CUIMC Publications

Longitudinal associations between exercise and biomarkers in autosomal dominant Alzheimer's disease

Record Created:

Wednesday, January 8, 2025 - 09:50

Sewell, K. R., Doecke, J. D., Xiong, C., Benzinger, T., Masters, C. L., Laske, C., Jucker, M., Lopera, F., Gordon, B. A., Llibre‐Guerra, J., Levin, J., Huey, E. D., Hassenstab, J., Schofield, P. R., Day, G. S., Fox, N. C., Chhatwal, J., Ibanez, L., … Roh, J. H. (2024). Longitudinal associations between exercise and biomarkers in autosomal dominant Alzheimer’s disease. Alzheimer’s & Dementia, 20(11), 7923–7939. Portico. https://doi.org/10.1002/alz.14270

Authors:

Kelsey R. Sewell

James D. Doecke

Chengjie Xiong

Tammie L.S. Benzinger

Colin L. Masters

Christoph Laske

Mathias Jucker

Francisco Lopera

Brian A. Gordon

Jorge J. Llibre‐Guerra

Johannes Levin

Edward D. Huey

Jason Hassenstab

Peter R. Schofield

Gregory S. Day

Nick C. Fox

Jasmeer P. Chhatwal

Laura Ibáñez

Jee Hoon Roh

Richard J. Perrin

Jae‐Hong Lee

Ricardo Allegri

Charlene Supnet

Sarah B. Berman

Alisha Daniels

James M. Noble

Ralph N. Martins

Stephanie R. Rainey‐Smith

Jeremiah J. Peiffer

Samantha L. Gardener

Randall J. Bateman

John C. Morris

Eric McDade

Kirk I. Erickson

Hamid R. Sohrabi

Belinda M. Brown

Affiliated Authors:

James M. Noble

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Neurology

Subjects:

Alzheimer Disease (MeSH)

Biomarkers (MeSH)

Exercise (MeSH)

Amyloid beta-Peptides (MeSH)

Positron-Emission Tomography (MeSH)

Magnetic Resonance Imaging (MeSH)

Brain (MeSH)

Attention-Deficit/Hyperactivity Disorder (OpenAlex Topic)

Epidemiology and Management of Bipolar Disorder (OpenAlex Topic)

Mechanisms of Alzheimer's Disease (OpenAlex Topic)

Author Keywords:

alzheimer's disease

exercise

magnetic resonance imaging

physical activity

positron emission tomography

Grants:

U19AG032438 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1002/alz.14270

PMID:

39324510

DOI:

10.1002/alz.14270

Journal:

Publication Date:

2024-09-26

Data Source:

OpenAlex

Source Link:

α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden

Record Created:

Thursday, December 5, 2024 - 09:27

Levin, J., Baiardi, S., Quadalti, C., Rossi, M., Mammana, A., Vöglein, J., Bernhardt, A., Perrin, R. J., Jucker, M., Preische, O., Hofmann, A., Höglinger, G. U., Cairns, N. J., Franklin, E. E., Chrem, P., Cruchaga, C., Berman, S. B., Chhatwal, J. P., Daniels, A., … Parchi, P. (2024). α‐Synuclein seed amplification assay detects Lewy body co‐pathology in autosomal dominant Alzheimer’s disease late in the disease course and dependent on Lewy pathology burden. Alzheimer’s & Dementia, 20(6), 4351–4365. Portico. https://doi.org/10.1002/alz.13818

Authors:

Johannes Levin

Simone Baiardi

Corinne Quadalti

Marcello Rossi

Angela Mammana

Jonathan Vöglein

Alexander Bernhardt

Richard J. Perrin

Mathias Jucker

Oliver Preische

Anna Hofmann

Günter U. Höglinger

Nigel J. Cairns

Erin E. Franklin

Patricio Chrem

Carlos Cruchaga

Sarah B. Berman

Jasmeer P. Chhatwal

Alisha Daniels

Gregory S. Day

Natalie S. Ryan

Alison M. Goate

Brian A. Gordon

Edward D. Huey

Laura Ibanez

Celeste M. Karch

Jae-Hong Lee

Jorge Llibre-Guerra

Francisco Lopera

Colin L. Masters

John C. Morris

James M. Noble

Alan E. Renton

Jee Hoon Roh

Matthew P. Frosch

C. Dirk Keene

Catriona McLean

Raquel Sanchez-Valle

Peter R. Schofield

Charlene Supnet-Bell

Chengjie Xiong

Armin Giese

Oskar Hansson

Randall J. Bateman

Eric McDade

Piero Parchi

Affiliated Authors:

James M. Noble

Columbia Affiliation:

Author Keywords:

alpha-synuclein seed amplification assay

dominantly inherited alzheimer network

lewy body pathology

real-time quaking-induced conversion

Grants:

R01MH120794 (NIH – National Institute of Mental Health)

U01AG079850 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

P30AG066444 (NIH – National Institute On Aging)

P01AG026276 (NIH – National Institute On Aging)

P01AG003991 (NIH – National Institute On Aging)

R01AG062268 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1002/alz.13818

PMID:

38666355

DOI:

10.1002/alz.13818

Journal:

Publication Date:

2024-06-01

Data Source:

Scopus

Source Link:

Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study

Record Created:

Wednesday, August 14, 2024 - 11:13

Wisch, J. K., McKay, N. S., Boerwinkle, A. H., Kennedy, J., Flores, S., Handen, B. L., Christian, B. T., Head, E., Mapstone, M., Rafii, M. S., O’Bryant, S. E., Price, J. C., Laymon, C. M., Krinsky-McHale, S. J., Lai, F., Rosas, H. D., Hartley, S. L., Zaman, S., Lott, I. T., … Mori, H. (2024). Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer’s disease: a cross-sectional study. The Lancet Neurology, 23(5), 500–510. https://doi.org/10.1016/s1474-4422(24)00084-x

Authors:

Julie K Wisch

Nicole S McKay

Anna H Boerwinkle

James Kennedy

Shaney Flores

Benjamin L Handen

Bradley T Christian

Elizabeth Head

Mark Mapstone

Michael S Rafii

Sid E O&#039;Bryant

Julie C Price

Charles M Laymon

Sharon J Krinsky-McHale

Florence Lai

H Diana Rosas

Sigan L Hartley

Shahid Zaman

Ira T Lott

Dana Tudorascu

Matthew Zammit

Adam M Brickman

Joseph H Lee

Thomas D Bird

Annie Cohen

Patricio Chrem

Alisha Daniels

Jasmeer P Chhatwal

Carlos Cruchaga

Laura Ibanez

Mathias Jucker

Celeste M Karch

Gregory S Day

Jae-Hong Lee

Johannes Levin

Jorge Llibre-Guerra

Yan Li

Francisco Lopera

Jee Hoon Roh

John M Ringman

Charlene Supnet-Bell

Christopher H van Dyck

Chengjie Xiong

Guoqiao Wang

John C Morris

Eric McDade

Randall J Bateman

Tammie L S Benzinger

Brian A Gordon

Beau M Ances

Affiliated Authors:

Adam M Brickman

Joseph H Lee

Columbia Affiliation:

Subjects:

Alzheimer Disease (MeSH)

Down Syndrome (MeSH)

Cognitive Dysfunction (MeSH)

Grants:

R01MH120794 (NIH – National Institute of Mental Health)

U01AG079850 (NIH – National Institute On Aging)

R01AG053267 (NIH – National Institute On Aging)

R61AG066543 (NIH – National Institute On Aging)

R01AG062268 (NIH – National Institute On Aging)

U01AG051412 (NIH – National Institute On Aging)

R01AG046179 (NIH – National Institute On Aging)

U01AG051406 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

R56AG053267 (NIH – National Institute On Aging)

U01AG042791 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1016/s1474-4422(24)00084-x

PMID:

38631766

DOI:

10.1016/s1474-4422(24)00084-x

Journal:

Lancet Neurology

Publication Date:

2024-05-01

Data Source:

PubMed

Source Link:

Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU): Trial Satisfaction and Attitudes towards Future Clinical Trials

Record Created:

Monday, August 12, 2024 - 12:14

Liu, H., Li, J., Ziegemeier, E., Adams, S., McDade, E., Clifford, D. B., Cao, Y., Wang, G., Li, Y., Mills, S. L., Santacruz, A. M., Belyew, S., Grill, J. D., Snider, B. J., Mummery, C. J., Surti, G., Hannequin, D., Wallon, D., Berman, S. B., … Llibre-Guerra, J. J. (2024). Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU): Trial Satisfaction and Attitudes towards Future Clinical Trials. The Journal of Prevention of Alzheimer’s Disease. https://doi.org/10.14283/jpad.2024.61

Authors:

Haiyan Liu

J. Li

E. Ziegemeier

S. Adams

E. McDade

D.B. Clifford

Y. Cao

G. Wang

Y. Li

S.L. Mills

A.M. Santacruz

S. Belyew

J.D. Grill

B.J. Snider

C.J. Mummery

G. Surti

D. Hannequin

D. Wallon

S.B. Berman

I.Z. Jimenez-Velazquez

E.D. Roberson

C.H. van Dyck

L.S. Honig

R. Sanchez-Valle

W.S. Brooks

S. Gauthier

D. Galasko

C.L. Masters

J. Brosch

G.Y.R. Hsiung

S. Jayadev

M. Formaglio

M. Masellis

R. Clarnette

J. Pariente

B. Dubois

F. Pasquier

R.J. Bateman

Jorge J. Llibre-Guerra

Affiliated Authors:

L.S. Honig

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Neurology
  Division of Aging and Dementia

Author Keywords:

dominantly inherited alzheimer's disease (diad)

dominantly inherited alzheimer network-trial unit (dian-tu)

alzheimer's disease (ad)

clinical trial satisfaction

home health nursing (hhn)

alzheimer’s disease (ad)

dominantly inherited alzheimer’s disease (diad)

Grants:

R01AG046179 (NIH – National Institute On Aging)

U01AG042791 (NIH – National Institute On Aging)

R01AG053267 (NIH – National Institute On Aging)

R56AG053267 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.14283/jpad.2024.61

PMID:

38706272

DOI:

10.14283/jpad.2024.61

Journal:

Journal of Prevention of Alzheimer's Disease

Publication Date:

2024-05-01

Data Source:

Scopus

Source Link:

Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer's disease

Record Created:

Monday, August 12, 2024 - 12:19

Wang, G., Li, Y., Xiong, C., Benzinger, T. L. S., Gordon, B. A., Hassenstab, J., Aschenbrenner, A. J., McDade, E., Clifford, D. B., Libre‐Guerra, J. J., Shi, X., Mummery, C. J., van Dyck, C. H., Lah, J. J., Honig, L. S., Day, G., Ringman, J. M., Brooks, W. S., … Fox, N. C. (2024). Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer’s disease. Alzheimer’s & Dementia, 20(4), 2698–2706. Portico. https://doi.org/10.1002/alz.13735

Authors:

Guoqiao Wang

Yan Li

Johannes Levin

Tammie L.S. Benzinger

Brian A. Gordon

Jason Hassenstab

Andrew J. Aschenbrenner

Eric McDade

David B. Clifford

Jorge J. Libre‐Guerra

Xinyu Shi

Catherine J. Mummery

Christopher H. van Dyck

James J. Lah

Lawrence S. Honig

Gregory S. Day

John M. Ringman

William S. Brooks

Nick C. Fox

Kazushi Suzuki

Johannes Levin

Mathias Jucker

Paul Delmar

Tobias Bittner

Randall J. Bateman

Affiliated Authors:

Lawrence S. Honig

Columbia Affiliation:

Subjects:

Alzheimer Disease (MeSH)

Diagnosis and Management of Alzheimer's Disease (OpenAlex Topic)

Mechanisms of Alzheimer's Disease (OpenAlex Topic)

Regularization and Variable Selection Methods (OpenAlex Topic)

Author Keywords:

dominantly inherited alzheimer network

autosomal dominant alzheimer's disease

gantenerumab

latent class analysis

solanezumab

surrogate biomarker

Grants:

UL1TR002345 (NIH – National Center for Advancing Translational Sciences)

