Institute for Cancer Genetics

Displaying 51 - 100 of 176CSV
Georgieva, D., Wang, N., Taglialatela, A., Jerabek, S., Reczek, C. R., Lim, P. X., Sung, J., Du, Q., Horiguchi, M., Jasin, M., Ciccia, A., Baer, R., & Egli, D. (2024). BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks. Cell Reports, 43(4), 114006. https://doi.org/10.1016/j.celrep.2024.114006
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Chen, X., Tsvetkov, A. S., Shen, H.-M., Isidoro, C., Ktistakis, N. T., Linkermann, A., Koopman, W. J. H., Simon, H.-U., Galluzzi, L., Luo, S., Xu, D., Gu, W., Peulen, O., Cai, Q., Rubinsztein, D. C., Chi, J.-T., Zhang, D. D., Li, C., Toyokuni, S., … Tang, D. (2024). International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis. Autophagy, 20(6), 1213–1246. https://doi.org/10.1080/15548627.2024.2319901
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Fang, Y., Hua, X., Shan, C.-M., Toda, T., Qiao, F., Zhang, Z., & Jia, S. (2024). Coordination of histone chaperones for parental histone segregation and epigenetic inheritance. Genes & Development, 38(3–4), 189–204. https://doi.org/10.1101/gad.351278.123
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Kim, D.-Y., Kim, H., Ko, E.-J., Koh, S. B., Kim, H., Lee, J. Y., Lee, C. M., Eo, W. K., Kim, K. H., & Cha, H.-J. (2024). Correlation analysis of cancer stem cell marker CD133 and human endogenous retrovirus (HERV)-K env in SKOV3 ovarian cancer cells. Genes & Genomics, 46(4), 511–518. https://doi.org/10.1007/s13258-024-01499-6
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Columbia Affiliation
Gan, S., Yang, W.-S., Wei, L., Zhang, Z., & Xu, R.-M. (2024). Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2. Science China Life Sciences, 67(6), 1305–1307. https://doi.org/10.1007/s11427-024-2560-8
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Dai, E., Chen, X., Linkermann, A., Jiang, X., Kang, R., Kagan, V. E., Bayir, H., Yang, W. S., Garcia-Saez, A. J., Ioannou, M. S., Janowitz, T., Ran, Q., Gu, W., Gan, B., Krysko, D. V., Zhu, X., Wang, J., Krautwald, S., Toyokuni, S., … Tang, D. (2024). A guideline on the molecular ecosystem regulating ferroptosis. Nature Cell Biology. https://doi.org/10.1038/s41556-024-01360-8
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Qiu, B., Zandkarimi, F., Bezjian, C. T., Reznik, E., Soni, R. K., Gu, W., Jiang, X., & Stockwell, B. R. (2024). Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis. Cell, 187(5), 1177-1190.e18. https://doi.org/10.1016/j.cell.2024.01.030
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Yang, X., Wang, Z., Samovich, S. N., Kapralov, A. A., Amoscato, A. A., Tyurin, V. A., Dar, H. H., Li, Z., Duan, S., Kon, N., Chen, D., Tycko, B., Zhang, Z., Jiang, X., Bayir, H., Stockwell, B. R., Kagan, V. E., & Gu, W. (2024). PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression. Cell Metabolism, 36(4), 762-777.e9. https://doi.org/10.1016/j.cmet.2024.01.006
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Leuzzi, G., Vasciaveo, A., Taglialatela, A., Chen, X., Firestone, T. M., Hickman, A. R., Mao, W., Thakar, T., Vaitsiankova, A., Huang, J.-W., Cuella-Martin, R., Hayward, S. B., Kesner, J. S., Ghasemzadeh, A., Nambiar, T. S., Ho, P., Rialdi, A., Hebrard, M., Li, Y., … Ciccia, A. (2024). SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion. Cell, 187(4), 861-881.e32. https://doi.org/10.1016/j.cell.2024.01.008
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Gurbatri, C. R., Radford, G. A., Vrbanac, L., Im, J., Thomas, E. M., Coker, C., Taylor, S. R., Jang, Y., Sivan, A., Rhee, K., Saleh, A. A., Chien, T., Zandkarimi, F., Lia, I., Lannagan, T. R. M., Wang, T., Wright, J. A., Kobayashi, H., Ng, J. Q., … Danino, T. (2024). Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-44776-4
