CD8-Positive T-Lymphocytes

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Varanasi, S. K., Chen, D., Liu, Y., Johnson, M. A., Miller, C. M., Ganguly, S., Lande, K., LaPorta, M. A., Hoffmann, F. A., Mann, T. H., Teneche, M. G., Casillas, E., Mangalhara, K. C., Mathew, V., Sun, M., Jensen, I. J., Farsakoglu, Y., Chen, T., Parisi, B., … Kaech, S. M. (2025). Bile acid synthesis impedes tumor-specific T cell responses during liver cancer. Science, 387(6730), 192–201. https://doi.org/10.1126/science.adl4100
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Lee, C. S., Chen, S., Berry, C. T., Kelly, A. R., Herman, P. J., Oh, S., O’Connor, R. S., Payne, A. S., & Ellebrecht, C. T. (2024). Fate induction in CD8 CAR T cells through asymmetric cell division. Nature, 633(8030), 670–677. https://doi.org/10.1038/s41586-024-07862-7
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Dahlquist, K. J. V., Huggins, M. A., Yousefzadeh, M. J., Soto-Palma, C., Cholensky, S. H., Pierson, M., Smith, D. M., Hamilton, S. E., & Camell, C. D. (2024). PD1 blockade improves survival and CD8+ cytotoxic capacity, without increasing inflammation, during normal microbial experience in old mice. Nature Aging, 4(7), 915–925. https://doi.org/10.1038/s43587-024-00620-4
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Li, Y., Li, J., Li, W., Liang, S., Wei, W., Chu, J., Lai, J., Lin, Y., Chen, H., Su, J., Hu, X., Wang, G., Meng, J., Jiang, J., Ye, L., & An, S. (2024). Scm6A: A Fast and Low-cost Method for Quantifying m6A Modifications at the Single-cell Level. Genomics, Proteomics & Bioinformatics. https://doi.org/10.1093/gpbjnl/qzae039
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Bredel, D., Tihic, E., Mouraud, S., Danlos, F.-X., Susini, S., Aglave, M., Alfaro, A., Mohamed-Djalim, C., Rouanne, M., Halse, H., Bigorgne, A., Tselikas, L., Dalle, S., Hartl, D. M., Baudin, E., Guettier, C., Vibert, E., Rosmorduc, O., Robert, C., … Bonvalet, M. (2023). Immune checkpoints are predominantly co-expressed by clonally expanded CD4+FoxP3+ intratumoral T-cells in primary human cancers. Journal of Experimental & Clinical Cancer Research, 42(1). https://doi.org/10.1186/s13046-023-02897-6
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Zhao, Q., Hu, J., Kong, L., Jiang, S., Tian, X., Wang, J., Hashizume, R., Jia, Z., Fowlkes, N. W., Yan, J., Xia, X., Yi, S. F., Dao, L. H., Masopust, D., Heimberger, A. B., & Li, S. (2023). FGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-36430-2
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Lopes-Ribeiro, Á., Oliveira, P. de M., Retes, H. M., Barbosa-Stancioli, E. F., da Fonseca, F. G., Tsuji, M., & Coelho-dos-Reis, J. G. A. (2023). Surveillance of SARS-CoV-2 immunogenicity: loss of immunodominant HLA-A*02-restricted epitopes that activate CD8+ T cells. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1229712
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Tran, L. M., Macedo, C., Zahorchak, A. F., Gu, X., Elinoff, B., Singhi, A. D., Isett, B., Zeevi, A., Sykes, M., Breen, K., Srivastava, A., Ables, E. M., Landsittel, D., Styn, M. A., Humar, A., Lakkis, F. G., Metes, D. M., & Thomson, A. W. (2023). Donor-derived regulatory dendritic cell infusion modulates effector CD8 + T cell and NK cell responses after liver transplantation. Science Translational Medicine, 15(717). https://doi.org/10.1126/scitranslmed.adf4287
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Wang, P. H., Washburn, R. S., Mariuzza, D. L., Lin, W.-H. W., Gill, A. L., Ahmed, R., & Reiner, S. L. (2023). Reciprocal transmission of activating and inhibitory signals and cell fate in regenerating T cells. Cell Reports, 42(10), 113155. https://doi.org/10.1016/j.celrep.2023.113155
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Gill, A. L., Wang, P. H., Lee, J., Hudson, W. H., Ando, S., Araki, K., Hu, Y., Wieland, A., Im, S., Gavora, A., Medina, C. B., Freeman, G. J., Hashimoto, M., Reiner, S. L., & Ahmed, R. (2023). PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors. Science Immunology, 8(86). https://doi.org/10.1126/sciimmunol.adg0539
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Lukas, E., Hogan, T., Williams, C., Seddon, B., & Yates, A. J. (2023). Quantifying cellular dynamics in mice using a novel fluorescent division reporter system. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1157705
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Rustam, S., Hu, Y., Mahjour, S. B., Rendeiro, A. F., Ravichandran, H., Urso, A., D’Ovidio, F., Martinez, F. J., Altorki, N. K., Richmond, B., Polosukhin, V., Kropski, J. A., Blackwell, T. S., Randell, S. H., Elemento, O., & Shaykhiev, R. (2023). A Unique Cellular Organization of Human Distal Airways and Its Disarray in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine, 207(9), 1171–1182. https://doi.org/10.1164/rccm.202207-1384oc
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Rancan, C., Arias-Badia, M., Dogra, P., Chen, B., Aran, D., Yang, H., Luong, D., Ilano, A., Li, J., Chang, H., Kwek, S. S., Zhang, L., Lanier, L. L., Meng, M. V., Farber, D. L., & Fong, L. (2023). Exhausted intratumoral Vδ2− γδ T cells in human kidney cancer retain effector function. Nature Immunology, 24(4), 612–624. https://doi.org/10.1038/s41590-023-01448-7
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Savage, T. M., Vincent, R. L., Rae, S. S., Huang, L. H., Ahn, A., Pu, K., Li, F., de los Santos-Alexis, K., Coker, C., Danino, T., & Arpaia, N. (2023). Chemokines expressed by engineered bacteria recruit and orchestrate antitumor immunity. Science Advances, 9(10). https://doi.org/10.1126/sciadv.adc9436
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Anandakumaran, P. N., Ayers, A. G., Muranski, P., Creusot, R. J., & Sia, S. K. (2022). Rapid video-based deep learning of cognate versus non-cognate T cell-dendritic cell interactions. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-021-04286-5
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Wang, P. H., Washburn, R., Maniar, R., Mu, M., Ringham, O., Kratchmarov, R., Henick, B. S., & Reiner, S. L. (2022). Cutting Edge: Promoting T Cell Factor 1+ T Cell Self-Renewal to Improve Programmed Cell Death Protein 1 Blockade. The Journal of Immunology, 209(4), 660–664. https://doi.org/10.4049/jimmunol.2200317
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Liu, C., Lin, B., Wu, M., Song, Y., Ke, T., Chou, Y., Liu, C., Lin, C., Radojcic, V., Drake, C., & Yen, H. (2022). Adoptive transfer of IL‐4 reprogrammed Tc17 cells elicits anti‐tumour immunity through functional plasticity. Immunology, 166(3), 310–326. Portico. https://doi.org/10.1111/imm.13473
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Matos, T. R., Gehad, A., Teague, J. E., Dyring-Andersen, B., Benezeder, T., Dowlatshahi, M., Crouch, J., Watanabe, Y., O’Malley, J. T., Kupper, T. S., Yang, C., Watanabe, R., & Clark, R. A. (2022). Central memory T cells are the most effective precursors of resident memory T cells in human skin. Science Immunology, 7(70). https://doi.org/10.1126/sciimmunol.abn1889
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He, X., Zhou, S., Dolan, M., Shi, Y., Wang, J., Quinn, B., Jahagirdar, D., Huang, W.-C., Tsuji, M., Pili, R., Ito, F., Ortega, J., Abrams, S. I., Ebos, J. M. L., & Lovell, J. F. (2021). Immunization with short peptide particles reveals a functional CD8+T-cell neoepitope in a murine renal carcinoma model. Journal for ImmunoTherapy of Cancer, 9(12), e003101. https://doi.org/10.1136/jitc-2021-003101
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Poon, M. M. L., Byington, E., Meng, W., Kubota, M., Matsumoto, R., Grifoni, A., Weiskopf, D., Dogra, P., Lam, N., Szabo, P. A., Ural, B. B., Wells, S. B., Rosenfeld, A. M., Brusko, M. A., Brusko, T. M., Connors, T. J., Sette, A., Sims, P. A., Luning Prak, E. T., … Farber, D. L. (2021). Heterogeneity of human anti-viral immunity shaped by virus, tissue, age, and sex. Cell Reports, 37(9), 110071. https://doi.org/10.1016/j.celrep.2021.110071
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