Science Immunology

Displaying 1 - 19 of 19
Maurer, K., Park, C. Y., Mani, S., Borji, M., Raths, F., Gouin, K. H., Penter, L., Jin, Y., Zhang, J. Y., Shin, C., Brenner, J. R., Southard, J., Krishna, S., Lu, W., Lyu, H., Abbondanza, D., Mangum, C., Olsen, L. R., Lawson, M. J., … Azizi, E. (2025). Coordinated immune networks in leukemia bone marrow microenvironments distinguish response to cellular therapy. Science Immunology, 10(103). https://doi.org/10.1126/sciimmunol.adr0782
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Bosticardo, M., Dobbs, K., Delmonte, O. M., Martins, A. J., Pala, F., Kawai, T., Kenney, H., Magro, G., Rosen, L. B., Yamazaki, Y., Yu, H.-H., Calzoni, E., Lee, Y. N., Liu, C., Stoddard, J., Niemela, J., Fink, D., Castagnoli, R., Ramba, M., … Gentile, N. (2025). Multiomics dissection of human RAG deficiency reveals distinctive patterns of immune dysregulation but a common inflammatory signature. Science Immunology, 10(103). https://doi.org/10.1126/sciimmunol.adq1697
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Li, F., Yang, Z., Savage, T. M., Vincent, R. L., de los Santos-Alexis, K., Ahn, A., Rouanne, M., Mariuzza, D. L., Danino, T., & Arpaia, N. (2024). Programmable bacteria synergize with PD-1 blockade to overcome cancer cell–intrinsic immune resistance mechanisms. Science Immunology, 9(100). https://doi.org/10.1126/sciimmunol.adn9879
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Araujo, L. P., Edwards, M., Irie, K., Huang, Y., Kawano, Y., Tran, A., De Michele, S., Bhagat, G., Wang, H. H., & Ivanov, I. I. (2024). Context-dependent role of group 3 innate lymphoid cells in mucosal protection. Science Immunology, 9(98). https://doi.org/10.1126/sciimmunol.ade7530
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Gray, J. I., Caron, D. P., Wells, S. B., Guyer, R., Szabo, P., Rainbow, D., Ergen, C., Rybkina, K., Bradley, M. C., Matsumoto, R., Pethe, K., Kubota, M., Teichmann, S., Jones, J., Yosef, N., Atkinson, M., Brusko, M., Brusko, T. M., Connors, T. J., … Farber, D. L. (2024). Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span. Science Immunology, 9(96). https://doi.org/10.1126/sciimmunol.adn3954
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Sanidad, K. Z., Rager, S. L., Carrow, H. C., Ananthanarayanan, A., Callaghan, R., Hart, L. R., Li, T., Ravisankar, P., Brown, J. A., Amir, M., Jin, J. C., Savage, A. R., Luo, R., Rowdo, F. M., Martin, M. L., Silver, R. B., Guo, C.-J., Krumsiek, J., Inohara, N., & Zeng, M. Y. (2024). Gut bacteria–derived serotonin promotes immune tolerance in early life. Science Immunology, 9(93). https://doi.org/10.1126/sciimmunol.adj4775
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Philips, E. A., Liu, J., Kvalvaag, A., Mørch, A. M., Tocheva, A. S., Ng, C., Liang, H., Ahearn, I. M., Pan, R., Luo, C. C., Leithner, A., Qin, Z., Zhou, Y., Garcia-España, A., Mor, A., Littman, D. R., Dustin, M. L., Wang, J., & Kong, X.-P. (2024). Transmembrane domain–driven PD-1 dimers mediate T cell inhibition. Science Immunology, 9(93). https://doi.org/10.1126/sciimmunol.ade6256
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Bastard, P., Vazquez, S. E., Liu, J., Laurie, M. T., Wang, C. Y., Gervais, A., Le Voyer, T., Bizien, L., Zamecnik, C., Philippot, Q., Rosain, J., Catherinot, E., Willmore, A., Mitchell, A. M., Bair, R., Garçon, P., Kenney, H., Fekkar, A., … Salagianni, M. (2023). Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs. Science Immunology, 8(90). https://doi.org/10.1126/sciimmunol.abp8966
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Dorrity, T. J., Shin, H., Wiegand, K. A., Aruda, J., Closser, M., Jung, E., Gertie, J. A., Leone, A., Polfer, R., Culbertson, B., Yu, L., Wu, C., Ito, T., Huang, Y., Steckelberg, A.-L., Wichterle, H., & Chung, H. (2023). Long 3′UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation. Science Immunology, 8(88). https://doi.org/10.1126/sciimmunol.adg2979
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Gill, A. L., Wang, P. H., Lee, J., Hudson, W. H., Ando, S., Araki, K., Hu, Y., Wieland, A., Im, S., Gavora, A., Medina, C. B., Freeman, G. J., Hashimoto, M., Reiner, S. L., & Ahmed, R. (2023). PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors. Science Immunology, 8(86). https://doi.org/10.1126/sciimmunol.adg0539
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Kornberg, A., Botella, T., Moon, C. S., Rao, S., Gelbs, J., Cheng, L., Miller, J., Bacarella, A. M., García-Vilas, J. A., Vargas, J., Yu, X., Krupska, I., Bush, E., Garcia-Carrasquillo, R., Lebwohl, B., Krishnareddy, S., Lewis, S., Green, P. H. R., Bhagat, G., … Han, A. (2023). Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease. Science Immunology, 8(85). https://doi.org/10.1126/sciimmunol.adf4312
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Clement, C. C., Osan, J., Buque, A., Nanaware, P. P., Chang, Y.-C., Perino, G., Shetty, M., Yamazaki, T., Tsai, W. L., Urbanska, A. M., Calvo-Calle, J. M., Ramsamooj, S., Ramsamooj, S., Vergani, D., Mieli-Vergani, G., Terziroli Beretta-Piccoli, B., Gadina, M., Montagna, C., Goncalves, M. D., … Santambrogio, L. (2022). PDIA3 epitope-driven immune autoreactivity contributes to hepatic damage in type 2 diabetes. Science Immunology, 7(74). https://doi.org/10.1126/sciimmunol.abl3795
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Rae, W., Sowerby, J. M., Verhoeven, D., Youssef, M., Kotagiri, P., Savinykh, N., Coomber, E. L., Boneparth, A., Chan, A., Gong, C., Jansen, M. H., du Long, R., Santilli, G., Simeoni, I., Stephens, J., Wu, K., Zinicola, M., Allen, H. L., Baxendale, H., … Smith, K. G. C. (2022). Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations. Science Immunology, 7(74). https://doi.org/10.1126/sciimmunol.abn3800
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Laffleur, B., Batista, C. R., Zhang, W., Lim, J., Yang, B., Rossille, D., Wu, L., Estrella, J., Rothschild, G., Pefanis, E., & Basu, U. (2022). RNA exosome drives early B cell development via noncoding RNA processing mechanisms. Science Immunology, 7(72). https://doi.org/10.1126/sciimmunol.abn2738
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Matos, T. R., Gehad, A., Teague, J. E., Dyring-Andersen, B., Benezeder, T., Dowlatshahi, M., Crouch, J., Watanabe, Y., O’Malley, J. T., Kupper, T. S., Yang, C., Watanabe, R., & Clark, R. A. (2022). Central memory T cells are the most effective precursors of resident memory T cells in human skin. Science Immunology, 7(70). https://doi.org/10.1126/sciimmunol.abn1889
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Hoshino, A., Boutboul, D., Zhang, Y., Kuehn, H. S., Hadjadj, J., Özdemir, N., Celkan, T., Walz, C., Picard, C., Lenoir, C., Mahlaoui, N., Klein, C., Peng, X., Azar, A., Reigh, E., Cheminant, M., Fischer, A., Rieux-Laucat, F., Callebaut, I., … Latour, S. (2022). Gain-of-function IKZF1 variants in humans cause immune dysregulation associated with abnormal T/B cell late differentiation. Science Immunology, 7(69). https://doi.org/10.1126/sciimmunol.abi7160
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Thapa, P., Guyer, R. S., Yang, A. Y., Parks, C. A., Brusko, T. M., Brusko, M., Connors, T. J., & Farber, D. L. (2021). Infant T cells are developmentally adapted for robust lung immune responses through enhanced T cell receptor signaling. Science Immunology, 6(66). https://doi.org/10.1126/sciimmunol.abj0789
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