Impact of LS Mutation on Pharmacokinetics of Preventive HIV Broadly Neutralizing Monoclonal Antibodies: A Cross-Protocol Analysis of 16 Clinical Trials in People without HIV

Mayer, B. T., Zhang, L., deCamp, A. C., Yu, C., Sato, A., Angier, H., Seaton, K. E., Yates, N., Ledgerwood, J. E., Mayer, K., Caskey, M., Nussenzweig, M., Stephenson, K., Julg, B., Barouch, D. H., Sobieszczyk, M. E., Edupuganti, S., Kelley, C. F., McElrath, M. J., … Huang, Y. (2024). Impact of LS Mutation on Pharmacokinetics of Preventive HIV Broadly Neutralizing Monoclonal Antibodies: A Cross-Protocol Analysis of 16 Clinical Trials in People without HIV. Pharmaceutics, 16(5), 594. https://doi.org/10.3390/pharmaceutics16050594
Authors:
Bryan T. Mayer
Lily Zhang
Allan C. deCamp
Chenchen Yu
Alicia Sato
Heather Angier
Kelly E. Seaton
Nicole L. Yates
Julie E. Ledgerwood
Kenneth H. Mayer
Marina Caskey
Michel C. Nussenzweig
Kathryn E. Stephenson
Boris Jülg
Dan H. Barouch
Magdalena E. Sobieszczyk
Srilatha Edupuganti
Colleen F. Kelley
M. Juliana McElrath
Huub C. Gelderblom
Michael Pensiero
Adrian B. McDermott
Lúcio Gama
Richard A. Koup
Peter B. Gilbert
Myron S. Cohen
Lawrence Corey
Ollivier Hyrien
Georgia D. Tomaras
Yunda Huang
Affiliated Authors:
Magdalena E. Sobieszczyk
Columbia Affiliation:
Subjects:
Therapeutic Antibodies: Development, Engineering, and Applications (OpenAlex Topic)
Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (OpenAlex Topic)
Role of Complement System in Immune Response (OpenAlex Topic)
Author Keywords:
hiv prevention
ls mutation
monoclonal antibodies
population pharmacokinetics modeling
targeted maximum likelihood estimation (tmle)
two-compartment model
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Publication Type:
Article
Unique ID:
10.3390/pharmaceutics16050594
PMID:
38794258
DOI:
10.3390/pharmaceutics16050594
Journal:
Pharmaceutics
Publication Date:
Data Source:
OpenAlex
Source Link:
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