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Samovich, S. N., Mikulska‐Ruminska, K., Dar, H. H., Tyurina, Y. Y., Tyurin, V. A., Souryavong, A. B., Kapralov, A. A., Amoscato, A. A., Beharier, O., Karumanchi, S. A., St Croix, C. M., Yang, X., Holman, T. R., VanDemark, A. P., Sadovsky, Y., Mallampalli, R. K., Wenzel, S. E., Gu, W., Bunimovich, Y. L., … Bayir, H. (2024). Strikingly High Activity of 15‐Lipoxygenase Towards Di‐Polyunsaturated Arachidonoyl/Adrenoyl‐Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death. Angewandte Chemie International Edition, 63(9). Portico. https://doi.org/10.1002/anie.202314710
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Shih, B. B., Ma, C., Cortes, J. R., Reglero, C., Miller, H., Quinn, S. A., Albero, R., Laurent, A. P., Mackey, A., Ferrando, A. A., Geskin, L., & Palomero, T. (2024). Romidepsin and Afatinib Abrogate Jak–Signal Transducer and Activator of Transcription Signaling and Elicit Synergistic Antitumor Effects in Cutaneous T-Cell Lymphoma. Journal of Investigative Dermatology, 144(7), 1579-1589.e8. https://doi.org/10.1016/j.jid.2023.12.010
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Ko, E.-J., Kim, D.-Y., Kim, M.-H., An, H., Kim, J., Jeong, J.-Y., Song, K. S., & Cha, H.-J. (2024). Functional Analysis of Membrane-Associated Scaffolding Tight Junction (TJ) Proteins in Tumorigenic Characteristics of B16-F10 Mouse Melanoma Cells. International Journal of Molecular Sciences, 25(2), 833. https://doi.org/10.3390/ijms25020833
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Columbia Affiliation
Cui, W., Guo, M., Liu, D., Xiao, P., Yang, C., Huang, H., Liang, C., Yang, Y., Fu, X., Zhang, Y., Liu, J., Shi, S., Cong, J., Han, Z., Xu, Y., Du, L., Yin, C., Zhang, Y., Sun, J., … Chu, B. (2024). Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition. Nature Cell Biology, 26(1), 124–137. https://doi.org/10.1038/s41556-023-01314-6
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Picca, A., Di Stefano, A. L., Savatovsky, J., Ducray, F., Chinot, O., Moyal, E. C.-J., Augereau, P., Le Rhun, E., Schmitt, Y., Rousseaux, N., Yepnang, A. M. M., Estellat, C., Charbonneau, F., Letourneur, Q., Branger, D. F., Meyronet, D., Fardeau, C., Mokhtari, K., Bielle, F., … Sanson, M. (2024). TARGET: A phase I/II open-label multicenter study to assess safety and efficacy of fexagratinib in patients with relapsed/refractory FGFR fusion-positive glioma. Neuro-Oncology Advances, 6(1). https://doi.org/10.1093/noajnl/vdae068
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Columbia Affiliation
Li, Y., Shah, R. B., Sarti, S., Belcher, A. L., Lee, B. J., Gorbatenko, A., Nemati, F., Yu, H., Stanley, Z., Rahman, M., Shao, Z., Silva, J. M., Zha, S., & Sidi, S. (2023). A noncanonical IRAK4-IRAK1 pathway counters DNA damage–induced apoptosis independently of TLR/IL-1R signaling. Science Signaling, 16(816). https://doi.org/10.1126/scisignal.adh3449
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Feng, W. W., Bang, S., Takacs, E. M., Day, C., Crawford, K. J., Al-Sheyab, R., Almufarrej, D. B., Wells, W., Ilchenko, S., Kasumov, T., Kon, N., Novak, C. M., Gu, W., & Kurokawa, M. (2023). Hepatic Huwe1 loss protects mice from non-alcoholic fatty liver disease through lipid metabolic rewiring. IScience, 26(12), 108405. https://doi.org/10.1016/j.isci.2023.108405
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Morgado-Palacin, L., Brown, J. A., Martinez, T. F., Garcia-Pedrero, J. M., Forouhar, F., Quinn, S. A., Reglero, C., Vaughan, J., Heydary, Y. H., Donaldson, C., Rodriguez-Perales, S., Allonca, E., Granda-Diaz, R., Fernandez, A. F., Fraga, M. F., Kim, A. L., Santos-Juanes, J., Owens, D. M., Rodrigo, J. P., … Ferrando, A. A. (2023). The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-36713-8
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Yi, J., Tavana, O., Li, H., Wang, D., Baer, R. J., & Gu, W. (2023). Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-37617-3
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Chen, X., Li, Y., Zhu, F., Xu, X., Estrella, B., Pazos, M. A., McGuire, J. T., Karagiannis, D., Sahu, V., Mustafokulov, M., Scuoppo, C., Sánchez-Rivera, F. J., Soto-Feliciano, Y. M., Pasqualucci, L., Ciccia, A., Amengual, J. E., & Lu, C. (2023). Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-39990-5
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Dmello, C., Zhao, J., Chen, L., Gould, A., Castro, B., Arrieta, V. A., Zhang, D. Y., Kim, K.-S., Kanojia, D., Zhang, P., Miska, J., Yeeravalli, R., Habashy, K., Saganty, R., Kang, S. J., Fares, J., Liu, C., Dunn, G., Bartom, E., … Sonabend, A. M. (2023). Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-36878-2
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Boutin, R., Lee, H.-F., Guan, T. L., Nguyen, T. T., Huang, X. F., Waller, D. D., Lu, J., Christine Chio, I. I., Michel, R. P., Sebag, M., & Tsantrizos, Y. S. (2023). Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor Efficacy in Multiple Myeloma, Pancreatic Ductal Adenocarcinoma, and Colorectal Cancer. Journal of Medicinal Chemistry, 66(23), 15776–15800. https://doi.org/10.1021/acs.jmedchem.3c01271
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Lin, W.-H. W., Rodriguez Cortes, J., Aitken, M., Reglero, C., Laurent, A., Cooke, A., Belver, L., Bhagat, G., Rabadan, R., Ferrando, A. A., & Palomero, T. (2023). Role of the S1P Signaling Pathway in the Pathogenesis of Angioimmunoblastic T-Cell Lymphoma. Blood, 142(Supplement 1), 526–526. https://doi.org/10.1182/blood-2023-174090
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De Simone, P., Bal, E., Holmes, A., Hilton, L., Basso, K., Soni, R. K., Morin, R., Dalla-Favera, R., & Pasqualucci, L. (2023). BTG2 Super-Enhancer Mutations Disrupt TFAP4 Binding and Deregulate BTG2 Expression in Diffuse Large B-Cell Lymphoma. Blood, 142(Supplement 1), 523–523. https://doi.org/10.1182/blood-2023-190230
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Minns, H., Padilla, O., Wei, H.-J., Gartrell, R. D., Webster-Carrion, A., Tazhibi, M., McQuillan, N., Zhang, X., Gallitto, M., Yeh, R., Zhang, Z., Hei, T., Szalontay, L., Pavisic, J., Garty, G., Garvin, J., Canoll, P., Vanpouille-Box, C., Menon, V., … Wu, C.-C. (2023). 53 Inducing immune response with FLASH and conventional radiation in diffuse midline glioma (DMG). Regular and Young Investigator Award Abstracts. https://doi.org/10.1136/jitc-2023-sitc2023.0053
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Vincent, R. L., Gurbatri, C. R., Li, F., Vardoshvili, A., Coker, C., Im, J., Ballister, E. R., Rouanne, M., Savage, T., de los Santos-Alexis, K., Redenti, A., Brockmann, L., Komaranchath, M., Arpaia, N., & Danino, T. (2023). Probiotic-guided CAR-T cells for solid tumor targeting. Science, 382(6667), 211–218. https://doi.org/10.1126/science.add7034
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Tavakol, D. N., Nash, T. R., Kim, Y., He, S., Fleischer, S., Graney, P. L., Brown, J. A., Liberman, M., Tamargo, M., Harken, A., Ferrando, A. A., Amundson, S., Garty, G., Azizi, E., Leong, K. W., Brenner, D. J., & Vunjak-Novakovic, G. (2023). Modeling and countering the effects of cosmic radiation using bioengineered human tissues. Biomaterials, 301, 122267. https://doi.org/10.1016/j.biomaterials.2023.122267
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Zhang, L., Zhang, J., Xuan, X., Wu, D., Yu, J., Wang, P., Yang, X., Zhang, J., Gan, W., He, M., Liu, X.-M., Zhou, J., Wang, D., Gu, W., & Li, D. (2023). A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression. Cell Reports, 42(8), 112833. https://doi.org/10.1016/j.celrep.2023.112833
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Liu, C.-P., Yu, Z., Xiong, J., Hu, J., Song, A., Ding, D., Yu, C., Yang, N., Wang, M., Yu, J., Hou, P., Zeng, K., Li, Z., Zhang, Z., Zhang, X., Li, W., Zhang, Z., Zhu, B., Li, G., & Xu, R.-M. (2023). Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381(6660). https://doi.org/10.1126/science.add8673
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Yang, X., Wang, Z., Zandkarimi, F., Liu, Y., Duan, S., Li, Z., Kon, N., Zhang, Z., Jiang, X., Stockwell, B. R., & Gu, W. (2023). Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism. Cell Metabolism, 35(8), 1474-1490.e8. https://doi.org/10.1016/j.cmet.2023.06.014
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Brownlie, R. J., Kennedy, R., Wilson, E. B., Milanovic, M., Taylor, C. F., Wang, D., Davies, J. R., Owston, H., Adams, E. J., Stephenson, S., Caeser, R., Gewurz, B. E., Giannoudis, P. V., Scuoppo, C., McGonagle, D., Hodson, D. J., Tooze, R. M., Doody, G. M., Cook, G., … Klein, U. (2023). Cytokine receptor IL27RA is an NF-κB–responsive gene involved in CD38 upregulation in multiple myeloma. Blood Advances, 7(15), 3874–3890. https://doi.org/10.1182/bloodadvances.2022009044
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Columbia Affiliation
Shao, Z., Lee, B. J., Zhang, H., Lin, X., Li, C., Jiang, W., Chirathivat, N., Gershik, S., Shen, M. M., Baer, R., & Zha, S. (2023). Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner. Proceedings of the National Academy of Sciences, 120(31). https://doi.org/10.1073/pnas.2301972120
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Vaitsiankova, A., Thakar, T., & Ciccia, A. (2023). Base-editing screens illuminate variant effects in human hematopoiesis. Cell Reports Methods, 3(7), 100541. https://doi.org/10.1016/j.crmeth.2023.100541
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Min, J., Zhao, J., Zagelbaum, J., Lee, J., Takahashi, S., Cummings, P., Schooley, A., Dekker, J., Gottesman, M. E., Rabadan, R., & Gautier, J. (2023). Mechanisms of insertions at a DNA double-strand break. Molecular Cell, 83(14), 2434-2448.e7. https://doi.org/10.1016/j.molcel.2023.06.016
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Kabir, M., Sun, N., Hu, X., Martin, T. C., Yi, J., Zhong, Y., Xiong, Y., Kaniskan, H. Ü., Gu, W., Parsons, R., & Jin, J. (2023). Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53. Journal of the American Chemical Society, 145(27), 14932–14944. https://doi.org/10.1021/jacs.3c04640
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Schvartzman, J.-M., Forsyth, G., Walch, H., Chatila, W., Taglialatela, A., Lee, B. J., Zhu, X., Gershik, S., Cimino, F. V., Santella, A., Menghrajani, K., Ciccia, A., Koche, R., Sánchez-Vega, F., Zha, S., & Thompson, C. B. (2023). Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination. Molecular Cell, 83(13), 2347-2356.e8. https://doi.org/10.1016/j.molcel.2023.05.026
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Yi, J., Li, H., Chu, B., Kon, N., Hu, X., Hu, J., Xiong, Y., Kaniskan, H. U., Jin, J., & Gu, W. (2023). Inhibition of USP7 induces p53-independent tumor growth suppression in triple-negative breast cancers by destabilizing FOXM1. Cell Death & Differentiation, 30(7), 1799–1810. https://doi.org/10.1038/s41418-023-01180-7
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Zhu, Y., Jiang, W., Lee, B. J., Li, A., Gershik, S., & Zha, S. (2023). Phosphorylation of DNA-PKcs at the S2056 cluster ensures efficient and productive lymphocyte development in XLF-deficient mice. Proceedings of the National Academy of Sciences, 120(25). https://doi.org/10.1073/pnas.2221894120
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DeBlasi, J. M., Falzone, A., Caldwell, S., Prieto-Farigua, N., Prigge, J. R., Schmidt, E. E., Chio, I. I. C., Karreth, F. A., & DeNicola, G. M. (2023). Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression. Cancer Research, 83(12), 1953–1967. https://doi.org/10.1158/0008-5472.can-22-3848
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Ma, L., Liu, Y., Wang, Y., Yang, J., Lu, J., Feng, H., Ye, S., & Liu, Y. (2023). Identification of PTPN20 as an innate immunity-related gene in gastric cancer with Helicobacter pylori infection. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1212692
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Kokossis, D., Wei, H.-J., Gallitto, M., Yoh, N., McQuillan, N., Tazhibi, M., Berg, X., Zhang, X., Szalontay, L., Gartrell, R. D., Pavisic, J., Zhang, Z., Molotkov, A., Mintz, A., Konofagou, E. E., & Wu, C.-C. (2023). SURG-06. ENHANCED DELIVERY OF ANTI-PD1 FOR TREATMENT OF DIFFUSE MIDLINE GLIOMA USING FOCUSED ULTRASOUND-MEDIATED BLOOD-BRAIN BARRIER OPENING. Neuro-Oncology, 25(Supplement_1), i73–i73. https://doi.org/10.1093/neuonc/noad073.282
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