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Sun, Z., Yi, Z., Wei, C., Wang, W., Ren, T., Cravedi, P., Tedla, F., Ward, S. C., Azeloglu, E., Schrider, D. R., Li, Y., Khan, A., Zanoni, F., Fu, J., Ali, S., Liu, S., Liang, D., Liu, T., Li, H., … Zhang, W. (2025). LILRB3 genetic variation is associated with kidney transplant failure in African American recipients. Nature Medicine. https://doi.org/10.1038/s41591-025-03568-z

Carroll, E. E., Shen, Q., Kansara, V., Casson, N., Michalak, A., Niesvizky-Kogan, I., Lim, J., Postelnik, A., Viereck, M. J., Egawa, S., Kahan, J., Carmona, J. C., Kruger, L., Song, Y. L., Velazquez, A., Schevon, C. A., Connolly, E. S., Ghoshal, S., Agarwal, S., … Claassen, J. (2025). Sleep spindles as a predictor of cognitive motor dissociation and recovery of consciousness after acute brain injury. Nature Medicine. https://doi.org/10.1038/s41591-025-03578-x

Tagore, S., Caprio, L., Amin, A. D., Bestak, K., Luthria, K., D’Souza, E., Barrera, I., Melms, J. C., Wu, S., Abuzaid, S., Wang, Y., Jakubikova, V., Koch, P., Brodtman, D. Z., Bawa, B., Deshmukh, S. K., Ebel, L., Ibarra-Arellano, M. A., Jaiswal, A., … Izar, B. (2025). Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases. Nature Medicine. https://doi.org/10.1038/s41591-025-03530-z

Prat-Ortega, G., Ensel, S., Donadio, S., Borda, L., Boos, A., Yadav, P., Verma, N., Ho, J., Carranza, E., Frazier-Kim, S., Fields, D. P., Fisher, L. E., Weber, D. J., Balzer, J., Duong, T., Weinstein, S. D., Eliasson, M. J. L., Montes, J., Chen, K. S., … Capogrosso, M. (2025). First-in-human study of epidural spinal cord stimulation in individuals with spinal muscular atrophy. Nature Medicine. https://doi.org/10.1038/s41591-024-03484-8

Soto, C., Mollenhauer, B., Hansson, O., Kang, U. J., Alcalay, R. N., Standaert, D., Trenkwalder, C., Marek, K., Galasko, D., & Poston, K. (2025). Toward a biological definition of neuronal and glial synucleinopathies. Nature Medicine. https://doi.org/10.1038/s41591-024-03469-7

Alber, D. A., Yang, Z., Alyakin, A., Yang, E., Rai, S., Valliani, A. A., Zhang, J., Rosenbaum, G. R., Amend-Thomas, A. K., Kurland, D. B., Kremer, C. M., Eremiev, A., Negash, B., Wiggan, D. D., Nakatsuka, M. A., Sangwon, K. L., Neifert, S. N., Khan, H. A., Save, A. V., … Oermann, E. K. (2025). Medical large language models are vulnerable to data-poisoning attacks. Nature Medicine. https://doi.org/10.1038/s41591-024-03445-1

Lynch, V. D., Sullivan, J. A., Flores, A. B., Xie, X., Aggarwal, S., Nethery, R. C., Kioumourtzoglou, M.-A., Nigra, A. E., & Parks, R. M. (2025). Large floods drive changes in cause-specific mortality in the United States. Nature Medicine. https://doi.org/10.1038/s41591-024-03358-z

Lopez, J., Powles, T., Braiteh, F., Siu, L. L., LoRusso, P., Friedman, C. F., Balmanoukian, A. S., Gordon, M., Yachnin, J., Rottey, S., Karydis, I., Fisher, G. A., Schmidt, M., Schuler, M., Sullivan, R. J., Burris, H. A., Galvao, V., Henick, B. S., Dirix, L., … Camidge, D. R. (2025). Autogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trial. Nature Medicine, 31(1), 152–164. https://doi.org/10.1038/s41591-024-03334-7

Elhussein, A., Baymuradov, U., Phatnani, H., Kwan, J., Sareen, D., Broach, J. R., Simmons, Z., Arcila-Londono, X., Lee, E. B., Van Deerlin, V. M., Shneider, N. A., Fraenkel, E., Ostrow, L. W., Baas, F., Zaitlen, N., Berry, J. D., Malaspina, A., Fratta, P., … Gürsoy, G. (2024). A framework for sharing of clinical and genetic data for precision medicine applications. Nature Medicine, 30(12), 3578–3589. https://doi.org/10.1038/s41591-024-03239-5

Ounadjela, J. R., Zhang, K., Kobayashi-Kirschvink, K. J., Jin, K., J. C. Russell, A., Lackner, A. I., Callahan, C., Viggiani, F., Dey, K. K., Jagadeesh, K., Maxian, T., Prandstetter, A.-M., Nadaf, N., Gong, Q., Raichur, R., Zvezdov, M. L., Hui, M., Simpson, M., Liu, X., … Shu, J. (2024). Spatial multiomic landscape of the human placenta at molecular resolution. Nature Medicine. https://doi.org/10.1038/s41591-024-03073-9

Van Bavel, J. J., Gadarian, S. K., Knowles, E., & Ruggeri, K. (2024). Political polarization and health. Nature Medicine, 30(11), 3085–3093. https://doi.org/10.1038/s41591-024-03307-w

Chouffani El Fassi, S., Abdullah, A., Fang, Y., Natarajan, S., Masroor, A. B., Kayali, N., Prakash, S., & Henderson, G. E. (2024). Not all AI health tools with regulatory authorization are clinically validated. Nature Medicine. https://doi.org/10.1038/s41591-024-03203-3

Ziegler, A., Carroll, J., Bain, J. M., Sands, T. T., Fee, R. J., Uher, D., Kanner, C. H., Montes, J., Glass, S., Douville, J., Mignon, L., Gleeson, J. G., Crooke, S. T., & Chung, W. K. (2024). Antisense oligonucleotide therapy in an individual with KIF1A-associated neurological disorder. Nature Medicine. https://doi.org/10.1038/s41591-024-03197-y

Zhong, L., Lopez, D., Pei, S., & Gao, J. (2024). Healthcare system resilience and adaptability to pandemic disruptions in the United States. Nature Medicine, 30(8), 2311–2319. https://doi.org/10.1038/s41591-024-03103-6

Xue, C., Kowshik, S. S., Lteif, D., Puducheri, S., Jasodanand, V. H., Zhou, O. T., Walia, A. S., Guney, O. B., Zhang, J. D., Pham, S. T., Kaliaev, A., Andreu-Arasa, V. C., Dwyer, B. C., Farris, C. W., Hao, H., Kedar, S., Mian, A. Z., Murman, D. L., O’Shea, S. A., … Kolachalama, V. B. (2024). AI-based differential diagnosis of dementia etiologies on multimodal data. Nature Medicine. https://doi.org/10.1038/s41591-024-03118-z

Pian, J. M. Y., Owusu, N., Vitarello, J., Yan, W. X., Lo, A. W., & Yu, T. W. (2024). How to pay for individualized genetic medicines. Nature Medicine, 30(7), 1816–1818. https://doi.org/10.1038/s41591-024-03071-x

Prada, D., Baccarelli, A. A., Kupsco, A., & Parks, R. M. (2024). Climate change and health: understanding mechanisms will inform mitigation and prevention strategies. Nature Medicine, 30(6), 1522–1524. https://doi.org/10.1038/s41591-024-02925-8

Zinter, M. S., Dvorak, C. C., Mayday, M. Y., Reyes, G., Simon, M. R., Pearce, E. M., Kim, H., Shaw, P. J., Rowan, C. M., Auletta, J. J., Martin, P. L., Godder, K., Duncan, C. N., Lalefar, N. R., Kreml, E. M., Hume, J. R., Abdel-Azim, H., Hurley, C., … Cuvelier, G. D. E. (2024). Pathobiological signatures of dysbiotic lung injury in pediatric patients undergoing stem cell transplantation. Nature Medicine, 30(7), 1982–1993. https://doi.org/10.1038/s41591-024-02999-4

Lazarus, J. V., White, T. M., Wyka, K., Ratzan, S. C., Rabin, K., Larson, H. J., Martinon-Torres, F., Kuchar, E., Abdool Karim, S. S., Giles-Vernick, T., Müller, S., Batista, C., Myburgh, N., Kampmann, B., & El-Mohandes, A. (2024). Influence of COVID-19 on trust in routine immunization, health information sources and pandemic preparedness in 23 countries in 2023. Nature Medicine, 30(6), 1559–1563. https://doi.org/10.1038/s41591-024-02939-2

Rappaport, A. R., Kyi, C., Lane, M., Hart, M. G., Johnson, M. L., Henick, B. S., Liao, C.-Y., Mahipal, A., Shergill, A., Spira, A. I., Goldman, J. W., Scallan, C. D., Schenk, D., Palmer, C. D., Davis, M. J., Kounlavouth, S., Kemp, L., Yang, A., Li, Y. J., … Jooss, K. (2024). A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results. Nature Medicine, 30(4), 1013–1022. https://doi.org/10.1038/s41591-024-02851-9

Moqri, M., Herzog, C., Poganik, J. R., Ying, K., Justice, J. N., Belsky, D. W., Higgins-Chen, A. T., Chen, B. H., Cohen, A. A., Fuellen, G., Hägg, S., Marioni, R. E., Widschwendter, M., Fortney, K., Fedichev, P. O., Zhavoronkov, A., Barzilai, N., Lasky-Su, J., Kiel, D. P., … Ferrucci, L. (2024). Validation of biomarkers of aging. Nature Medicine, 30(2), 360–372. https://doi.org/10.1038/s41591-023-02784-9

Lewis V, C., Huebner, J., Hripcsak, G., & Sabatello, M. (2023). Underrepresentation of blind and deaf participants in the All of Us Research Program. Nature Medicine, 29(11), 2742–2747. https://doi.org/10.1038/s41591-023-02607-x

Johnson, E. C. B., Bian, S., Haque, R. U., Carter, E. K., Watson, C. M., Gordon, B. A., Ping, L., Duong, D. M., Epstein, M. P., McDade, E., Barthélemy, N. R., Karch, C. M., Xiong, C., Cruchaga, C., Perrin, R. J., Wingo, A. P., Wingo, T. S., Chhatwal, J. P., Day, G. S., … Ringman, J. (2023). Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease. Nature Medicine, 29(8), 1979–1988. https://doi.org/10.1038/s41591-023-02476-4

Moazami, N., Stern, J. M., Khalil, K., Kim, J. I., Narula, N., Mangiola, M., Weldon, E. P., Kagermazova, L., James, L., Lawson, N., Piper, G. L., Sommer, P. M., Reyentovich, A., Bamira, D., Saraon, T., Kadosh, B. S., DiVita, M., Goldberg, R. I., Hussain, S. T., … Montgomery, R. A. (2023). Pig-to-human heart xenotransplantation in two recently deceased human recipients. Nature Medicine, 29(8), 1989–1997. https://doi.org/10.1038/s41591-023-02471-9

Inker, L. A., Collier, W., Greene, T., Miao, S., Chaudhari, J., Appel, G. B., Badve, S. V., Caravaca-Fontán, F., Del Vecchio, L., Floege, J., Goicoechea, M., Haaland, B., Herrington, W. G., Imai, E., Jafar, T. H., Lewis, J. B., Li, P. K. T., Maes, B. D., Neuen, B. L., … Saddelli, M. (2023). A meta-analysis of GFR slope as a surrogate endpoint for kidney failure. Nature Medicine, 29(7), 1867–1876. https://doi.org/10.1038/s41591-023-02418-0

Rolland, T., Cliquet, F., Anney, R. J. L., Moreau, C., Traut, N., Mathieu, A., Huguet, G., Duan, J., Warrier, V., Portalier, S., Dry, L., Leblond, C. S., Douard, E., Amsellem, F., Malesys, S., Maruani, A., Toro, R., Børglum, A. D., Grove, J., … Bourgeron, T. (2023). Phenotypic effects of genetic variants associated with autism. Nature Medicine, 29(7), 1671–1680. https://doi.org/10.1038/s41591-023-02408-2

Haney, M., Vallée, M., Fabre, S., Collins Reed, S., Zanese, M., Campistron, G., Arout, C. A., Foltin, R. W., Cooper, Z. D., Kearney-Ramos, T., Metna, M., Justinova, Z., Schindler, C., Hebert-Chatelain, E., Bellocchio, L., Cathala, A., Bari, A., Serrat, R., Finlay, D. B., … Piazza, P. V. (2023). Signaling-specific inhibition of the CB1 receptor for cannabis use disorder: phase 1 and phase 2a randomized trials. Nature Medicine, 29(6), 1487–1499. https://doi.org/10.1038/s41591-023-02381-w

Effect of air pollution on the human immune system. (2022). Nature Medicine, 28(12), 2482–2483. https://doi.org/10.1038/s41591-022-02093-7

Ural, B. B., Caron, D. P., Dogra, P., Wells, S. B., Szabo, P. A., Granot, T., Senda, T., Poon, M. M. L., Lam, N., Thapa, P., Lee, Y. S., Kubota, M., Matsumoto, R., & Farber, D. L. (2022). Inhaled particulate accumulation with age impairs immune function and architecture in human lung lymph nodes. Nature Medicine, 28(12), 2622–2632. https://doi.org/10.1038/s41591-022-02073-x

Carvajal, R. D., Butler, M. O., Shoushtari, A. N., Hassel, J. C., Ikeguchi, A., Hernandez-Aya, L., Nathan, P., Hamid, O., Piulats, J. M., Rioth, M., Johnson, D. B., Luke, J. J., Espinosa, E., Leyvraz, S., Collins, L., Goodall, H. M., Ranade, K., Holland, C., Abdullah, S. E., … Sato, T. (2022). Clinical and molecular response to tebentafusp in previously treated patients with metastatic uveal melanoma: a phase 2 trial. Nature Medicine, 28(11), 2364–2373. https://doi.org/10.1038/s41591-022-02015-7

Silverman, B. C., Ne’eman, A., Strauss, D. H., DeCormier Plosky, W., Francis, L. P., Stein, M. A., & Bierer, B. E. (2022). Supported decision-making can advance clinical research participation for people with disabilities. Nature Medicine, 28(11), 2250–2253. https://doi.org/10.1038/s41591-022-02035-3

Staffaroni, A. M., Quintana, M., Wendelberger, B., Heuer, H. W., Russell, L. L., Cobigo, Y., Wolf, A., Goh, S.-Y. M., Petrucelli, L., Gendron, T. F., Heller, C., Clark, A. L., Taylor, J. C., Wise, A., Ong, E., Forsberg, L., Brushaber, D., Rojas, J. C., VandeVrede, L., … Afonso, S. (2022). Temporal order of clinical and biomarker changes in familial frontotemporal dementia. Nature Medicine, 28(10), 2194–2206. https://doi.org/10.1038/s41591-022-01942-9

Gilbert, P. B., Huang, Y., deCamp, A. C., Karuna, S., Zhang, Y., Magaret, C. A., Giorgi, E. E., Korber, B., Edlefsen, P. T., Rossenkhan, R., Juraska, M., Rudnicki, E., Kochar, N., Huang, Y., Carpp, L. N., Barouch, D. H., Mkhize, N. N., Hermanus, T., Kgagudi, P., … Morris, L. (2022). Neutralization titer biomarker for antibody-mediated prevention of HIV-1 acquisition. Nature Medicine, 28(9), 1924–1932. https://doi.org/10.1038/s41591-022-01953-6

Tcheandjieu, C., Zhu, X., Hilliard, A. T., Clarke, S. L., Napolioni, V., Ma, S., Lee, K. M., Fang, H., Chen, F., Lu, Y., Tsao, N. L., Raghavan, S., Koyama, S., Gorman, B. R., Vujkovic, M., Klarin, D., Levin, M. G., Sinnott-Armstrong, N., Wojcik, G. L., … Assimes, T. L. (2022). Large-scale genome-wide association study of coronary artery disease in genetically diverse populations. Nature Medicine, 28(8), 1679–1692. https://doi.org/10.1038/s41591-022-01891-3

Palmer, C. D., Rappaport, A. R., Davis, M. J., Hart, M. G., Scallan, C. D., Hong, S.-J., Gitlin, L., Kraemer, L. D., Kounlavouth, S., Yang, A., Smith, L., Schenk, D., Skoberne, M., Taquechel, K., Marrali, M., Jaroslavsky, J. R., Nganje, C. N., Maloney, E., Zhou, R., … Jooss, K. (2022). Individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA neoantigen vaccine for advanced metastatic solid tumors: phase 1 trial interim results. Nature Medicine, 28(8), 1619–1629. https://doi.org/10.1038/s41591-022-01937-6

Pickersgill, S. J., Msemburi, W. T., Cobb, L., Ide, N., Moran, A. E., Su, Y., Xu, X., & Watkins, D. A. (2022). Modeling global 80-80-80 blood pressure targets and cardiovascular outcomes. Nature Medicine, 28(8), 1693–1699. https://doi.org/10.1038/s41591-022-01890-4

Church, A. J., Corson, L. B., Kao, P.-C., Imamovic-Tuco, A., Reidy, D., Doan, D., Kang, W., Pinto, N., Maese, L., Laetsch, T. W., Kim, A., Colace, S. I., Macy, M. E., Applebaum, M. A., Bagatell, R., Sabnis, A. J., Weiser, D. A., Glade-Bender, J. L., Homans, A. C., … Janeway, K. A. (2022). Molecular profiling identifies targeted therapy opportunities in pediatric solid cancer. Nature Medicine, 28(8), 1581–1589. https://doi.org/10.1038/s41591-022-01856-6

Khan, A., Turchin, M. C., Patki, A., Srinivasasainagendra, V., Shang, N., Nadukuru, R., Jones, A. C., Malolepsza, E., Dikilitas, O., Kullo, I. J., Schaid, D. J., Karlson, E., Ge, T., Meigs, J. B., Smoller, J. W., Lange, C., Crosslin, D. R., Jarvik, G. P., Bhatraju, P. K., … Kiryluk, K. (2022). Genome-wide polygenic score to predict chronic kidney disease across ancestries. Nature Medicine, 28(7), 1412–1420. https://doi.org/10.1038/s41591-022-01869-1

Strauss, K. A., Farrar, M. A., Muntoni, F., Saito, K., Mendell, J. R., Servais, L., McMillan, H. J., Finkel, R. S., Swoboda, K. J., Kwon, J. M., Zaidman, C. M., Chiriboga, C. A., Iannaccone, S. T., Krueger, J. M., Parsons, J. A., Shieh, P. B., Kavanagh, S., Wigderson, M., Tauscher-Wisniewski, S., … Macek, T. A. (2022). Onasemnogene abeparvovec for presymptomatic infants with three copies of SMN2 at risk for spinal muscular atrophy: the Phase III SPR1NT trial. Nature Medicine, 28(7), 1390–1397. https://doi.org/10.1038/s41591-022-01867-3

Strauss, K. A., Farrar, M. A., Muntoni, F., Saito, K., Mendell, J. R., Servais, L., McMillan, H. J., Finkel, R. S., Swoboda, K. J., Kwon, J. M., Zaidman, C. M., Chiriboga, C. A., Iannaccone, S. T., Krueger, J. M., Parsons, J. A., Shieh, P. B., Kavanagh, S., Tauscher-Wisniewski, S., McGill, B. E., & Macek, T. A. (2022). Onasemnogene abeparvovec for presymptomatic infants with two copies of SMN2 at risk for spinal muscular atrophy type 1: the Phase III SPR1NT trial. Nature Medicine, 28(7), 1381–1389. https://doi.org/10.1038/s41591-022-01866-4

Choutka, J., Jansari, V., Hornig, M., & Iwasaki, A. (2022). Unexplained post-acute infection syndromes. Nature Medicine, 28(5), 911–923. https://doi.org/10.1038/s41591-022-01810-6

Kumar, A., Im, K., Banjevic, M., Ng, P. C., Tunstall, T., Garcia, G., Galhardo, L., Sun, J., Schaedel, O. N., Levy, B., Hongo, D., Kijacic, D., Kiehl, M., Tran, N. D., Klatsky, P. C., & Rabinowitz, M. (2022). Whole-genome risk prediction of common diseases in human preimplantation embryos. Nature Medicine, 28(3), 513–516. https://doi.org/10.1038/s41591-022-01735-0

Powles, T., Yuen, K. C., Gillessen, S., Kadel, E. E., Rathkopf, D., Matsubara, N., Drake, C. G., Fizazi, K., Piulats, J. M., Wysocki, P. J., Buchschacher, G. L., Alekseev, B., Mellado, B., Karaszewska, B., Doss, J. F., Rasuo, G., Datye, A., Mariathasan, S., Williams, P., & Sweeney, C. J. (2022). Atezolizumab with enzalutamide versus enzalutamide alone in metastatic castration-resistant prostate cancer: a randomized phase 3 trial. Nature Medicine, 28(1), 144–153. https://doi.org/10.1038/s41591-021-01600-6

Das, A., Sudhaman, S., Morgenstern, D., Coblentz, A., Chung, J., Stone, S. C., Alsafwani, N., Liu, Z. A., Karsaneh, O. A. A., Soleimani, S., Ladany, H., Chen, D., Zatzman, M., Cabric, V., Nobre, L., Bianchi, V., Edwards, M., Sambira Nahum, L. C., Ercan, A. B., … Tabori, U. (2022). Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency. Nature Medicine, 28(1), 125–135. https://doi.org/10.1038/s41591-021-01581-6

Korobeynikov, V. A., Lyashchenko, A. K., Blanco-Redondo, B., Jafar-Nejad, P., & Shneider, N. A. (2022). Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis. Nature Medicine, 28(1), 104–116. https://doi.org/10.1038/s41591-021-01615-z

Barak, T., Ristori, E., Ercan-Sencicek, A. G., Miyagishima, D. F., Nelson-Williams, C., Dong, W., Jin, S. C., Prendergast, A., Armero, W., Henegariu, O., Erson-Omay, E. Z., Harmancı, A. S., Guy, M., Gültekin, B., Kilic, D., Rai, D. K., Goc, N., Aguilera, S. M., Gülez, B., … Günel, M. (2021). PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans. Nature Medicine, 27(12), 2165–2175. https://doi.org/10.1038/s41591-021-01572-7

Gotlib, J., Reiter, A., Radia, D. H., Deininger, M. W., George, T. I., Panse, J., Vannucchi, A. M., Platzbecker, U., Alvarez-Twose, I., Mital, A., Hermine, O., Dybedal, I., Hexner, E. O., Hicks, L. K., Span, L., Mesa, R., Bose, P., Pettit, K. M., Heaney, M. L., … DeAngelo, D. J. (2021). Efficacy and safety of avapritinib in advanced systemic mastocytosis: interim analysis of the phase 2 PATHFINDER trial. Nature Medicine, 27(12), 2192–2199. https://doi.org/10.1038/s41591-021-01539-8