CUIMC Publications

Antibody evasiveness of SARS-CoV-2 subvariants KP.3.1.1 and XEC

Record Created:

Friday, August 1, 2025 - 13:43

Wang, Q., Guo, Y., Mellis, I. A., Wu, M., Mohri, H., Gherasim, C., Valdez, R., Purpura, L. J., Yin, M. T., Gordon, A., & Ho, D. D. (2025). Antibody evasiveness of SARS-CoV-2 subvariants KP.3.1.1 and XEC. Cell Reports, 44(4), 115543. https://doi.org/10.1016/j.celrep.2025.115543

Authors:

Qian Wang

Yicheng Guo

Ian A Mellis

Madeline Wu

Hiroshi Mohri

Carmen Gherasim

Riccardo Valdez

Lawrence J Purpura

Michael T Yin

Aubree Gordon

David D Ho

Affiliated Authors:

Qian Wang

Yicheng Guo

Ian A Mellis

Madeline Wu

Hiroshi Mohri

Lawrence J Purpura

Michael T Yin

David D Ho

Columbia Affiliation:

Subjects:

SARS-CoV-2 (MeSH)

Antibodies, Neutralizing (MeSH)

Antibodies, Viral (MeSH)

COVID-19 (MeSH)

Author Keywords:

ace2 inhibition

antibody evasion

cp: immunology

cp: microbiology

jn.1 subvariants

kp.3.1.1

monoclonal antibodies

mrna vaccines

sars-cov-2

serum neutralization

xec

pemivibart

polyethyleneimine

ace2 protein, human

angiotensin-converting enzyme 2

antibodies, monoclonal

antibodies, neutralizing

antibodies, viral

spike glycoprotein, coronavirus

spike protein, sars-cov-2

graphpad prism v.10

pymol v2.5.4

racmacs v1.1.4

racmacs version 1.1.4

version 4.0.3

angiotensin converting enzyme 2

monoclonal antibody

neutralizing antibody

receptor binding domain

sars-cov-2 antibody

unclassified drug

coronavirus spike glycoprotein

virus antibody

adult

animal cell

antibody response

antigenicity

article

controlled study

female

gene mutation

hek293t cell line

human

human cell

ic50

immune evasion

immunization

limit of detection

luciferase assay

male

middle aged

protein expression

sanger sequencing

sars-cov-2 kp.3.1.1

sars-cov-2 xec

severe acute respiratory syndrome coronavirus 2

site directed mutagenesis

structure analysis

vaccination

vero c1008 cell line

vesicular stomatitis

virus infectivity

virus neutralization

virus replication

animal

coronavirus disease 2019

genetics

immunology

metabolism

mutation

neutralization test

virology

animals

covid-19

humans

neutralization tests

sars-cov-2 variants

Grants:

K23AI171263 (NIH – National Institute of Allergy and Infectious Diseases)

Publication Type:

Article

Unique ID:

10.1016/j.celrep.2025.115543

PMID:

40202847

DOI:

10.1016/j.celrep.2025.115543

Journal:

Cell Reports

Publication Date:

2025-04-09

Data Source:

PubMed

Source Link:

SARS-CoV-2 omicron BA.2.87.1 exhibits higher susceptibility to serum neutralization than EG.5.1 and JN.1

Record Created:

Monday, May 5, 2025 - 09:26

Wang, Q., Guo, Y., Schwanz, L. T., Mellis, I. A., Sun, Y., Qu, Y., Urtecho, G., Valdez, R., Stoneman, E., Gordon, A., Wang, H. H., Ho, D. D., & Liu, L. (2024). SARS-CoV-2 omicron BA.2.87.1 exhibits higher susceptibility to serum neutralization than EG.5.1 and JN.1. Emerging Microbes & Infections, 13(1). https://doi.org/10.1080/22221751.2024.2359004

Authors:

Qian Wang

Yicheng Guo

Logan T Schwanz

Ian A Mellis

Yiwei Sun

Yiming Qu

Guillaume Urtecho

Riccardo Valdez

Emily Stoneman

Aubree Gordon

Harris H Wang

David D Ho

Lihong Liu

Affiliated Authors:

Qian Wang

Yicheng Guo

Logan T Schwanz

Ian A Mellis

Yiwei Sun

Yiming Qu

Guillaume Urtecho

Harris H Wang

David D Ho

Lihong Liu

Columbia Affiliation:

Subjects:

SARS-CoV-2 (MeSH)

Spike Glycoprotein, Coronavirus (MeSH)

COVID-19 (MeSH)

Antibodies, Neutralizing (MeSH)

Antibodies, Viral (MeSH)

Immune Evasion (MeSH)

Author Keywords:

covid-19

sars-cov-2

eg.5.1

jn.1

ba.2.87.1

polyclonal sera

mrna vaccines

antibody evasion

receptor engagement

viral infectivity

polyclonal sera; mrna vaccines

Grants:

R21HG013161 (NIH – National Human Genome Research Institute)

Publication Type:

Article

Unique ID:

10.1080/22221751.2024.2359004

PMID:

38779718

DOI:

10.1080/22221751.2024.2359004

Journal:

Emerging Microbes and Infections

Publication Date:

2024-12-01

Data Source:

PubMed

Source Link:

Robust SARS-CoV-2-neutralizing antibodies sustained through 6 months post XBB.1.5 mRNA vaccine booster

Record Created:

Monday, August 12, 2024 - 12:03

Wang, Q., Mellis, I. A., Guo, Y., Gherasim, C., Valdez, R., Gordon, A., Ho, D. D., & Liu, L. (2024). Robust SARS-CoV-2-neutralizing antibodies sustained through 6 months post XBB.1.5 mRNA vaccine booster. Cell Reports Medicine, 5(9), 101701. https://doi.org/10.1016/j.xcrm.2024.101701

Authors:

Qian Wang

Ian A Mellis

Yicheng Guo

Carmen Gherasim

Riccardo Valdez

Aubree Gordon

David D Ho

Lihong Liu

Affiliated Authors:

Qian Wang

Ian A Mellis

Yicheng Guo

David D Ho

Columbia Affiliation:

Subjects:

Antibodies, Neutralizing (MeSH)

SARS-CoV-2 (MeSH)

Antibodies, Viral (MeSH)

COVID-19 (MeSH)

COVID-19 Vaccines (MeSH)

Immunization, Secondary (MeSH)

mRNA Vaccines (MeSH)

Author Keywords:

antibody decay rate

covid-19

neutralizing antibody responses

omicron subvariant jn.1

sars-cov-2

xbb.1.5 monovalent mrna vaccine

Publication Type:

Article

Unique ID:

10.1016/j.xcrm.2024.101701

PMID:

39208800

DOI:

10.1016/j.xcrm.2024.101701

Journal:

Cell Reports Medicine

Publication Date:

2024-09-17

Data Source:

PubMed

Source Link:

Functional and structural basis of human parainfluenza virus type 3 neutralization with human monoclonal antibodies

Record Created:

Wednesday, October 2, 2024 - 16:29

Suryadevara, N., Otrelo-Cardoso, A. R., Kose, N., Hu, Y.-X., Binshtein, E., Wolters, R. M., Greninger, A. L., Handal, L. S., Carnahan, R. H., Moscona, A., Jardetzky, T. S., & Crowe, J. E. (2024). Functional and structural basis of human parainfluenza virus type 3 neutralization with human monoclonal antibodies. Nature Microbiology, 9(8), 2128–2143. https://doi.org/10.1038/s41564-024-01722-w

Authors:

Naveenchandra Suryadevara

Ana Rita Otrelo-Cardoso

Nurgun Kose

Yao-Xiong Hu

Elad Binshtein

Rachael M Wolters

Alexander L Greninger

Laura S Handal

Robert H Carnahan

Anne Moscona

Theodore S Jardetzky

James E Crowe

Affiliated Authors:

Anne Moscona

Columbia Affiliation:

Vagelos College of Physicians and Surgeons

Subjects:

Parainfluenza Virus 3, Human (MeSH)

Antibodies, Monoclonal (MeSH)

Antibodies, Neutralizing (MeSH)

Antibodies, Viral (MeSH)

Sigmodontinae (MeSH)

Viral Fusion Proteins (MeSH)

HN Protein (MeSH)

Respirovirus Infections (MeSH)

Grants:

R01AI114736 (NIH – National Institute of Allergy and Infectious Diseases)

U24GM129541 (NIH – National Institute of General Medical Sciences)

K01OD036063 (NIH – Office of the Director, National Institutes of Health)

Publication Type:

Article

Unique ID:

10.1038/s41564-024-01722-w

PMID:

38858594

DOI:

10.1038/s41564-024-01722-w

Journal:

Nature Microbiology

Publication Date:

2024-08-01

Data Source:

PubMed

Source Link:

A neutralizing antibody prevents postfusion transition of measles virus fusion protein

Record Created:

Wednesday, August 14, 2024 - 10:59

Zyla, D. S., Della Marca, R., Niemeyer, G., Zipursky, G., Stearns, K., Leedale, C., Sobolik, E. B., Callaway, H. M., Hariharan, C., Peng, W., Parekh, D., Marcink, T. C., Diaz Avalos, R., Horvat, B., Mathieu, C., Snijder, J., Greninger, A. L., Hastie, K. M., Niewiesk, S., … Ollmann Saphire, E. (2024). A neutralizing antibody prevents postfusion transition of measles virus fusion protein. Science, 384(6703). https://doi.org/10.1126/science.adm8693

Authors:

Dawid S Zyla

Roberta Della Marca

Gele Niemeyer

Gillian Zipursky

Kyle Stearns

Cameron Leedale

Elizabeth B Sobolik

Heather M Callaway

Chitra Hariharan

Weiwei Peng

Diptiben Parekh

Tara C Marcink

Ruben Diaz Avalos

Branka Horvat

Cyrille Mathieu

Joost Snijder

Alexander L Greninger

Kathryn M Hastie

Stefan Niewiesk

Anne Moscona

Matteo Porotto

Erica Ollmann Saphire

Affiliated Authors:

Roberta Della Marca

Gillian Zipursky

Kyle Stearns

Tara C Marcink

Anne Moscona

Matteo Porotto

Columbia Affiliation:

Vagelos College of Physicians and Surgeons

Subjects:

Antibodies, Neutralizing (MeSH)

Measles virus (MeSH)

Cryoelectron Microscopy (MeSH)

Viral Fusion Proteins (MeSH)

Antibodies, Monoclonal (MeSH)

Antibodies, Viral (MeSH)

Publication Type:

Article

Unique ID:

10.1126/science.adm8693

PMID:

38935733

DOI:

10.1126/science.adm8693

Journal:

Science

Publication Date:

2024-06-28

Data Source:

PubMed

Source Link:

Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody

Record Created:

Wednesday, August 14, 2024 - 10:52

Olia, A. S., Prabhakaran, M., Harris, D. R., Cheung, C. S.-F., Gillespie, R. A., Gorman, J., Hoover, A., Morano, N. C., Ourahmane, A., Srikanth, A., Wang, S., Wu, W., Zhou, T., Andrews, S. F., Kanekiyo, M., Shapiro, L., McDermott, A. B., & Kwong, P. D. (2024). Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1399960

Authors:

Adam S Olia

Madhu Prabhakaran

Darcy R Harris

Crystal Sao-Fong Cheung

Rebecca A Gillespie

Jason Gorman

Abigayle Hoover

Nicholas C Morano

Amine Ourahmane

Abhinaya Srikanth

Shuishu Wang

Weiwei Wu

Tongqing Zhou

Sarah F Andrews

Masaru Kanekiyo

Lawrence Shapiro

Adrian B McDermott

Peter D Kwong

Affiliated Authors:

Nicholas C Morano

Lawrence Shapiro

Peter D Kwong

Columbia Affiliation:

Subjects:

Influenza A virus (MeSH)

Antibodies, Viral (MeSH)

Antibodies, Neutralizing (MeSH)

Antibodies, Anti-Idiotypic (MeSH)

Hemagglutinin Glycoproteins, Influenza Virus (MeSH)

Author Keywords:

anti-idiotype

broadly neutralizing antibody

cryo-em

influenza a virus

medi8852

vh6-1 class

Grants:

ZIAAI005143 (NIH – National Institute of Allergy and Infectious Diseases)

ZIAAI005024 (NIH – National Institute of Allergy and Infectious Diseases)

ZIAAI005003 (NIH – National Institute of Allergy and Infectious Diseases)

ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)

Publication Type:

Article

Unique ID:

10.3389/fimmu.2024.1399960

PMID:

38873606

DOI:

10.3389/fimmu.2024.1399960

Journal:

Frontiers in Immunology

Publication Date:

2024-06-14

Data Source:

PubMed

Source Link:

Seasonal human coronavirus humoral responses in AZD1222 (ChaAdOx1 nCoV-19) COVID-19 vaccinated adults reveal limited cross-immunity

Record Created:

Friday, July 26, 2024 - 09:49

Stanley, A. M., Aksyuk, A. A., Wilkins, D., Green, J. A., Lan, D., Shoemaker, K., Tieu, H.-V., Sobieszczyk, M. E., Falsey, A. R., & Kelly, E. J. (2024). Seasonal human coronavirus humoral responses in AZD1222 (ChaAdOx1 nCoV-19) COVID-19 vaccinated adults reveal limited cross-immunity. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1401728

Authors:

Ann Marie Stanley

Anastasia A Aksyuk

Deidre Wilkins

Justin A Green

Dongmei Lan

Kathryn Shoemaker

Hong-Van Tieu

Magdalena E Sobieszczyk

Ann R Falsey

Elizabeth J Kelly

Affiliated Authors:

Hong-Van Tieu

Magdalena E Sobieszczyk

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Medicine
  Division of Infectious Diseases

Subjects:

COVID-19 (MeSH)

ChAdOx1 nCoV-19 (MeSH)

Antibodies, Viral (MeSH)

SARS-CoV-2 (MeSH)

COVID-19 Vaccines (MeSH)

Immunity, Humoral (MeSH)

Author Keywords:

azd1222 (chaadox1 ncov-19)

seasonal coronavirus

human coronaviruses

cross-immunity

sars-cov-2

covid-19

humoral responses

covid-19 vaccination

Grants:

UM1AI148450 (NIH – National Institute of Allergy and Infectious Diseases)

UM1AI148684 (NIH – National Institute of Allergy and Infectious Diseases)

U01AI069470 (NIH – National Institute of Allergy and Infectious Diseases)

UM1AI069470 (NIH – National Institute of Allergy and Infectious Diseases)

Publication Type:

Article

Unique ID:

10.3389/fimmu.2024.1401728

PMID:

38827749

DOI:

10.3389/fimmu.2024.1401728

Journal:

Frontiers in Immunology

Publication Date:

2024-06-03

Data Source:

PubMed

Source Link:

Human neutralizing antibodies target a conserved lateral patch on H7N9 hemagglutinin head

Record Created:

Friday, July 26, 2024 - 09:49

Jia, M., Zhao, H., Morano, N. C., Lu, H., Lui, Y.-M., Du, H., Becker, J. E., Yuen, K.-Y., Ho, D. D., Kwong, P. D., Shapiro, L., To, K. K.-W., & Wu, X. (2024). Human neutralizing antibodies target a conserved lateral patch on H7N9 hemagglutinin head. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-48758-4

Authors:

Manxue Jia

Hanjun Zhao

Nicholas C Morano

Hong Lu

Yin-Ming Lui

Haijuan Du

Jordan E Becker

Kwok-Yung Yuen

David D Ho

Peter D Kwong

Lawrence Shapiro

Kelvin Kai-Wang To

Xueling Wu

Affiliated Authors:

Manxue Jia

Nicholas C Morano

Hong Lu

Jordan E Becker

David D Ho

Peter D Kwong

Lawrence Shapiro

Xueling Wu

Columbia Affiliation:

Subjects:

Influenza A Virus, H7N9 Subtype (MeSH)

Antibodies, Neutralizing (MeSH)

Hemagglutinin Glycoproteins, Influenza Virus (MeSH)

Influenza, Human (MeSH)

Antibodies, Viral (MeSH)

Antibodies, Monoclonal (MeSH)

Grants:

ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)

Publication Type:

Article

Unique ID:

10.1038/s41467-024-48758-4

PMID:

38802413

DOI:

10.1038/s41467-024-48758-4

Journal:

Nature Communications

Publication Date:

2024-05-27

Data Source:

PubMed

Source Link:

Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants

Record Created:

Monday, August 12, 2024 - 12:01

Wang, Q., Iketani, S., Li, Z., Liu, L., Guo, Y., Huang, Y., Bowen, A. D., Liu, M., Wang, M., Yu, J., Valdez, R., Lauring, A. S., Sheng, Z., Wang, H. H., Gordon, A., Liu, L., & Ho, D. D. (2023). Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants. Cell, 186(2), 279-286.e8. https://doi.org/10.1016/j.cell.2022.12.018

Authors:

Qian Wang

Sho Iketani

Zhiteng Li

Liyuan Liu

Yicheng Guo

Yiming Huang

Anthony D Bowen

Michael Liu

Maple Wang

Jian Yu

Riccardo Valdez

Adam S Lauring

Zizhang Sheng

Harris H Wang

Aubree Gordon

Lihong Liu

David D Ho

Affiliated Authors:

Qian Wang

Sho Iketani

Zhiteng Li

Liyuan Liu

Yicheng Guo

Yiming Huang

Anthony D Bowen

Michael Liu

Maple Wang

Jian Yu

Zizhang Sheng

Harris H Wang

Lihong Liu

David D Ho

Columbia Affiliation:

Subjects:

Antibodies, Viral (MeSH)

COVID-19 (MeSH)

SARS-CoV-2 (MeSH)

Immune Evasion (MeSH)

Author Keywords:

antibody evasion

bq.1

bq.1.1

covid-19

mrna vaccine

neutralizing monoclonal antibody

receptor binding affinity

sars-cov-2

xbb

xbb.1

Grants:

UM1AI069470 (NIH – National Institute of Allergy and Infectious Diseases)

T32AI100852 (NIH – National Institute of Allergy and Infectious Diseases)

Publication Type:

Article

Unique ID:

10.1016/j.cell.2022.12.018

PMID:

36580913

DOI:

10.1016/j.cell.2022.12.018

Journal:

Cell

Publication Date:

2023-01-19

Data Source:

PubMed

Source Link:

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

Record Created:

Friday, August 16, 2024 - 12:56

Wang, P., Casner, R. G., Nair, M. S., Yu, J., Guo, Y., Wang, M., Chan, J. F.-W., Cerutti, G., Iketani, S., Liu, L., Sheng, Z., Chen, Z., Yuen, K.-Y., Kwong, P. D., Huang, Y., Shapiro, L., & Ho, D. D. (2021). A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses. Emerging Microbes & Infections, 11(1), 147–157. https://doi.org/10.1080/22221751.2021.2011623

Authors:

Pengfei Wang

Ryan G Casner

Manoj S Nair

Jian Yu

Yicheng Guo

Maple Wang

Jasper F-W Chan

Gabriele Cerutti

Sho Iketani

Lihong Liu

Zizhang Sheng

Zhiwei Chen

Kwok-Yung Yuen

Peter D Kwong

Yaoxing Huang

Lawrence Shapiro

David D Ho

Affiliated Authors:

Pengfei Wang

Ryan G Casner

Manoj S Nair

Jian Yu

Yicheng Guo

Maple Wang

Gabriele Cerutti

Sho Iketani

Lihong Liu

Zizhang Sheng

Peter D Kwong

Yaoxing Huang

Lawrence Shapiro

David D Ho

Columbia Affiliation:

Subjects:

Coronavirus Disease 2019 Research (OpenAlex Topic)

Viral Diseases in Livestock and Poultry (OpenAlex Topic)

Gastrointestinal Viral Infections and Vaccines Development (OpenAlex Topic)

Antibodies, Monoclonal (MeSH)

Antibodies, Neutralizing (MeSH)

Antibodies, Viral (MeSH)

SARS-CoV-2 (MeSH)

Author Keywords:

sars-cov-2

antibody

variants

sarbecovirus

sars-cov

Grants:

T32AI106711 (NIH – National Institute of Allergy and Infectious Diseases)

ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)

ZIAAI005149 (NIH – National Institute of Allergy and Infectious Diseases)

T32GM008224 (NIH – National Institute of General Medical Sciences)

Publication Type:

Article

Unique ID:

10.1080/22221751.2021.2011623

PMID:

34836485

DOI:

10.1080/22221751.2021.2011623

Journal:

Emerging Microbes and Infections

Publication Date:

2022-12-01

Data Source:

PubMed

Source Link:

Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5

Record Created:

Friday, September 6, 2024 - 14:52

Wang, Q., Guo, Y., Iketani, S., Nair, M. S., Li, Z., Mohri, H., Wang, M., Yu, J., Bowen, A. D., Chang, J. Y., Shah, J. G., Nguyen, N., Chen, Z., Meyers, K., Yin, M. T., Sobieszczyk, M. E., Sheng, Z., Huang, Y., Liu, L., & Ho, D. D. (2022). Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5. Nature, 608(7923), 603–608. https://doi.org/10.1038/s41586-022-05053-w

Authors:

Qian Wang

Yicheng Guo

Sho Iketani

Manoj S. Nair

Zhiteng Li

Hiroshi Mohri

Maple Wang

Jian Yu

Anthony D. Bowen

Jennifer Y. Chang

Jayesh G. Shah

Nadia Nguyen

Zhiwei Chen

Kathrine Meyers

Michael T. Yin

Magdalena E. Sobieszczyk

Zizhang Sheng

Yaoxing Huang

Lihong Liu

David D. Ho

Affiliated Authors:

Qian Wang

Yicheng Guo

Sho Iketani

Manoj S. Nair

Zhiteng Li

Hiroshi Mohri

Maple Wang

Jian Yu

Anthony D. Bowen

Jennifer Y. Chang

Jayesh G. Shah

Nadia Nguyen

Kathrine Meyers

Michael T. Yin

Magdalena E. Sobieszczyk

Zizhang Sheng

Yaoxing Huang

Lihong Liu

David D. Ho

Columbia Affiliation:

Subjects:

Antibodies, Viral (MeSH)

Antigenic Drift and Shift (MeSH)

COVID-19 (MeSH)

Mutation (MeSH)

SARS-CoV-2 (MeSH)

Grants:

T32AI100852 (NIH – National Institute of Allergy and Infectious Diseases)

Publication Type:

Article

Unique ID:

10.1038/s41586-022-05053-w

PMID:

35790190

DOI:

10.1038/s41586-022-05053-w

Journal:

Publication Date:

2022-08-18

Data Source:

Scopus

Source Link:

Omicron infection enhances Delta antibody immunity in vaccinated persons

Record Created:

Thursday, December 12, 2024 - 15:23

Khan, K., Karim, F., Cele, S., Reedoy, K., San, J. E., Lustig, G., Tegally, H., Rosenberg, Y., Bernstein, M., Jule, Z., Ganga, Y., Ngcobo, N., Mazibuko, M., Mthabela, N., Mhlane, Z., Mbatha, N., Miya, Y., Giandhari, J., Ramphal, Y., … Sigal, A. (2022). Omicron infection enhances Delta antibody immunity in vaccinated persons. Nature, 607(7918), 356–359. https://doi.org/10.1038/s41586-022-04830-x

Authors:

Khadija Khan

Farina Karim

Sandile Cele

Kajal Reedoy

James Emmanuel San

Gila Lustig

Houriiyah Tegally

Yuval Rosenberg

Mallory Bernstein

Zesuliwe Jule

Yashica Ganga

Nokuthula Ngcobo

Matilda Mazibuko

Ntombifuthi Mthabela

Zoey Mhlane

Nikiwe Mbatha

Yoliswa Miya

Jennifer Giandhari

Yajna Ramphal

Taryn Naidoo

Aida Sivro

Natasha Samsunder

Ayesha B. M. Kharsany

Daniel Amoako

Jinal N. Bhiman

Nithendra Manickchund

Quarraisha Abdool Karim

Nombulelo Magula

Salim S. Abdool Karim

Glenda Gray

Willem Hanekom

Anne von Gottberg

Rohen Harrichandparsad

Kobus Herbst

Prakash Jeena

Thandeka Khoza

Henrik Kløverpris

Alasdair Leslie

Rajhmun Madansein

Mohlopheni Marakalala

Mosa Moshabela

Kogie Naidoo

Zaza Ndhlovu

Thumbi Ndung’u

Kennedy Nyamande

Vinod Patel

Theresa Smit

Adrie Steyn

Emily Wong

Ron Milo

Bernadett I. Gosnell

Richard J. Lessells

Penny L. Moore

Tulio de Oliveira

Mahomed-Yunus S. Moosa

Alex Sigal

Affiliated Authors:

Quarraisha Abdool Karim

Salim S. Abdool Karim

Columbia Affiliation:

Mailman School of Public Health
- Department of Epidemiology

Subjects:

Antibodies, Neutralizing (MeSH)

Antibodies, Viral (MeSH)

COVID-19 (MeSH)

COVID-19 Vaccines (MeSH)

Cross Protection (MeSH)

SARS-CoV-2 (MeSH)

Vaccination (MeSH)

Grants:

R01AI138546 (NIH – National Institute of Allergy and Infectious Diseases)

Publication Type:

Article

Unique ID:

10.1038/s41586-022-04830-x

PMID:

35523247

DOI:

10.1038/s41586-022-04830-x

Journal:

Publication Date:

2022-07-14

Data Source:

Scopus

Source Link:

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

Record Created:

Thursday, December 19, 2024 - 08:49

Cele, S., Jackson, L., Khoury, D. S., Khan, K., Moyo-Gwete, T., Tegally, H., San, J. E., Cromer, D., Scheepers, C., Amoako, D. G., Karim, F., Bernstein, M., Lustig, G., Archary, D., Smith, M., Ganga, Y., Jule, Z., Reedoy, K., Hwa, S.-H., … Sigal, A. (2021). Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization. Nature, 602(7898), 654–656. https://doi.org/10.1038/s41586-021-04387-1

Authors:

Sandile Cele

Laurelle Jackson

David S. Khoury

Khadija Khan

Thandeka Moyo-Gwete

Houriiyah Tegally

James Emmanuel San

Deborah Cromer

Cathrine Scheepers

Daniel G. Amoako

Farina Karim

Mallory Bernstein

Gila Lustig

Derseree Archary

Muneerah Smith

Yashica Ganga

Zesuliwe Jule

Kajal Reedoy

Shi-Hsia Hwa

Jennifer Giandhari

Jonathan M. Blackburn

Bernadett I. Gosnell

Salim S. Abdool Karim

Willem Hanekom

Mary-Ann Davies

Marvin Hsiao

Darren Martin

Koleka Mlisana

Constantinos Kurt Wibmer

Carolyn Williamson

Denis York

Rohen Harrichandparsad

Kobus Herbst

Prakash Jeena

Thandeka Khoza

Henrik Kløverpris

Alasdair Leslie

Rajhmun Madansein

Nombulelo Magula

Nithendra Manickchund

Mohlopheni Marakalala

Matilda Mazibuko

Mosa Moshabela

Ntombifuthi Mthabela

Kogie Naidoo

Zaza Ndhlovu

Thumbi Ndung’u

Nokuthula Ngcobo

Kennedy Nyamande

Vinod Patel

Theresa Smit

Adrie Steyn

Emily Wong

Anne von Gottberg

Jinal N. Bhiman

Richard J. Lessells

Mahomed-Yunus S. Moosa

Miles P. Davenport

Tulio de Oliveira

Penny L. Moore

Alex Sigal

Affiliated Authors:

Salim S. Abdool Karim

Columbia Affiliation:

Mailman School of Public Health
- Department of Epidemiology

Subjects:

Antibodies, Neutralizing (MeSH)

Antibodies, Viral (MeSH)

BNT162 Vaccine (MeSH)

Immune Evasion (MeSH)

Neutralization Tests (MeSH)

SARS-CoV-2 (MeSH)

Grants:

R01AI138546 (NIH – National Institute of Allergy and Infectious Diseases)

Publication Type:

Article

Unique ID:

10.1038/s41586-021-04387-1

PMID:

35016196

DOI:

10.1038/s41586-021-04387-1

Journal:

Publication Date:

2022-02-24

Data Source:

Scopus

Source Link:

Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2

Record Created:

Tuesday, February 18, 2025 - 11:21

Liu, L., Iketani, S., Guo, Y., Chan, J. F.-W., Wang, M., Liu, L., Luo, Y., Chu, H., Huang, Y., Nair, M. S., Yu, J., Chik, K. K.-H., Yuen, T. T.-T., Yoon, C., To, K. K.-W., Chen, H., Yin, M. T., Sobieszczyk, M. E., Huang, Y., … Ho, D. D. (2021). Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2. Nature, 602(7898), 676–681. https://doi.org/10.1038/s41586-021-04388-0

Authors:

Lihong Liu

Sho Iketani

Yicheng Guo

Jasper F.-W. Chan

Maple Wang

Liyuan Liu

Yang Luo

Hin Chu

Yiming Huang

Manoj S. Nair

Jian Yu

Kenn K.-H. Chik

Terrence T.-T. Yuen

Chaemin Yoon

Kelvin K.-W. To

Honglin Chen

Michael T. Yin

Magdalena E. Sobieszczyk

Yaoxing Huang

Harris H. Wang

Zizhang Sheng

Kwok-Yung Yuen

David D. Ho

Affiliated Authors:

Lihong Liu

Sho Iketani

Yicheng Guo

Maple Wang

Liyuan Liu

Yang Luo

Yiming Huang

Manoj S. Nair

Jian Yu

Michael T. Yin

Magdalena E. Sobieszczyk

Yaoxing Huang

Harris H. Wang

Zizhang Sheng

David D. Ho

Columbia Affiliation:

Subjects:

Antibodies, Neutralizing (MeSH)

Antibodies, Viral (MeSH)

COVID-19 (MeSH)

Immune Evasion (MeSH)

SARS-CoV-2 (MeSH)

Grants:

T32AI106711 (NIH – National Institute of Allergy and Infectious Diseases)

Publication Type:

Article

Unique ID:

10.1038/s41586-021-04388-0

PMID:

35016198

DOI:

10.1038/s41586-021-04388-0

Journal:

Publication Date:

2022-02-24

Data Source:

Scopus

Source Link:

Pre-Existing Cross-Reactive Antibody Responses Do Not Significantly Impact Inactivated COVID-19 Vaccine-Induced Neutralization

Record Created:

Tuesday, February 18, 2025 - 11:21

Wang, J., Guo, C., Cai, L., Liao, C., Yi, H., Li, Q., Hu, H., Deng, Q., Lu, Y., Guo, Z., Chen, Z., & Lu, J. (2021). Pre-Existing Cross-Reactive Antibody Responses Do Not Significantly Impact Inactivated COVID-19 Vaccine-Induced Neutralization. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.772511

Authors:

Jin Wang

Cheng Guo

Lin Cai

Conghui Liao

Huaimin Yi

Qianlin Li

Huan Hu

Qiang Deng

Yuying Lu

Zhongmin Guo

Zeliang Chen

Jiahai Lu

Affiliated Authors:

Cheng Guo

Columbia Affiliation:

Subjects:

Antibodies, Viral (MeSH)

COVID-19 (MeSH)

COVID-19 Vaccines (MeSH)

Cross Reactions (MeSH)

SARS-CoV-2 (MeSH)

Author Keywords:

sars-cov-2

seasonal coronavirus

inactivated vaccine

neutralization

cross-reactive antibody immunity

Publication Type:

Article

Unique ID:

10.3389/fimmu.2021.772511

PMID:

34868035

DOI:

10.3389/fimmu.2021.772511

Journal:

Frontiers in Immunology

Publication Date:

2021-12-07

Data Source:

PubMed

Source Link:

SARS-CoV-2 infection generates tissue-localized immunological memory in humans

Record Created:

Monday, April 28, 2025 - 12:41

Poon, M. M. L., Rybkina, K., Kato, Y., Kubota, M., Matsumoto, R., Bloom, N. I., Zhang, Z., Hastie, K. M., Grifoni, A., Weiskopf, D., Wells, S. B., Ural, B. B., Lam, N., Szabo, P. A., Dogra, P., Lee, Y. S., Gray, J. I., Bradley, M. C., Brusko, M. A., … Farber, D. L. (2021). SARS-CoV-2 infection generates tissue-localized immunological memory in humans. Science Immunology, 6(65). https://doi.org/10.1126/sciimmunol.abl9105

Authors:

Maya M.L. Poon

Ksenia Rybkina

Yu Kato

Masaru Kubota

Rei Matsumoto

Nathaniel I. Bloom

Zeli Zhang

Kathryn M. Hastie

Alba Grifoni

Daniela Weiskopf

Steven B. Wells

Basak B. Ural

Nora Lam

Peter A. Szabo

Pranay Dogra

Yoon S. Lee

Joshua I. Gray

Marissa C. Bradley

Maigan A. Brusko

Todd M. Brusko

Erica O. Saphire

Thomas J. Connors

Alessandro Sette

Shane Crotty

Donna L. Farber

Affiliated Authors:

Maya M.L. Poon

Ksenia Rybkina

Masaru Kubota

Rei Matsumoto

Steven B. Wells

Basak B. Ural

Nora Lam

Peter A. Szabo

Pranay Dogra

Yoon S. Lee

Joshua I. Gray

Marissa C. Bradley

Thomas J. Connors

Donna L. Farber

Columbia Affiliation:

Vagelos College of Physicians and Surgeons

Subjects:

Coronavirus Disease 2019 Research (OpenAlex Topic)

Neurological Manifestations of COVID-19 Infection (OpenAlex Topic)

Trained Immunity in Health and Disease (OpenAlex Topic)

Antibodies, Viral (MeSH)

COVID-19 (MeSH)

Immunity, Cellular (MeSH)

Immunologic Memory (MeSH)

Lymphocytes (MeSH)

SARS-CoV-2 (MeSH)

Grants:

S10RR027050 (NIH – National Center for Research Resources)

U01HL145547 (NIH – National Heart, Lung, and Blood Institute)

K23AI141686 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI100119 (NIH – National Institute of Allergy and Infectious Diseases)

U19AI142742 (NIH – National Institute of Allergy and Infectious Diseases)

U19AI128949 (NIH – National Institute of Allergy and Infectious Diseases)

P01AI106697 (NIH – National Institute of Allergy and Infectious Diseases)

U01AI100119 (NIH – National Institute of Allergy and Infectious Diseases)

S10OD020056 (NIH – Office of the Director, National Institutes of Health)

Publication Type:

Article

Unique ID:

10.1126/sciimmunol.abl9105

PMID:

34618554

DOI:

10.1126/sciimmunol.abl9105

Journal:

Science Immunology

Publication Date:

2021-11-01

Data Source:

Scopus

Source Link:

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study

Record Created:

Thursday, May 8, 2025 - 11:41

Hastie, K. M., Li, H., Bedinger, D., Schendel, S. L., Dennison, S. M., Li, K., Rayaprolu, V., Yu, X., Mann, C., Zandonatti, M., Diaz Avalos, R., Zyla, D., Buck, T., Hui, S., Shaffer, K., Hariharan, C., Yin, J., Olmedillas, E., Enriquez, A., … Saphire, E. O. (2021). Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study. Science, 374(6566), 472–478. https://doi.org/10.1126/science.abh2315

Authors:

Kathryn M. Hastie

Haoyang Li

Daniel Bedinger

Sharon L. Schendel

S. Moses Dennison

Kan Li

Vamseedhar Rayaprolu

Xiaoying Yu

Colin Mann

Michelle Zandonatti

Ruben Diaz Avalos

Dawid Zyla

Tierra Buck

Sean Hui

Kelly Shaffer

Chitra Hariharan

Jieyun Yin

Eduardo Olmedillas

Adrian Enriquez

Diptiben Parekh

Milite Abraha

Elizabeth Feeney

Gillian Q. Horn

Yoann Aldon

Hanif Ali

Sanja Aracic

Ronald R. Cobb

Ross S. Federman

Joseph M. Fernandez

Jacob Glanville

Robin Green

Gevorg Grigoryan

Ana G. Lujan Hernandez

David D. Ho

Kuan-Ying A. Huang

John Ingraham

Weidong Jiang

Paul Kellam

Cheolmin Kim

Minsoo Kim

Hyeong Mi Kim

Chao Kong

Shelly J. Krebs

Fei Lan

Guojun Lang

Sooyoung Lee

Cheuk Lun Leung

Junli Liu

Yanan Lu

Anna MacCamy

Andrew T. McGuire

Anne L. Palser

Terence H. Rabbitts

Zahra Rikhtegaran Tehrani

Mohammad M. Sajadi

Rogier W. Sanders

Aaron K. Sato

Liang Schweizer

Jimin Seo

Bingqing Shen

Jonne L. Snitselaar

Leonidas Stamatatos

Yongcong Tan

Milan T. Tomic

Marit J. van Gils

Sawsan Youssef

Jian Yu

Tom Z. Yuan

Qian Zhang

Bjoern Peters

Georgia D. Tomaras

Timothy Germann

Erica Ollmann Saphire

Affiliated Authors:

David D. Ho

Jian Yu

Columbia Affiliation:

Subjects:

Antibodies, Neutralizing (MeSH)

Antibodies, Viral (MeSH)

Epitope Mapping (MeSH)

Immunodominant Epitopes (MeSH)

SARS-CoV-2 (MeSH)

Spike Glycoprotein, Coronavirus (MeSH)

Publication Type:

Article

Unique ID:

10.1126/science.abh2315

PMID:

34554826

DOI:

10.1126/science.abh2315

Journal:

Science

Publication Date:

2021-10-22

Data Source:

Scopus

Source Link:

Rapid and Flexible Platform To Assess Anti-SARS-CoV-2 Antibody Neutralization and Spike Protein-Specific Antivirals

Record Created:

Friday, May 23, 2025 - 11:16

Stelitano, D., Weisberg, S. P., Goldklang, M. P., Zhu, Y., Bovier, F. T., Kalantarov, G. F., Greco, G., Decimo, D., Franci, G., Cennamo, M., Portella, G., Galdiero, M., Mathieu, C., Horvat, B., Trakht, I. N., Moscona, A., Whitt, M. A., & Porotto, M. (2021). Rapid and Flexible Platform To Assess Anti-SARS-CoV-2 Antibody Neutralization and Spike Protein-Specific Antivirals. MSphere, 6(4). https://doi.org/10.1128/msphere.00571-21

Authors:

Debora Stelitano

Stuart P. Weisberg

Monica P. Goldklang

Yun Zhu

Francesca T. Bovier

Gavreel F. Kalantarov

Giuseppe Greco

Didier Decimo

Gianluigi Franci

Michele Cennamo

Giuseppe Portella

Massimiliano Galdiero

Cyrille Mathieu

Branka Horvat

Ilya N. Trakht

Anne Moscona

Michael A. Whitt

Matteo Porottoa

Affiliated Authors:

Debora Stelitano

Stuart P. Weisberg

Monica P. Goldklang

Yun Zhu

Francesca T. Bovier

Gavreel F. Kalantarov

Ilya N. Trakht

Anne Moscona

Matteo Porottoa

Columbia Affiliation:

Vagelos College of Physicians and Surgeons

Subjects:

Antibodies, Neutralizing (MeSH)

Antibodies, Viral (MeSH)

Antiviral Agents (MeSH)

COVID-19 (MeSH)

SARS-CoV-2 (MeSH)

Spike Glycoprotein, Coronavirus (MeSH)

Author Keywords:

sars-cov-2

spike protein

immunity

Grants:

R01AI121349 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI119762 (NIH – National Institute of Allergy and Infectious Diseases)

R56AI119762 (NIH – National Institute of Allergy and Infectious Diseases)

R56AI146980 (NIH – National Institute of Allergy and Infectious Diseases)

R01NS105699 (NIH – National Institute of Neurological Disorders and Stroke)

Publication Type:

Article

Unique ID:

10.1128/mSphere.00571-21

PMID:

34319126

DOI:

10.1128/mSphere.00571-21

Journal:

MSphere

Publication Date:

2021-08-01

Data Source:

Scopus

Source Link:

SARS-CoV-2 Transmission Risk among National Basketball Association Players, Staff, and Vendors Exposed to Individuals with Positive Test Results after COVID-19 Recovery during the 2020 Regular and Postseason

Record Created:

Tuesday, June 24, 2025 - 11:05

Mack, C. D., DiFiori, J., Tai, C. G., Shiue, K. Y., Grad, Y. H., Anderson, D. J., Ho, D. D., Sims, L., LeMay, C., Mancell, J., & Maragakis, L. L. (2021). SARS-CoV-2 Transmission Risk Among National Basketball Association Players, Staff, and Vendors Exposed to Individuals With Positive Test Results After COVID-19 Recovery During the 2020 Regular and Postseason. JAMA Internal Medicine. https://doi.org/10.1001/jamainternmed.2021.2114

Authors:

Christina D. Mack

John Difiori

Caroline G. Tai

Kristin Y. Shiue

Yonatan H. Grad

Deverick J. Anderson

David D. Ho

Leroy Sims

Christopher Lemay

Jimmie Mancell

Lisa L Maragakis

Affiliated Authors:

David D. Ho

Columbia Affiliation:

Subjects:

Antibodies, Viral (MeSH)

Basketball (MeSH)

COVID-19 (MeSH)

Disease Transmission, Infectious (MeSH)

Pandemics (MeSH)

SARS-CoV-2 (MeSH)

Publication Type:

Article

Unique ID:

10.1001/jamainternmed.2021.2114

PMID:

33885715

DOI:

10.1001/jamainternmed.2021.2114

Journal:

JAMA Internal Medicine

Publication Date:

2021-07-01

Data Source:

Scopus

Source Link:

Structural basis for accommodation of emerging B.1.351 and B.1.1.7 variants by two potent SARS-CoV-2 neutralizing antibodies

Record Created:

Thursday, July 10, 2025 - 15:07

Cerutti, G., Rapp, M., Guo, Y., Bahna, F., Bimela, J., Reddem, E. R., Yu, J., Wang, P., Liu, L., Huang, Y., Ho, D. D., Kwong, P. D., Sheng, Z., & Shapiro, L. (2021). Structural basis for accommodation of emerging B.1.351 and B.1.1.7 variants by two potent SARS-CoV-2 neutralizing antibodies. Structure, 29(7), 655-663.e4. https://doi.org/10.1016/j.str.2021.05.014

Authors:

Gabriele Cerutti

Micah Rapp

Yicheng Guo

Fabiana Bahna

Jude Bimela

Eswar R. Reddem

Jian Yu

Pengfei Wang

Lihong Liu

Yaoxing Huang

David D. Ho

Peter D. Kwong

Zizhang Sheng

Lawrence Shapiro

Affiliated Authors:

Gabriele Cerutti

Micah Rapp

Yicheng Guo

Fabiana Bahna

Jude Bimela

Eswar R. Reddem

Jian Yu

Pengfei Wang

Lihong Liu

Yaoxing Huang

David D. Ho

Peter D. Kwong

Zizhang Sheng

Lawrence Shapiro

Columbia Affiliation:

Subjects:

Angiotensin-Converting Enzyme 2 (MeSH)

Antibodies, Monoclonal (MeSH)

Antibodies, Neutralizing (MeSH)

Antibodies, Viral (MeSH)

Receptors, Virus (MeSH)

SARS-CoV-2 (MeSH)

Spike Glycoprotein, Coronavirus (MeSH)

Author Keywords:

b.1.351 and b.1.1.7 variants

covid-19

sars-cov-2

cryo-em

low-frequency immune response

neutralizing antibody

receptor-binding domain

Grants:

R21AI143407 (NIH – National Institute of Allergy and Infectious Diseases)

ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)

R21AI144408 (NIH – National Institute of Allergy and Infectious Diseases)

U24GM129539 (NIH – National Institute of General Medical Sciences)

DP5OD023118 (NIH – Office of the Director, National Institutes of Health)

Publication Type:

Article

Unique ID:

10.1016/j.str.2021.05.014

PMID:

34111408

DOI:

10.1016/j.str.2021.05.014

Journal:

Structure

Publication Date:

2021-07-01

Data Source:

Scopus

Source Link:

Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7

Record Created:

Thursday, July 10, 2025 - 15:07

Wang, P., Nair, M. S., Liu, L., Iketani, S., Luo, Y., Guo, Y., Wang, M., Yu, J., Zhang, B., Kwong, P. D., Graham, B. S., Mascola, J. R., Chang, J. Y., Yin, M. T., Sobieszczyk, M., Kyratsous, C. A., Shapiro, L., Sheng, Z., Huang, Y., & Ho, D. D. (2021). Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7. Nature, 593(7857), 130–135. https://doi.org/10.1038/s41586-021-03398-2

Authors:

Pengfei Wang

Manoj S. Nair

Lihong Liu

Sho Iketani

Yang Luo

Yicheng Guo

Maple Wang

Jian Yu

Baoshan Zhang

Peter D. Kwong

Barney S. Graham

John R. Mascola

Jennifer Y. Chang

Michael T. Yin

Magdalena Sobieszczyk

Christos A. Kyratsous

Lawrence Shapiro

Zizhang Sheng

Yaoxing Huang

David D. Ho

Affiliated Authors:

Pengfei Wang

Manoj S. Nair

Lihong Liu

Sho Iketani

Yang Luo

Yicheng Guo

Maple Wang

Jian Yu

Peter D. Kwong

Jennifer Y. Chang

Michael T. Yin

Magdalena Sobieszczyk

Lawrence Shapiro

Zizhang Sheng

Yaoxing Huang

David D. Ho

Columbia Affiliation:

Subjects:

Coronavirus Disease 2019 Research (OpenAlex Topic)

Coronavirus Disease 2019 (OpenAlex Topic)

Diagnostic Methods for COVID-19 Detection (OpenAlex Topic)

Antibodies, Neutralizing (MeSH)

Antibodies, Viral (MeSH)

COVID-19 (MeSH)

COVID-19 Vaccines (MeSH)

Immune Evasion (MeSH)

SARS-CoV-2 (MeSH)

Spike Glycoprotein, Coronavirus (MeSH)

Grants:

ZIAAI005023 (NIH – National Institute of Allergy and Infectious Diseases)

Publication Type:

Article

Unique ID:

10.1038/s41586-021-03398-2

PMID:

33684923

DOI:

10.1038/s41586-021-03398-2

Journal:

Publication Date:

2021-05-06

Data Source:

Scopus

Source Link:

Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization

Record Created:

Thursday, July 24, 2025 - 08:29

Wang, P., Casner, R. G., Nair, M. S., Wang, M., Yu, J., Cerutti, G., Liu, L., Kwong, P. D., Huang, Y., Shapiro, L., & Ho, D. D. (2021). Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization. Cell Host & Microbe, 29(5), 747-751.e4. https://doi.org/10.1016/j.chom.2021.04.007

Authors:

Pengfei Wang

Ryan G Casner

Manoj S Nair

Maple Wang

Jian Yu

Gabriele Cerutti

Lihong Liu

Peter D Kwong

Yaoxing Huang

Lawrence Shapiro

David D Ho

Affiliated Authors:

Pengfei Wang

Ryan G Casner

Manoj S Nair

Maple Wang

Jian Yu

Gabriele Cerutti

Lihong Liu

Peter D Kwong

Yaoxing Huang

Lawrence Shapiro

David D Ho

Columbia Affiliation:

Subjects:

Coronavirus Disease 2019 Research (OpenAlex Topic)

Diagnostic Methods for COVID-19 Detection (OpenAlex Topic)

Coronavirus Disease 2019 (OpenAlex Topic)

Antibodies, Neutralizing (MeSH)

Antibodies, Viral (MeSH)

SARS-CoV-2 (MeSH)

Author Keywords:

antibody

convalescent plasma

mutation

neutralization

ntd

p.1

rbd

sars-cov-2

vaccine

variant

Grants:

ZIAAI005023 (NIH – National Institute of Allergy and Infectious Diseases)

Publication Type:

Article

Unique ID:

10.1016/j.chom.2021.04.007

PMID:

33887205

DOI:

10.1016/j.chom.2021.04.007

Journal:

Cell Host and Microbe

Publication Date:

2021-04-23

Data Source:

PubMed

Source Link:

Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies

Record Created:

Tuesday, July 22, 2025 - 10:41

Zhou, D., Chan, J. F.-W., Zhou, B., Zhou, R., Li, S., Shan, S., Liu, L., Zhang, A. J., Chen, S. J., Chan, C. C.-S., Xu, H., Poon, V. K.-M., Yuan, S., Li, C., Chik, K. K.-H., Chan, C. C.-Y., Cao, J., Chan, C.-Y., Kwan, K.-Y., … Chen, Z. (2021). Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies. Cell Host & Microbe, 29(4), 551-563.e5. https://doi.org/10.1016/j.chom.2021.02.019

Authors:

Dongyan Zhou

Biao Zhou

Runhong Zhou

Shuang Li

Li Liu

Serena J. Chen

Haoran Xu

Chun-Yin Chan

Ka-Yi Kwan

Zhenglong Du

Thomas Tsz-Kan Lau

Zhiwei Chen

Jasper Fuk-Woo Chan

Anna Jinxia Zhang

Chris Chung-Sing Chan

Vincent Kwok-Man Poon

Shuofeng Yuan

Cun Li

Kenn Ka-Heng Chik

Chris Chun-Yiu Chan

Jianli Cao

Jie Zhou

Kelvin Kai-Wang To

Kwok-Yung Yuen

Sisi Shan

Qi Zhang

Linqi Zhang

David D. Ho

Affiliated Authors:

David D. Ho

Columbia Affiliation:

Subjects:

Antibodies, Neutralizing (MeSH)

Antibodies, Viral (MeSH)

COVID-19 (MeSH)

SARS-CoV-2 (MeSH)

Turbinates (MeSH)

Author Keywords:

covid-19

sars-cov-2

human neutralizing antibody

lung injury

nasal turbinate

phage display

receptor binding domain

upper respiratory tract

Publication Type:

Article

Unique ID:

10.1016/j.chom.2021.02.019

PMID:

33657424

DOI:

10.1016/j.chom.2021.02.019

Journal:

Cell Host and Microbe

Publication Date:

2021-04-14

Data Source:

Web of Science

Source Link:

Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class

Record Created:

Thursday, July 24, 2025 - 08:31

Rapp, M., Guo, Y., Reddem, E. R., Yu, J., Liu, L., Wang, P., Cerutti, G., Katsamba, P., Bimela, J. S., Bahna, F. A., Mannepalli, S. M., Zhang, B., Kwong, P. D., Huang, Y., Ho, D. D., Shapiro, L., & Sheng, Z. (2021). Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class. Cell Reports, 35(1), 108950. https://doi.org/10.1016/j.celrep.2021.108950

Authors:

Micah Rapp

Yicheng Guo

Eswar R Reddem

Jian Yu

Lihong Liu

Pengfei Wang

Gabriele Cerutti

Phinikoula Katsamba

Jude S Bimela

Fabiana A Bahna

Seetha M Mannepalli

Baoshan Zhang

Peter D Kwong

Yaoxing Huang

David D Ho

Lawrence Shapiro

Zizhang Sheng

Affiliated Authors:

Micah Rapp

Yicheng Guo

Eswar R Reddem

Jian Yu

Lihong Liu

Pengfei Wang

Gabriele Cerutti

Phinikoula Katsamba

Jude S Bimela

Fabiana A Bahna

Seetha M Mannepalli

Peter D Kwong

Yaoxing Huang

David D Ho

Lawrence Shapiro

Zizhang Sheng

Columbia Affiliation:

Subjects:

Antibodies, Neutralizing (MeSH)

Antibodies, Viral (MeSH)

COVID-19 (MeSH)

Immunoglobulin Variable Region (MeSH)

SARS-CoV-2 (MeSH)

Author Keywords:

covid-19

multi-donor antibody class

neutralizing antibody

quaternary recognition

rbd

sars-cov-2

spike

Grants:

ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)

U24GM129539 (NIH – National Institute of General Medical Sciences)

P30GM124165 (NIH – National Institute of General Medical Sciences)

P41GM103310 (NIH – National Institute of General Medical Sciences)

Publication Type:

Article

Unique ID:

10.1016/j.celrep.2021.108950

PMID:

33794145

DOI:

10.1016/j.celrep.2021.108950

Journal:

Cell Reports

Publication Date:

2021-04-02

Data Source:

PubMed

Source Link:

Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite

Record Created:

Tuesday, July 22, 2025 - 10:40

Cerutti, G., Guo, Y., Zhou, T., Gorman, J., Lee, M., Rapp, M., Reddem, E. R., Yu, J., Bahna, F., Bimela, J., Huang, Y., Katsamba, P. S., Liu, L., Nair, M. S., Rawi, R., Olia, A. S., Wang, P., Zhang, B., Chuang, G.-Y., … Shapiro, L. (2021). Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite. Cell Host & Microbe, 29(5), 819-833.e7. https://doi.org/10.1016/j.chom.2021.03.005

Authors:

Gabriele Cerutti

Yicheng Guo

Tongqing Zhou

Jason Gorman

Myungjin Lee

Micah Rapp

Eswar R Reddem

Jian Yu

Fabiana Bahna

Jude Bimela

Yaoxing Huang

Phinikoula S Katsamba

Lihong Liu

Manoj S Nair

Reda Rawi

Adam S Olia

Pengfei Wang

Baoshan Zhang

Gwo-Yu Chuang

David D Ho

Zizhang Sheng

Peter D Kwong

Lawrence Shapiro

Affiliated Authors:

Gabriele Cerutti

Yicheng Guo

Micah Rapp

Eswar R Reddem

Jian Yu

Fabiana Bahna

Jude Bimela

Yaoxing Huang

Phinikoula S Katsamba

Lihong Liu

Manoj S Nair

Pengfei Wang

David D Ho

Zizhang Sheng

Peter D Kwong

Lawrence Shapiro

Columbia Affiliation:

Subjects:

Antibodies, Neutralizing (MeSH)

Antibodies, Viral (MeSH)

SARS-CoV-2 (MeSH)

Spike Glycoprotein, Coronavirus (MeSH)

Author Keywords:

antibody class

antigenic supersite

covid-19

multi-donor antibody

n-terminal domain

neutralizing antibody

sars-cov-2

Grants:

R21AI143407 (NIH – National Institute of Allergy and Infectious Diseases)

ZIAAI005147 (NIH – National Institute of Allergy and Infectious Diseases)

ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)

R21AI144408 (NIH – National Institute of Allergy and Infectious Diseases)

ZICAI005112 (NIH – National Institute of Allergy and Infectious Diseases)

P41GM103310 (NIH – National Institute of General Medical Sciences)

U24GM129539 (NIH – National Institute of General Medical Sciences)

P30GM124165 (NIH – National Institute of General Medical Sciences)

DP5OD023118 (NIH – Office of the Director, National Institutes of Health)

Publication Type:

Article

Unique ID:

10.1016/j.chom.2021.03.005

PMID:

33789084

DOI:

10.1016/j.chom.2021.03.005

Journal:

Cell Host and Microbe

Publication Date:

2021-04-01

Data Source:

PubMed

Source Link:

Identification of Immunohistochemical Reagents for In Situ Protein Expression Analysis of Coronavirus-associated Changes in Human Tissues

Record Created:

Tuesday, July 22, 2025 - 10:39

Szabolcs, M., Sauter, J. L., Frosina, D., Geronimo, J. A., Hernandez, E., Selbs, E., Rapkiewicz, A. V., Rekhtman, N., Baine, M. K., Jäger, E., Travis, W. D., & Jungbluth, A. A. (2020). Identification of Immunohistochemical Reagents for In Situ Protein Expression Analysis of Coronavirus-associated Changes in Human Tissues. Applied Immunohistochemistry & Molecular Morphology, 29(1), 5–12. https://doi.org/10.1097/pai.0000000000000878

Authors:

Matthias Szabolcs

Jennifer L. Sauter

Denise Frosina

Jerica A. Geronimo

Enmily Hernandez

Natasha Rekhtman

Marina K. Baine

William D. Travis

Achim A. Jungbluth

Elena Selbs

Amy Rapkiewicz

Elke Jager

Affiliated Authors:

Matthias Szabolcs

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Pathology and Cell Biology

Subjects:

Antibodies, Monoclonal (MeSH)

Antibodies, Viral (MeSH)

COVID-19 (MeSH)

Immunohistochemistry (MeSH)

SARS-CoV-2 (MeSH)

Author Keywords:

sars-cov2

covid-19

immunohistochemistry

specific monoclonal antibodies

Grants:

P30CA008748 (NIH – National Cancer Institute)

Publication Type:

Article

Unique ID:

10.1097/PAI.0000000000000878

PMID:

33086222

DOI:

10.1097/PAI.0000000000000878

Journal:

Applied Immunohistochemistry and Molecular Morphology

Publication Date:

2021-01-01

Data Source:

Web of Science

Source Link: