Fernández-Tussy, P., Cardelo, M. P., Zhang, H., Sun, J., Price, N. L., Boutagy, N. E., Goedeke, L., Cadena-Sandoval, M., Xirouchaki, C. E., Brown, W., Yang, X., Pastor-Rojo, O., Haeusler, R. A., Bennett, A. M., Tiganis, T., Suárez, Y., & Fernández-Hernando, C. (2024). miR-33 deletion in hepatocytes attenuates MASLD-MASH-HCC progression. JCI Insight, 9(19). https://doi.org/10.1172/jci.insight.168476

Markosyan, N., Kim, I.-K., Arora, C., Quinones-Ware, L., Joshi, N., Cheng, N., Schechter, E. Y., Tobias, J. W., Hochberg, J. E., Corse, E., Liu, K., Rodriguez DiBlasi, V., Chan, L.-C. (Eric), Smyth, E. M., FitzGerald, G. A., Stanger, B. Z., & Vonderheide, R. H. (2024). Pivotal roles for cancer cell–intrinsic mPGES-1 and autocrine EP4 signaling in suppressing antitumor immunity. JCI Insight, 9(21). https://doi.org/10.1172/jci.insight.178644

Elaimy, A. L., El-Derany, M. O., James, J., Wang, Z., Pearson, A. N., Holcomb, E. A., Huber, A. K., Gijón, M., Bell, H. N., Sanghvi, V. R., Frankel, T. L., Su, G. L., Tapper, E. B., Tai, A. W., Ramnath, N., Centonze, C. P., Dobrosotskaya, I., Moeller, J. A., Bryant, A. K., … Green, M. D. (2024). SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma. JCI Insight, 9(21). https://doi.org/10.1172/jci.insight.184826

Vieira Neto, E., Wang, M., Szuminsky, A. J., Ferraro, L., Koppes, E., Wang, Y., Van’t Land, C., Mohsen, A.-W., Zanatta, G., El-Gharbawy, A. H., Anthonymuthu, T. S., Tyurina, Y. Y., Tyurin, V. A., Kagan, V., Bayır, H., & Vockley, J. (2024). Mitochondrial bioenergetics and cardiolipin remodeling abnormalities in mitochondrial trifunctional protein deficiency. JCI Insight, 9(17). https://doi.org/10.1172/jci.insight.176887

Burg, N., Malpass, R., Alex, L., Tran, M., Englebrecht, E., Kuo, A., Pannelini, T., Minett, M., Athukorala, K., Worgall, T., Faust, H. J., Goodman, S., Mehta, B., Brenner, M., Vestweber, D., Wei, K., Blobel, C., Hla, T., & Salmon, J. E. (2024). Endothelial cell sphingosine 1-phosphate receptor 1 restrains VE-cadherin cleavage and attenuates experimental inflammatory arthritis. JCI Insight, 9(11). https://doi.org/10.1172/jci.insight.171467

Anderson, E., Powell, M., Yang, E., Kar, A., Leung, T. M., Sison, C., Steinberg, R., Mims, R., Choudhury, A., Espinosa, C., Zelmanovich, J., Okoye, N. C., Choi, E. J., Marder, G., Narain, S., Gregersen, P. K., Mackay, M., Diamond, B., Levy, T., … Davidson, A. (2024). Factors associated with immune responses to SARS-CoV-2 vaccination in individuals with autoimmune diseases. JCI Insight, 9(13). https://doi.org/10.1172/jci.insight.180750

Nguyen, T. T. T., Torrini, C., Shang, E., Shu, C., Mun, J.-Y., Gao, Q., Humala, N., Akman, H. O., Zhang, G., Westhoff, M.-A., Karpel-Massler, G., Bruce, J. N., Canoll, P., & Siegelin, M. D. (2024). OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma. JCI Insight. https://doi.org/10.1172/jci.insight.172565

Hernandez-Ono, A., Zhao, Y. P., Murray, J. W., Östlund, C., Lee, M. J., Shi, A., Dauer, W. T., Worman, H. J., Ginsberg, H. N., & Shin, J.-Y. (2024). Dynamic regulation of hepatic lipid metabolism by torsinA and its activators. JCI Insight. https://doi.org/10.1172/jci.insight.175328

Weh, K. M., Howard, C. L., Zhang, Y., Tripp, B. A., Clarke, J. L., Howell, A. B., Rubenstein, J. H., Abrams, J. A., Westerhoff, M., & Kresty, L. A. (2024). Prebiotic proanthocyanidins inhibit bile reflux-induced esophageal adenocarcinoma through reshaping the gut microbiome and esophageal metabolome. JCI Insight. https://doi.org/10.1172/jci.insight.168112

Mendelson, K., Martin, T. C., Nguyen, C. B., Hsu, M., Xu, J., Lang, C. C. V., Dummer, R., Saenger, Y., Messina, J. L., Sondak, V. K., Desman, G., Hasson, D., Bernstein, E., Parsons, R. E., & Celebi, J. T. (2024). Differential histone acetylation and super-enhancer regulation underlie melanoma cell dedifferentiation. JCI Insight. https://doi.org/10.1172/jci.insight.166611

Gaydosik, A. M., Stonesifer, C. J., Tabib, T., Lafyatis, R., Geskin, L. J., & Fuschiotti, P. (2023). The mycosis fungoides cutaneous microenvironment shapes dysfunctional cell trafficking, antitumor immunity, matrix interactions, and angiogenesis. JCI Insight, 8(19). https://doi.org/10.1172/jci.insight.170015

Jha, N. N., Kim, J.-K., Her, Y.-R., & Monani, U. R. (2023). Muscle: to the neuromuscular disease phenotype in spinal muscular atrophy. JCI Insight, 8(18). https://doi.org/10.1172/jci.insight.171878

Fan, L.-C., McConn, K., Plataki, M., Kenny, S., Williams, N. C., Kim, K., Quirke, J. A., Chen, Y., Sauler, M., Möbius, M. E., Chung, K.-P., Area Gomez, E., Choi, A. M. K., Xu, J.-F., & Cloonan, S. M. (2023). Alveolar type II epithelial cell FASN maintains lipid homeostasis in experimental COPD. JCI Insight, 8(16). https://doi.org/10.1172/jci.insight.163403

Sugiura, K., Masuike, Y., Suzuki, K., Shin, A. E., Sakai, N., Matsubara, H., Otsuka, M., Sims, P. A., Lengner, C. J., & Rustgi, A. K. (2023). LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3. JCI Insight, 8(14). https://doi.org/10.1172/jci.insight.167310

Liao, X., Kennel, P. J., Liu, B., Nash, T. R., Zhuang, R. Z., Godier-Furnemont, A. F., Xue, C., Lu, R., Colombo, P. C., Uriel, N., Reilly, M. P., Marx, S. O., Vunjak-Novakovic, G., & Topkara, V. K. (2023). Effect of mechanical unloading on genome-wide DNA methylation profile of the failing human heart. JCI Insight, 8(4). https://doi.org/10.1172/jci.insight.161788

Li, T., Kikuchi, O., Zhou, J., Wang, Y., Pokharel, B., Bastl, K., Gokhale, P., Knott, A., Zhang, Y., Doench, J. G., Ho, Z. V., Catenacci, D. V. T., & Bass, A. J. (2023). Developing SHP2-based combination therapy for KRAS-amplified cancer. JCI Insight, 8(3). https://doi.org/10.1172/jci.insight.152714

Good, P. I., Li, L., Hurst, H. A., Serrano Herrera, I., Xu, K., Rao, M., Bateman, D. A., Al-Awqati, Q., D’Agati, V. D., Costantini, F., & Lin, F. (2023). Low nephron endowment increases susceptibility to renal stress and chronic kidney disease. JCI Insight, 8(3). https://doi.org/10.1172/jci.insight.161316

