., Cronier, D., Houvras, Y., Rodriguez Lorenc, K., Kroog, G. S., Dhodapkar, M. V., Lentzsch, S., Cooper, D., & Jagannath, S. (2022). S189: EARLY, DEEP, AND DURABLE RESPONSES, AND LOW RATES OF CRS WITH REGN5458, A BCMAXCD3 BISPECIFIC ANTIBODY, IN A PHASE 1/2 FIRST-IN-HUMAN STUDY IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA. HemaSphere, 6, 90–91. https://doi.org/10.1097/01.hs9.0000843648.44771.79
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Petri, M. A., Bertsias, G., Daniels, M., Fox, N. L., Hahn, B. H., Hammer, A., Harris, J., Quasny, H., Tani, C., & Askanase, A. (2022). POS0183 THE EFFECT OF BELIMUMAB ON SRI-4 RESPONSE IN MULTIPLE SUBGROUPS OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: RESULTS OF A LARGE INTEGRATED ANALYSIS. Annals of the Rheumatic Diseases, 81, 323. https://doi.org/10.1136/annrheumdis-2022-eular.1807
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