HIV-1
Morris, D. J., Gorman, J., Zhou, T., Lora, J., Connell, A. J., Li, H., Liu, W., Roark, R. S., Campion, M. S., Carey, J. W., Habib, R., Li, Y., Martella, C. L., Park, Y., Singh, A., Sowers, K. J., Teng, I.-T., Wang, S., Chohan, N., … Shaw, G. M. (2025). Transient glycan shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques. Cell Reports, 44(6), 115848. https://doi.org/10.1016/j.celrep.2025.115848
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Thakur, B., Katte, R. H., Xu, W., Janowska, K., Sammour, S., Henderson, R., Lu, M., Kwong, P. D., & Acharya, P. (2025). Conformational trajectory of the HIV-1 fusion peptide during CD4-induced envelope opening. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-59721-2
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Chang, L.-C., Yin, M. T., Laird, G. M., Ritter, K. D., Shah, J. G., & Debnath, A. K. (2025). A First-in-Class Dual Degrader of Bcl-2/Bcl-xL Reverses HIV Latency and Minimizes Ex Vivo Reservoirs from Patients. International Journal of Molecular Sciences, 26(6), 2772. https://doi.org/10.3390/ijms26062772
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Mason, R. D., Zhang, B., Morano, N. C., Shen, C.-H., McKee, K., Heimann, A., Du, R., Nazzari, A. F., Hodges, S., Kanai, T., Lin, B. C., Louder, M. K., Doria-Rose, N. A., Zhou, T., Shapiro, L., Roederer, M., Kwong, P. D., & Gorman, J. (2025). Structural development of the HIV-1 apex-directed PGT145-PGDM1400 antibody lineage. Cell Reports, 44(1), 115223. https://doi.org/10.1016/j.celrep.2024.115223
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Cale, E. M., Shen, C.-H., Olia, A. S., Radakovich, N. A., Rawi, R., Yang, Y., Ambrozak, D. R., Bennici, A. K., Chuang, G.-Y., Crooks, E. D., Driscoll, J. I., Lin, B. C., Louder, M. K., Madden, P. J., Messina, M. A., Osawa, K., Stewart-Jones, G. B. E., Verardi, R., Vrakas, Z., … Gorman, J. (2024). A multidonor class of highly glycan-dependent HIV-1 gp120-gp41 interface-targeting broadly neutralizing antibodies. Cell Reports, 43(12), 115010. https://doi.org/10.1016/j.celrep.2024.115010
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Reveiz, M., Xu, K., Lee, M., Wang, S., Olia, A. S., Harris, D. R., Liu, K., Liu, T., Schaub, A. J., Stephens, T., Wang, Y., Zhang, B., Huang, R., Tsybovsky, Y., Kwong, P. D., & Rawi, R. (2024). Vaccine-elicited and naturally elicited antibodies differ in their recognition of the HIV-1 fusion peptide. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1484029
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Xu, J., Zhou, T., McKee, K., Zhang, B., Liu, C., Nazzari, A. F., Pegu, A., Shen, C., Becker, J. E., Bender, M. F., Chan, P., Changela, A., Chaudhary, R., Chen, X., Einav, T., Kwon, Y. D., Lin, B. C., Louder, M. K., Merriam, J. S., … Kwong, P. D. (2024). Ultrapotent Broadly Neutralizing Human‐llama Bispecific Antibodies against HIV‐1. Advanced Science, 11(26). Portico. https://doi.org/10.1002/advs.202309268
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Prakash, P., Khodke, P., Balasubramaniam, M., Davids, B.-O., Hollis, T., Davis, J., Kumbhar, B., & Dash, C. (2024). Three prime repair exonuclease 1 preferentially degrades the integration-incompetent HIV-1 DNA through favorable kinetics, thermodynamic, structural, and conformational properties. Journal of Biological Chemistry, 300(7), 107438. https://doi.org/10.1016/j.jbc.2024.107438
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Tenggara, M. K., Oh, S.-H., Yang, C., Nariya, H. K., Metz, A. M., Upadhyay, A. A., Gudipati, D. R., Guo, L., McGhee, E. G., Gill, K., Viox, E. G., Mason, R. D., Doria-Rose, N. A., Foulds, K. E., Mascola, J. R., Du, Y., Fu, H., Altman, J. D., Yan, Q., … Kong, R. (2024). Frequency-potency analysis of IgG+ memory B cells delineates neutralizing antibody responses at single-cell resolution. Cell Reports, 43(3), 113948. https://doi.org/10.1016/j.celrep.2024.113948