Kang, J., Postigo-Fernandez, J., Kim, K., Zhu, C., Yu, J., Meroni, M., Mayfield, B., Bartolomé, A., Dapito, D. H., Ferrante, A. W., Dongiovanni, P., Valenti, L., Creusot, R. J., & Pajvani, U. B. (2023). Notch-mediated hepatocyte MCP-1 secretion causes liver fibrosis. JCI Insight, 8(3). https://doi.org/10.1172/jci.insight.165369

Kolesnikova, M., Oh, J. K., Wang, J., Lee, W., Zernant, J., Su, P.-Y., Kim, A. H., Jenny, L. A., Yang, T., Allikmets, R., & Tsang, S. H. (2022). A pathogenic in-frame deletion-insertion variant in BEST1 phenocopies Stargardt disease. JCI Insight, 7(23). https://doi.org/10.1172/jci.insight.162687

Salinas, S. A., Mace, E. M., Conte, M. I., Park, C. S., Li, Y., Rosario-Sepulveda, J. I., Mahapatra, S., Moore, E. K., Hernandez, E. R., Chinn, I. K., Reed, A. E., Lee, B. J., Frumovitz, A., Gibbs, R. A., Posey, J. E., Forbes Satter, L. R., Thatayatikom, A., Allenspach, E. J., Wensel, T. G., … Orange, J. S. (2022). An ELF4 hypomorphic variant results in NK cell deficiency. JCI Insight, 7(23). https://doi.org/10.1172/jci.insight.155481

Conte, M. I., Poli, M. C., Taglialatela, A., Leuzzi, G., Chinn, I. K., Salinas, S. A., Rey-Jurado, E., Olivares, N., Veramendi-Espinoza, L., Ciccia, A., Lupski, J. R., Aldave Becerra, J. C., Mace, E. M., & Orange, J. S. (2022). Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia. JCI Insight, 7(21). https://doi.org/10.1172/jci.insight.154948

Benner, S. E., Eby, Y., Zhu, X., Fernandez, R. E., Patel, E. U., Ruff, J. E., Habtehyimer, F., Schmidt, H. A., Kirby, C. S., Hussain, S., Ostrander, D., Desai, N. M., Florman, S., Rana, M. M., Friedman-Moraco, R., Pereira, M. R., Mehta, S., Stock, P., Gilbert, A., … Tobian, A. A. R. (2022). The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir. JCI Insight, 7(21). https://doi.org/10.1172/jci.insight.162968

Sannigrahi, M. K., Rajagopalan, P., Lai, L., Liu, X., Sahu, V., Nakagawa, H., Jalaly, J. B., Brody, R. M., Morgan, I. M., Windle, B. E., Wang, X., Gimotty, P. A., Kelly, D. P., White, E. A., & Basu, D. (2022). HPV E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis. JCI Insight, 7(18). https://doi.org/10.1172/jci.insight.159600

Perdigoto, A. L., Deng, S., Du, K. C., Kuchroo, M., Burkhardt, D. B., Tong, A., Israel, G., Robert, M. E., Weisberg, S. P., Kirkiles-Smith, N., Stamatouli, A. M., Kluger, H. M., Quandt, Z., Young, A., Yang, M.-L., Mamula, M. J., Pober, J. S., Anderson, M. S., Krishnaswamy, S., & Herold, K. C. (2022). Immune cells and their inflammatory mediators modify β cells and cause checkpoint inhibitor–induced diabetes. JCI Insight, 7(17). https://doi.org/10.1172/jci.insight.156330

Singhal, S. K., Byun, J. S., Yan, T., Yancey, R., Caban, A., Gil Hernandez, S., Bufford, S., Hewitt, S. M., Winfield, J., Pradhan, J., Mustkov, V., McDonald, J. A., Pérez-Stable, E. J., Nápoles, A. M., Vohra, N., De Siervi, A., Yates, C., Davis, M. B., Yang, M., … Gardner, K. (2022). Protein expression of the gp78 E3 ligase predicts poor breast cancer outcome based on race. JCI Insight, 7(13). https://doi.org/10.1172/jci.insight.157465

Chait, M., Yilmaz, M. M., Shakil, S., Ku, A. W., Dogra, P., Connors, T. J., Szabo, P. A., Gray, J. I., Wells, S. B., Kubota, M., Matsumoto, R., Poon, M. M. L., Snyder, M. E., Baldwin, M. R., Sims, P. A., Saqi, A., Farber, D. L., & Weisberg, S. P. (2022). Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19. JCI Insight, 7(11). https://doi.org/10.1172/jci.insight.157608

Masuda, K., Kornberg, A., Miller, J., Lin, S., Suek, N., Botella, T., Secener, K. A., Bacarella, A. M., Cheng, L., Ingham, M., Rosario, V., Al-Mazrou, A. M., Lee-Kong, S. A., Kiran, R. P., Stoeckius, M., Smibert, P., Del Portillo, A., Oberstein, P. E., Sims, P. A., … Han, A. (2022). Multiplexed single-cell analysis reveals prognostic and nonprognostic T cell types in human colorectal cancer. JCI Insight, 7(7). https://doi.org/10.1172/jci.insight.154646

Bartolomé, A., Suda, N., Yu, J., Zhu, C., Son, J., Ding, H., Califano, A., Accili, D., & Pajvani, U. B. (2022). Notch-mediated Ephrin signaling disrupts islet architecture and β cell function. JCI Insight, 7(6). https://doi.org/10.1172/jci.insight.157694

Shen, T. H., Stauber, J., Xu, K., Jacunski, A., Paragas, N., Callahan, M., Banlengchit, R., Levitman, A. D., Desanti De Oliveira, B., Beenken, A., Grau, M. S., Mathieu, E., Zhang, Q., Li, Y., Gopal, T., Askanase, N., Arumugam, S., Mohan, S., Good, P. I., … Barasch, J. (2022). Snapshots of nascent RNA reveal cell- and stimulus-specific responses to acute kidney injury. JCI Insight, 7(6). https://doi.org/10.1172/jci.insight.146374

Matsui, M., Bouchareb, R., Storto, M., Hussain, Y., Gregg, A., Marx, S. O., & Pitt, G. S. (2022). Increased Ca2+ influx through CaV1.2 drives aortic valve calcification. JCI Insight, 7(5). https://doi.org/10.1172/jci.insight.155569

Lee, W., Zernant, J., Su, P.-Y., Nagasaki, T., Tsang, S. H., & Allikmets, R. (2022). A genotype-phenotype correlation matrix for ABCA4 disease based on long-term prognostic outcomes. JCI Insight, 7(2). https://doi.org/10.1172/jci.insight.156154

Brener, M. I., Hulke, M. L., Fukuma, N., Golob, S., Zilinyi, R. S., Zhou, Z., Tzimas, C., Russo, I., McGroder, C., Pfeiffer, R. D., Chong, A., Zhang, G., Burkhoff, D., Leon, M. B., Maurer, M. S., Moses, J. W., Uhlemann, A.-C., Hibshoosh, H., Uriel, N., … Tsai, E. J. (2022). Clinico-histopathologic and single-nuclei RNA-sequencing insights into cardiac injury and microthrombi in critical COVID-19. JCI Insight, 7(2). https://doi.org/10.1172/jci.insight.154633

Roubinian, N. H., Reese, S. E., Qiao, H., Plimier, C., Fang, F., Page, G. P., Cable, R. G., Custer, B., Gladwin, M. T., Goel, R., Harris, B., Hendrickson, J. E., Kanias, T., Kleinman, S., Mast, A. E., Sloan, S. R., Spencer, B. R., Spitalnik, S. L., Busch, M. P., & Hod, E. A. (2022). Donor genetic and nongenetic factors affecting red blood cell transfusion effectiveness. JCI Insight, 7(1). https://doi.org/10.1172/jci.insight.152598