P30AG066530 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

R01AG046179 (NIH – National Institute On Aging)

R01AG053267 (NIH – National Institute On Aging)

U01AG042791 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1002/alz.13735

PMID:

38400532

DOI:

10.1002/alz.13735

Journal:

Publication Date:

2024-02-23

Data Source:

OpenAlex

Source Link:

Presenilin‐1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage

Record Created:

Friday, July 26, 2024 - 14:42

Joseph‐Mathurin, N., Feldman, R. L., Lu, R., Shirzadi, Z., Toomer, C., Saint Clair, J. R., Ma, Y., McKay, N. S., Strain, J. F., Kilgore, C., Friedrichsen, K. A., Chen, C. D., Gordon, B. A., Chen, G., Hornbeck, R. C., Massoumzadeh, P., McCullough, A. A., Wang, Q., … Li, Y. (2024). Presenilin‐1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage. Alzheimer’s & Dementia, 20(4), 2680–2697. Portico. https://doi.org/10.1002/alz.13729

Authors:

Nelly Joseph‐Mathurin

Rebecca L. Feldman

Ruijin Lu

Zahra Shirzadi

Carmen Toomer

John Mallen-St. Clair

Yinjiao Ma

Nicole S. McKay

Jeremy F. Strain

Collin B. Kilgore

Karl A. Friedrichsen

Charles D. Chen

Brian A. Gordon

Gengsheng Chen

Russ C. Hornbeck

Parinaz Massoumzadeh

Austin McCullough

Qing Wang

Yan Li

Guoqiao Wang

Sarah Keefe

Stephanie A. Schultz

Carlos Cruchaga

Gregory M. Preboske

Clifford R. Jack

Jorge J Llibre‐Guerra

Ricardo Allegri

Beau M. Ances

Sarah Berman

William S. Brooks

David M. Cash

Gregory S. Day

Nick C. Fox

Michael Fulham

Bernardino Ghetti

Keith A. Johnson

Mathias Jucker

William E. Klunk

Christian la Fougère

Johannes Levin

Yoshiki Niimi

Hwamee Oh

Richard J. Perrin

Gerald Reischl

John M. Ringman

Andrew J. Saykin

Peter R. Schofield

Yi Su

Charlene Supnet

Jonathan Vöglein

Igor Yakushev

Adam M. Brickman

John C. Morris

Eric McDade

Johannes Levin

Randall J. Bateman

Jasmeer P. Chhatwal

Tammie L.S. Benzinger

Affiliated Authors:

Adam M. Brickman

Columbia Affiliation:

Subjects:

Alzheimer Disease (MeSH)

Amyloidosis (MeSH)

Cerebral Small Vessel Diseases (MeSH)

Mechanisms of Alzheimer's Disease (OpenAlex Topic)

Molecular Mechanisms of Amyloidosis (OpenAlex Topic)

Diagnosis and Management of Alzheimer's Disease (OpenAlex Topic)

Author Keywords:

autosomal dominantalzheimer's disease (adad)

cerebral amyloid angiopathy (caa)

codon 200

dominantly inherited alzheimer's disease (diad)

microbleeds

microhemorrhages

peakwidth of skeletonized mean diffusivity (psmd)

pib-pet

presenilin-1

psen1

small vessel disease (svd)

whitematter hyperintensity (wmh)

autosomal dominant alzheimer's disease (adad)

peak width of skeletonized mean diffusivity (psmd)

white matter hyperintensity (wmh)

pib‐pet

presenilin‐1

Grants:

R03AG072375 (NIH – National Institute On Aging)

R01AG074909 (NIH – National Institute On Aging)

P30AG072980 (NIH – National Institute On Aging)

K01AG084816 (NIH – National Institute On Aging)

K01AG080123 (NIH – National Institute On Aging)

P30AG066530 (NIH – National Institute On Aging)

T32AG078117 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1002/alz.13729

PMID:

38380882

DOI:

10.1002/alz.13729

Journal:

Publication Date:

2024-02-21

Data Source:

OpenAlex

Source Link:

Examining Associations Between Smartphone Use and Clinical Severity in Frontotemporal Dementia: Proof-of-Concept Study

Record Created:

Friday, July 26, 2024 - 14:42

Paolillo, E. W., Casaletto, K. B., Clark, A. L., Taylor, J. C., Heuer, H. W., Wise, A. B., Dhanam, S., Sanderson-Cimino, M., Saloner, R., Kramer, J. H., Kornak, J., Kremers, W., Forsberg, L., Appleby, B., Bayram, E., Bozoki, A., Brushaber, D., Darby, R. R., … Day, G. S. (2024). Examining Associations Between Smartphone Use and Clinical Severity in Frontotemporal Dementia: Proof-of-Concept Study. JMIR Aging, 7, e52831. https://doi.org/10.2196/52831

Authors:

Emily W. Paolillo

Kaitlin B. Casaletto

Annie L. Clark

Jack C. Taylor

Hilary W. Heuer

Amy B. Wise

Sreya Dhanam

Mark Sanderson-Cimino

Rowan Saloner

Joel H. Kramer

Matthew G. H. Hall

Katherine P. Rankin

Julio C. Rojas

Lawren Vandevrede

Howard J. Rosen

Adam L. Boxer

Adam M. Staffaroni

John Kornak

Leah Forsberg

Toji Miyagawa

Bradley F. Boeve

Walter Kremers

Brian Appleby

Danielle Brushaber

Nupur Ghoshal

Carly Mester

Ece Bayram

Lawrence S. Honig

Irene Litvan

Andrea Bozoki

Edward Huey

R. Ryan Darby

Ian R. Mackenzie

Gregory S. Day

Neill Graff-Radford

Zbigniew K. Wszolek

Bradford C. Dickerson

Bonnie Wong

Kimiko Domoto-Reilly

Fanny Elahi

Julie A. Fields

Maria Lapid

Belen Pascual

Joseph C. Masdeu

Mario F. Mendez

Eliana Marisa Ramos

Georges Naasan

Peter Pressman

Affiliated Authors:

Lawrence S. Honig

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Neurology

Author Keywords:

digital

technology

remote

monitoring

cognition

neuropsychology

cognitive impairment

neurodegenerative

screening

clinical trials

mobile phone

Grants:

U01NS100610 (NIH – National Institute of Neurological Disorders and Stroke)

RF1NS050915 (NIH – National Institute of Neurological Disorders and Stroke)

U54NS092089 (NIH – National Institute of Neurological Disorders and Stroke)

R01NS050915 (NIH – National Institute of Neurological Disorders and Stroke)

R25NS098999 (NIH – National Institute of Neurological Disorders and Stroke)

U01NS120901 (NIH – National Institute of Neurological Disorders and Stroke)

R21NS114764 (NIH – National Institute of Neurological Disorders and Stroke)

K08NS105916 (NIH – National Institute of Neurological Disorders and Stroke)

R01AG038791 (NIH – National Institute On Aging)

K23AG073514 (NIH – National Institute On Aging)

U01AG016976 (NIH – National Institute On Aging)

RF1AG032289 (NIH – National Institute On Aging)

R01AG058233 (NIH – National Institute On Aging)

K24AG045333 (NIH – National Institute On Aging)

K23AG061253 (NIH – National Institute On Aging)

K23AG059888 (NIH – National Institute On Aging)

P30AG062422 (NIH – National Institute On Aging)

K23AG064029 (NIH – National Institute On Aging)

P01AG019724 (NIH – National Institute On Aging)

P30AG062677 (NIH – National Institute On Aging)

R01AG032289 (NIH – National Institute On Aging)

U01AG057195 (NIH – National Institute On Aging)

U19AG063911 (NIH – National Institute On Aging)

R01AG032306 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

U01AG045390 (NIH – National Institute On Aging)

U24AG021886 (NIH – National Institute On Aging)

RF1AG077557 (NIH – National Institute On Aging)

IK2CX002180 (NIH – Veterans Affairs)

Publication Type:

Article

Unique ID:

10.2196/52831

PMID:

38922667

DOI:

10.2196/52831

Journal:

JMIR Aging

Publication Date:

2024-01-01

Data Source:

Web of Science

Source Link:

T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease

Record Created:

Wednesday, December 11, 2024 - 12:24

Rahmani, F., Brier, M. R., Gordon, B. A., McKay, N., Flores, S., Keefe, S., Hornbeck, R., Ances, B., Joseph‐Mathurin, N., Xiong, C., Wang, G., Raji, C. A., Libre‐Guerra, J. J., Perrin, R. J., McDade, E., Daniels, A., Karch, C., Day, G. S., … Brickman, A. M. (2023). T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease. Human Brain Mapping, 44(18), 6375–6387. Portico. https://doi.org/10.1002/hbm.26514

Authors:

Farzaneh Rahmani

Matthew R Brier

Brian A Gordon

Nicole McKay

Shaney Flores

Sarah Keefe

Russ Hornbeck

Beau Ances

Nelly Joseph-Mathurin

Chengjie Xiong

Guoqiao Wang

Cyrus A Raji

Jorge J Libre-Guerra

Richard J Perrin

Eric McDade

Alisha Daniels

Celeste Karch

Gregory S Day

Adam M Brickman

Michael Fulham

Clifford R Jack

Christian la La Fougère

Gerald Reischl

Peter R Schofield

Hwamee Oh

Johannes Levin

Jonathan Vöglein

David M Cash

Igor Yakushev

Takeshi Ikeuchi

William E Klunk

John C Morris

Randall J Bateman

Tammie L S Benzinger

Affiliated Authors:

Adam M Brickman

Columbia Affiliation:

Subjects:

Alzheimer Disease (MeSH)

Author Keywords:

amyloid pet

dominantly inherited alzheimer disease

quantitative mr imaging

t1 and flair signal intensity

tau pet

Grants:

UF1AG032438 (NIH – National Institute On Aging)

K01AG080123 (NIH – National Institute On Aging)

R01AG052550 (NIH – National Institute On Aging)

U01AG042791 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1002/hbm.26514

PMID:

37867465

DOI:

10.1002/hbm.26514

Journal:

Human Brain Mapping

Publication Date:

2023-10-23

Data Source:

PubMed

Source Link:

Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome

Record Created:

Tuesday, July 30, 2024 - 12:35

Gorijala, P., Aslam, M. M., Dang, L. T., Xicota, L., Fernandez, M. V., Sung, Y. J., Fan, K., Feingold, E., Surace, E. I., Chhatwal, J. P., Hom, C. L., Hartley, S. L., Hassenstab, J., Perrin, R. J., Mapstone, M., Zaman, S. H., Ances, B. M., Kamboh, M. I., … Lee, J. H. (2023). Alzheimer’s polygenic risk scores are associated with cognitive phenotypes in Down syndrome. Alzheimer’s & Dementia, 20(2), 1038–1049. Portico. https://doi.org/10.1002/alz.13506

Authors:

Priyanka Gorijala

M Muaaz Aslam

Lam-Ha T Dang

L Xicota

Maria V Fernandez

Yun Ju Sung

Kang-Hsien Fan

Eleanor Feingold

Ezequiel I Surace

Jasmeer P Chhatwal

Christy L Hom

Sigan L Hartley

Jason Hassenstab

Richard J Perrin

Mark Mapstone

Shahid H Zaman

Beau M Ances

M Ilyas Kamboh

Joseph H Lee

Carlos Cruchaga

Affiliated Authors:

Lam-Ha T Dang

L Xicota

Joseph H Lee

Columbia Affiliation:

Subjects:

Prevalence and Impact of Down Syndrome (OpenAlex Topic)

Epidemiology and Implications of Multimorbidity in Healthcare (OpenAlex Topic)

Alzheimer Disease (MeSH)

Down Syndrome (MeSH)

Cognitive Dysfunction (MeSH)

Author Keywords:

amyloid precursor protein

apoliprotein e apoe

area under the curve

cerebrospinal fluid biomarkers

cognitive batteries

dominantly inherited alzheimer network

down syndrome

early-onset alzheimer's disease

early-onset autosomal dominant

genetic architecture

genetic risk factor

late-onset alzheimer's disease

polygenic risk score

psen1

psen2

sporadic late-onset alzheimer's disease

Grants:

U54HD090256 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)

P50HD105353 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)

U54HD087011 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)

UL1TR002373 (NIH – National Center for Advancing Translational Sciences)

UL1TR002345 (NIH – National Center for Advancing Translational Sciences)

UL1TR001857 (NIH – National Center for Advancing Translational Sciences)

UL1TR001414 (NIH – National Center for Advancing Translational Sciences)

UL1TR001873 (NIH – National Center for Advancing Translational Sciences)

P30AG062715 (NIH – National Institute On Aging)

R01AG044546 (NIH – National Institute On Aging)

RF1AG058501 (NIH – National Institute On Aging)

U01AG051406 (NIH – National Institute On Aging)

P30AG066519 (NIH – National Institute On Aging)

RF1AG074007 (NIH – National Institute On Aging)

P30AG066444 (NIH – National Institute On Aging)

U24AG021886 (NIH – National Institute On Aging)

P50AG005681 (NIH – National Institute On Aging)

P01AG003991 (NIH – National Institute On Aging)

RF1AG044546 (NIH – National Institute On Aging)

U19AG068054 (NIH – National Institute On Aging)

R01AG064877 (NIH – National Institute On Aging)

P50AG008702 (NIH – National Institute On Aging)

P30AG062421 (NIH – National Institute On Aging)

P01AG026276 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

R01AG064614 (NIH – National Institute On Aging)

U01AG024904 (NIH – National Institute On Aging)

U01AG051412 (NIH – National Institute On Aging)

RF1AG071706 (NIH – National Institute On Aging)

RF1AG053303 (NIH – National Institute On Aging)

U01AG058922 (NIH – National Institute On Aging)

P50AG005133 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1002/alz.13506

PMID:

37855447

DOI:

10.1002/alz.13506

Journal:

Publication Date:

2023-10-19

Data Source:

PubMed

Source Link:

Investigation of sex differences in mutation carriers of the Dominantly Inherited Alzheimer Network

Record Created:

Friday, July 26, 2024 - 15:15

Wagemann, O., Li, Y., Hassenstab, J., Aschenbrenner, A. J., McKay, N. S., Gordon, B. A., Benzinger, T. L. S., Xiong, C., Cruchaga, C., Renton, A. E., Perrin, R. J., Berman, S. B., Chhatwal, J. P., Farlow, M. R., Day, G. S., Ikeuchi, T., Jucker, M., Lopera, F., … Mori, H. (2023). Investigation of sex differences in mutation carriers of the Dominantly Inherited Alzheimer Network. Alzheimer’s & Dementia, 20(1), 47–62. Portico. https://doi.org/10.1002/alz.13460

Authors:

Olivia Wagemann

Yan Li

Jason Hassenstab

Andrew J Aschenbrenner

Nicole S McKay

Brian A Gordon

Tammie L S Benzinger

Chengjie Xiong

Carlos Cruchaga

Alan E Renton

Richard J Perrin

Sarah B Berman

Jasmeer P Chhatwal

Martin R Farlow

Gregory S Day

Takeshi Ikeuchi

Mathias Jucker

Francisco Lopera

Hiroshi Mori

James M Noble

Raquel Sánchez-Valle

Peter R Schofield

John C Morris

Alisha Daniels

Johannes Levin

Randall J Bateman

Eric McDade

Jorge J Llibre-Guerra

Affiliated Authors:

James M Noble

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Neurology

Subjects:

Diagnosis and Management of Alzheimer's Disease (OpenAlex Topic)

Mechanisms of Alzheimer's Disease (OpenAlex Topic)

Analysis of Gene Interaction Networks (OpenAlex Topic)

Alzheimer Disease (MeSH)

Author Keywords:

cognition

dominantly inherited alzheimer's disease

gender

presymptomatic alzheimer's disease

sex

Grants:

U19AG032438 (NIH – National Institute On Aging)

UF1AG032438 (NIH – National Institute On Aging)

R01AG053267 (NIH – National Institute On Aging)

K01AG073526 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1002/alz.13460

PMID:

37740921

DOI:

10.1002/alz.13460

Journal:

Publication Date:

2023-09-23

Data Source:

PubMed

Source Link:

Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease

Record Created:

Friday, July 26, 2024 - 10:21

Johnson, E. C. B., Bian, S., Haque, R. U., Carter, E. K., Watson, C. M., Gordon, B. A., Ping, L., Duong, D. M., Epstein, M. P., McDade, E., Barthélemy, N. R., Karch, C. M., Xiong, C., Cruchaga, C., Perrin, R. J., Wingo, A. P., Wingo, T. S., Chhatwal, J. P., Day, G. S., … Ringman, J. (2023). Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease. Nature Medicine, 29(8), 1979–1988. https://doi.org/10.1038/s41591-023-02476-4

Authors:

Erik C B Johnson

Shijia Bian

Rafi U Haque

E Kathleen Carter

Caroline M Watson

Brian A Gordon

Lingyan Ping

Duc M Duong

Michael P Epstein

Eric McDade

Nicolas R Barthélemy

Celeste M Karch

Chengjie Xiong

Carlos Cruchaga

Richard J Perrin

Aliza P Wingo

Thomas S Wingo

Jasmeer P Chhatwal

Gregory S Day

James M Noble

Sarah B Berman

Ralph Martins

Neill R Graff-Radford

Peter R Schofield

Takeshi Ikeuchi

Hiroshi Mori

Johannes Levin

Martin Farlow

James J Lah

Christian Haass

Mathias Jucker

John C Morris

Tammie L S Benzinger

Blaine R Roberts

Randall J Bateman

Anne M Fagan

Nicholas T Seyfried

Allan I Levey

Affiliated Authors:

James M Noble

Columbia Affiliation:

Subjects:

Alzheimer Disease (MeSH)

Proteomics (MeSH)

Grants:

R01NS123571 (NIH – National Institute of Neurological Disorders and Stroke)

R01NS092865 (NIH – National Institute of Neurological Disorders and Stroke)

UF1AG032438 (NIH – National Institute On Aging)

U19AG024904 (NIH – National Institute On Aging)

RF1AG071170 (NIH – National Institute On Aging)

R01AG056533 (NIH – National Institute On Aging)

U01AG061357 (NIH – National Institute On Aging)

P30AG066444 (NIH – National Institute On Aging)

P01AG003991 (NIH – National Institute On Aging)

R01AG072120 (NIH – National Institute On Aging)

P30AG066511 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

K08AG068604 (NIH – National Institute On Aging)

R01AG075827 (NIH – National Institute On Aging)

P01AG026276 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1038/s41591-023-02476-4

PMID:

37550416

DOI:

10.1038/s41591-023-02476-4

Journal:

Nature Medicine

Publication Date:

2023-08-01

Data Source:

PubMed

Source Link:

Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN)

Record Created:

Wednesday, August 7, 2024 - 16:26

McKay, N. S., Gordon, B. A., Hornbeck, R. C., Dincer, A., Flores, S., Keefe, S. J., Joseph-Mathurin, N., Jack, C. R., Koeppe, R., Millar, P. R., Ances, B. M., Chen, C. D., Daniels, A., Hobbs, D. A., Jackson, K., Koudelis, D., Massoumzadeh, P., McCullough, A., Nickels, M. L., … la Fougère, C. (2023). Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN). Nature Neuroscience, 26(8), 1449–1460. https://doi.org/10.1038/s41593-023-01359-8

Authors:

Nicole S McKay

Brian A Gordon

Russ C Hornbeck

Aylin Dincer

Shaney Flores

Sarah J Keefe

Nelly Joseph-Mathurin

Clifford R Jack

Robert Koeppe

Peter R Millar

Beau M Ances

Charles D Chen

Alisha Daniels

Diana A Hobbs

Kelley Jackson

Deborah Koudelis

Parinaz Massoumzadeh

Austin McCullough

Michael L Nickels

Farzaneh Rahmani

Laura Swisher

Qing Wang

Ricardo F Allegri

Sarah B Berman

Adam M Brickman

William S Brooks

David M Cash

Jasmeer P Chhatwal

Gregory S Day

Martin R Farlow

Christian la Fougère

Nick C Fox

Michael Fulham

Bernardino Ghetti

Neill Graff-Radford

Takeshi Ikeuchi

William Klunk

Jae-Hong Lee

Johannes Levin

Ralph Martins

Colin L Masters

Jonathan McConathy

Hiroshi Mori

James M Noble

Gerald Reischl

Christopher Rowe

Stephen Salloway

Raquel Sanchez-Valle

Peter R Schofield

Hiroyuki Shimada

Mikio Shoji

Yi Su

Kazushi Suzuki

Jonathan Vöglein

Igor Yakushev

Carlos Cruchaga

Jason Hassenstab

Celeste Karch

Eric McDade

Richard J Perrin

Chengjie Xiong

John C Morris

Randall J Bateman

Tammie L S Benzinger

Affiliated Authors:

Adam M Brickman

James M Noble

Columbia Affiliation:

Subjects:

Mechanisms of Alzheimer's Disease (OpenAlex Topic)

Diagnosis and Management of Alzheimer's Disease (OpenAlex Topic)

Analysis of Brain Functional Connectivity Networks (OpenAlex Topic)

Alzheimer Disease (MeSH)

Arthrogryposis (MeSH)

Grants:

UL1TR002345 (NIH – National Center for Advancing Translational Sciences)

UF1AG032438 (NIH – National Institute On Aging)

RF1AG079569 (NIH – National Institute On Aging)

R01AG053267 (NIH – National Institute On Aging)

R01AG058676 (NIH – National Institute On Aging)

U19AG024904 (NIH – National Institute On Aging)

R56AG053267 (NIH – National Institute On Aging)

U01AG059798 (NIH – National Institute On Aging)

K23AG064029 (NIH – National Institute On Aging)

R01AG068319 (NIH – National Institute On Aging)

R01AG057840 (NIH – National Institute On Aging)

R01AG052550 (NIH – National Institute On Aging)

P01AG026276 (NIH – National Institute On Aging)

K01AG080123 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

P01AG025204 (NIH – National Institute On Aging)

R01AG054567 (NIH – National Institute On Aging)

RF1AG073424 (NIH – National Institute On Aging)

R03AG072375 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1038/s41593-023-01359-8

PMID:

37429916

DOI:

10.1038/s41593-023-01359-8

Journal:

Nature Neuroscience

Publication Date:

2023-08-01

Data Source:

PubMed

Source Link:

Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer's Disease

Record Created:

Wednesday, August 7, 2024 - 16:29

Horie, K., Li, Y., Barthélemy, N. R., Gordon, B., Hassenstab, J., Benzinger, T. L. S., Fagan, A. M., Morris, J. C., Karch, C. M., Xiong, C., Allegri, R., Mendez, P. C., Ikeuchi, T., Kasuga, K., Noble, J., Farlow, M., Chhatwal, J., Day, G., … Schofield, P. R. (2023). Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer’s Disease. Annals of Neurology, 93(6), 1158–1172. Portico. https://doi.org/10.1002/ana.26620

Authors:

Kanta Horie

Yan Li

Nicolas R Barthélemy

Brian Gordon

Jason Hassenstab

Tammie L S Benzinger

Anne M Fagan

John C Morris

Celeste M Karch

Chengjie Xiong

Ricardo Allegri

Patricio Chrem Mendez

Takeshi Ikeuchi

Kensaku Kasuga

James Noble

Martin Farlow

Jasmeer Chhatwal

Gregory Day

Peter R Schofield

Colin L Masters

Johannes Levin

Mathias Jucker

Jae-Hong Lee

Jee Hoon Roh

Chihiro Sato

Pallavi Sachdev

Akihiko Koyama

Larisa Reyderman

Randall J Bateman

Eric McDade

Affiliated Authors:

James Noble

Columbia Affiliation:

Subjects:

Alzheimer Disease (MeSH)

Cognitive Dysfunction (MeSH)

Grants:

R01NS095773 (NIH – National Institute of Neurological Disorders and Stroke)

UF1AG032438 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

K23AG046363 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1002/ana.26620

PMID:

