Diagnosis and Management of Alzheimer's Disease

Displaying 1 - 50 of 168CSV
Katsumi, Y., Touroutoglou, A., Brickhouse, M., Eloyan, A., Eckbo, R., Zaitsev, A., La Joie, R., Lagarde, J., Schonhaut, D., Thangarajah, M., Taurone, A., Vemuri, P., Jack, C. R., Dage, J. L., Nudelman, K. N. H., Foroud, T., Hammers, D. B., Ghetti, B., … Murray, M. E. (2025). Dissociable spatial topography of cortical atrophy in early‐onset and late‐onset Alzheimer’s disease: A head‐to‐head comparison of the LEADS and ADNI cohorts. Alzheimer’s & Dementia, 21(2). Portico. https://doi.org/10.1002/alz.14489
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Hammers, D. B., Musema, J., Eloyan, A., Thangarajah, M., Taurone, A., La Joie, R., Touroutoglou, A., Vemuri, P., Kramer, J., Aisen, P., Dage, J. L., Nudelman, K. N., Kirby, K., Atri, A., Clark, D., Day, G. S., Duara, R., Graff-Radford, N. R., Grant, I., … Apostolova, L. G. (2025). Characterizing and validating 12-month reliable cognitive change in Early-Onset Alzheimer’s Disease for use in clinical trials. The Journal of Prevention of Alzheimer’s Disease, 100075. https://doi.org/10.1016/j.tjpad.2025.100075
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Putcha, D., Katsumi, Y., Touroutoglou, A., Eloyan, A., Taurone, A., Thangarajah, M., Aisen, P., Dage, J. L., Foroud, T., Jack, C. R., Kramer, J. H., Nudelman, K. N. H., Raman, R., Vemuri, P., Atri, A., Day, G. S., Duara, R., Graff-Radford, N. R., Grant, I. M., … Honig, L. S. (2025). Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer’s disease: a neuropsychological data-driven approach. Alzheimer’s Research & Therapy, 17(1). https://doi.org/10.1186/s13195-025-01689-8
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Mielke, M. M., Evans, J. K., Neiberg, R. H., Molina-Henry, D. P., Marcovina, S. M., Johnson, K. C., Carmichael, O. T., Rapp, S. R., Sachs, B. C., Ding, J., Shappell, H. M., Luchsinger, J. A., Espeland, M. A., & Hayden, K. M. (2025). Alzheimer Disease Blood Biomarkers and Cognition Among Individuals With Diabetes and Overweight or Obesity. JAMA Network Open, 8(2), e2458149. https://doi.org/10.1001/jamanetworkopen.2024.58149
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Pandey, N., Yang, Z., Cieza, B., Reyes-Dumeyer, D., Kang, M. S., Montesinos, R., Soto-Añari, M., Custodio, N., Honig, L. S., & Tosto, G. (2025). Plasma phospho-tau217 as a predictive biomarker for Alzheimer’s disease in a large south American cohort. Alzheimer’s Research & Therapy, 17(1). https://doi.org/10.1186/s13195-024-01655-w
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Vargas‐Gonzalez, J., Dimal, N., Cortez, K., Heuer, H., Forsberg, L. K., Appleby, B. S., Barmada, S., Bozoki, A., Clark, D., Cobigo, Y., Darby, R. R., Dickerson, B. C., Domoto‐Reilly, K., Galasko, D. R., Geschwind, D. H., Ghoshal, N., Graff‐Radford, N. R., Grant, I. M., … Irwin, D. (2024). Psychotropic medication usage in sporadic versus genetic behavioral‐variant frontotemporal dementia. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.14448
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Hammers, D. B., Eloyan, A., Thangarajah, M., Taurone, A., Beckett, L., Gao, S., Polsinelli, A. J., Kirby, K., Dage, J. L., Nudelman, K., Aisen, P., Reman, R., La Joie, R., Lagarde, J., Atri, A., Clark, D., Day, G. S., Duara, R., … Graff‐Radford, N. R. (2024). Differences in baseline cognitive performance between participants with early‐onset and late‐onset Alzheimer’s disease: Comparison of LEADS and ADNI. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.14218