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Joseph, S. B., Abrahams, M.-R., Moeser, M., Tyers, L., Archin, N. M., Council, O. D., Sondgeroth, A., Spielvogel, E., Emery, A., Zhou, S., Doolabh, D., Ismail, S. D., Karim, S. A., Margolis, D. M., Pond, S. K., Garrett, N., Swanstrom, R., & Williamson, C. (2024). The timing of HIV-1 infection of cells that persist on therapy is not strongly influenced by replication competency or cellular tropism of the provirus. PLOS Pathogens, 20(2), e1011974. https://doi.org/10.1371/journal.ppat.1011974
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Shalekoff, S., Dias, B. D. C., Loubser, S., Strehlau, R., Kuhn, L., & Tiemessen, C. T. (2024). Higher CCR5 density on CD4+ T-cells in mothers and infants is associated with increased risk of in-utero HIV-1 transmission. AIDS, 38(7), 945–954. https://doi.org/10.1097/qad.0000000000003857
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Reeves, D. B., Mayer, B. T., deCamp, A. C., Huang, Y., Zhang, B., Carpp, L. N., Magaret, C. A., Juraska, M., Gilbert, P. B., Montefiori, D. C., Bar, K. J., Cardozo-Ojeda, E. F., Schiffer, J. T., Rossenkhan, R., Edlefsen, P., Morris, L., Mkhize, N. N., Williamson, C., Mullins, J. I., … Edupuganti, S. (2023). High monoclonal neutralization titers reduced breakthrough HIV-1 viral loads in the Antibody Mediated Prevention trials. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-43384-y
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Singh, Y., Castillo-Mancilla, J., Madimabe, R., Jennings, L., Ferraris, C. M., Robbins, R. N., Anderson, P. L., Remien, R. H., & Orrell, C. (2023). Tenofovir diphosphate in dried blood spots and HIV-1 resistance in South Africa. AIDS Research and Therapy, 20(1). https://doi.org/10.1186/s12981-023-00552-w
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Matassoli, F., Cagigi, A., Shen, C.-H., Henry, A. R., Johnston, T. S., Schramm, C. A., Cottrell, C. A., Kalyuzhniy, O., Spangler, A., Ndung’u, T., Dong, K., Eller, L., Robb, M., Eller, M., Naluyima, P., Kwong, P. D., Douek, D. C., Schief, W. R., Andrews, S. F., & McDermott, A. B. (2023). High frequency of HIV precursor-target-specific B cells in sub-Saharan populations. Cell Reports, 42(12), 113450. https://doi.org/10.1016/j.celrep.2023.113450
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Sobieszczyk, M. E., Mannheimer, S., Paez, C. A., Yu, C., Gamble, T., Theodore, D. A., Chege, W., Yacovone, M., Hanscom, B., Heptinstall, J., Seaton, K. E., Zhang, L., Miner, M. D., Eaton, A., Weiner, J. A., Mayer, K., Kalams, S., Stephenson, K., Julg, B., … Montefiori, D. (2023). Safety, tolerability, pharmacokinetics, and immunological activity of dual-combinations and triple-combinations of anti-HIV monoclonal antibodies PGT121, PGDM1400, 10-1074, and VRC07-523LS administered intravenously to HIV-uninfected adults: a phase 1 randomised trial. The Lancet HIV, 10(10), e653–e662. https://doi.org/10.1016/s2352-3018(23)00140-6
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Schulz, V. E., Tuff, J. F., Tough, R. H., Lewis, L., Chimukangara, B., Garrett, N., Abdool Karim, Q., Abdool Karim, S. S., McKinnon, L. R., Kharsany, A. B. M., & McLaren, P. J. (2023). Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population. Journal of Virology, 97(10). https://doi.org/10.1128/jvi.00954-23
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Glögl, M., Friedrich, N., Cerutti, G., Lemmin, T., Kwon, Y. D., Gorman, J., Maliqi, L., Mittl, P. R. E., Hesselman, M. C., Schmidt, D., Weber, J., Foulkes, C., Dingens, A. S., Bylund, T., Olia, A. S., Verardi, R., Reinberg, T., Baumann, N. S., Rusert, P., … Trkola, A. (2023). Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization. Nature Structural & Molecular Biology, 30(9), 1323–1336. https://doi.org/10.1038/s41594-023-01062-z
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McLaren, P. J., Porreca, I., Iaconis, G., Mok, H. P., Mukhopadhyay, S., Karakoc, E., Cristinelli, S., Pomilla, C., Bartha, I., Thorball, C. W., Tough, R. H., Angelino, P., Kiar, C. S., Carstensen, T., Fatumo, S., Porter, T., Jarvis, I., Skarnes, W. C., Bassett, A., … Fellay, J. (2023). Africa-specific human genetic variation near CHD1L associates with HIV-1 load. Nature, 620(7976), 1025–1030. https://doi.org/10.1038/s41586-023-06370-4
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Wang, S., Matassoli, F., Zhang, B., Liu, T., Shen, C.-H., Bylund, T., Johnston, T., Henry, A. R., Teng, I.-T., Tripathi, P., Becker, J. E., Changela, A., Chaudhary, R., Cheng, C., Gaudinski, M., Gorman, J., Harris, D. R., Lee, M., Morano, N. C., … Kwong, P. D. (2023). HIV-1 neutralizing antibodies elicited in humans by a prefusion-stabilized envelope trimer form a reproducible class targeting fusion peptide. Cell Reports, 42(7), 112755. https://doi.org/10.1016/j.celrep.2023.112755
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Xu, Y., Ferguson, T., Masuda, K., Siddiqui, M. A., Smith, K. P., Vest, O., Brooks, B., Zhou, Z., Obliosca, J., Kong, X.-P., Jiang, X., Yamashita, M., Moriya, T., & Tison, C. (2023). Short Carbon Nanotube-Based Delivery of mRNA for HIV-1 Vaccines. Biomolecules, 13(7), 1088. https://doi.org/10.3390/biom13071088
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Ken, M. L., Roy, R., Geng, A., Ganser, L. R., Manghrani, A., Cullen, B. R., Schulze-Gahmen, U., Herschlag, D., & Al-Hashimi, H. M. (2023). RNA conformational propensities determine cellular activity. Nature, 617(7962), 835–841. https://doi.org/10.1038/s41586-023-06080-x
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Fritschi, C. J., Anang, S., Gong, Z., Mohammadi, M., Richard, J., Bourassa, C., Severino, K. T., Richter, H., Yang, D., Chen, H.-C., Chiu, T.-J., Seaman, M. S., Madani, N., Abrams, C., Finzi, A., Hendrickson, W. A., Sodroski, J. G., & Smith, A. B. (2023). Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity. Proceedings of the National Academy of Sciences, 120(13). https://doi.org/10.1073/pnas.2222073120
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Rosenberg, N. E., Shook-Sa, B. E., Liu, M., Stranix-Chibanda, L., Yotebieng, M., Sam-Agudu, N. A., Hudgens, M. G., Phiri, S. J., Mutale, W., Bekker, L.-G., Moyo, S., Zuma, K., Charurat, M. E., Justman, J., & Chi, B. H. (2023). Adult HIV-1 incidence across 15 high-burden countries in sub-Saharan Africa from 2015 to 2019: a pooled analysis of nationally representative data. The Lancet HIV, 10(3), e175–e185. https://doi.org/10.1016/s2352-3018(22)00328-9
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Jin, D., Zhu, Y., Schubert, H. L., Goff, S. P., & Musier-Forsyth, K. (2023). HIV-1 Gag Binds the Multi-Aminoacyl-tRNA Synthetase Complex via the EPRS Subunit. Viruses, 15(2), 474. https://doi.org/10.3390/v15020474
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Karim, Q. A., Archary, D., Barré-Sinoussi, F., Broliden, K., Cabrera, C., Chiodi, F., Fidler, S. J., Gengiah, T. N., Herrera, C., Kharsany, A. B. M., Liebenberg, L. J. P., Mahomed, S., Menu, E., Moog, C., Scarlatti, G., Seddiki, N., Sivro, A., & Cavarelli, M. (2022). Women for science and science for women: Gaps, challenges and opportunities towards optimizing pre-exposure prophylaxis for HIV-1 prevention. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.1055042
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Geis, F. K., Kelenis, D. P., & Goff, S. P. (2022). Two lymphoid cell lines potently silence unintegrated HIV-1 DNAs. Retrovirology, 19(1). https://doi.org/10.1186/s12977-022-00602-7
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Gunaratne, S. H., Tieu, H. V., Wilkin, T. J., & Taylor, B. S. (2022). CROI 2022: advances in antiviral therapy for HIV, COVID-19, and viral hepatitis. Topics in antiviral medicine, 30(3), 490–521.
