Neurological Manifestations of COVID-19 Infection

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Mandel, H., Yoo, Y. J., Allen, A. J., Abedian, S., Verzani, Z., Karlson, E. W., Kleinman, L. C., Mudumbi, P. C., Oliveira, C. R., Muszynski, J. A., Gross, R. S., Carton, T. W., Kim, C., Taylor, E., Park, H., Divers, J., Kelly, J. D., Arnold, J., Geary, C. R., … Moffitt, R. A. (2025). Long-COVID incidence proportion in adults and children between 2020 and 2024. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciaf046
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Saak, T. M., Tervo, J. P., Vilarello, B. J., Jacobson, P. T., Caruana, F. F., Spence, M. D. A., Gallagher, L. W., Gudis, D. A., Motter, J. N., Devanand, D. P., & Overdevest, J. B. (2024). Depression, Anxiety, and Neuropsychiatric Symptom Burden in a Longitudinal Cohort with Persistent Psychophysical Post-COVID Olfactory Dysfunction. Brain Sciences, 14(12), 1277. https://doi.org/10.3390/brainsci14121277
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Groh, J. R., Miner, A. E., Farris, C., Tripodis, Y., Nowinski, C. J., Cui, A., Pettway, E. C., Tuz‐Zahra, F., Alshikho, M. J., Brickman, A. M., Lenio, S., Ly, M. T., Altaras, C., Budson, A. E., Turk, K. W., Qiu, W., Goldstein, L. E., Martin, B., Palmisano, J. N., … Alosco, M. L. (2024). Unique Pattern of White Matter Hyperintensities in Middle Age and Older Adults with History of Repetitive Head Impact Exposure. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.091572
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Biber, S. A., Prado, M. G., Culhane, J. E., Phuong, J., Keller, B., Lerch, M., Wang, S., Noble, J. M., Moulder, K. L., Saykin, A. J., Gao, S., Lai, A., Natarajan, K., Kukull, W. A., Mooney, S., & Stephens, K. (2024). Advancing Alzheimer’s disease and related dementias (ADRD) and COVID‐19 research by linking real‐world data with a standardized longitudinal ADRD data platform. Alzheimer’s & Dementia, 20(S8). Portico. https://doi.org/10.1002/alz.094785
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Zidar, D. A., Wilson, B. M., Al-Kindi, S. G., Sweet, D., Juchnowski, S., Huntington, L., Shive, C., Bosch, J., King, C., Karn, J., Chung, M. K., Gillombardo, C. B., Karnib, M., Sundaram, V., Parikh, S. A., Jain, M., Gunzler, D. D., Skarbinski, J., Tang, W. H. W., … Dalton, J. E. (2024). Pre-exposure immunohematologic features of heart failure associate with COVID-19 mortality. Npj Cardiovascular Health, 1(1). https://doi.org/10.1038/s44325-024-00025-7
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Lipton, M. L., Fleysher, R., Song, J. Y., Ye, K., Zimmerman, M. E., Lipton, R. B., & Daily, J. P. (2024). Brain effects of mild COVID-19 in healthy young adults: A pilot study. Heliyon, 10(15), e34764. https://doi.org/10.1016/j.heliyon.2024.e34764
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Formánek, T., Potočár, L., Wolfova, K., Melicharová, H., Mladá, K., Wiedemann, A., Chen, D., Mohr, P., Winkler, P., Jones, P. B., & Jarkovský, J. (2024). Deaths with COVID-19 and from all-causes following first-ever SARS-CoV-2 infection in individuals with preexisting mental disorders: A national cohort study from Czechia. PLOS Medicine, 21(7), e1004422. https://doi.org/10.1371/journal.pmed.1004422
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Oelsner, E. C., Sun, Y., Balte, P. P., Allen, N. B., Andrews, H., Carson, A., Cole, S. A., Coresh, J., Couper, D., Cushman, M., Daviglus, M., Demmer, R. T., Elkind, M. S. V., Gallo, L. C., Gutierrez, J. D., Howard, V. J., Isasi, C. R., Judd, S. E., Kanaya, A. M., … Post, W. S. (2024). Epidemiologic Features of Recovery From SARS-CoV-2 Infection. JAMA Network Open, 7(6), e2417440. https://doi.org/10.1001/jamanetworkopen.2024.17440
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Francoeur, C., Alcamo, A. M., Robertson, C. L., Wainwright, M. S., Roa, J. D., Lovett, M. E., Stulce, C., Yacoub, M., Potera, R. M., Zivick, E., Holloway, A., Nagpal, A., Wellnitz, K., Even, K. M., Brunow de Carvalho, W., Rodriguez, I. S., Schwartz, S. P., Walker, T. C., … Campos-Miño, S. (2024). Severe Pediatric Neurological Manifestations With SARS-CoV-2 or MIS-C Hospitalization and New Morbidity. JAMA Network Open, 7(6), e2414122. https://doi.org/10.1001/jamanetworkopen.2024.14122
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Coleman, B., Casiraghi, E., Callahan, T. J., Blau, H., Chan, L. E., Laraway, B., Clark, K. B., Re’em, Y., Gersing, K. R., Wilkins, K. J., Harris, N. L., Valentini, G., Haendel, M. A., Reese, J. T., & Robinson, P. N. (2024). Association of post-COVID phenotypic manifestations with new-onset psychiatric disease. Translational Psychiatry, 14(1). https://doi.org/10.1038/s41398-024-02967-z
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Cañas, A., Wolf, A., Chen, E. C., Ruddy, J., El-Sadek, S., Gomez, L., Furfaro, D., Fullilove, R., Burkart, K. M., Zelnick, J., & O’Donnell, M. R. (2024). Racial and ethnic disparities post-hospitalization for COVID-19: barriers to access to care for survivors of COVID-19 acute respiratory distress syndrome. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-61097-0
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Adeuyan, O., Magro, C. M., Trager, M. H., Gordon, E. R., Lapolla, B. A., Schreidah, C. M., Fahmy, L. M., & Geskin, L. J. (2024). Plasma cell and neutrophil enriched neovascularization with granulomatous lymphangitis in POEMS syndrome. JAAD Case Reports, 49, 125–128. https://doi.org/10.1016/j.jdcr.2024.03.025
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McGroder, C. F., Salvatore, M. M., D’Souza, B. M., Hoffman, E. A., Baldwin, M. R., & Garcia, C. K. (2024). Improved pulmonary function and exercise tolerance despite persistent pulmonary fibrosis over 1 year after severe COVID-19 infection. Thorax, 79(5), 472–475. https://doi.org/10.1136/thorax-2023-220370
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Igbinoba, Z., Capaccione, K. M., Dsouza, B., Shetty, A., & Salvatore, M. M. (2023). Radiographic analysis provides evidence for the etiology of pulmonary cysts in COVID-19. Imaging, 15(2), 87–93. https://doi.org/10.1556/1647.2023.00159
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Hendrickson, R. C., McCall, C. A., Rosser, A. F., Pagulayan, K. F., Chang, B. P., Sano, E. D., Thomas, R. G., & Raskind, M. A. (2023). The relative contribution of COVID-19 infection versus COVID-19 related occupational stressors to insomnia in healthcare workers. Sleep Medicine: X, 5, 100067. https://doi.org/10.1016/j.sleepx.2023.100067
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Browne, L. Y., Cedeno, J. A., White, P. G., Cesar, O., Azad, D. Z., Tosto, G., Osorio, R. S., & Bubu, O. M. M. (2023). The Black Experience of COVID‐19. What is next for Clinical Psychologists in Alzheimer’s Disease research post‐pandemic? Alzheimer’s & Dementia, 19(S19). Portico. https://doi.org/10.1002/alz.073473
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Boruah, A. P., Thakur, K. T., Gadani, S. P., Kothari, K. U., Chomba, M., Guekht, A., Heydari, K., Hoo, F. K., Hwang, S., Michael, B. D., Pandit, M. V., Pardo, C. A., Prasad, K., Sardar, Z., Seeher, K., Solomon, T., Winkler, A. S., Wood, G. K., & Schiess, N. (2023). Pre-existing neurological conditions and COVID-19 co-infection: Data from systematic reviews, meta-analyses, and scoping reviews. Journal of the Neurological Sciences, 455, 120858. https://doi.org/10.1016/j.jns.2023.120858
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Smith-Jeffcoat, S. E., Biddle, J. E., Talbot, H. K., Olivo, V., Sano, E., Goodman, S. H., Petrie, J., Ledezma, K. I., Bullock, A., Rao, S., Mellis, A., Johnson, S., Kirking, H. L., Rolfes, M. A., Zhu, Y., Schmitz, J., Hart, K. W., Battan-Wraith, S., Merrill, L. S., … Salvatore, P. P. (2023). 930. COVID-19 symptom and viral load rebound among individuals reporting nirmatrelvir/ritonavir use compared to propensity score matched individuals not taking COVID-19 treatment. Open Forum Infectious Diseases, 10(Supplement_2). https://doi.org/10.1093/ofid/ofad500.975
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Floris-Moore, M., Stockwell, M., Grijalva, C. G., Keipp Talbot, H., Mellis, A., Smith-Jeffcoat, S. E., Rolfes, M. A., Saydah, S., Biddle, J. E., Lin, J. T., Schmitz, J., Chappell, J., Hart, K. W., McLaren, S. H., Sano, E., Saiman, L., Maldonado, Y. A., Ellingson, K., Lutrick, K., … Bowman, N. M. (2023). 400. Predictors of Post-COVID Conditions after SARS-CoV-2 Infection in Adults Enrolled in a Multistate Household Transmission Study. Open Forum Infectious Diseases, 10(Supplement_2). https://doi.org/10.1093/ofid/ofad500.470
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Soni, M. K., Migliori, E., Fu, J., Assal, A., Chan, H. T., Pan, J., Khatiwada, P., Ciubotariu, R., May, M. S., Pereira, M. R., De Giorgi, V., Sykes, M., Mapara, M. Y., & Muranski, P. J. (2023). The prospect of universal coronavirus immunity: characterization of reciprocal and non-reciprocal T cell responses against SARS-CoV2 and common human coronaviruses. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1212203
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Sánchez-Rico, M., Edán-Sánchez, A., Olfson, M., Alvarado, J. M., Airagnes, G., Rezaei, K., Delcuze, A., Peyre, H., Limosin, F., & Hoertel, N. (2023). Antipsychotic use and 28-day mortality in patients hospitalized with COVID-19: A multicenter observational retrospective study. European Neuropsychopharmacology, 75, 93–104. https://doi.org/10.1016/j.euroneuro.2023.06.005
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Blumberg, E. A., Nam, H. H., Covington, S., Danziger-Isakov, L., Kumar, D., Michaels, M. G., Razonable, R. R., & Pereira, M. R. (2023). Into the unknown: The end of the coronavirus disease 2019 public health emergency in the United States and potential impacts on organ transplant recipients. American Journal of Transplantation, 23(10), 1507–1510. https://doi.org/10.1016/j.ajt.2023.07.007
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Saad-Roy, C. M., Morris, S. E., Baker, R. E., Farrar, J., Graham, A. L., Levin, S. A., Wagner, C. E., Metcalf, C. Jessica. E., & Grenfell, B. T. (2023). Medium-term scenarios of COVID-19 as a function of immune uncertainties and chronic disease. Journal of The Royal Society Interface, 20(205). https://doi.org/10.1098/rsif.2023.0247
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Kikuchi, N., Minami, Y., Asami, Y., Hattori, H., Ichihara, Y., Saito, S., Hiroshi, N., Yamaguchi, J., & Nunoda, S. (2023). (1061) Long-Term Changes in Renal Function After Implantation of Left Ventricular Assist Device and Differences by Type of Devices from Japanese Registry for Mechanical Assisted Circulatory Support (J-MACS). The Journal of Heart and Lung Transplantation, 42(4), S458–S459. https://doi.org/10.1016/j.healun.2023.02.1272
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Muri, J., Cecchinato, V., Cavalli, A., Shanbhag, A. A., Matkovic, M., Biggiogero, M., Maida, P. A., Moritz, J., Toscano, C., Ghovehoud, E., Furlan, R., Barbic, F., Voza, A., De Nadai, G., Cervia, C., Zurbuchen, Y., Taeschler, P., Murray, L. A., Danelon-Sargenti, G., … Robbiani, D. F. (2023). Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course. Nature Immunology, 24(4), 604–611. https://doi.org/10.1038/s41590-023-01445-w
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Reese, J. T., Blau, H., Casiraghi, E., Bergquist, T., Loomba, J. J., Callahan, T. J., Laraway, B., Antonescu, C., Coleman, B., Gargano, M., Wilkins, K. J., Cappelletti, L., Fontana, T., Ammar, N., Antony, B., Murali, T. M., Caufield, J. H., Karlebach, G., McMurry, J. A., … Divers, J. (2023). Generalisable long COVID subtypes: findings from the NIH N3C and RECOVER programmes. EBioMedicine, 87, 104413. https://doi.org/10.1016/j.ebiom.2022.104413
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Khan, A., Heide, S., Flatley, A., Khan, A., & Nobler, M. (2022). Tinnitus and biopsychosocial ramifications of COVID-19 associated with severe suicide attempt-a case report. Psychiatry Research Case Reports, 1(2), 100067. https://doi.org/10.1016/j.psycr.2022.100067
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Abramov, A., Su, I., Agerstrand, C., Flatley, M., Dubois, R., Feldhaus, D., Stanifer, B. P., Sonett, J., Brodie, D., & Lemaitre, P. (2022). Extracorporeal Membrane Oxygenation Support in COVID-19 Patients: A Propensity Score Analysis. ASAIO Journal, 68(12), e224–e229. https://doi.org/10.1097/mat.0000000000001829
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Reyes C, Pistillo A, Fernández-Bertolín S, et al (2021). Characteristics and outcomes of patients with COVID-19 with and without prevalent hypertension: a multinational cohort study. BMJ Open, 11:e057632. doi:10.1136/bmjopen-2021-057632

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Zeijlon, R., Hällgren, P., Le, V., Chamat, J., Wågerman, J., Enabtawi, I., Rawshani, A., Unenge, S., Jha, S., Omerovic, E., & Redfors, B. (2022). The role of admission electrocardiogram in predicting outcome in patients hospitalized for COVID-19. Journal of Electrocardiology, 75, 10–18. https://doi.org/10.1016/j.jelectrocard.2022.10.005
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Hedvat, J., Lange, N. W., Salerno, D. M., DeFilippis, E. M., Kovac, D., Corbo, H., Chen, J. K., Choe, J. Y., Lee, J. H., Anamisis, A., Jennings, D. L., Codispodo, G., Shertel, T., Brown, R. S., & Pereira, M. R. (2022). COVID-19 therapeutics and outcomes among solid organ transplant recipients during the Omicron BA.1 era. American Journal of Transplantation, 22(11), 2682–2688. https://doi.org/10.1111/ajt.17140
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Villalba, J. A., Hilburn, C. F., Garlin, M. A., Elliott, G. A., Li, Y., Kunitoki, K., Poli, S., Alba, G. A., Madrigal, E., Taso, M., Price, M. C., Aviles, A. J., Araujo-Medina, M., Bonanno, L., Boyraz, B., Champion, S. N., Harris, C. K., Helland, T. L., Hutchison, B., … Shih, A. R. (2022). Vasculopathy and Increased Vascular Congestion in Fatal COVID-19 and Acute Respiratory Distress Syndrome. American Journal of Respiratory and Critical Care Medicine, 206(7), 857–873. https://doi.org/10.1164/rccm.202109-2150oc
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Lonze, B. E., Spiegler, P., Wesson, R. N., Alachkar, N., Petkova, E., Weldon, E. P., Dieter, R. A., Li, Y., Quinn, M., Mattoo, A., Soomro, I., Cohen, S. M., Leung, S., Deterville, C. L., Landrum, B. M., Ali, M. I., Cohen, D. J., Singer, A. L., Sen, A., … Montgomery, R. A. (2022). A Randomized Double-Blinded Placebo Controlled Trial of Clazakizumab for the Treatment of COVID-19 Pneumonia With Hyperinflammation*. Critical Care Medicine, 50(9), 1348–1359. https://doi.org/10.1097/ccm.0000000000005591
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Dsouza, B., Capaccione, K. M., Soleiman, A., Leb, J., & Salvatore, M. (2022). COVID-19 on Chest CT: Translating Known Microscopic Findings to Imaging Observations. Life, 12(6), 855. https://doi.org/10.3390/life12060855
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Chait, M., Yilmaz, M. M., Shakil, S., Ku, A. W., Dogra, P., Connors, T. J., Szabo, P. A., Gray, J. I., Wells, S. B., Kubota, M., Matsumoto, R., Poon, M. M. L., Snyder, M. E., Baldwin, M. R., Sims, P. A., Saqi, A., Farber, D. L., & Weisberg, S. P. (2022). Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19. JCI Insight, 7(11). https://doi.org/10.1172/jci.insight.157608
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Nemani, K., Williams, S. Z., Olfson, M., Leckman-Westin, E., Finnerty, M., Kammer, J., Smith, T. E., Silverman, D. J., Lindenmayer, J.-P., Capichioni, G., Clelland, J., & Goff, D. C. (2022). Association Between the Use of Psychotropic Medications and the Risk of COVID-19 Infection Among Long-term Inpatients With Serious Mental Illness in a New York State–wide Psychiatric Hospital System. JAMA Network Open, 5(5), e2210743. https://doi.org/10.1001/jamanetworkopen.2022.10743
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Fink, E. L., Robertson, C. L., Wainwright, M. S., Roa, J. D., Lovett, M. E., Stulce, C., Yacoub, M., Potera, R. M., Zivick, E., Holloway, A., Nagpal, A., Wellnitz, K., Czech, T., Even, K. M., Brunow de Carvalho, W., Rodriguez, I. S., Schwartz, S. P., Walker, T. C., Campos-Miño, S., … Schober, M. E. (2022). Prevalence and Risk Factors of Neurologic Manifestations in Hospitalized Children Diagnosed with Acute SARS-CoV-2 or MIS-C. Pediatric Neurology, 128, 33–44. https://doi.org/10.1016/j.pediatrneurol.2021.12.010
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Gordon-Lipkin, E., Kruk, S., Thompson, E., Yeske, P., Martin, L., Hirano, M., Cohen, B. H., Marcum, C. S., & McGuire, P. J. (2022). Risk mitigation behaviors to prevent infection in the mitochondrial disease community during the COVID-19 pandemic. Molecular Genetics and Metabolism Reports, 30, 100837. https://doi.org/10.1016/j.ymgmr.2021.100837
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Clelland, C. L., Ramiah, K., Steinberg, L., & Clelland, J. D. (2021). Analysis of the impact of antidepressants and other medications on COVID-19 infection risk in a chronic psychiatric in-patient cohort. BJPsych Open, 8(1). https://doi.org/10.1192/bjo.2021.1053
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Kumar, A., Narayan, R. K., Prasoon, P., Kumari, C., Kaur, G., Kumar, S., Kulandhasamy, M., Sesham, K., Pareek, V., Faiq, M. A., Pandey, S. N., Singh, H. N., Kant, K., Shekhawat, P. S., Raza, K., & Kumar, S. (2022). Mecanismos del COVID-19 en el cuerpo humano: Lo que sabemos hasta ahora. Kompass Neumología, 4(1), 3–20. Portico. https://doi.org/10.1159/000521507
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Lukman, P. R., Saputra, A., Elvira, S. D., Heriani, Almasyhur, A. F., Putri, L. A., Alfonso, C. A., & Noviasari, R. R. (2021). Efficacy of video-based psychotherapy in reducing psychological distress of COVID-19 patients treated in isolation ward. Medical Journal of Indonesia, 30(4), 250–255. https://doi.org/10.13181/mji.oa.215473
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