Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome

Gorijala, P., Aslam, M. M., Dang, L. T., Xicota, L., Fernandez, M. V., Sung, Y. J., Fan, K., Feingold, E., Surace, E. I., Chhatwal, J. P., Hom, C. L., Hartley, S. L., Hassenstab, J., Perrin, R. J., Mapstone, M., Zaman, S. H., Ances, B. M., Kamboh, M. I., … Lee, J. H. (2023). Alzheimer’s polygenic risk scores are associated with cognitive phenotypes in Down syndrome. Alzheimer’s & Dementia, 20(2), 1038–1049. Portico. https://doi.org/10.1002/alz.13506
Authors:
Priyanka Gorijala
M Muaaz Aslam
Lam-Ha T Dang
L Xicota
Maria V Fernandez
Yun Ju Sung
Kang-Hsien Fan
Eleanor Feingold
Ezequiel I Surace
Jasmeer P Chhatwal
Christy L Hom
Sigan L Hartley
Jason Hassenstab
Richard J Perrin
Mark Mapstone
Shahid H Zaman
Beau M Ances
M Ilyas Kamboh
Joseph H Lee
Carlos Cruchaga
Affiliated Authors:
Lam-Ha T Dang
L Xicota
Joseph H Lee
Columbia Affiliation:
Subjects:
Prevalence and Impact of Down Syndrome (OpenAlex Topic)
Epidemiology and Implications of Multimorbidity in Healthcare (OpenAlex Topic)
Alzheimer Disease (MeSH)
Down Syndrome (MeSH)
Cognitive Dysfunction (MeSH)
Author Keywords:
amyloid precursor protein
apoliprotein e apoe
area under the curve
cerebrospinal fluid biomarkers
cognitive batteries
dominantly inherited alzheimer network
down syndrome
early-onset alzheimer's disease
early-onset autosomal dominant
genetic architecture
genetic risk factor
late-onset alzheimer's disease
polygenic risk score
psen1
psen2
sporadic late-onset alzheimer's disease
elink
Publication Type:
Article
Unique ID:
10.1002/alz.13506
PMID:
37855447
DOI:
10.1002/alz.13506
Journal:
Alzheimer's and Dementia
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Scopus Record
View OpenAlex Record

Record Created: