Science Immunology
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Maurer, K., Park, C. Y., Mani, S., Borji, M., Raths, F., Gouin, K. H., Penter, L., Jin, Y., Zhang, J. Y., Shin, C., Brenner, J. R., Southard, J., Krishna, S., Lu, W., Lyu, H., Abbondanza, D., Mangum, C., Olsen, L. R., Lawson, M. J., … Azizi, E. (2025). Coordinated immune networks in leukemia bone marrow microenvironments distinguish response to cellular therapy. Science Immunology, 10(103). https://doi.org/10.1126/sciimmunol.adr0782
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Columbia Affiliation
Bosticardo, M., Dobbs, K., Delmonte, O. M., Martins, A. J., Pala, F., Kawai, T., Kenney, H., Magro, G., Rosen, L. B., Yamazaki, Y., Yu, H.-H., Calzoni, E., Lee, Y. N., Liu, C., Stoddard, J., Niemela, J., Fink, D., Castagnoli, R., Ramba, M., … Gentile, N. (2025). Multiomics dissection of human RAG deficiency reveals distinctive patterns of immune dysregulation but a common inflammatory signature. Science Immunology, 10(103). https://doi.org/10.1126/sciimmunol.adq1697
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Li, F., Yang, Z., Savage, T. M., Vincent, R. L., de los Santos-Alexis, K., Ahn, A., Rouanne, M., Mariuzza, D. L., Danino, T., & Arpaia, N. (2024). Programmable bacteria synergize with PD-1 blockade to overcome cancer cell–intrinsic immune resistance mechanisms. Science Immunology, 9(100). https://doi.org/10.1126/sciimmunol.adn9879
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Araujo, L. P., Edwards, M., Irie, K., Huang, Y., Kawano, Y., Tran, A., De Michele, S., Bhagat, G., Wang, H. H., & Ivanov, I. I. (2024). Context-dependent role of group 3 innate lymphoid cells in mucosal protection. Science Immunology, 9(98). https://doi.org/10.1126/sciimmunol.ade7530
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Gray, J. I., Caron, D. P., Wells, S. B., Guyer, R., Szabo, P., Rainbow, D., Ergen, C., Rybkina, K., Bradley, M. C., Matsumoto, R., Pethe, K., Kubota, M., Teichmann, S., Jones, J., Yosef, N., Atkinson, M., Brusko, M., Brusko, T. M., Connors, T. J., … Farber, D. L. (2024). Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span. Science Immunology, 9(96). https://doi.org/10.1126/sciimmunol.adn3954
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Sanidad, K. Z., Rager, S. L., Carrow, H. C., Ananthanarayanan, A., Callaghan, R., Hart, L. R., Li, T., Ravisankar, P., Brown, J. A., Amir, M., Jin, J. C., Savage, A. R., Luo, R., Rowdo, F. M., Martin, M. L., Silver, R. B., Guo, C.-J., Krumsiek, J., Inohara, N., & Zeng, M. Y. (2024). Gut bacteria–derived serotonin promotes immune tolerance in early life. Science Immunology, 9(93). https://doi.org/10.1126/sciimmunol.adj4775
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Philips, E. A., Liu, J., Kvalvaag, A., Mørch, A. M., Tocheva, A. S., Ng, C., Liang, H., Ahearn, I. M., Pan, R., Luo, C. C., Leithner, A., Qin, Z., Zhou, Y., Garcia-España, A., Mor, A., Littman, D. R., Dustin, M. L., Wang, J., & Kong, X.-P. (2024). Transmembrane domain–driven PD-1 dimers mediate T cell inhibition. Science Immunology, 9(93). https://doi.org/10.1126/sciimmunol.ade6256
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Bastard, P., Vazquez, S. E., Liu, J., Laurie, M. T., Wang, C. Y., Gervais, A., Le Voyer, T., Bizien, L., Zamecnik, C., Philippot, Q., Rosain, J., Catherinot, E., Willmore, A., Mitchell, A. M., Bair, R., Garçon, P., Kenney, H., Fekkar, A., … Salagianni, M. (2023). Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs. Science Immunology, 8(90). https://doi.org/10.1126/sciimmunol.abp8966
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Dorrity, T. J., Shin, H., Wiegand, K. A., Aruda, J., Closser, M., Jung, E., Gertie, J. A., Leone, A., Polfer, R., Culbertson, B., Yu, L., Wu, C., Ito, T., Huang, Y., Steckelberg, A.-L., Wichterle, H., & Chung, H. (2023). Long 3′UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation. Science Immunology, 8(88). https://doi.org/10.1126/sciimmunol.adg2979
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Columbia Affiliation
Vagelos College of Physicians and Surgeons; Department of Microbiology and Immunology; Department of Biochemistry and Molecular Biophysics; Department of Pathology and Cell Biology; Department of Neuroscience; Department of Rehabilitation and Regenerative Medicine; Motor Neuron Center; Department of Neurology
Gill, A. L., Wang, P. H., Lee, J., Hudson, W. H., Ando, S., Araki, K., Hu, Y., Wieland, A., Im, S., Gavora, A., Medina, C. B., Freeman, G. J., Hashimoto, M., Reiner, S. L., & Ahmed, R. (2023). PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors. Science Immunology, 8(86). https://doi.org/10.1126/sciimmunol.adg0539
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Kornberg, A., Botella, T., Moon, C. S., Rao, S., Gelbs, J., Cheng, L., Miller, J., Bacarella, A. M., García-Vilas, J. A., Vargas, J., Yu, X., Krupska, I., Bush, E., Garcia-Carrasquillo, R., Lebwohl, B., Krishnareddy, S., Lewis, S., Green, P. H. R., Bhagat, G., … Han, A. (2023). Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease. Science Immunology, 8(85). https://doi.org/10.1126/sciimmunol.adf4312
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Columbia Affiliation
Center for Stem Cell Therapies; Center for Human Development; Vagelos College of Physicians and Surgeons; Department of Medicine; Division of Digestive and Liver Diseases; Mailman School of Public Health; Department of Epidemiology; Department of Pathology and Cell Biology; Center for Translational Immunology; Department of Microbiology and Immunology; Department of Genetics and Development; Department of Pediatrics; Celiac Disease Center; Department of Systems Biology
Mace, E. M. (2023). Bearing a grudge—How human natural killer cells remember past insults. Science Immunology, 8(79). https://doi.org/10.1126/sciimmunol.adg4688
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Jensen, I. J., & Farber, D. L. (2022). Gutsy memory T cells stand their ground against pathogens. Science Immunology, 7(77). https://doi.org/10.1126/sciimmunol.ade7168
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Columbia Affiliation
Clement, C. C., Osan, J., Buque, A., Nanaware, P. P., Chang, Y.-C., Perino, G., Shetty, M., Yamazaki, T., Tsai, W. L., Urbanska, A. M., Calvo-Calle, J. M., Ramsamooj, S., Ramsamooj, S., Vergani, D., Mieli-Vergani, G., Terziroli Beretta-Piccoli, B., Gadina, M., Montagna, C., Goncalves, M. D., … Santambrogio, L. (2022). PDIA3 epitope-driven immune autoreactivity contributes to hepatic damage in type 2 diabetes. Science Immunology, 7(74). https://doi.org/10.1126/sciimmunol.abl3795
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Rae, W., Sowerby, J. M., Verhoeven, D., Youssef, M., Kotagiri, P., Savinykh, N., Coomber, E. L., Boneparth, A., Chan, A., Gong, C., Jansen, M. H., du Long, R., Santilli, G., Simeoni, I., Stephens, J., Wu, K., Zinicola, M., Allen, H. L., Baxendale, H., … Smith, K. G. C. (2022). Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations. Science Immunology, 7(74). https://doi.org/10.1126/sciimmunol.abn3800
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Laffleur, B., Batista, C. R., Zhang, W., Lim, J., Yang, B., Rossille, D., Wu, L., Estrella, J., Rothschild, G., Pefanis, E., & Basu, U. (2022). RNA exosome drives early B cell development via noncoding RNA processing mechanisms. Science Immunology, 7(72). https://doi.org/10.1126/sciimmunol.abn2738
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Matos, T. R., Gehad, A., Teague, J. E., Dyring-Andersen, B., Benezeder, T., Dowlatshahi, M., Crouch, J., Watanabe, Y., O’Malley, J. T., Kupper, T. S., Yang, C., Watanabe, R., & Clark, R. A. (2022). Central memory T cells are the most effective precursors of resident memory T cells in human skin. Science Immunology, 7(70). https://doi.org/10.1126/sciimmunol.abn1889
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Hoshino, A., Boutboul, D., Zhang, Y., Kuehn, H. S., Hadjadj, J., Özdemir, N., Celkan, T., Walz, C., Picard, C., Lenoir, C., Mahlaoui, N., Klein, C., Peng, X., Azar, A., Reigh, E., Cheminant, M., Fischer, A., Rieux-Laucat, F., Callebaut, I., … Latour, S. (2022). Gain-of-function IKZF1 variants in humans cause immune dysregulation associated with abnormal T/B cell late differentiation. Science Immunology, 7(69). https://doi.org/10.1126/sciimmunol.abi7160
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Thapa, P., Guyer, R. S., Yang, A. Y., Parks, C. A., Brusko, T. M., Brusko, M., Connors, T. J., & Farber, D. L. (2021). Infant T cells are developmentally adapted for robust lung immune responses through enhanced T cell receptor signaling. Science Immunology, 6(66). https://doi.org/10.1126/sciimmunol.abj0789
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