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Benner, S. E., Eby, Y., Zhu, X., Fernandez, R. E., Patel, E. U., Ruff, J. E., Habtehyimer, F., Schmidt, H. A., Kirby, C. S., Hussain, S., Ostrander, D., Desai, N. M., Florman, S., Rana, M. M., Friedman-Moraco, R., Pereira, M. R., Mehta, S., Stock, P., Gilbert, A., … Tobian, A. A. R. (2022). The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir. JCI Insight, 7(21). https://doi.org/10.1172/jci.insight.162968
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Parmley, L. E., Harris, T. G., Hakim, A. J., Musuka, G., Chingombe, I., Mugurungi, O., Moyo, B., Mapingure, M., Gozhora, P., Samba, C., & Rogers, J. H. (2022). Recent HIV Infection Among Men Who Have Sex with Men, Transgender Women, and Genderqueer Individuals with Newly Diagnosed HIV Infection in Zimbabwe: Results from a Respondent-Driven Sampling Survey. AIDS Research and Human Retroviruses, 38(11), 834–839. https://doi.org/10.1089/aid.2021.0216
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Ebonwu, J., Lassaunière, R., Paximadis, M., Strehlau, R., Gray, G. E., Kuhn, L., & Tiemessen, C. T. (2022). FCGR3A gene duplication, FcγRIIb-232TT and FcγRIIIb-HNA1a associate with an increased risk of vertical acquisition of HIV-1. PLOS ONE, 17(9), e0273933. https://doi.org/10.1371/journal.pone.0273933
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Gilbert, P. B., Huang, Y., deCamp, A. C., Karuna, S., Zhang, Y., Magaret, C. A., Giorgi, E. E., Korber, B., Edlefsen, P. T., Rossenkhan, R., Juraska, M., Rudnicki, E., Kochar, N., Huang, Y., Carpp, L. N., Barouch, D. H., Mkhize, N. N., Hermanus, T., Kgagudi, P., … Morris, L. (2022). Neutralization titer biomarker for antibody-mediated prevention of HIV-1 acquisition. Nature Medicine, 28(9), 1924–1932. https://doi.org/10.1038/s41591-022-01953-6
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Buckmaster, M. V., & Goff, S. P. (2022). Riplet Binds the Zinc Finger Antiviral Protein (ZAP) and Augments ZAP-Mediated Restriction of HIV-1. Journal of Virology, 96(16). https://doi.org/10.1128/jvi.00526-22
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Gaebler, C., Nogueira, L., Stoffel, E., Oliveira, T. Y., Breton, G., Millard, K. G., Turroja, M., Butler, A., Ramos, V., Seaman, M. S., Reeves, J. D., Petroupoulos, C. J., Shimeliovich, I., Gazumyan, A., Jiang, C. S., Jilg, N., Scheid, J. F., Gandhi, R., Walker, B. D., … Nussenzweig, M. C. (2022). Prolonged viral suppression with anti-HIV-1 antibody therapy. Nature, 606(7913), 368–374. https://doi.org/10.1038/s41586-022-04597-1
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Delany-Moretlwe, S., Hughes, J. P., Bock, P., Ouma, S. G., Hunidzarira, P., Kalonji, D., Kayange, N., Makhema, J., Mandima, P., Mathew, C., Spooner, E., Mpendo, J., Mukwekwerere, P., Mgodi, N., Ntege, P. N., Nair, G., Nakabiito, C., Nuwagaba-Biribonwoha, H., Panchia, R., … Gaffoor, Z. (2022). Cabotegravir for the prevention of HIV-1 in women: results from HPTN 084, a phase 3, randomised clinical trial. The Lancet, 399(10337), 1779–1789. https://doi.org/10.1016/s0140-6736(22)00538-4
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Lulseged, S., Melaku, Z., Habteselassie, A., West, C. A., Gelibo, T., Belete, W., Tefera, F., Farahani, M., Demissie, M., Teferi, W., Abdella, S., Birhanu, S., & Ross, C. E. (2022). Progress towards controlling the HIV epidemic in urban Ethiopia: Findings from the 2017–2018 Ethiopia population-based HIV impact assessment survey. PLOS ONE, 17(2), e0264441. https://doi.org/10.1371/journal.pone.0264441
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Geis, F. K., Sabo, Y., Chen, X., Li, Y., Lu, C., & Goff, S. P. (2022). CHAF1A/B mediate silencing of unintegrated HIV-1 DNAs early in infection. Proceedings of the National Academy of Sciences, 119(4). https://doi.org/10.1073/pnas.2116735119
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Vagelos College of Physicians and Surgeons; Department of Medicine; Division of Infectious Diseases; Department of Genetics and Development; Department of Biochemistry and Molecular Biophysics; Department of Microbiology and Immunology; Aaron Diamond AIDS Research Center; Herbert Irving Comprehensive Cancer Center
Ebonwu, J., Lassaunière, R., Paximadis, M., Goosen, M., Strehlau, R., Gray, G. E., Kuhn, L., & Tiemessen, C. T. (2021). An HIV Vaccine Protective Allele in FCGR2C Associates With Increased Odds of Perinatal HIV Acquisition. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.760571
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Nkambule, R., Philip, N. M., Reid, G., Mnisi, Z., Nuwagaba-Biribonwoha, H., Ao, T. T., Ginindza, C., Duong, Y. T., Patel, H., Saito, S., Solmo, C., Brown, K., Moore, C. S., Voetsch, A. C., Bicego, G., Bock, N., Mhlanga, F., Dlamini, T., Mabuza, K., … Justman, J. (2021). HIV incidence, viremia, and the national response in Eswatini: Two sequential population-based surveys. PLOS ONE, 16(12), e0260892. https://doi.org/10.1371/journal.pone.0260892
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Chan, K.-W., Luo, C. C., Lu, H., Wu, X., & Kong, X.-P. (2021). A site of vulnerability at V3 crown defined by HIV-1 bNAb M4008_N1. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-26846-z
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Siddiqui, M. A., & Yamashita, M. (2021). Toll-Like Receptor (TLR) Signaling Enables Cyclic GMP-AMP Synthase (cGAS) Sensing of HIV-1 Infection in Macrophages. MBio, 12(6). https://doi.org/10.1128/mbio.02817-21
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Saito, A., & Yamashita, M. (2021). HIV-1 capsid variability: viral exploitation and evasion of capsid-binding molecules. Retrovirology, 18(1). https://doi.org/10.1186/s12977-021-00577-x
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Low, A., Sachathep, K., Rutherford, G., Nitschke, A.-M., Wolkon, A., Banda, K., Miller, L. A., Solmo, C., Jackson, K., Patel, H., McCracken, S., Findley, S., & Mutenda, N. (2021). Migration in Namibia and its association with HIV acquisition and treatment outcomes. PLOS ONE, 16(9), e0256865. https://doi.org/10.1371/journal.pone.0256865
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