36843330

DOI:

10.1002/ana.26620

Journal:

Annals of Neurology

Publication Date:

2023-06-01

Data Source:

PubMed

Source Link:

First presentation with neuropsychiatric symptoms in autosomal dominant Alzheimer's disease: The Dominantly Inherited Alzheimer's Network Study

Record Created:

Monday, August 12, 2024 - 11:12

O’Connor, A., Rice, H., Barnes, J., Ryan, N. S., Liu, K. Y., Allegri, R. F., Berman, S., Ringman, J. M., Cruchaga, C., Farlow, M. R., Hassenstab, J., Lee, J.-H., Perrin, R. J., Xiong, C., Gordon, B., Levey, A. I., Goate, A., Graff-Radford, N., Levin, J., … Fox, N. C. (2022). First presentation with neuropsychiatric symptoms in autosomal dominant Alzheimer’s disease: the Dominantly Inherited Alzheimer’s Network Study. Journal of Neurology, Neurosurgery & Psychiatry, 94(5), 403–405. https://doi.org/10.1136/jnnp-2022-329843

Authors:

Antoinette O'Connor

Helen Rice

Josephine Barnes

Natalie S. Ryan

Kathy Y. Liu

Ricardo Francisco Allegri

Sarah Berman

John M. Ringman

Carlos Cruchaga

Martin R. Farlow

Jason Hassenstab

Jae-Hong Lee

Richard J. Perrin

Chengjie Xiong

Brian Gordon

Allan I. Levey

Alison Goate

Neil Graff-Radford

Johannes Levin

Mathias Jucker

Tammie Benzinger

Eric McDade

Hiroshi Mori

James M. Noble

Peter R. Schofield

Ralph N. Martins

Stephen Salloway

Jasmeer Chhatwal

John C. Morris

Randall Bateman

Rob Howard

Suzanne Reeves

Nick C. Fox

Affiliated Authors:

James M. Noble

Columbia Affiliation:

Author Keywords:

alzheimer's disease

behavioural disorder

cognition

neuropsychiatry

Grants:

R01AG052550 (NIH – National Institute On Aging)

K01AG053474 (NIH – National Institute On Aging)

UF1AG032438 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1136/jnnp-2022-329843

PMID:

36522155

DOI:

10.1136/jnnp-2022-329843

Journal:

Journal of Neurology, Neurosurgery and Psychiatry

Publication Date:

2023-05-01

Data Source:

Scopus

Source Link:

Longitudinal head-to-head comparison of 11C-PiB and 18F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-β monoclonal antibodies in dominantly inherited Alzheimer's disease

Record Created:

Tuesday, August 13, 2024 - 11:25

Chen, C. D., McCullough, A., Gordon, B., Joseph-Mathurin, N., Flores, S., McKay, N. S., Hobbs, D. A., Hornbeck, R., Fagan, A. M., Cruchaga, C., Goate, A. M., Perrin, R. J., Wang, G., Li, Y., Shi, X., Xiong, C., Pontecorvo, M. J., Klein, G., … Su, Y. (2023). Longitudinal head-to-head comparison of 11C-PiB and 18F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-β monoclonal antibodies in dominantly inherited Alzheimer’s disease. European Journal of Nuclear Medicine and Molecular Imaging, 50(9), 2669–2682. https://doi.org/10.1007/s00259-023-06209-0

Authors:

Charles D Chen

Austin McCullough

Brian Gordon

Nelly Joseph-Mathurin

Shaney Flores

Nicole S McKay

Diana A Hobbs

Russ Hornbeck

Anne M Fagan

Carlos Cruchaga

Alison M Goate

Richard J Perrin

Guoqiao Wang

Yan Li

Xinyu Shi

Chengjie Xiong

Michael J Pontecorvo

Gregory Klein

Yi Su

William E Klunk

Clifford Jack

Robert Koeppe

B Joy Snider

Sarah B Berman

Erik D Roberson

Jared Brosch

Ghulam Surti

Ivonne Z Jiménez-Velázquez

Douglas Galasko

Lawrence S Honig

William S Brooks

Roger Clarnette

David Wallon

Bruno Dubois

Jérémie Pariente

Florence Pasquier

Raquel Sanchez-Valle

Sergey Shcherbinin

Ixavier Higgins

Ilke Tunali

Colin L Masters

Christopher H van Dyck

Mario Masellis

Robin Hsiung

Serge Gauthier

Steve Salloway

David B Clifford

Susan Mills

Charlene Supnet-Bell

Eric McDade

Randall J Bateman

Tammie L S Benzinger

Affiliated Authors:

Lawrence S Honig

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Neurology

Subjects:

Alzheimer Disease (MeSH)

Author Keywords:

18f-florbetapir

dominantly inherited alzheimer’s disease

gantenerumab

pittsburgh compound b

Grants:

K01AG080123 (NIH – National Institute On Aging)

P30AG066462 (NIH – National Institute On Aging)

P30AG066508 (NIH – National Institute On Aging)

P30AG072980 (NIH – National Institute On Aging)

P30NS098577 (NIH – National Institute of Neurological Disorders and Stroke)

R01AG046179 (NIH – National Institute On Aging)

R01AG052550 (NIH – National Institute On Aging)

R01AG053267 (NIH – National Institute On Aging)

R01AG068319 (NIH – National Institute On Aging)

S10OD025214 (NIH – Office of the Director, National Institutes of Health)

T32AG058518 (NIH – National Institute On Aging)

U01AG042791 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

UF1AG032438 (NIH – National Institute On Aging)

UL1TR001863 (NIH – National Center for Advancing Translational Sciences)

Publication Type:

Article

Unique ID:

10.1007/s00259-023-06209-0

PMID:

37017737

DOI:

10.1007/s00259-023-06209-0

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Publication Date:

2023-04-06

Data Source:

PubMed

Source Link:

Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease

Record Created:

Wednesday, September 24, 2025 - 12:33

Vöglein, J., Franzmeier, N., Morris, J. C., Dieterich, M., McDade, E., Simons, M., Preische, O., Hofmann, A., Hassenstab, J., Benzinger, T. L., Fagan, A., Noble, J. M., Berman, S. B., Graff‐Radford, N. R., Ghetti, B., Farlow, M. R., Chhatwal, J. P., Salloway, S., … Xiong, C. (2022). Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease. Alzheimer’s & Dementia, 19(2), 632–645. Portico. https://doi.org/10.1002/alz.12684

Authors:

Jonathan Vöglein

Nicolai Franzmeier

John C Morris

Marianne Dieterich

Eric McDade

Mikael Simons

Oliver Preische

Anna Hofmann

Jason Hassenstab

Tammie L Benzinger

Anne Fagan

James M Noble

Sarah B Berman

Neill R Graff-Radford

Bernardino Ghetti

Martin R Farlow

Jasmeer P Chhatwal

Stephen Salloway

Chengjie Xiong

Celeste M Karch

Nigel Cairns

Richard J Perrin

Gregory Day

Ralph Martins

Raquel Sanchez-Valle

Hiroshi Mori

Hiroyuki Shimada

Takeshi Ikeuchi

Kazushi Suzuki

Peter R Schofield

Colin L Masters

Alison Goate

Virginia Buckles

Nick C Fox

Patricio Chrem

Ricardo Allegri

John M Ringman

Igor Yakushev

Christoph Laske

Mathias Jucker

Günter Höglinger

Randall J Bateman

Adrian Danek

Johannes Levin

Affiliated Authors:

James M Noble

Columbia Affiliation:

Subjects:

Mechanisms of Alzheimer's Disease (OpenAlex Topic)

Diagnosis and Management of Alzheimer's Disease (OpenAlex Topic)

Pathophysiology of Parkinson's Disease (OpenAlex Topic)

Alzheimer Disease (MeSH)

Cognitive Dysfunction (MeSH)

Author Keywords:

alzheimer disease

autosomal dominant alzheimer disease

differential diagnosis

neurological examination

neurological examination findings

predictive value

prognosis

Grants:

R01EB028297 (NIH – National Institute of Biomedical Imaging and Bioengineering)

R01NS075321 (NIH – National Institute of Neurological Disorders and Stroke)

R01NS092865 (NIH – National Institute of Neurological Disorders and Stroke)

UH3NS100614 (NIH – National Institute of Neurological Disorders and Stroke)

R01NS114382 (NIH – National Institute of Neurological Disorders and Stroke)

R01NS067443 (NIH – National Institute of Neurological Disorders and Stroke)

R01NS097799 (NIH – National Institute of Neurological Disorders and Stroke)

R01NR017571 (NIH – National Institute of Nursing Research)

P30AG066444 (NIH – National Institute On Aging)

R01AG067505 (NIH – National Institute On Aging)

P01AG003991 (NIH – National Institute On Aging)

RF1AG064584 (NIH – National Institute On Aging)

RF1AG053550 (NIH – National Institute On Aging)

R01AG053267 (NIH – National Institute On Aging)

K23AG064029 (NIH – National Institute On Aging)

R21AG064776 (NIH – National Institute On Aging)

R01AG062667 (NIH – National Institute On Aging)

R01AG066711 (NIH – National Institute On Aging)

U01AG051218 (NIH – National Institute On Aging)

P30AG066530 (NIH – National Institute On Aging)

R01AG054536 (NIH – National Institute On Aging)

R01AG071865 (NIH – National Institute On Aging)

P01AG036694 (NIH – National Institute On Aging)

R01AG060929 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

R01AG054513 (NIH – National Institute On Aging)

R01AG068319 (NIH – National Institute On Aging)

R21AG065753 (NIH – National Institute On Aging)

R01AG054567 (NIH – National Institute On Aging)

R01AG025340 (NIH – National Institute On Aging)

U19AG024904 (NIH – National Institute On Aging)

U2CAG057441 (NIH – National Institute On Aging)

P01AG052350 (NIH – National Institute On Aging)

T35AG044303 (NIH – National Institute On Aging)

UF1AG032438 (NIH – National Institute On Aging)

RF1AG056573 (NIH – National Institute On Aging)

R01AG062007 (NIH – National Institute On Aging)

R01AG070883 (NIH – National Institute On Aging)

P30AG066462 (NIH – National Institute On Aging)

R01AG052550 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1002/alz.12684

PMID:

35609137

DOI:

10.1002/alz.12684

Journal:

Publication Date:

2023-02-01

Data Source:

PubMed

Source Link:

Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study

Record Created:

Friday, August 16, 2024 - 12:29

Boerwinkle, A. H., Gordon, B. A., Wisch, J., Flores, S., Henson, R. L., Butt, O. H., McKay, N., Chen, C. D., Benzinger, T. L. S., Fagan, A. M., Handen, B. L., Christian, B. T., Head, E., Mapstone, M., Rafii, M. S., O’Bryant, S., Lai, F., Rosas, H. D., Lee, J. H., … Xu, X. (2023). Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer’s disease: a cross-sectional study. The Lancet Neurology, 22(1), 55–65. https://doi.org/10.1016/s1474-4422(22)00408-2

Authors:

Anna H Boerwinkle

Brian A Gordon

Julie Wisch

Shaney Flores

Rachel L Henson

Omar H Butt

Nicole McKay

Charles D Chen

Tammie L S Benzinger

Anne M Fagan

Benjamin L Handen

Bradley T Christian

Elizabeth Head

Mark Mapstone

Michael S Rafii

Sid O&#039;Bryant

Florence Lai

H Diana Rosas

Joseph H Lee

Wayne Silverman

Adam M Brickman

Jasmeer P Chhatwal

Carlos Cruchaga

Richard J Perrin

Chengjie Xiong

Jason Hassenstab

Eric McDade

Randall J Bateman

Beau M Ances

Affiliated Authors:

Joseph H Lee

Adam M Brickman

Columbia Affiliation:

Subjects:

Alzheimer Disease (MeSH)

Amyloid beta-Peptides (MeSH)

Down Syndrome (MeSH)

Cerebral Cortex (MeSH)

Grants:

P50HD103525 (NIH – Eunice Kennedy Shriver National Institute of Child Health & Human Development)

K01AG053474 (NIH – National Institute On Aging)

U01AG051412 (NIH – National Institute On Aging)

R01AG052550 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

R61AG066543 (NIH – National Institute On Aging)

P30AG066519 (NIH – National Institute On Aging)

UF1AG032438 (NIH – National Institute On Aging)

R33AG066543 (NIH – National Institute On Aging)

U01AG051406 (NIH – National Institute On Aging)

U19AG068054 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1016/s1474-4422(22)00408-2

PMID:

36517172

DOI:

10.1016/s1474-4422(22)00408-2

Journal:

Lancet Neurology

Publication Date:

2023-01-01

Data Source:

PubMed

Source Link:

Biomarker clustering in autosomal dominant Alzheimer's disease

Record Created:

Friday, August 16, 2024 - 12:57

Luckett, P. H., Chen, C., Gordon, B. A., Wisch, J., Berman, S. B., Chhatwal, J. P., Cruchaga, C., Fagan, A. M., Farlow, M. R., Fox, N. C., Jucker, M., Levin, J., Masters, C. L., Mori, H., Noble, J. M., Salloway, S., Schofield, P. R., Brickman, A. M., … Brooks, W. S. (2022). Biomarker clustering in autosomal dominant Alzheimer’s disease. Alzheimer’s & Dementia, 19(1), 274–284. Portico. https://doi.org/10.1002/alz.12661

Authors:

Patrick H Luckett

Charlie Chen

Brian A Gordon

Julie Wisch

Sarah B Berman

Jasmeer P Chhatwal

Carlos Cruchaga

Anne M Fagan

Martin R Farlow

Nick C Fox

Mathias Jucker

Johannes Levin

Colin L Masters

Hiroshi Mori

James M Noble

Stephen Salloway

Peter R Schofield

Adam M Brickman

William S Brooks

David M Cash

Michael J Fulham

Bernardino Ghetti

Clifford R Jack

Jonathan Vöglein

William E Klunk

Robert Koeppe

Yi Su

Michael Weiner

Qing Wang

Daniel Marcus

Deborah Koudelis

Nelly Joseph-Mathurin

Lisa Cash

Russ Hornbeck

Chengjie Xiong

Richard J Perrin

Celeste M Karch

Jason Hassenstab

Eric McDade

John C Morris

Tammie L S Benzinger

Randall J Bateman

Beau M Ances

Affiliated Authors:

James M Noble

Columbia Affiliation:

Subjects:

Alzheimer Disease (MeSH)

Author Keywords:

autosomal dominant alzheimer's disease

biomarkers

machine learning

Grants:

UL1TR002345 (NIH – National Center for Advancing Translational Sciences)

UL1TR000448 (NIH – National Center for Advancing Translational Sciences)

R01EB009352 (NIH – National Institute of Biomedical Imaging and Bioengineering)

R01MH098062 (NIH – National Institute of Mental Health)

P30NS098577 (NIH – National Institute of Neurological Disorders and Stroke)

R01AG058676 (NIH – National Institute On Aging)

P30AG066444 (NIH – National Institute On Aging)

U19AG024904 (NIH – National Institute On Aging)

R01AG046179 (NIH – National Institute On Aging)

P01AG003991 (NIH – National Institute On Aging)

RF1AG059009 (NIH – National Institute On Aging)

K23AG046363 (NIH – National Institute On Aging)

U01AG042791 (NIH – National Institute On Aging)

R01AG052550 (NIH – National Institute On Aging)

P30AG019610 (NIH – National Institute On Aging)

U24AG057437 (NIH – National Institute On Aging)

P30AG072980 (NIH – National Institute On Aging)

P50AG005131 (NIH – National Institute On Aging)

R01AG053798 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

P50AG005681 (NIH – National Institute On Aging)

K01AG053474 (NIH – National Institute On Aging)

UF1AG032438 (NIH – National Institute On Aging)

P01AG026276 (NIH – National Institute On Aging)

S10OD025214 (NIH – Office of the Director, National Institutes of Health)

Publication Type:

Article

Unique ID:

10.1002/alz.12661

PMID:

35362200

DOI:

10.1002/alz.12661

Journal:

Publication Date:

2023-01-01

Data Source:

PubMed

Source Link:

Record Created:

Friday, August 16, 2024 - 13:07

Joseph‐Mathurin, N., Llibre‐Guerra, J. J., Li, Y., McCullough, A. A., Hofmann, C., Wojtowicz, J., Park, E., Wang, G., Preboske, G. M., Wang, Q., Gordon, B. A., Chen, C. D., Flores, S., Aggarwal, N. T., Berman, S. B., Bird, T. D., Black, S. E., Borowski, B., … Brooks, W. S. (2022). Amyloid‐Related Imaging Abnormalities in the DIAN‐TU‐001 Trial of Gantenerumab and Solanezumab: Lessons from a Trial in Dominantly Inherited Alzheimer Disease. Annals of Neurology, 92(5), 729–744. Portico. https://doi.org/10.1002/ana.26511

Authors:

Nelly Joseph-Mathurin

Jorge J Llibre-Guerra

Yan Li

Austin A McCullough

Carsten Hofmann

Jakub Wojtowicz

Ethan Park

Guoqiao Wang

Gregory M Preboske

Qing Wang

Brian A Gordon

Charles D Chen

Shaney Flores

Neelum T Aggarwal

Sarah B Berman

Thomas D Bird

Sandra E Black

Bret Borowski

William S Brooks

Jasmeer P Chhatwal

Roger Clarnette

Carlos Cruchaga

Anne M Fagan

Martin Farlow

Nick C Fox

Serge Gauthier

Jason Hassenstab

Diana A Hobbs

Karen C Holdridge

Lawrence S Honig

Russ C Hornbeck

Ging-Yuek R Hsiung

Clifford R Jack

Ivonne Z Jimenez-Velazquez

Mathias Jucker

Gregory Klein

Johannes Levin

Michele Mancini

Mario Masellis

Nicole S McKay

Catherine J Mummery

John M Ringman

Hiroyuki Shimada

B Joy Snider

Kazushi Suzuki

David Wallon

Chengjie Xiong

Roy Yaari

Eric McDade

Richard J Perrin

Randall J Bateman

Stephen P Salloway

Tammie L S Benzinger

David B Clifford

Affiliated Authors:

Lawrence S Honig

Columbia Affiliation:

Subjects:

Mechanisms of Alzheimer's Disease (OpenAlex Topic)

Diagnosis and Management of Alzheimer's Disease (OpenAlex Topic)

Molecular Mechanisms of Amyloidosis (OpenAlex Topic)

Alzheimer Disease (MeSH)

Grants:

U01AG042791 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

R01AG053267 (NIH – National Institute On Aging)

P30AG066444 (NIH – National Institute On Aging)

R01AG046179 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1002/ana.26511

PMID:

36151869

DOI:

10.1002/ana.26511

Journal:

Annals of Neurology

Publication Date:

2022-11-01

Data Source:

PubMed

Source Link:

Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology

Record Created:

Tuesday, September 24, 2024 - 15:29

Morris, J. C., Weiner, M., Xiong, C., Beckett, L., Coble, D., Saito, N., Aisen, P. S., Allegri, R., Benzinger, T. L. S., Berman, S. B., Cairns, N. J., Carrillo, M. C., Chui, H. C., Chhatwal, J. P., Cruchaga, C., Fagan, A. M., Farlow, M., Fox, N. C., Ghetti, B., … Buckles, V. D. (2022). Autosomal dominant and sporadic late onset Alzheimer’s disease share a commonin vivopathophysiology. Brain, 145(10), 3594–3607. https://doi.org/10.1093/brain/awac181

Authors:

John C. Morris

Michael Weiner

Chengjie Xiong

Laurel Beckett

Dean Coble

Naomi Saito

Paul S. Aisen

Ricardo Allegri

Tammie L.S. Benzinger

Sarah B. Berman

Nigel J. Cairns

Maria C. Carrillo

Helena C. Chui

Jasmeer P. Chhatwal

Carlos Cruchaga

Anne M. Fagan

Martin Farlow

Nick C. Fox

Bernardino Ghetti

Alison M. Goate

Brian A. Gordon

Neill Graff-Radford

Gregory S. Day

Jason Hassenstab

Takeshi Ikeuchi

Clifford R. Jack

William J. Jagust

Mathias Jucker

Johannes Levin

Parinaz Massoumzadeh

Colin L. Masters

Ralph Martins

Eric McDade

Hiroshi Mori

James M. Noble

Ronald C. Petersen

John M. Ringman

Stephen Salloway

Andrew J. Saykin

Peter R. Schofield

Leslie M. Shaw

Arthur W. Toga

John Q. Trojanowski

Jonathan Vöglein

Stacie Weninger

Randall J. Bateman

Virginia D. Buckles

Affiliated Authors:

James M. Noble

Columbia Affiliation:

Subjects:

Alzheimer Disease (MeSH)

Amyloidosis (MeSH)

Author Keywords:

alzheimer pathophysiology

biomarkers

rates of change

Grants:

P01AG003991 (NIH – National Institute On Aging)

UF1AG032438 (NIH – National Institute On Aging)

U19AG024904 (NIH – National Institute On Aging)

P01AG026276 (NIH – National Institute On Aging)

P30AG072979 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

S10OD025214 (NIH – Office of the Director, National Institutes of Health)

Publication Type:

Article

Unique ID:

10.1093/brain/awac181

PMID:

35580594

DOI:

10.1093/brain/awac181

Journal:

Brain

Publication Date:

2022-10-01

Data Source:

Scopus

Source Link:

Avoid or Embrace? Practice Effects in Alzheimer's Disease Prevention Trials

Record Created:

Monday, October 14, 2024 - 17:45

Aschenbrenner, A. J., Hassenstab, J., Wang, G., Li, Y., Xiong, C., McDade, E., Clifford, D. B., Salloway, S., Farlow, M., Yaari, R., Cheng, E. Y. J., Holdridge, K. C., Mummery, C. J., Masters, C. L., Hsiung, G.-Y., Surti, G., Day, G. S., Weintraub, S., Honig, L. S., … Bateman, R. J. (2022). Avoid or Embrace? Practice Effects in Alzheimer’s Disease Prevention Trials. Frontiers in Aging Neuroscience, 14. https://doi.org/10.3389/fnagi.2022.883131

Authors:

Andrew J Aschenbrenner

Jason Hassenstab

Guoqiao Wang

Yan Li

Chengjie Xiong

Eric McDade

David B Clifford

Stephen Salloway

Martin Farlow

Roy Yaari

Eden Y J Cheng

Karen C Holdridge

Catherine J Mummery

Colin L Masters

Ging-Yuek Hsiung

Ghulam Surti

Gregory S Day

Sandra Weintraub

Lawrence S Honig

James E Galvin

John M Ringman

William S Brooks

Nick C Fox

Peter J Snyder

Kazushi Suzuki

Hiroyuki Shimada

Susanne Gräber

Randall J Bateman

Affiliated Authors:

Lawrence S Honig

Columbia Affiliation:

Subjects:

Diagnosis and Management of Alzheimer's Disease (OpenAlex Topic)

Health Economics and Quality of Life Assessment (OpenAlex Topic)

Analysis of Brain Functional Connectivity Networks (OpenAlex Topic)

Author Keywords:

practice effects

alzheimer's disease

clinical trials

learning

assessment frequency

alternative forms

alzheimer’s disease

Grants:

P30AG072977 (NIH – National Institute On Aging)

R01AG053267 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

P30AG013854 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.3389/fnagi.2022.883131

PMID:

35783127

DOI:

10.3389/fnagi.2022.883131

Journal:

Frontiers in Aging Neuroscience

Publication Date:

2022-07-06

Data Source:

PubMed

Source Link:

CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease

Record Created:

Thursday, December 19, 2024 - 08:49

Strain, J. F., Barthelemy, N., Horie, K., Gordon, B. A., Kilgore, C., Aschenbrenner, A., Cruchaga, C., Xiong, C., Joseph-Mathurin, N., Hassenstab, J., Fagan, A. M., Li, Y., Karch, C. M., Perrin, R. J., Berman, S. B., Chhatwal, J. P., Graff-Radford, N. R., Mori, H., Levin, J., … Ances, B. M. (2022). CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease. Neurobiology of Disease, 168, 105714. https://doi.org/10.1016/j.nbd.2022.105714

Authors:

Jeremy F. Strain

Nicolas Barthelemy

Kanta Horie

Brian A. Gordon

Collin Kilgore

Andrew Aschenbrenner

Carlos Cruchaga

Jason Hassenstab

Anne M. Fagan

Yan Li

Richard J. Perrin

David M. Holtzman

John C. Morris

Eric M. McDade

Randall J. Bateman

Beau M. Ances

Nelly Joseph-Mathurin

Celeste M. Karch

Tammie L. S. Benzinger

Chengjie Xiong

Daniel S. Marcus

Sarah B. Berman

Jasmeer P. Chhatwal

Neill R. Graff-Radford

Hiroshi Mori

Johannes Levin

Ricardo Allegri

Peter R. Schofield

James M. Noble

Affiliated Authors:

James M. Noble

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Neurology

Author Keywords:

phosphorylated tau

adad

white matter

pca

csf

Grants:

UL1TR000448 (NIH – National Center for Advancing Translational Sciences)

UL1TR002345 (NIH – National Center for Advancing Translational Sciences)

P30NS048056 (NIH – National Institute of Neurological Disorders and Stroke)

P30NS098577 (NIH – National Institute of Neurological Disorders and Stroke)

R01NR012657 (NIH – National Institute of Nursing Research)

R01NR014449 (NIH – National Institute of Nursing Research)

R01NR012907 (NIH – National Institute of Nursing Research)

R01AG054567 (NIH – National Institute On Aging)

P30AG066444 (NIH – National Institute On Aging)

P50AG005681 (NIH – National Institute On Aging)

R01AG052550 (NIH – National Institute On Aging)

UF1AG032438 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

P01AG003991 (NIH – National Institute On Aging)

R01AG043434 (NIH – National Institute On Aging)

K01AG053474 (NIH – National Institute On Aging)

P01AG026276 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1016/j.nbd.2022.105714

PMID:

35358703

DOI:

10.1016/j.nbd.2022.105714

Journal:

Neurobiology of Disease

Publication Date:

2022-06-15

Data Source:

Web of Science

Source Link:

Variant-dependent heterogeneity in amyloid β burden in autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analyses of an observational study

Record Created:

Wednesday, February 12, 2025 - 14:08

Chhatwal, J. P., Schultz, S. A., McDade, E., Schultz, A. P., Liu, L., Hanseeuw, B. J., Joseph-Mathurin, N., Feldman, R., Fitzpatrick, C. D., Sparks, K. P., Levin, J., Berman, S. B., Renton, A. E., Esposito, B. T., Fernandez, M. V., Sung, Y. J., Lee, J. H., Klunk, W. E., Hofmann, A., … Sperling, R. A. (2022). Variant-dependent heterogeneity in amyloid β burden in autosomal dominant Alzheimer’s disease: cross-sectional and longitudinal analyses of an observational study. The Lancet Neurology, 21(2), 140–152. https://doi.org/10.1016/s1474-4422(21)00375-6

Authors:

Jasmeer P Chhatwal

Stephanie A Schultz

Eric McDade

Aaron P Schultz

Lei Liu

Bernard J Hanseeuw

Nelly Joseph-Mathurin

Rebecca Feldman

Colleen D Fitzpatrick

Kathryn P Sparks

Johannes Levin

Sarah B Berman

Alan E Renton

Bianca T Esposito

Maria Vitoria Fernandez

Yun Ju Sung

Jae Hong Lee

William E Klunk

Anna Hofmann

James M Noble

Neill Graff-Radford

Hiroshi Mori

Steven M Salloway

Colin L Masters

Ralph Martins

Celeste M Karch

Chengjie Xiong

Carlos Cruchaga

Richard J Perrin

Brian A Gordon

Tammie L S Benzinger

Nick C Fox

Peter R Schofield

Anne M Fagan

Alison M Goate

John C Morris

Randall J Bateman

Keith A Johnson

Reisa A Sperling

Affiliated Authors:

James M Noble

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Neurology

Subjects:

Alzheimer Disease (MeSH)

Amyloid beta-Peptides (MeSH)

Grants:

U19AG032438 (NIH – National Institute On Aging)

K23AG049087 (NIH – National Institute On Aging)

K01AG053474 (NIH – National Institute On Aging)

UF1AG032438 (NIH – National Institute On Aging)

P30AG066444 (NIH – National Institute On Aging)

R01AG071865 (NIH – National Institute On Aging)

P01AG036694 (NIH – National Institute On Aging)

S10OD025214 (NIH – Office of the Director, National Institutes of Health)

Publication Type:

Article

Unique ID:

10.1016/S1474-4422(21)00375-6

PMID:

35065037

DOI:

10.1016/S1474-4422(21)00375-6

Journal:

Lancet Neurology

Publication Date:

2022-02-01

Data Source:

Scopus

Source Link:

Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Record Created:

Tuesday, February 18, 2025 - 11:20

Gonneaud, J., Baria, A. T., Pichet Binette, A., Gordon, B. A., Chhatwal, J. P., Cruchaga, C., Jucker, M., Levin, J., Salloway, S., Farlow, M., Gauthier, S., Benzinger, T. L. S., Morris, J. C., Bateman, R. J., Breitner, J. C. S., Poirier, J., Vachon-Presseau, E., Villeneuve, S., … Vachon-Presseau, E. (2021). Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-25492-9

Authors:

Julie Gonneaud

Alex T. Baria

Alexa Pichet Binette

Brian A. Gordon

Jasmeer P. Chhatwal

Carlos Cruchaga

Mathias Jucker

Johannes Levin

Stephen Salloway

Martin Farlow

Serge Gauthier

Tammie L. S. Benzinger

John C. Morris

Randall J. Bateman

John C. S. Breitner

Judes Poirier

Etienne Vachon-Presseau

Sylvia Villeneuve

Michael Weiner

Howard J. Rosen

Bruce L. Miller

Paul Aisen

Ronald G. Thomas

Michael Donohue

Sarah Walter

Devon Gessert

Tamie Sather

Gus Jiminez

Ronald Petersen

Clifford R. Jack

Matthew Bernstein

Bret Borowski

Jeff Gunter

Matt Senjem

Prashanthi Vemuri

David Jones

Kejal Kantarci

Chad Ward

Sara S. Mason

Colleen S. Albers

David Knopman

Kris Johnson

William Jagust

Susan Landau

John Q. Trojanowki

Arthur W. Toga

Karen Crawford

Scott Neu

Laurel Beckett

Danielle Harvey

Charles DeCarli

Robert C. Green

Andrew J. Saykin

Tatiana M. Foroud

Li Shen

Faber Kelley

Sungeun Kim

Kwangsik Nho

Ann Marie Hake

Brandy R. Matthews

Scott Herring

Cynthia Hunt

Nigel J. Cairns

Erin Householder

Lisa Taylor Reinwald

Leslie M. Shaw

Steven E. Arnold

Jason H. Karlawish

David Wolk

Enchi Liu

Tom Montine

Nick Fox

Paul Thompson

Norbert Schuff

Robert A. Koeppe

Judith L. Heidebrink

Joanne L. Lord

Norm Foster

Eric M. Reiman

Kewei Chen

Adam Fleisher

Pierre Tariot

Stephanie Reeder

Chet Mathis

Oscar L. Lopez

MaryAnn Oakley

Donna M. Simpson

Virginia Lee

Magdalena Korecka

Michal Figurski

Steven Potkin

Zaven Kachaturian

Richard Frank

Peter J. Snyder

Susan Molchan

Jeffrey Kaye

Joseph Quinn

Betty Lind

Raina Carter

Sara Dolen

Lon S. Schneider

Sonia Pawluczyk

Mauricio Beccera

Liberty Teodoro

Bryan M. Spann

James Brewer

Helen Vanderswag

Rachelle S. Doody

Javier Villanueva Meyer

Munir Chowdhury

Susan Rountree

Mimi Dang

Yaakov Stern

Lawrence S. Honig

Karen L. Bell

Beau Ances

Maria Carroll

Sue Leon

Mark A. Mintun

Stacy Schneider

Angela OliverNG

Randall Griffith

David Clark

David Geldmacher

John Brockington

Erik Roberson

Hillel Grossman

Effie Mitsis

Leyla deToledo-Morrell

Raj C. Shah

Ranjan Duara

Daniel Varon

Maria T. Greig

Peggy Roberts

Marilyn Albert

Chiadi Onyike

Daniel D’Agostino

Stephanie Kielb

James E. Galvin

Dana M. Pogorelec

Brittany Cerbone

Christina A. Michel

Henry Rusinek

Mony J. de Leon

Lidia Glodzik

Susan De Santi

P. Murali Doraiswamy

Jeffrey R. Petrella

Terence Z. Wong

Charles D. Smith

Greg Jicha

Peter Hardy

Partha Sinha

Elizabeth Oates

Gary Conrad

Anton P. Porsteinsson

Bonnie S. Goldstein

Kim Martin

Kelly M. Makino

M. Saleem Ismail

Connie Brand

Ruth A. Mulnard

Gaby Thai

Catherine Mc Adams Ortiz

Kyle Womack

Dana Mathews

Mary Quiceno

Ramon Diaz Arrastia

Richard King

Myron Weiner

Kristen Martin Cook

Michael DeVous

Allan I. Levey

James J. Lah

Janet S. Cellar

Jeffrey M. Burns

Heather S. Anderson

Russell H. Swerdlow

Liana Apostolova

Kathleen Tingus

Ellen Woo

Daniel H. S. Silverman

Po H. Lu

George Bartzokis

Neill R. Graff Radford

Francine ParfittH

Tracy Kendall

Heather Johnson

Christopher H. van Dyck

Richard E. Carson

Martha G. MacAvoy

Howard Chertkow

Howard Bergman

Chris Hosein

Sandra Black

Bojana Stefanovic

Curtis Caldwell

Ging Yuek Robin Hsiung

Howard Feldman

Benita Mudge

Michele Assaly Past

Andrew Kertesz

John Rogers

Dick Trost

Charles Bernick

Donna Munic

Diana Kerwin

Marek Marsel Mesulam

Kristine Lipowski

Chuang Kuo Wu

Nancy Johnson

Carl Sadowsky

Walter Martinez

Teresa Villena

Raymond Scott Turner

Kathleen Johnson

Brigid Reynolds

Reisa A. Sperling

Keith A. Johnson

Gad Marshall

Meghan Frey

Jerome Yesavage

Joy L. Taylor

Barton Lane

Allyson Rosen

Jared Tinklenberg

Marwan N. Sabbagh

Christine M. Belden

Sandra A. Jacobson

Sherye A. Sirrel

Neil Kowall

Ronald Killiany

Andrew E. Budson

Alexander Norbash

Patricia Lynn Johnson

Thomas O. Obisesan

Saba Wolday

Joanne Allard

Alan Lerner

Paula Ogrocki

Leon Hudson

Evan Fletcher

Owen Carmichael

John Olichney

Smita Kittur

Michael Borrie

T.Y. Lee

Rob Bartha

Sterling Johnson

Sanjay Asthana

Cynthia M. Carlsson

Adrian Preda

Dana Nguyen

Vernice Bates

Horacio Capote

Michelle Rainka

Douglas W. Scharre

Maria Kataki

Anahita Adeli

Earl A. Zimmerman

Dzintra Celmins

Alice D. Brown

Godfrey D. Pearlson

Karen Blank

Karen Anderson

Robert B. Santulli

Tamar J. Kitzmiller

Eben S. Schwartz

Kaycee M. Sinks

Jeff D. Williamson

Pradeep Garg

Franklin Watkins

Brian R. Ott

Henry Querfurth

Geoffrey Tremont

Paul Malloy

Stephen Correia

Jacobo Mintzer

Kenneth Spicer

David Bachman

Elizabether Finger

Stephen Pasternak

Irina Rachinsky

Dick Drost

Nunzio Pomara

Raymundo Hernando

Antero Sarrael

Susan K. Schultz

Laura L. Boles Ponto

Hyungsub Shim

Karen Elizabeth Smith

Norman Relkin

Gloria Chaing

Lisa Raudin

Amanda Smith

Kristin Fargher

Balebail Ashok Raj

Ricardo Allegri

Randy Bateman

Jacob Bechara

Sarah Berman

Courtney Bodge

Susan Brandon

William Brooks

Jill Buck

Virginia Buckles

Sochenda Chea

Patricio Chrem

Helena Chui

Jake Cinco

Tamara Donahue

Jane Douglas

Noelia Edigo

Nilufer Erekin-Taner

Anne Fagan

Colleen Fitzpatrick

Gigi Flynn

Erin Franklin

Hisako Fujii

Cortaiga Gant

Samantha Gardener

Bernardino Ghetti

Alison Goate

Jill Goldman

Neill Graff-Radford

Julia Gray

Alexander Groves

Jason Hassenstab

Laura Hoechst-Swisher

David Holtzman

Russ Hornbeck

Siri Houeland DiBari

Takeshi Ikeuchi

Snezana Ikonomovic

Clifford Jack

Gina Jerome

Celeste Karch

Kensaku Kasuga

Takeshi Kawarabayashi

William Klunk

Elke Kuder-Buletta

Christoph Laske

Jae-Hong Lee

Ralph Martins

Neal Scott Mason

Colin Masters

Denise Maue-Dreyfus

Eric McDade

Hiroshi Mori

Akem Nagamatsu

Katie Neimeyer

James Noble

Joanne Norton

Richard Perrin

Marc Raichle

Alan Renton

John Ringman

Jee Hoon Roh

Hiroyuki Shimada

Wendy Sigurdson

Hamid Sohrabi

Paige Sparks

Kazushi Suzuki

Kevin Taddei

Peter Wang

Chengjie Xiong

Xiong Xu

Pierre Bellec

Véronique Bohbot

Mallar Chakravarty

Louis Collins

Pierre Etienne

Alan Evans

Rick Hoge

Yasser Ituria-Medina

Vasavan Nair

Jamie Near

Natasha Rajah

Pedro Rosa-Neto

Christine Tardif

Jennifer Tremblay-Mercier

Affiliated Authors:

Yaakov Stern

Lawrence S. Honig

Karen L. Bell

Columbia Affiliation:

Grants:

U19AG032438 (NIH – National Institute On Aging)

U01AG024904 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1038/s41467-021-25492-9

PMID:

34504080

DOI:

10.1038/s41467-021-25492-9

Journal:

Nature Communications

Publication Date:

2021-12-01

Data Source:

Scopus

Source Link:

A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease

Record Created:

Monday, April 28, 2025 - 12:39

Salloway, S., Farlow, M., McDade, E., Clifford, D. B., Wang, G., Llibre-Guerra, J. J., Hitchcock, J. M., Mills, S. L., Santacruz, A. M., Aschenbrenner, A. J., Hassenstab, J., Benzinger, T. L. S., Gordon, B. A., Fagan, A. M., Coalier, K. A., Cruchaga, C., Goate, A. A., Perrin, R. J., Xiong, C., … van Dyck, C. H. (2021). A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease. Nature Medicine, 27(7), 1187–1196. https://doi.org/10.1038/s41591-021-01369-8

Authors:

Stephen Salloway

Martin Farlow

Eric McDade

David B. Clifford

Guoqiao Wang

Jorge J. Llibre-Guerra

Janice M. Hitchcock

Susan L. Mills

Anna M. Santacruz

Andrew J. Aschenbrenner

Jason Hassenstab

Tammie L. S. Benzinger

Brian A. Gordon

Anne M. Fagan

Kelley A. Coalier

Carlos Cruchaga

Alison A. Goate

Richard J. Perrin

Chengjie Xiong

Yan Li

John C. Morris

B. Joy Snider

Catherine Mummery

G. Mustafa Surti

Didier Hannequin

David Wallon

Sarah B. Berman

James J. Lah

Ivonne Z. Jimenez-Velazquez

Erik D. Roberson

Christopher H. van Dyck

Lawrence S. Honig

Raquel Sánchez-Valle

William S. Brooks

Serge Gauthier

Douglas R. Galasko

Colin L. Masters

Jared R. Brosch

Ging-Yuek Robin Hsiung

Suman Jayadev

Maité Formaglio

Mario Masellis

Roger Clarnette

Jérémie Pariente

Bruno Dubois

Florence Pasquier

Clifford R. Jack

Robert Koeppe

Peter J. Snyder

Paul S. Aisen

Ronald G. Thomas

Scott M. Berry

Barbara A. Wendelberger

Scott W. Andersen

Karen C. Holdridge

Mark A. Mintun

Roy Yaari

John R. Sims

Monika Baudler

Paul Delmar

Rachelle S. Doody

Paulo Fontoura

Caroline Giacobino

Geoffrey A. Kerchner

Randall J. Bateman

Affiliated Authors:

Lawrence S. Honig

Subjects:

Alzheimer Disease (MeSH)

Antibodies, Monoclonal, Humanized (MeSH)

Grants:

R01AG046179 (NIH – National Institute On Aging)

U01AG042791 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1038/s41591-021-01369-8

PMID:

34155411

DOI:

10.1038/s41591-021-01369-8

Journal:

Nature Medicine

Publication Date:

2021-07-01

Data Source:

Scopus

Source Link:

Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease

Record Created:

Thursday, July 10, 2025 - 15:07

Ewers, M., Luan, Y., Frontzkowski, L., Neitzel, J., Rubinski, A., Dichgans, M., Hassenstab, J., Gordon, B. A., Chhatwal, J. P., Levin, J., Schofield, P., Benzinger, T. L. S., Morris, J. C., Goate, A., Karch, C. M., Fagan, A. M., McDade, E., Allegri, R., … Berman, S. (2021). Segregation of functional networks is associated with cognitive resilience in Alzheimer’s disease. Brain, 144(7), 2176–2185. https://doi.org/10.1093/brain/awab112

Authors:

Michael Ewers

Ying Luan

Lukas Frontzkowski

Julia Neitzel

Anna Rubinski

Martin Dichgans

Jason Hassenstab

Brian A Gordon

Jasmeer P Chhatwal

Johannes Levin

Peter Schofield

Tammie L. S Benzinger

John C Morris

Alison Goate

Celeste M Karch

Anne M Fagan

Eric McDade

Ricardo Allegri

Sarah Berman

Helena Chui

Carlos Cruchaga

Marty Farlow

Neill Graff-Radford

Mathias Jucker

Jae-Hong Lee

Ralph N Martins

Hiroshi Mori

Richard Perrin

Chengjie Xiong

Martin Rossor

Nick C Fox

Antoinette O'Connor

Stephen Salloway

Adrian Danek

Katharina Buerger

Randall J Bateman

Christian Habeck

Yaakov Stern

Nicolai Franzmeier

Affiliated Authors:

Christian Habeck

Yaakov Stern

Columbia Affiliation:

Author Keywords:

modularity

resilience

reserve

system segregation

tau-pet

Grants:

U19AG032438 (NIH – National Institute On Aging)

U01AG024904 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1093/brain/awab112

PMID:

33725114

DOI:

10.1093/brain/awab112

Journal:

Brain

Publication Date:

2021-07-01

Data Source:

Scopus

Source Link:

Modeling autosomal dominant Alzheimer's disease with machine learning

Record Created:

Thursday, July 10, 2025 - 15:07

Luckett, P. H., McCullough, A., Gordon, B. A., Strain, J., Flores, S., Dincer, A., McCarthy, J., Kuffner, T., Stern, A., Meeker, K. L., Berman, S. B., Chhatwal, J. P., Cruchaga, C., Fagan, A. M., Farlow, M. R., Fox, N. C., Jucker, M., Levin, J., … Masters, C. L. (2021). Modeling autosomal dominant Alzheimer’s disease with machine learning. Alzheimer’s & Dementia, 17(6), 1005–1016. Portico. https://doi.org/10.1002/alz.12259

Authors:

Patrick H. Luckett

Austin McCullough

Brian A. Gordon

Jeremy Strain

Shaney Flores

Aylin Dincer

John McCarthy

Todd Kuffner

Ari Stern

Karin L. Meeker

Sarah B. Berman

Jasmeer P. Chhatwal

Carlos Cruchaga

Anne M. Fagan

Martin R. Farlow

Nick C. Fox

Mathias Jucker

Johannes Levin

Colin L. Masters

Hiroshi Mori

James M. Noble

Stephen Salloway

Peter R. Schofield

Adam M. Brickman

William S. Brooks

David M. Cash

Michael J. Fulham

Bernardino Ghetti

Clifford R. Jack

Jonathan Vöglein

William Klunk

Robert Koeppe

Hwamee Oh

Yi Su

Michael Weiner

Qing Wang

Laura Swisher

Dan Marcus

Deborah Koudelis

Nelly Joseph-Mathurin

Lisa Cash

Russ Hornbeck

Chengjie Xiong

Richard J. Perrin

Celeste M. Karch

Jason Hassenstab

Eric McDade

John C. Morris

Tammie L.S. Benzinger

Randall J. Bateman

Beau M. Ances

Affiliated Authors:

James M. Noble

Columbia Affiliation:

Subjects:

Alzheimer Disease (MeSH)

Machine Learning (MeSH)

Magnetic Resonance Imaging (MeSH)

Positron-Emission Tomography (MeSH)

Author Keywords:

pittsburgh compound b (pib)

autosomal dominant alzheimer's disease (adad)

fluorodeoxyglucose (fdg)

machine learning

magnetic resonance imaging (mri)

Grants:

UL1TR002345 (NIH – National Center for Advancing Translational Sciences)

UL1TR000448 (NIH – National Center for Advancing Translational Sciences)

S10RR022984 (NIH – National Center for Research Resources)

R01EB009352 (NIH – National Institute of Biomedical Imaging and Bioengineering)

P30NS098577 (NIH – National Institute of Neurological Disorders and Stroke)

P01AG026276 (NIH – National Institute On Aging)

P30AG066444 (NIH – National Institute On Aging)

P01AG003991 (NIH – National Institute On Aging)

UF1AG032438 (NIH – National Institute On Aging)

P50AG005131 (NIH – National Institute On Aging)

P50AG005681 (NIH – National Institute On Aging)

R01AG046179 (NIH – National Institute On Aging)

U01AG042791 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

R01AG052550 (NIH – National Institute On Aging)

K01AG053474 (NIH – National Institute On Aging)

S10OD018091 (NIH – Office of the Director, National Institutes of Health)

Publication Type:

Article

Unique ID:

10.1002/alz.12259

PMID:

33480178

DOI:

10.1002/alz.12259

Journal:

Publication Date:

2021-06-01

Data Source:

Scopus

Source Link:

Resting-State Functional Connectivity Disruption as a Pathological Biomarker in Autosomal Dominant Alzheimer Disease

Record Created:

Tuesday, July 15, 2025 - 09:02

Smith, R. X., Strain, J. F., Tanenbaum, A., Fagan, A. M., Hassenstab, J., McDade, E., Schindler, S. E., Gordon, B. A., Xiong, C., Chhatwal, J., Jack, C., Karch, C., Berman, S., Brosch, J. R., Lah, J. J., Brickman, A. M., Cash, D. M., Fox, N. C., … Graff-Radford, N. R. (2021). Resting-State Functional Connectivity Disruption as a Pathological Biomarker in Autosomal Dominant Alzheimer Disease. Brain Connectivity, 11(3), 239–249. https://doi.org/10.1089/brain.2020.0808

Authors:

Robert X. Smith

Jeremy F. Strain

Aaron Tanenbaum

Anne M. Fagan

Jason Hassenstab

Eric McDade

Suzanne E. Schindler

David M. Holtzman

John C. Morris

Randall J. Bateman

Beau M. Ances

Brian A. Gordon

Daniel S. Marcus

Tammie L. S. Benzinger

Chengjie Xiong

Celeste Karch

Jasmeer Chhatwal

Clifford Jack

Sarah Berman

Jared R. Brosch

Martin R. Farlow

James J. Lah

Adam M. Brickman

James Noble

David M. Cash

Nick C. Fox

Neill R. Graff-Radford

Johannes Levin

Colin L. Masters

Christoph Laske

Peter R. Schofield

Affiliated Authors:

Adam M. Brickman

James Noble

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Neurology

Author Keywords:

18f-fluorodeoxyglucose (fdg)

amyloid

autosomal dominant alzheimer disease

cerebrospinal fluid (csf)

estimated years to onset (eyo)

hippocampus

positron emission tomography (pet)

resting-state functional connectivity

tau

Grants:

P30AG066444 (NIH – National Institute On Aging)

P01AG026276 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

K01AG053474 (NIH – National Institute On Aging)

P01AG003991 (NIH – National Institute On Aging)

P50AG005681 (NIH – National Institute On Aging)

UF1AG032438 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1089/brain.2020.0808

PMID:

33430685

DOI:

10.1089/brain.2020.0808

Journal:

Brain Connectivity

Publication Date:

2021-04-01

Data Source:

Web of Science

Source Link:

Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer's disease

Record Created:

Thursday, July 24, 2025 - 08:30

Montal, V., Vilaplana, E., Pegueroles, J., Bejanin, A., Alcolea, D., Carmona‐Iragui, M., Clarimón, J., Levin, J., Cruchaga, C., Graff‐Radford, N. R., Noble, J. M., Lee, J., Allegri, R., Karch, C. M., Laske, C., Schofield, P. R., Salloway, S., Ances, B., … Benzinger, T. (2020). Biphasic cortical macro‐ and microstructural changes in autosomal dominant Alzheimer’s disease. Alzheimer’s & Dementia, 17(4), 618–628. Portico. https://doi.org/10.1002/alz.12224

Authors:

Victor Montal

Eduard Vilaplana

Jordi Pegueroles

Alexandre Bejanin

Daniel Alcolea

Maria Carmona-Iragui

Jordi Clarimon

Rafael Blesa

Alberto Lleo

Juan Fortea

Johannes Levin

Carlos Cruchaga

Beau Ances

Eric McDale

Randall Bateman

Tammie Benzinger

Neill R. Graff-Radford

James M. Noble

Jae-Hong Lee

Ricardo Allegri

Celeste M. Karch

Christoph Laske

Peter R. Schofield

Stephen Salloway

Raquel Sanchez-Valle

Affiliated Authors:

James M. Noble

Columbia Affiliation:

Author Keywords:

alzheimer's disease

autosomal-dominant alzheimer's disease

biphasic cortical changes

cortical diffusivity

magnetic resonance imaging

preclinical alzheimer's disease

alzheimer' s disease

autosomal‐ dominant alzheimer' s disease

preclinical alzheimer' s disease

Grants:

UL1TR002345 (NIH – National Center for Advancing Translational Sciences)

R01EB009352 (NIH – National Institute of Biomedical Imaging and Bioengineering)

R01AG052550 (NIH – National Institute On Aging)

RF1AG056850 (NIH – National Institute On Aging)

U01AG059798 (NIH – National Institute On Aging)

P01AG003991 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

R21AG056974 (NIH – National Institute On Aging)

P50AG008702 (NIH – National Institute On Aging)

RF1AG061566 (NIH – National Institute On Aging)

UF1AG032438 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1002/alz.12224

PMID:

33196147

DOI:

10.1002/alz.12224

Journal:

Publication Date:

2021-04-01

Data Source:

Web of Science

Source Link:

Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease

Record Created:

Thursday, July 24, 2025 - 08:31

Joseph-Mathurin, N., Wang, G., Kantarci, K., Jack, C. R., McDade, E., Hassenstab, J., Blazey, T. M., Gordon, B. A., Su, Y., Chen, G., Massoumzadeh, P., Hornbeck, R. C., Allegri, R. F., Ances, B. M., Berman, S. B., Brickman, A. M., Brooks, W. S., Cash, D. M., Chhatwal, J. P., … Sanchez- Valle, R. (2021). Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease. Neurology, 96(12). https://doi.org/10.1212/wnl.0000000000011542

Authors:

Nelly Joseph-Mathurin

Tyler M. Blazey

Brian A. Gordon

Gengsheng Chen

Parinaz Massoumzadeh

Russ C. Hornbeck

Tammie L. S. Benzinger

Eric McDade

Jason Hassenstab

Beau M. Ances

Richard J. Perrin

John C. Morris

Randall J. Bateman

Carlos Cruchaga

Celeste M. Karch

Guoqiao Wang

Chengjie Xiong

Yi Su

Ricardo F. Allegri

Sarah B. Berman

Adam M. Brickman

William S. Brooks

Peter R. Schofield

David M. Cash

Nick C. Fox

Antoinette O'Connor

Jasmeer P. Chhatwal

Keith A. Johnson

Helena C. Chui

John M. Ringman

Stephen Correia

Athene K. W. Lee

Stephen Salloway

Martin R. Farlow

Andrew J. Saykin

Bernardino Ghetti

Michael Fulham

Neill R. Graff-Radford

Christoph Laske

Johannes Levin

Igor Yakushev

Colin L. Masters

James M. Noble

Kejal Kantarci

Clifford R. Jack

Gregory M. Preboske

Christopher C. Rowe

Victor L. Villemagne

Hiroyuki Shimada

Mikio Shoji

Kazushi Suzuki

Affiliated Authors:

Adam M. Brickman

James M. Noble

Columbia Affiliation:

Subjects:

Management and Pathophysiology of Intracerebral Hemorrhage (OpenAlex Topic)

Diagnosis and Management of Alzheimer's Disease (OpenAlex Topic)

Mechanisms of Alzheimer's Disease (OpenAlex Topic)

Alzheimer Disease (MeSH)

Cerebral Hemorrhage (MeSH)

Grants:

R01EB009352 (NIH – National Institute of Biomedical Imaging and Bioengineering)

P30NS098577 (NIH – National Institute of Neurological Disorders and Stroke)

R01AG052550 (NIH – National Institute On Aging)

UF1AG032438 (NIH – National Institute On Aging)

U01AG042791 (NIH – National Institute On Aging)

K01AG053474 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

U01AG032438 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1212/WNL.0000000000011542

PMID:

33495373

DOI:

10.1212/WNL.0000000000011542

Journal:

Neurology

Publication Date:

2021-03-23

Data Source:

Web of Science

Source Link:

Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer disease

Record Created:

Tuesday, July 29, 2025 - 13:19

Dincer, A., Gordon, B. A., Hari-Raj, A., Keefe, S. J., Flores, S., McKay, N. S., Paulick, A. M., Shady Lewis, K. E., Feldman, R. L., Hornbeck, R. C., Allegri, R., Ances, B. M., Berman, S. B., Brickman, A. M., Brooks, W. S., Cash, D. M., Chhatwal, J. P., Farlow, M. R., la Fougère, C., … L.S. Benzinger, T. (2020). Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer disease. NeuroImage: Clinical, 28, 102491. https://doi.org/10.1016/j.nicl.2020.102491

Authors:

Aylin Dincer

Brian A Gordon

Amrita Hari-Raj

Sarah J Keefe

Shaney Flores

Nicole S McKay

Angela M Paulick

Kristine E Shady Lewis

Rebecca L Feldman

Russ C Hornbeck

Ricardo Allegri

Beau M Ances

Sarah B Berman

Adam M Brickman

William S Brooks

David M Cash

Jasmeer P Chhatwal

Martin R Farlow

Christian la Fougère

Nick C Fox

Michael J Fulham

Clifford R Jack

Nelly Joseph-Mathurin

Celeste M Karch

Athene Lee

Johannes Levin

Colin L Masters

Eric M McDade

Hwamee Oh

Richard J Perrin

Cyrus Raji

Stephen P Salloway

Peter R Schofield

Yi Su

Victor L Villemagne

Qing Wang

Michael W Weiner

Chengjie Xiong

Igor Yakushev

John C Morris

Randall J Bateman

Tammie L S Benzinger

Affiliated Authors:

Adam M Brickman

Columbia Affiliation:

Subjects:

Alzheimer Disease (MeSH)

Author Keywords:

alzheimer disease

amyloid

autosomal dominant alzheimer disease

cortical signature

cortical thickness

preclinical

Grants:

UL1TR002345 (NIH – National Center for Advancing Translational Sciences)

S10RR022984 (NIH – National Center for Research Resources)

R01EB009352 (NIH – National Institute of Biomedical Imaging and Bioengineering)

P30NS098577 (NIH – National Institute of Neurological Disorders and Stroke)

R01AG052550 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

K01AG053474 (NIH – National Institute On Aging)

P30AG019610 (NIH – National Institute On Aging)

P30AG066444 (NIH – National Institute On Aging)

P01AG026276 (NIH – National Institute On Aging)

UF1AG032438 (NIH – National Institute On Aging)

P01AG003991 (NIH – National Institute On Aging)

P50AG005681 (NIH – National Institute On Aging)

S10OD018091 (NIH – Office of the Director, National Institutes of Health)

Publication Type:

Article

Unique ID:

10.1016/j.nicl.2020.102491

PMID:

33395982

DOI:

10.1016/j.nicl.2020.102491

Journal:

NeuroImage: Clinical

Publication Date:

2021-01-06

Data Source:

PubMed

Source Link:

Pattern and degree of individual brain atrophy predicts dementia onset in dominantly inherited Alzheimer's disease

Record Created:

Friday, August 22, 2025 - 09:00

Keret, O., Staffaroni, A. M., Ringman, J. M., Cobigo, Y., Goh, S. M., Wolf, A., Allen, I. E., Salloway, S., Chhatwal, J., Brickman, A. M., Reyes‐Dumeyer, D., Bateman, R. J., Benzinger, T. L. S., Morris, J. C., Ances, B. M., Joseph‐Mathurin, N., Perrin, R. J., Gordon, B. A., … Levin, J. (2021). Pattern and degree of individual brain atrophy predicts dementia onset in dominantly inherited Alzheimer’s disease. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 13(1). Portico. https://doi.org/10.1002/dad2.12197

Authors:

Ophir Keret

Isabel Elaine Allen

Bruce L. Miller

Gil D. Rabinovici

Howard J. Rosen

Adam M. Staffaroni

Yann Cobigo

Sheng-Yang M. Goh

Amy Wolf

John M. Ringman

Stephen Salloway

Jasmeer Chhatwal

Adam M. Brickman

Dolly Reyes-Dumeyer

Randal J. Bateman

Tammie L. S. Benzinger

John C. Morris

Beau M. Ances

Nelly Joseph-Mathurin

Richard J. Perrin

Brian A. Gordon

Johannes Levin

Jonathan Voeglein

Mathias Jucker

Christian Fougere

Ralph N. Martins

Hamid R. Sohrabi

Kevin Taddei

Victor L. Villemagne

Peter R. Schofield

William S. Brooks

Michael Fulham

Colin L. Masters

Bernardino Ghetti

Andrew J. Saykin

Clifford R. Jack

Neill R. Graff-Radford

Michael Weiner

David M. Cash

Ricardo F. Allegri

Patricio Chrem

Su Yi

Affiliated Authors:

Adam M. Brickman

Dolly Reyes-Dumeyer

Columbia Affiliation:

Author Keywords:

autosomal dominant alzheimer's disease

brain atrophy

dominantly inherited alzheimer network

preclinical alzheimer's disease

Grants:

P01AG019724 (NIH – National Institute On Aging)

P01AG026276 (NIH – National Institute On Aging)

P01AG003991 (NIH – National Institute On Aging)

P30AG066444 (NIH – National Institute On Aging)

P50AG005681 (NIH – National Institute On Aging)

U19AG032438 (NIH – National Institute On Aging)

Publication Type:

Article

Unique ID:

10.1002/dad2.12197

PMID:

34258377

DOI:

10.1002/dad2.12197

Journal:

Alzheimer's and Dementia: Diagnosis, Assessment, and Disease Monitoring

Publication Date:

2021-01-01

Data Source:

Web of Science

Source Link: