CUIMC Publications

Tissue immunity to SARS-CoV-2: Role in protection and immunopathology

Record Created:

Friday, August 16, 2024 - 12:20

Rybkina, K., Davis‐Porada, J., & Farber, D. L. (2022). Tissue immunity to SARS‐CoV‐2: Role in protection and immunopathology*. Immunological Reviews, 309(1), 25–39. Portico. https://doi.org/10.1111/imr.13112

Authors:

Ksenia Rybkina

Julia Davis-Porada

Donna L Farber

Affiliated Authors:

Ksenia Rybkina

Julia Davis-Porada

Donna L Farber

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Microbiology and Immunology
- Department of Surgery

Subjects:

COVID-19 (MeSH)

SARS-CoV-2 (MeSH)

Author Keywords:

lung immunity

lymph nodes

mucosal immunity

tissue resident memory cells

Grants:

U01HL145547 (NIH – National Heart, Lung, and Blood Institute)

R01AI100119 (NIH – National Institute of Allergy and Infectious Diseases)

U01AI100119 (NIH – National Institute of Allergy and Infectious Diseases)

P01AI106697 (NIH – National Institute of Allergy and Infectious Diseases)

U19AI128949 (NIH – National Institute of Allergy and Infectious Diseases)

T32GM007367 (NIH – National Institute of General Medical Sciences)

Publication Type:

Article

Unique ID:

10.1111/imr.13112

PMID:

35752871

DOI:

10.1111/imr.13112

Journal:

Immunological Reviews

Publication Date:

2022-06-26

Data Source:

PubMed

Source Link:

Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19

Record Created:

Thursday, January 16, 2025 - 13:26

Chait, M., Yilmaz, M. M., Shakil, S., Ku, A. W., Dogra, P., Connors, T. J., Szabo, P. A., Gray, J. I., Wells, S. B., Kubota, M., Matsumoto, R., Poon, M. M. L., Snyder, M. E., Baldwin, M. R., Sims, P. A., Saqi, A., Farber, D. L., & Weisberg, S. P. (2022). Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19. JCI Insight, 7(11). https://doi.org/10.1172/jci.insight.157608

Authors:

Michael Chait

Mine M. Yilmaz

Shanila Shakil

Amy W. Ku

Pranay Dogra

Thomas J. Connors

Peter A. Szabo

Joshua I. Gray

Steven B. Wells

Masaru Kubota

Rei Matsumoto

Maya M.L. Poon

Mark E. Snyder

Matthew R. Baldwin

Peter A. Sims

Anjali Saqi

Donna L. Farber

Stuart P. Weisberg

Affiliated Authors:

Michael Chait

Mine M. Yilmaz

Shanila Shakil

Amy W. Ku

Pranay Dogra

Thomas J. Connors

Peter A. Szabo

Joshua I. Gray

Steven B. Wells

Masaru Kubota

Rei Matsumoto

Maya M.L. Poon

Matthew R. Baldwin

Peter A. Sims

Anjali Saqi

Donna L. Farber

Stuart P. Weisberg

Columbia Affiliation:

Vagelos College of Physicians and Surgeons

Subjects:

Acute Lung Injury (MeSH)

COVID-19 (MeSH)

Coronavirus Disease 2019 (OpenAlex Topic)

Neurological Manifestations of COVID-19 Infection (OpenAlex Topic)

Mechanical Ventilation in Respiratory Failure and ARDS (OpenAlex Topic)

Author Keywords:

aging

covid-19

macrophages

pulmonary surfactants

t cells

Grants:

P30CA013696 (NIH – National Cancer Institute)

U01HL145547 (NIH – National Heart, Lung, and Blood Institute)

K23AI141686 (NIH – National Institute of Allergy and Infectious Diseases)

U19AI128949 (NIH – National Institute of Allergy and Infectious Diseases)

P01AI106697 (NIH – National Institute of Allergy and Infectious Diseases)

K08DK122130 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

Publication Type:

Article

Unique ID:

10.1172/jci.insight.157608

PMID:

35446789

DOI:

10.1172/jci.insight.157608

Journal:

JCI Insight

Publication Date:

2022-06-08

Data Source:

Scopus

Source Link:

Cross-tissue immune cell analysis reveals tissue-specific features in humans

Record Created:

Thursday, January 16, 2025 - 13:25

Domínguez Conde, C., Xu, C., Jarvis, L. B., Rainbow, D. B., Wells, S. B., Gomes, T., Howlett, S. K., Suchanek, O., Polanski, K., King, H. W., Mamanova, L., Huang, N., Szabo, P. A., Richardson, L., Bolt, L., Fasouli, E. S., Mahbubani, K. T., Prete, M., Tuck, L., … Teichmann, S. A. (2022). Cross-tissue immune cell analysis reveals tissue-specific features in humans. Science, 376(6594). https://doi.org/10.1126/science.abl5197

Authors:

Cecilia Domínguez Conde

Chuan Xu

Lorna B. Jarvis

Daniel B. Rainbow

Steven B. Wells

Tomás Gomes

S. K. Howlett

Ondřej Suchánek

Krzysztof Polański

Hamish W. King

Lira Mamanova

Ni Huang

Peter A. Szabo

Laura Richardson

Liam Bolt

Eirini S. Fasouli

Krishnaa T. Mahbubani

Martin Prete

Elizabeth Tuck

Nathan Richoz

Zewen Kelvin Tuong

LS Campos

Hani S. Mousa

Edward Needham

Sophie Pritchard

Tong Li

Rasa Elmentaite

Jong-Eun Park

Elior Rahmani

David Chen

David Menon

Omer Ali Bayraktar

Louisa K. James

Kerstin B. Meyer

Nir Yosef

Menna R. Clatworthy

Peter A. Sims

Donna L. Färber

Kourosh Saeb‐Parsy

Joanne L. Jones

Sarah A. Teichmann

Affiliated Authors:

Steven B. Wells

Peter A. Szabo

David Chen

Peter A. Sims

Donna L. Färber

Columbia Affiliation:

Vagelos College of Physicians and Surgeons

Subjects:

B-Lymphocytes (MeSH)

Machine Learning (MeSH)

Sequence Analysis, RNA (MeSH)

Single-Cell Analysis (MeSH)

T-Lymphocytes (MeSH)

Transcriptome (MeSH)

Comprehensive Integration of Single-Cell Transcriptomic Data (OpenAlex Topic)

Natural Killer Cells in Immunity (OpenAlex Topic)

Regulatory T Cell Development and Function (OpenAlex Topic)

Grants:

U01HL145547 (NIH – National Heart, Lung, and Blood Institute)

U19AI128949 (NIH – National Institute of Allergy and Infectious Diseases)

P30DK132710 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

Publication Type:

Article

Unique ID:

10.1126/science.abl5197

PMID:

35549406

DOI:

10.1126/science.abl5197

Journal:

Science

Publication Date:

2022-05-12

Data Source:

OpenAlex

Source Link:

Heterogeneity of human anti-viral immunity shaped by virus, tissue, age, and sex

Record Created:

Wednesday, February 12, 2025 - 09:28

Poon, M. M. L., Byington, E., Meng, W., Kubota, M., Matsumoto, R., Grifoni, A., Weiskopf, D., Dogra, P., Lam, N., Szabo, P. A., Ural, B. B., Wells, S. B., Rosenfeld, A. M., Brusko, M. A., Brusko, T. M., Connors, T. J., Sette, A., Sims, P. A., Luning Prak, E. T., … Farber, D. L. (2021). Heterogeneity of human anti-viral immunity shaped by virus, tissue, age, and sex. Cell Reports, 37(9), 110071. https://doi.org/10.1016/j.celrep.2021.110071

Authors:

Maya M L Poon

Eve Byington

Wenzhao Meng

Masaru Kubota

Rei Matsumoto

Alba Grifoni

Daniela Weiskopf

Pranay Dogra

Nora Lam

Peter A Szabo

Basak Burcu Ural

Steven B Wells

Aaron M Rosenfeld

Maigan A Brusko

Todd M Brusko

Thomas J Connors

Alessandro Sette

Peter A Sims

Eline T Luning Prak

Yufeng Shen

Donna L Farber

Affiliated Authors:

Maya M L Poon

Eve Byington

Masaru Kubota

Rei Matsumoto

Pranay Dogra

Nora Lam

Peter A Szabo

Basak Burcu Ural

Steven B Wells

Thomas J Connors

Peter A Sims

Yufeng Shen

Donna L Farber

Columbia Affiliation:

Vagelos College of Physicians and Surgeons

Subjects:

Antiviral Agents (MeSH)

CD8-Positive T-Lymphocytes (MeSH)

Cytomegalovirus (MeSH)

Cytomegalovirus Infections (MeSH)

Immunologic Memory (MeSH)

Influenza A virus (MeSH)

Influenza, Human (MeSH)

Author Keywords:

anti-viral immunity

cytomegalovirus

human immunology

immunological memory

influenza

lymphoid organs

mucosal immunity

t lymphocytes

tissue resident memory t cells

Grants:

P30CA013696 (NIH – National Cancer Institute)

S10RR027050 (NIH – National Center for Research Resources)

U01HL145547 (NIH – National Heart, Lung, and Blood Institute)

P01AI106697 (NIH – National Institute of Allergy and Infectious Diseases)

U01AI100119 (NIH – National Institute of Allergy and Infectious Diseases)

U19AI128949 (NIH – National Institute of Allergy and Infectious Diseases)

S10OD020056 (NIH – Office of the Director, National Institutes of Health)

Publication Type:

Article

Unique ID:

10.1016/j.celrep.2021.110071

PMID:

34852222

DOI:

10.1016/j.celrep.2021.110071

Journal:

Cell Reports

Publication Date:

2021-12-02

Data Source:

PubMed

Source Link:

Molecular programs of fibrotic change in aging human lung

Record Created:

Monday, April 28, 2025 - 12:40

Lee, S., Islam, M. N., Boostanpour, K., Aran, D., Jin, G., Christenson, S., Matthay, M. A., Eckalbar, W. L., DePianto, D. J., Arron, J. R., Magee, L., Bhattacharya, S., Matsumoto, R., Kubota, M., Farber, D. L., Bhattacharya, J., Wolters, P. J., & Bhattacharya, M. (2021). Molecular programs of fibrotic change in aging human lung. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-26603-2

Authors:

Seoyeon Lee

Mohammad Naimul Islam

Kaveh Boostanpour

Dvir Aran

Guangchun Jin

Stephanie Christenson

Michael A. Matthay

Walter L. Eckalbar

Daryle J. DePianto

Joseph R. Arron

Liam Magee

Sunita Bhattacharya

Rei Matsumoto

Masaru Kubota

Donna L. Farber

Jahar Bhattacharya

Paul J. Wolters

Mallar Bhattacharya

Affiliated Authors:

Mohammad Naimul Islam

Guangchun Jin

Sunita Bhattacharya

Rei Matsumoto

Masaru Kubota

Donna L. Farber

Jahar Bhattacharya

Columbia Affiliation:

Vagelos College of Physicians and Surgeons

Subjects:

Collagen (MeSH)

Gene Expression Regulation (MeSH)

Idiopathic Pulmonary Fibrosis (MeSH)

Lung (MeSH)

Telomere Shortening (MeSH)

Grants:

R01HL036024 (NIH – National Heart, Lung, and Blood Institute)

R01HL139897 (NIH – National Heart, Lung, and Blood Institute)

R01HL057556 (NIH – National Heart, Lung, and Blood Institute)

U01HL145547 (NIH – National Heart, Lung, and Blood Institute)

R01HL131560 (NIH – National Heart, Lung, and Blood Institute)

Publication Type:

Article

Unique ID:

10.1038/s41467-021-26603-2

PMID:

34728633

DOI:

10.1038/s41467-021-26603-2

Journal:

Nature Communications

Publication Date:

2021-12-01

Data Source:

Scopus

Source Link:

SARS-CoV-2 infection generates tissue-localized immunological memory in humans

Record Created:

Monday, April 28, 2025 - 12:39

Poon, M. M. L., Rybkina, K., Kato, Y., Kubota, M., Matsumoto, R., Bloom, N. I., Zhang, Z., Hastie, K. M., Grifoni, A., Weiskopf, D., Wells, S. B., Ural, B. B., Lam, N., Szabo, P. A., Dogra, P., Lee, Y. S., Gray, J. I., Bradley, M. C., Brusko, M. A., … Farber, D. L. (2021). SARS-CoV-2 infection generates tissue-localized immunological memory in humans. Science Immunology, 6(65). https://doi.org/10.1126/sciimmunol.abl9105

Authors:

Maya M.L. Poon

Ksenia Rybkina

Yu Kato

Masaru Kubota

Rei Matsumoto

Nathaniel I. Bloom

Zeli Zhang

Kathryn M. Hastie

Alba Grifoni

Daniela Weiskopf

Steven B. Wells

Basak B. Ural

Nora Lam

Peter A. Szabo

Pranay Dogra

Yoon S. Lee

Joshua I. Gray

Marissa C. Bradley

Maigan A. Brusko

Todd M. Brusko

Erica O. Saphire

Thomas J. Connors

Alessandro Sette

Shane Crotty

Donna L. Farber

Affiliated Authors:

Maya M.L. Poon

Ksenia Rybkina

Masaru Kubota

Rei Matsumoto

Steven B. Wells

Basak B. Ural

Nora Lam

Peter A. Szabo

Pranay Dogra

Yoon S. Lee

Joshua I. Gray

Marissa C. Bradley

Thomas J. Connors

Donna L. Farber

Columbia Affiliation:

Vagelos College of Physicians and Surgeons

Subjects:

Coronavirus Disease 2019 Research (OpenAlex Topic)

Neurological Manifestations of COVID-19 Infection (OpenAlex Topic)

Trained Immunity in Health and Disease (OpenAlex Topic)

Antibodies, Viral (MeSH)

COVID-19 (MeSH)

Immunity, Cellular (MeSH)

Immunologic Memory (MeSH)

Lymphocytes (MeSH)

SARS-CoV-2 (MeSH)

Grants:

S10RR027050 (NIH – National Center for Research Resources)

U01HL145547 (NIH – National Heart, Lung, and Blood Institute)

K23AI141686 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI100119 (NIH – National Institute of Allergy and Infectious Diseases)

U19AI142742 (NIH – National Institute of Allergy and Infectious Diseases)

U19AI128949 (NIH – National Institute of Allergy and Infectious Diseases)

P01AI106697 (NIH – National Institute of Allergy and Infectious Diseases)

U01AI100119 (NIH – National Institute of Allergy and Infectious Diseases)

S10OD020056 (NIH – Office of the Director, National Institutes of Health)

Publication Type:

Article

Unique ID:

10.1126/sciimmunol.abl9105

PMID:

34618554

DOI:

10.1126/sciimmunol.abl9105

Journal:

Science Immunology

Publication Date:

2021-11-01

Data Source:

Scopus

Source Link:

Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19

Record Created:

Thursday, May 8, 2025 - 11:41

Szabo, P. A., Dogra, P., Gray, J. I., Wells, S. B., Connors, T. J., Weisberg, S. P., Krupska, I., Matsumoto, R., Poon, M. M. L., Idzikowski, E., Morris, S. E., Pasin, C., Yates, A. J., Ku, A., Chait, M., Davis-Porada, J., Guo, X. V., Zhou, J., Steinle, M., … Farber, D. L. (2021). Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19. Immunity, 54(4), 797-814.e6. https://doi.org/10.1016/j.immuni.2021.03.005

Authors:

Peter A. Szabo

Pranay Dogra

Joshua Gray

Maya M. L. Poon

Donna L. Farber

Steven B. Wells

Izabela Krupska

Peter A. Sims

Thomas J. Connors

Emma Idzikowski

Stuart P. Weisberg

Sinead E. Morris

Chloe Pasin

Andrew J. Yates

Amy Ku

Michael Chait

Anjali Saqi

Rei Matsumoto

Julia Davis-Porada

Xinzheng Guo

Jing Zhou

Matthew Steinle

Sean Mackay

Matthew R. Baldwin

Affiliated Authors:

Peter A. Szabo

Pranay Dogra

Joshua Gray

Maya M. L. Poon

Donna L. Farber

Steven B. Wells

Izabela Krupska

Peter A. Sims

Thomas J. Connors

Emma Idzikowski

Stuart P. Weisberg

Sinead E. Morris

Chloe Pasin

Andrew J. Yates

Amy Ku

Michael Chait

Anjali Saqi

Rei Matsumoto

Julia Davis-Porada

Xinzheng Guo

Matthew R. Baldwin

Columbia Affiliation:

Vagelos College of Physicians and Surgeons

Subjects:

COVID-19 (MeSH)

Lung (MeSH)

Myeloid Cells (MeSH)

Mechanical Ventilation in Respiratory Failure and ARDS (OpenAlex Topic)

Coronavirus Disease 2019 (OpenAlex Topic)

Neurological Manifestations of COVID-19 Infection (OpenAlex Topic)

Author Keywords:

ards

covid-19

chemokines

coronavirus disease 2019

cytokines

lung immunity

macrophages

monocytes

single-cell rna sequencing

tissue resident memory t cells

Grants:

U01HL145547 (NIH – National Heart, Lung, and Blood Institute)

U01AI150680 (NIH – National Institute of Allergy and Infectious Diseases)

K23AI141686 (NIH – National Institute of Allergy and Infectious Diseases)

K08DK122130 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

Publication Type:

Article

Unique ID:

10.1016/j.immuni.2021.03.005

PMID:

33765436

DOI:

10.1016/j.immuni.2021.03.005

Journal:

Immunity

Publication Date:

2021-04-13

Data Source:

Web of Science

Source Link:

Tissue-resident memory T cells in tumor immunity and immunotherapy

Record Created:

Thursday, July 24, 2025 - 08:32

Okła, K., Farber, D. L., & Zou, W. (2021). Tissue-resident memory T cells in tumor immunity and immunotherapy. Journal of Experimental Medicine, 218(4). https://doi.org/10.1084/jem.20201605

Authors:

Karolina Okła

Donna L Farber

Weiping Zou

Affiliated Authors:

Donna L Farber

Columbia Affiliation:

Subjects:

CD8-Positive T-Lymphocytes (MeSH)

Immunity (MeSH)

Immunologic Memory (MeSH)

Immunotherapy (MeSH)

Lymphocytes, Tumor-Infiltrating (MeSH)

Neoplasms (MeSH)

Tumor Microenvironment (MeSH)

Grants:

R01CA248430 (NIH – National Cancer Institute)

R01CA152470 (NIH – National Cancer Institute)

R01CA214911 (NIH – National Cancer Institute)

P30CA046592 (NIH – National Cancer Institute)

R01CA193136 (NIH – National Cancer Institute)

R01CA217510 (NIH – National Cancer Institute)

R01CA099985 (NIH – National Cancer Institute)

R01CA123088 (NIH – National Cancer Institute)

U01HL145547 (NIH – National Heart, Lung, and Blood Institute)

U19AI128949 (NIH – National Institute of Allergy and Infectious Diseases)

U01AI150680 (NIH – National Institute of Allergy and Infectious Diseases)

P01AI106697 (NIH – National Institute of Allergy and Infectious Diseases)

Publication Type:

Article

Unique ID:

10.1084/jem.20201605

PMID:

33755718

DOI:

10.1084/jem.20201605

Journal:

Journal of Experimental Medicine

Publication Date:

2021-03-24

Data Source:

PubMed

Source Link:

Tissue-specific immunity for a changing world

Record Created:

Tuesday, July 29, 2025 - 13:21

Weisberg, S. P., Ural, B. B., & Farber, D. L. (2021). Tissue-specific immunity for a changing world. Cell, 184(6), 1517–1529. https://doi.org/10.1016/j.cell.2021.01.042

Authors:

Stuart P Weisberg

Basak B Ural

Donna L Farber

Affiliated Authors:

Stuart P Weisberg

Basak B Ural

Donna L Farber

Columbia Affiliation:

Vagelos College of Physicians and Surgeons

Subjects:

Immunity (MeSH)

Organ Specificity (MeSH)

Grants:

U01HL145547 (NIH – National Heart, Lung, and Blood Institute)

T32HL105323 (NIH – National Heart, Lung, and Blood Institute)

U01AI150680 (NIH – National Institute of Allergy and Infectious Diseases)

U01AI100119 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI100119 (NIH – National Institute of Allergy and Infectious Diseases)

P01AI106697 (NIH – National Institute of Allergy and Infectious Diseases)

U19AI128949 (NIH – National Institute of Allergy and Infectious Diseases)

K08DK122130 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)

Publication Type:

Article

Unique ID:

10.1016/j.cell.2021.01.042

PMID:

33740452

DOI:

10.1016/j.cell.2021.01.042

Journal:

Cell

Publication Date:

2021-03-20

Data Source:

PubMed

Source Link: