Neurological Manifestations of COVID-19 Infection
Mandel, H., Yoo, Y. J., Allen, A. J., Abedian, S., Verzani, Z., Karlson, E. W., Kleinman, L. C., Mudumbi, P. C., Oliveira, C. R., Muszynski, J. A., Gross, R. S., Carton, T. W., Kim, C., Taylor, E., Park, H., Divers, J., Kelly, J. D., Arnold, J., Geary, C. R., … Moffitt, R. A. (2025). Long-COVID incidence proportion in adults and children between 2020 and 2024. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciaf046
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Saak, T. M., Tervo, J. P., Vilarello, B. J., Jacobson, P. T., Caruana, F. F., Spence, M. D. A., Gallagher, L. W., Gudis, D. A., Motter, J. N., Devanand, D. P., & Overdevest, J. B. (2024). Depression, Anxiety, and Neuropsychiatric Symptom Burden in a Longitudinal Cohort with Persistent Psychophysical Post-COVID Olfactory Dysfunction. Brain Sciences, 14(12), 1277. https://doi.org/10.3390/brainsci14121277
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Groh, J. R., Miner, A. E., Farris, C., Tripodis, Y., Nowinski, C. J., Cui, A., Pettway, E. C., Tuz‐Zahra, F., Alshikho, M. J., Brickman, A. M., Lenio, S., Ly, M. T., Altaras, C., Budson, A. E., Turk, K. W., Qiu, W., Goldstein, L. E., Martin, B., Palmisano, J. N., … Alosco, M. L. (2024). Unique Pattern of White Matter Hyperintensities in Middle Age and Older Adults with History of Repetitive Head Impact Exposure. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.091572
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Biber, S. A., Prado, M. G., Culhane, J. E., Phuong, J., Keller, B., Lerch, M., Wang, S., Noble, J. M., Moulder, K. L., Saykin, A. J., Gao, S., Lai, A., Natarajan, K., Kukull, W. A., Mooney, S., & Stephens, K. (2024). Advancing Alzheimer’s disease and related dementias (ADRD) and COVID‐19 research by linking real‐world data with a standardized longitudinal ADRD data platform. Alzheimer’s & Dementia, 20(S8). Portico. https://doi.org/10.1002/alz.094785
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Zidar, D. A., Wilson, B. M., Al-Kindi, S. G., Sweet, D., Juchnowski, S., Huntington, L., Shive, C., Bosch, J., King, C., Karn, J., Chung, M. K., Gillombardo, C. B., Karnib, M., Sundaram, V., Parikh, S. A., Jain, M., Gunzler, D. D., Skarbinski, J., Tang, W. H. W., … Dalton, J. E. (2024). Pre-exposure immunohematologic features of heart failure associate with COVID-19 mortality. Npj Cardiovascular Health, 1(1). https://doi.org/10.1038/s44325-024-00025-7
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Lipton, M. L., Fleysher, R., Song, J. Y., Ye, K., Zimmerman, M. E., Lipton, R. B., & Daily, J. P. (2024). Brain effects of mild COVID-19 in healthy young adults: A pilot study. Heliyon, 10(15), e34764. https://doi.org/10.1016/j.heliyon.2024.e34764
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Formánek, T., Potočár, L., Wolfova, K., Melicharová, H., Mladá, K., Wiedemann, A., Chen, D., Mohr, P., Winkler, P., Jones, P. B., & Jarkovský, J. (2024). Deaths with COVID-19 and from all-causes following first-ever SARS-CoV-2 infection in individuals with preexisting mental disorders: A national cohort study from Czechia. PLOS Medicine, 21(7), e1004422. https://doi.org/10.1371/journal.pmed.1004422
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Oelsner, E. C., Sun, Y., Balte, P. P., Allen, N. B., Andrews, H., Carson, A., Cole, S. A., Coresh, J., Couper, D., Cushman, M., Daviglus, M., Demmer, R. T., Elkind, M. S. V., Gallo, L. C., Gutierrez, J. D., Howard, V. J., Isasi, C. R., Judd, S. E., Kanaya, A. M., … Post, W. S. (2024). Epidemiologic Features of Recovery From SARS-CoV-2 Infection. JAMA Network Open, 7(6), e2417440. https://doi.org/10.1001/jamanetworkopen.2024.17440
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Francoeur, C., Alcamo, A. M., Robertson, C. L., Wainwright, M. S., Roa, J. D., Lovett, M. E., Stulce, C., Yacoub, M., Potera, R. M., Zivick, E., Holloway, A., Nagpal, A., Wellnitz, K., Even, K. M., Brunow de Carvalho, W., Rodriguez, I. S., Schwartz, S. P., Walker, T. C., … Campos-Miño, S. (2024). Severe Pediatric Neurological Manifestations With SARS-CoV-2 or MIS-C Hospitalization and New Morbidity. JAMA Network Open, 7(6), e2414122. https://doi.org/10.1001/jamanetworkopen.2024.14122
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Coleman, B., Casiraghi, E., Callahan, T. J., Blau, H., Chan, L. E., Laraway, B., Clark, K. B., Re’em, Y., Gersing, K. R., Wilkins, K. J., Harris, N. L., Valentini, G., Haendel, M. A., Reese, J. T., & Robinson, P. N. (2024). Association of post-COVID phenotypic manifestations with new-onset psychiatric disease. Translational Psychiatry, 14(1). https://doi.org/10.1038/s41398-024-02967-z
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Cañas, A., Wolf, A., Chen, E. C., Ruddy, J., El-Sadek, S., Gomez, L., Furfaro, D., Fullilove, R., Burkart, K. M., Zelnick, J., & O’Donnell, M. R. (2024). Racial and ethnic disparities post-hospitalization for COVID-19: barriers to access to care for survivors of COVID-19 acute respiratory distress syndrome. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-61097-0
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Adeuyan, O., Magro, C. M., Trager, M. H., Gordon, E. R., Lapolla, B. A., Schreidah, C. M., Fahmy, L. M., & Geskin, L. J. (2024). Plasma cell and neutrophil enriched neovascularization with granulomatous lymphangitis in POEMS syndrome. JAAD Case Reports, 49, 125–128. https://doi.org/10.1016/j.jdcr.2024.03.025
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McGroder, C. F., Salvatore, M. M., D’Souza, B. M., Hoffman, E. A., Baldwin, M. R., & Garcia, C. K. (2024). Improved pulmonary function and exercise tolerance despite persistent pulmonary fibrosis over 1 year after severe COVID-19 infection. Thorax, 79(5), 472–475. https://doi.org/10.1136/thorax-2023-220370
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Igbinoba, Z., Capaccione, K. M., Dsouza, B., Shetty, A., & Salvatore, M. M. (2023). Radiographic analysis provides evidence for the etiology of pulmonary cysts in COVID-19. Imaging, 15(2), 87–93. https://doi.org/10.1556/1647.2023.00159
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Hendrickson, R. C., McCall, C. A., Rosser, A. F., Pagulayan, K. F., Chang, B. P., Sano, E. D., Thomas, R. G., & Raskind, M. A. (2023). The relative contribution of COVID-19 infection versus COVID-19 related occupational stressors to insomnia in healthcare workers. Sleep Medicine: X, 5, 100067. https://doi.org/10.1016/j.sleepx.2023.100067
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Tsapanou, A., Zoi, P., KALLIGEROU, F., Blekou, P., & Sakka, P. (2023). Long COVID‐19 symptoms in people with Dementia or Mild Cognitive Impairment. Alzheimer’s & Dementia, 19(S19). Portico. https://doi.org/10.1002/alz.076160
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Browne, L. Y., Cedeno, J. A., White, P. G., Cesar, O., Azad, D. Z., Tosto, G., Osorio, R. S., & Bubu, O. M. M. (2023). The Black Experience of COVID‐19. What is next for Clinical Psychologists in Alzheimer’s Disease research post‐pandemic? Alzheimer’s & Dementia, 19(S19). Portico. https://doi.org/10.1002/alz.073473
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Boruah, A. P., Thakur, K. T., Gadani, S. P., Kothari, K. U., Chomba, M., Guekht, A., Heydari, K., Hoo, F. K., Hwang, S., Michael, B. D., Pandit, M. V., Pardo, C. A., Prasad, K., Sardar, Z., Seeher, K., Solomon, T., Winkler, A. S., Wood, G. K., & Schiess, N. (2023). Pre-existing neurological conditions and COVID-19 co-infection: Data from systematic reviews, meta-analyses, and scoping reviews. Journal of the Neurological Sciences, 455, 120858. https://doi.org/10.1016/j.jns.2023.120858
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Floris-Moore, M., Stockwell, M., Grijalva, C. G., Keipp Talbot, H., Mellis, A., Smith-Jeffcoat, S. E., Rolfes, M. A., Saydah, S., Biddle, J. E., Lin, J. T., Schmitz, J., Chappell, J., Hart, K. W., McLaren, S. H., Sano, E., Saiman, L., Maldonado, Y. A., Ellingson, K., Lutrick, K., … Bowman, N. M. (2023). 400. Predictors of Post-COVID Conditions after SARS-CoV-2 Infection in Adults Enrolled in a Multistate Household Transmission Study. Open Forum Infectious Diseases, 10(Supplement_2). https://doi.org/10.1093/ofid/ofad500.470
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Smith-Jeffcoat, S. E., Biddle, J. E., Talbot, H. K., Olivo, V., Sano, E., Goodman, S. H., Petrie, J., Ledezma, K. I., Bullock, A., Rao, S., Mellis, A., Johnson, S., Kirking, H. L., Rolfes, M. A., Zhu, Y., Schmitz, J., Hart, K. W., Battan-Wraith, S., Merrill, L. S., … Salvatore, P. P. (2023). 930. COVID-19 symptom and viral load rebound among individuals reporting nirmatrelvir/ritonavir use compared to propensity score matched individuals not taking COVID-19 treatment. Open Forum Infectious Diseases, 10(Supplement_2). https://doi.org/10.1093/ofid/ofad500.975
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Soni, M. K., Migliori, E., Fu, J., Assal, A., Chan, H. T., Pan, J., Khatiwada, P., Ciubotariu, R., May, M. S., Pereira, M. R., De Giorgi, V., Sykes, M., Mapara, M. Y., & Muranski, P. J. (2023). The prospect of universal coronavirus immunity: characterization of reciprocal and non-reciprocal T cell responses against SARS-CoV2 and common human coronaviruses. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1212203
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Vagelos College of Physicians and Surgeons; Department of Medicine; Division of Hematology/Oncology; Department of Microbiology and Immunology; Department of Surgery; Division of Abdominal Organ Transplantation; Department of Pathology and Cell Biology; Center for Translational Immunology; Herbert Irving Comprehensive Cancer Center; Division of Infectious Diseases
Blumberg, E. A., Nam, H. H., Covington, S., Danziger-Isakov, L., Kumar, D., Michaels, M. G., Razonable, R. R., & Pereira, M. R. (2023). Into the unknown: The end of the coronavirus disease 2019 public health emergency in the United States and potential impacts on organ transplant recipients. American Journal of Transplantation, 23(10), 1507–1510. https://doi.org/10.1016/j.ajt.2023.07.007
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Sánchez-Rico, M., Edán-Sánchez, A., Olfson, M., Alvarado, J. M., Airagnes, G., Rezaei, K., Delcuze, A., Peyre, H., Limosin, F., & Hoertel, N. (2023). Antipsychotic use and 28-day mortality in patients hospitalized with COVID-19: A multicenter observational retrospective study. European Neuropsychopharmacology, 75, 93–104. https://doi.org/10.1016/j.euroneuro.2023.06.005
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Saad-Roy, C. M., Morris, S. E., Baker, R. E., Farrar, J., Graham, A. L., Levin, S. A., Wagner, C. E., Metcalf, C. Jessica. E., & Grenfell, B. T. (2023). Medium-term scenarios of COVID-19 as a function of immune uncertainties and chronic disease. Journal of The Royal Society Interface, 20(205). https://doi.org/10.1098/rsif.2023.0247
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Kikuchi, N., Minami, Y., Asami, Y., Hattori, H., Ichihara, Y., Saito, S., Hiroshi, N., Yamaguchi, J., & Nunoda, S. (2023). (1061) Long-Term Changes in Renal Function After Implantation of Left Ventricular Assist Device and Differences by Type of Devices from Japanese Registry for Mechanical Assisted Circulatory Support (J-MACS). The Journal of Heart and Lung Transplantation, 42(4), S458–S459. https://doi.org/10.1016/j.healun.2023.02.1272
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Muri, J., Cecchinato, V., Cavalli, A., Shanbhag, A. A., Matkovic, M., Biggiogero, M., Maida, P. A., Moritz, J., Toscano, C., Ghovehoud, E., Furlan, R., Barbic, F., Voza, A., De Nadai, G., Cervia, C., Zurbuchen, Y., Taeschler, P., Murray, L. A., Danelon-Sargenti, G., … Robbiani, D. F. (2023). Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course. Nature Immunology, 24(4), 604–611. https://doi.org/10.1038/s41590-023-01445-w
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Reese, J. T., Blau, H., Casiraghi, E., Bergquist, T., Loomba, J. J., Callahan, T. J., Laraway, B., Antonescu, C., Coleman, B., Gargano, M., Wilkins, K. J., Cappelletti, L., Fontana, T., Ammar, N., Antony, B., Murali, T. M., Caufield, J. H., Karlebach, G., McMurry, J. A., … Divers, J. (2023). Generalisable long COVID subtypes: findings from the NIH N3C and RECOVER programmes. EBioMedicine, 87, 104413. https://doi.org/10.1016/j.ebiom.2022.104413
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Burack, D., Pereira, M. R., & Verna, E. (2022). 2116. Long-term (2-year) outcomes and complications of COVID-19 in solid organ transplant (SOT) recipients. Open Forum Infectious Diseases, 9(Supplement_2). https://doi.org/10.1093/ofid/ofac492.1737
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Abramov, A., Su, I., Agerstrand, C., Flatley, M., Dubois, R., Feldhaus, D., Stanifer, B. P., Sonett, J., Brodie, D., & Lemaitre, P. (2022). Extracorporeal Membrane Oxygenation Support in COVID-19 Patients: A Propensity Score Analysis. ASAIO Journal, 68(12), e224–e229. https://doi.org/10.1097/mat.0000000000001829
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Khan, A., Heide, S., Flatley, A., Khan, A., & Nobler, M. (2022). Tinnitus and biopsychosocial ramifications of COVID-19 associated with severe suicide attempt-a case report. Psychiatry Research Case Reports, 1(2), 100067. https://doi.org/10.1016/j.psycr.2022.100067
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Reyes C, Pistillo A, Fernández-Bertolín S, et al (2021). Characteristics and outcomes of patients with COVID-19 with and without prevalent hypertension: a multinational cohort study. BMJ Open, 11:e057632. doi:10.1136/bmjopen-2021-057632
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Zeijlon, R., Hällgren, P., Le, V., Chamat, J., Wågerman, J., Enabtawi, I., Rawshani, A., Unenge, S., Jha, S., Omerovic, E., & Redfors, B. (2022). The role of admission electrocardiogram in predicting outcome in patients hospitalized for COVID-19. Journal of Electrocardiology, 75, 10–18. https://doi.org/10.1016/j.jelectrocard.2022.10.005
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Hedvat, J., Lange, N. W., Salerno, D. M., DeFilippis, E. M., Kovac, D., Corbo, H., Chen, J. K., Choe, J. Y., Lee, J. H., Anamisis, A., Jennings, D. L., Codispodo, G., Shertel, T., Brown, R. S., & Pereira, M. R. (2022). COVID-19 therapeutics and outcomes among solid organ transplant recipients during the Omicron BA.1 era. American Journal of Transplantation, 22(11), 2682–2688. https://doi.org/10.1111/ajt.17140
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Villalba, J. A., Hilburn, C. F., Garlin, M. A., Elliott, G. A., Li, Y., Kunitoki, K., Poli, S., Alba, G. A., Madrigal, E., Taso, M., Price, M. C., Aviles, A. J., Araujo-Medina, M., Bonanno, L., Boyraz, B., Champion, S. N., Harris, C. K., Helland, T. L., Hutchison, B., … Shih, A. R. (2022). Vasculopathy and Increased Vascular Congestion in Fatal COVID-19 and Acute Respiratory Distress Syndrome. American Journal of Respiratory and Critical Care Medicine, 206(7), 857–873. https://doi.org/10.1164/rccm.202109-2150oc
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Nobel, Y. R., Su, S. H., Anderson, M. R., Luk, L., Small-Saunders, J. L., Reyes-Soffer, G., Gallagher, D., & Freedberg, D. E. (2021). Relationship Between Body Composition and Death in Patients with COVID-19 Differs Based on the Presence of Gastrointestinal Symptoms. Digestive Diseases and Sciences, 67(9), 4484–4491. https://doi.org/10.1007/s10620-021-07324-4
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Vagelos College of Physicians and Surgeons; Department of Medicine; Division of Digestive and Liver Diseases; Department of Radiology; Division of Endocrinology; Mailman School of Public Health; Department of Epidemiology; Division of Infectious Diseases; Institute of Human Nutrition; Division of Pulmonary, Allergy, and Critical Care Medicine
Lonze, B. E., Spiegler, P., Wesson, R. N., Alachkar, N., Petkova, E., Weldon, E. P., Dieter, R. A., Li, Y., Quinn, M., Mattoo, A., Soomro, I., Cohen, S. M., Leung, S., Deterville, C. L., Landrum, B. M., Ali, M. I., Cohen, D. J., Singer, A. L., Sen, A., … Montgomery, R. A. (2022). A Randomized Double-Blinded Placebo Controlled Trial of Clazakizumab for the Treatment of COVID-19 Pneumonia With Hyperinflammation*. Critical Care Medicine, 50(9), 1348–1359. https://doi.org/10.1097/ccm.0000000000005591
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Dsouza, B., Capaccione, K. M., Soleiman, A., Leb, J., & Salvatore, M. (2022). COVID-19 on Chest CT: Translating Known Microscopic Findings to Imaging Observations. Life, 12(6), 855. https://doi.org/10.3390/life12060855
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Chait, M., Yilmaz, M. M., Shakil, S., Ku, A. W., Dogra, P., Connors, T. J., Szabo, P. A., Gray, J. I., Wells, S. B., Kubota, M., Matsumoto, R., Poon, M. M. L., Snyder, M. E., Baldwin, M. R., Sims, P. A., Saqi, A., Farber, D. L., & Weisberg, S. P. (2022). Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19. JCI Insight, 7(11). https://doi.org/10.1172/jci.insight.157608
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Vagelos College of Physicians and Surgeons; Department of Surgery; Department of Medicine; Division of Pulmonary, Allergy, and Critical Care Medicine; Department of Systems Biology; Department of Biochemistry and Molecular Biophysics; Department of Pathology and Cell Biology; Department of Microbiology and Immunology; Department of Pediatrics
Nemani, K., Williams, S. Z., Olfson, M., Leckman-Westin, E., Finnerty, M., Kammer, J., Smith, T. E., Silverman, D. J., Lindenmayer, J.-P., Capichioni, G., Clelland, J., & Goff, D. C. (2022). Association Between the Use of Psychotropic Medications and the Risk of COVID-19 Infection Among Long-term Inpatients With Serious Mental Illness in a New York State–wide Psychiatric Hospital System. JAMA Network Open, 5(5), e2210743. https://doi.org/10.1001/jamanetworkopen.2022.10743
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Klouda, T., Hao, Y., Kim, H., Kim, J., Olejnik, J., Hume, A. J., Ayyappan, S., Hong, X., Melero-Martin, J., Fang, Y., Wang, Q., Zhou, X., Mühlberger, E., Jia, H., Padera, R. F., Raby, B. A., & Yuan, K. (2021). Interferon-alpha or -beta facilitates SARS-CoV-2 pulmonary vascular infection by inducing ACE2. Angiogenesis, 25(2), 225–240. https://doi.org/10.1007/s10456-021-09823-4
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Fink, E. L., Robertson, C. L., Wainwright, M. S., Roa, J. D., Lovett, M. E., Stulce, C., Yacoub, M., Potera, R. M., Zivick, E., Holloway, A., Nagpal, A., Wellnitz, K., Czech, T., Even, K. M., Brunow de Carvalho, W., Rodriguez, I. S., Schwartz, S. P., Walker, T. C., Campos-Miño, S., … Schober, M. E. (2022). Prevalence and Risk Factors of Neurologic Manifestations in Hospitalized Children Diagnosed with Acute SARS-CoV-2 or MIS-C. Pediatric Neurology, 128, 33–44. https://doi.org/10.1016/j.pediatrneurol.2021.12.010
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Gordon-Lipkin, E., Kruk, S., Thompson, E., Yeske, P., Martin, L., Hirano, M., Cohen, B. H., Marcum, C. S., & McGuire, P. J. (2022). Risk mitigation behaviors to prevent infection in the mitochondrial disease community during the COVID-19 pandemic. Molecular Genetics and Metabolism Reports, 30, 100837. https://doi.org/10.1016/j.ymgmr.2021.100837
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Xu, Y., Surface, M., Chan, A. K., Halpern, J., Vanegas-Arroyave, N., Ford, B., Feeney, M. P., Kwei, K. T., Katus, L. E., Kuo, S.-H., Shah, H., Waters, C., Winfield, L. M., Beck, J. C., Przedborski, S., Fahn, S., & Alcalay, R. N. (2021). COVID-19 manifestations in people with Parkinson’s disease: a USA cohort. Journal of Neurology, 269(3), 1107–1113. https://doi.org/10.1007/s00415-021-10784-3
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Clelland, C. L., Ramiah, K., Steinberg, L., & Clelland, J. D. (2021). Analysis of the impact of antidepressants and other medications on COVID-19 infection risk in a chronic psychiatric in-patient cohort. BJPsych Open, 8(1). https://doi.org/10.1192/bjo.2021.1053
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Kumar, A., Narayan, R. K., Prasoon, P., Kumari, C., Kaur, G., Kumar, S., Kulandhasamy, M., Sesham, K., Pareek, V., Faiq, M. A., Pandey, S. N., Singh, H. N., Kant, K., Shekhawat, P. S., Raza, K., & Kumar, S. (2022). Mecanismos del COVID-19 en el cuerpo humano: Lo que sabemos hasta ahora. Kompass Neumología, 4(1), 3–20. Portico. https://doi.org/10.1159/000521507
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Lukman, P. R., Saputra, A., Elvira, S. D., Heriani, Almasyhur, A. F., Putri, L. A., Alfonso, C. A., & Noviasari, R. R. (2021). Efficacy of video-based psychotherapy in reducing psychological distress of COVID-19 patients treated in isolation ward. Medical Journal of Indonesia, 30(4), 250–255. https://doi.org/10.13181/mji.oa.215473
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Ranard, B. L., Megjhani, M., Terilli, K., Doyle, K., Claassen, J., Pinsky, M. R., Clermont, G., Vodovotz, Y., Asgari, S., & Park, S. (2021). Identification of Endotypes of Hospitalized COVID-19 Patients. Frontiers in Medicine, 8. https://doi.org/10.3389/fmed.2021.770343
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Ferren, M., Favède, V., Decimo, D., Iampietro, M., Lieberman, N. A. P., Weickert, J.-L., Pelissier, R., Mazelier, M., Terrier, O., Moscona, A., Porotto, M., Greninger, A. L., Messaddeq, N., Horvat, B., & Mathieu, C. (2021). Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-26096-z
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Gladstone, D. E., Howard, C., Lyu, M.-A., Mock, J., Adams, D., Gibbs, K., Li, L., Huang, M., Zeng, K., D’Alessio, F., Herlihy, J., Trevino, S., Hari, P., Sadeghi, T., Parmar, S., Slutsky, A., & Mukherjee, S. (2021). Randomized, Multi-Center, Double-Blinded, Placebo Controlled Safety and Early Efficacy Trial of Cryopreserved Cord Blood Derived T-Regulatory Cell Infusions (CK0802) in the Treatment of COVID-19 Induced ARDS. (RESOLVE Trial). Blood, 138(Supplement 1), 828–828. https://doi.org/10.1182/blood-2021-153616
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Blackett, J. W., Wainberg, M., Elkind, M. S. V., & Freedberg, D. E. (2022). Potential Long Coronavirus Disease 2019 Gastrointestinal Symptoms 6 Months After Coronavirus Infection Are Associated With Mental Health Symptoms. Gastroenterology, 162(2), 648-650.e2. https://doi.org/10.1053/j.gastro.2021.10.040
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