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Hammers, D. B., Eloyan, A., Taurone, A., Thangarajah, M., Gao, S., Beckett, L., Polsinelli, A. J., Kirby, K., Dage, J. L., Nudelman, K., Aisen, P., Reman, R., La Joie, R., Lagarde, J., Atri, A., Clark, D., Day, G. S., Duara, R., … Graff‐Radford, N. R. (2024). Longitudinal cognitive performance of participants with sporadic early onset Alzheimer’s disease from LEADS. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.14439
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Wu, Y., Libby, J. B., Dumitrescu, L., De Jager, P. L., Menon, V., Schneider, J. A., Bennett, D. A., & Hohman, T. J. (2024). Association of ten VEGF family genes with Alzheimer’s disease endophenotypes at single cell resolution. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.14419
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Mielke, M. M., Kurzman, H. R., Hu, Y. H., Cho, M., Liss, J., Burns, J. M., Obisesan, T. O., Hornbecker, M., Pallay, A., Smith, S. R., Honig, L. S., Parker, M. W., Bell, J., & Hampel, H. (2024). Advancing Early Detection of Alzheimer’s Disease in the Primary Care Setting in the United States. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.086582
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Kenowsky, S., Shao, Y., Heller, S., Golomb, J. B., Vedvyas, A., Dafflisio, G., Zhang, Q., Torossian, H., Sadowski, M. J., Wisniewski, T., Masurkar, A. V., & Reisberg, B. (2024). Nonpharmacologic Management of Behavioral and Psychological Symptoms of Dementia in Community‐Residing Persons with Moderately‐Severe Alzheimer’s Disease: One Year Results from a Randomized Controlled Trial. Alzheimer’s & Dementia, 20(S4). Portico. https://doi.org/10.1002/alz.090018
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Biber, S. A., Prado, M. G., Culhane, J. E., Phuong, J., Keller, B., Lerch, M., Wang, S., Noble, J. M., Moulder, K. L., Saykin, A. J., Gao, S., Lai, A., Natarajan, K., Kukull, W. A., Mooney, S., & Stephens, K. (2024). Advancing Alzheimer’s disease and related dementias (ADRD) and COVID‐19 research by linking real‐world data with a standardized longitudinal ADRD data platform. Alzheimer’s & Dementia, 20(S8). Portico. https://doi.org/10.1002/alz.094785
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Honig, L. S., Kang, M. S., Reyes‐Dumeyer, D., Franco, Y., Medrano, M., Piriz, A., Recio, P., Mejia, D. R., Soriano, B., Lantigua, R. A., & Mayeux, R. (2024). Biomarkers, clinical status, and cognitive performance in a Caribbean Hispanic cohort. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.093556
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Wadhwani, A. R., Goldberg, D., Wolk, D. A., Lee, E. B., Farrell, K. W., Crary, J. F., Bennett, D. A., De Jager, P. L., Schneider, J. A., Zhou, W., McMillan, C. T., & Group, P. W. (2024). Shared and Distinct Epigenetic Profiles in Primary Age‐Related Tauopathy and Alzheimer’s Disease: Insights into Tangle Formation and Spread. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.092601
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Joyce, J. L., Cosentino, S., Rizer, S., Dargie, S. A., Chapman, S., Mora, L., Libon, D. J., Tom, S. E., Marder, K., & Rosser, M. (2024). Preliminary Findings from EMPOWER: Evaluating Memory as Part of Women’s Routine Care. Alzheimer’s & Dementia, 20(S3). Portico. https://doi.org/10.1002/alz.092824
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Fletcher, E., Chanti‐Ketterl, M., Hokett, E., Lor, Y., Venkatesan, U. M., Gilsanz, P., Whitmer, R. A., Chen, R., George, K. M., & Zlatar, Z. (2024). A machine learning approach to multifactorial modeling of episodic memory performance. Alzheimer’s & Dementia, 20(S3). Portico. https://doi.org/10.1002/alz.089749
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Columbia Affiliation
Reddy, J. S., Heath, L. M., Allen, M., Poehlman, W. L., Wang, Y., Johnson, R., Wang, E., Ma, Y., Ho, C. C. G., Lopes, K. de P., Linden, A. V., Quicksall, Z., Chen, X., Baheti, S., Nguyen, T., Yepez‐Sisalema, G., Mitchell, A. O., Oatman, S. R., … Wang, X. (2024). Multi‐omics profiling of Alzheimer’s disease in multi‐ethnic populations. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.090590
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Lippert, R. V., Edwards, N. C., Tosto, G., Pyne, J. D., Lao, P. J., & Brickman, A. M. (2024). Cumulative Incidence Rate Score for Alzheimer’s Disease Risk is Associated with White Matter Hyperintensity Volume in Older Adults Without Dementia. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.092734
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Lee, H., Tzuang, M., Chow, T. W., Kang, Y., Tee, B. L., Li, C., Ho, P., Gu, Y., Lu, A. T., Choi, Y., Jun, G. R., Wang, L., Yu, H. (Ho), & Park, V. T. (2024). Translation and Cultural Adaptation of Tools to Assess Diverse Asian American and Asian Canadian Populations: The Asian Cohort for Alzheimer’s Disease Study. Alzheimer’s & Dementia, 20(S7). Portico. https://doi.org/10.1002/alz.092279
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Kraal, A. Z., McFarlane, H. V., Pyne, J. D., Turney, I. C., Lao, P. J., Mazen, J., Brickman, A. M., & Manly, J. J. (2024). Does socioeconomic status modify the association between glycemic level and MRI markers of ADRD risk in middle‐aged adults? Alzheimer’s & Dementia, 20(S9). Portico. https://doi.org/10.1002/alz.094021
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Pandey, N., Honig, L. S., Reyes‐Dumeyer, D., Cieza, B., Montesinos, R., Cespedes, J., Soto‐Añari, M. F., Custodio, N., & Tosto, G. (2024). p‐tau217 in a large Peruvian cohort phenotyped for Alzheimer’s Disease. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.093382
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Du, A., Flores‐Aguilar, L., Edwards, N. C., Lao, P. J., Ryu, J. K., Akassoglou, K., Wilcock, D. M., Kofler, J., Ikonomovic, M. D., Lai, F., Brickman, A. M., & Head, E. (2024). Increased fibrin deposition in the brains of individuals with Down syndrome and Alzheimer’s disease. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.089882
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Goldberg, D., Wadhwani, A. R., Wolk, D. A., Lee, E. B., Bennett, D. A., De Jager, P. L., Schneider, J. A., Zhou, W., & McMillan, C. T. (2024). DNA methylation associates with regional tau pathology beyond age and APOE. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.092539
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Taga, M., Fujita, M., Parghi, N., & De Jager, P. L. (2024). Automated image segmentation uncovers the association of a microglial subtype defined by High CD74 Expression with cognitive decline. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.092664
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Kim, M. H., Ying, G., Morin, B. T., Olvera, A. G., Gibbons, L. E., Scollard, P., Lee, M. L., Klinedinst, B. S., Nakano, C., Mez, J., Crane, P. K., & Choi, S. (2024). The Role of Education on Brain Pathology and Cognitive Decline in the Language Domain Across Women and Men in the Alzheimer’s Disease Neuroimaging Initiative Sample. Alzheimer’s & Dementia, 20(S8). Portico. https://doi.org/10.1002/alz.095686
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Columbia Affiliation
Goldberg, T. E., Kim, H., Devanand, D., & Lee, S. (2024). Effects of APOE e4 and Neuropathological Diagnoses on Neuropsychiatric Symptoms: Mediation Analyses and Likely Causation in an Integrated NACC Database. Alzheimer’s & Dementia, 20(S8). Portico. https://doi.org/10.1002/alz.094887
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Chen, A., Bowles, E. J. A., Chubak, J., Cosentino, S., Genkinger, J. M., Levine, D. A., Tehranifar, P., Wolfova, K., & Tom, S. E. (2024). The Relationship between Cancer Diagnosis Timing and Cognition in Older Adults in the National Health and Nutrition Examination Survey. Alzheimer’s & Dementia, 20(S7). Portico. https://doi.org/10.1002/alz.092394
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Luchsinger, J. A., Feldman, H. H., Messer, K., Edland, S. D., Leger, G. C., Jacobs, D. M., Salmon, D. P., Revta, C., Lupo, J., Durant, J., & Gibson, G. E. (2024). A Seamless Phase 2A‐Phase 2B Multi‐Center Trial to Test the Benefits of Benfotiamine on the Progression of Alzheimer’s Disease‐Benfoteam: Design and Methods. Alzheimer’s & Dementia, 20(S6). Portico. https://doi.org/10.1002/alz.091963
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Yang, H., Kivisäkk, P., Viera, A. M. R., Maa, C., Kirn, D., Bellier, J., Liu, L., Selkoe, D. J., Schneider, J. A., Bennett, D. A., Jager, P. L. D., Johnson, K. A., Sperling, R. A., Arnold, S. E., & Chhatwal, J. P. (2024). The relationship between amyloid‐β, plasma/brain GFAP, and neocortical tau: a Mendelian randomization study. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.091415
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Rizer, S., Joyce, J. L., Dargie, S. A., Chapman, S., Libon, D. J., Mora, L., Tom, S. E., Marder, K., Rosser, M., & Cosentino, S. (2024). Digital Cognitive Screening Outcomes in Older Women at the Annual Well Woman Visit. Alzheimer’s & Dementia, 20(S3). Portico. https://doi.org/10.1002/alz.092636
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Bahl, A., Honig, L. S., Kang, M. S., Sanchez, D., Reyes‐Dumeyer, D., Manly, J. J., Lantigua, R. A., Dage, J. L., Brickman, A. M., Vardarajan, B. N., Mayeux, R., & Gu, Y. (2024). Blood‐Based Biomarkers to Aid in Alzheimer’s Disease Prediction or Diagnosis: Analysis in a Multi‐Ethnic Cohort Study. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.091795
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de la Colina, A. N., Charisis, S., Ntanasi, E., Mamalaki, E., Skaperda, Z., Kouretas, D., & Scarmeas, N. (2024). Comparison of cerebrospinal fluid and plasma oxidative stress biomarkers. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.085482
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Logue, M. W., Labadorf, A. T., O’Neill, N. K., Dickson, D. W., Flanagan, M. E., Franklin, E. E., Frosch, M. P., Gearing, M., Jin, L., Kofler, J., Lee, E. B., Mayeux, R., McKee, A. C., Miller, C. A., Murray, M. E., Nelson, P. T., Perrin, R. J., Schneider, J. A., Stein, T. D., … Farrer, L. A. (2024). Identification of differentially expressed genes in post‐mortem tissue from African American Alzheimer disease cases and controls. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.091575
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Lee, J. H., Scambray, K. A., Morris, E. P., Sol, K., Palms, J. D., Zaheed, A. B., Martinez, M. N., Schupf, N., Manly, J. J., Brickman, A. M., & Zahodne, L. B. (2024). Marital status, brain health, and cognitive reserve among diverse older adults. Journal of the International Neuropsychological Society, 1–10. https://doi.org/10.1017/s1355617724000638
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Boerwinkle, A. H., Wisch, J. K., Handen, B. L., Head, E., Mapstone, M., Rafii, M. S., O’Bryant, S. E., Krinsky‐McHale, S. J., Lai, F., Rosas, H. D., Zaman, S., Lott, I. T., Tudorascu, D., Zammit, M., Brickman, A. M., Lee, J. H., & Ances, B. M. (2024). The mediating role of plasma glial fibrillary acidic protein in amyloid and tau pathology in Down’s syndrome. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.14359
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Gatto, N. M., Renz, A., Tom, S. E., Lyons, M., Macuiba, J. A., Dodd, T. S., Lind, B. K., Gray, S. L., Meyers, K., Larson, E. B., Nelson, J. C., McEvoy, L. K., Sankaran, S., Key, D., Litondo, J. A., & Crane, P. K. (2024). The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A Resource for Research on Biological, Psychosocial and Behavioral Factors on the Aging Brain and Alzheimer’s Disease and Related Dementias. Brain Sciences, 14(11), 1075. https://doi.org/10.3390/brainsci14111075
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Wetmore, J. B., Rodriguez, S., Diaz Caro, D., Cabán, M., Uhlmann, W., Goldman, J., Leu, C., Godinez, J. D., Camarillo, I. A., Ferber, R., Blasco, D., Lantigua, R. A., Abraído‐Lanza, A., Chung, W. K., Roberts, J. S., Siegel, K., & Ottman, R. (2024). Designing and implementing the IDEAL Study: A randomized clinical trial of APOE genotype disclosure for late‐onset Alzheimer’s disease in an urban Latino population. Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 10(4). Portico. https://doi.org/10.1002/trc2.70016
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Savin, M. J., Wang, H., Pei, H., Aiello, A. E., Assuras, S., Caspi, A., Moffitt, T. E., Muenning, P. A., Ryan, C. P., Shi, B., Stern, Y., Sugden, K., Valeri, L., & Belsky, D. W. (2024). Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 16(4). Portico. https://doi.org/10.1002/dad2.70038
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Kim, Y., Stern, Y., Seo, S. W., Na, D. L., Jang, J., & Jang, H. (2024). Factors associated with cognitive reserve according to education level. Alzheimer’s & Dementia, 20(11), 7686–7697. Portico. https://doi.org/10.1002/alz.14236
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VandeBunte, A. M., Lee, H., Paolillo, E. W., Hsiung, G. R., Staffaroni, A. M., Saloner, R., Tartaglia, C., Yaffe, K., Knopman, D. S., Ramos, E. M., Rascovsky, K., Bozoki, A. C., Wong, B., Domoto‐Reilly, K., Snyder, A., Pressman, P., Mendez, M. F., Litvan, I., … Fields, J. A. (2024). Better cardiovascular health is associated with slowed clinical progression in autosomal dominant frontotemporal lobar degeneration variant carriers. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.14172
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Reddy, J. S., Heath, L., Linden, A. V., Allen, M., Lopes, K. de P., Seifar, F., Wang, E., Ma, Y., Poehlman, W. L., Quicksall, Z. S., Runnels, A., Wang, Y., Duong, D. M., Yin, L., Xu, K., Modeste, E. S., Shantaraman, A., Dammer, E. B., Ping, L., … Ertekin‐Taner, N. (2024). Bridging the gap: Multi‐omics profiling of brain tissue in Alzheimer’s disease and older controls in multi‐ethnic populations. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.14208
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Libon, D. J., Swenson, R., Price, C. C., Lamar, M., Cosentino, S., Bezdicek, O., Kling, M. A., Tobyne, S., Jannati, A., Banks, R., & Pascual-Leone, A. (2024). Digital assessment of cognition in neurodegenerative disease: a data driven approach leveraging artificial intelligence. Frontiers in Psychology, 15. https://doi.org/10.3389/fpsyg.2024.1415629
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Xue, C., Kowshik, S. S., Lteif, D., Puducheri, S., Jasodanand, V. H., Zhou, O. T., Walia, A. S., Guney, O. B., Zhang, J. D., Pham, S. T., Kaliaev, A., Andreu-Arasa, V. C., Dwyer, B. C., Farris, C. W., Hao, H., Kedar, S., Mian, A. Z., Murman, D. L., O’Shea, S. A., … Kolachalama, V. B. (2024). AI-based differential diagnosis of dementia etiologies on multimodal data. Nature Medicine. https://doi.org/10.1038/s41591-024-03118-z
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Kim, H., Lee, S., Levine, A., Huber, B., Andrews, H., Kerner, N. A., Cohen, D., Carlson, S., Bell, S. A., Rivera, A. M., Gordon, M. L., Simoes, S., Devanand, Davangere. P., Brickman, A. M., Schneider, L. S., Harvey, P. D., & Goldberg, T. E. (2024). Novel measures of cognition and function for the AD spectrum in the Novel Measures for Alzheimer’s Disease Prevention Trials (NoMAD) project: Psychometric properties, convergent validation, and contrasts with established measures. Alzheimer’s & Dementia. Portico. https://doi.org/10.1002/alz.13757
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Wang, H.-P., Scalco, R., Saito, N., Beckett, L., Nguyen, M.-L., Huie, E. Z., Honig, L. S., DeCarli, C., Rissman, R. A., Teich, A. F., Mungas, D. M., Jin, L.-W., & Dugger, B. N. (2024). The neuropathological landscape of small vessel disease and Lewy pathology in a cohort of Hispanic and non-Hispanic White decedents with Alzheimer disease. Acta Neuropathologica Communications, 12(1). https://doi.org/10.1186/s40478-024-01773-4
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Arce Rentería, M., Mobley, T. M., Evangelista, N. D., Medina, L. D., Deters, K. D., Fox‐Fuller, J. T., Minto, L. R., Avila‐Rieger, J., & Bettcher, B. M. (2023). Representativeness of samples enrolled in Alzheimer’s disease research centers. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 15(2). Portico. https://doi.org/10.1002/dad2.12450
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McCage, S., Walker, K., Cornelius, T., Jackson, J., Parker, R. A., Dams-O’Connor, K., Dickerson, B., Ritchie, C., Vranceanu, A.-M., & Bannon, S. M. (2024). A Live Video Resiliency Dyadic Intervention for Persons with Dementia and Their Care-Partners Early After Diagnosis: Protocol for Open Pilot of Resilient Together for Dementia (Preprint). JMIR Research Protocols. https://doi.org/10.2196/60382
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Howard, R. S., Goldberg, T. E., Luo, J., Munoz, C., & Schneider, L. S. (2023). Reliability of the NACC Telephone-administered Neuropsychological Battery (T-cog) and Montreal Cognitive Assessment for participants in the USC ADRC. Alzheimer's & dementia (Amsterdam, Netherlands), 15(1), e12406. https://doi.org/10.1002/dad2.12406

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Harnisch, M., Barnett, M. L., Coussens, S., Thomas, K. S., Olfson, M., Berhane, K., & Sacarny, A. (2024). Physician Antipsychotic Overprescribing Letters and Cognitive, Behavioral, and Physical Health Outcomes Among People With Dementia. JAMA Network Open, 7(4), e247604. https://doi.org/10.1001/jamanetworkopen.2024.7604
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Wang, G., Li, Y., Xiong, C., Benzinger, T. L. S., Gordon, B. A., Hassenstab, J., Aschenbrenner, A. J., McDade, E., Clifford, D. B., Libre‐Guerra, J. J., Shi, X., Mummery, C. J., van Dyck, C. H., Lah, J. J., Honig, L. S., Day, G., Ringman, J. M., Brooks, W. S., … Fox, N. C. (2024). Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer’s disease. Alzheimer’s & Dementia, 20(4), 2698–2706. Portico. https://doi.org/10.1002/alz.13735
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