Institute for Cancer Genetics

Displaying 1 - 50 of 176CSV
Bertulfo, K., Perez-Duran, P., Miller, H., Ma, C., Ambesi-Impiombato, A., Samon, J., Mackey, A., Lin, W.-H. W., Ferrando, A. A., & Palomero, T. (2025). Therapeutic targeting of the NOTCH1 and neddylation pathways in T cell acute lymphoblastic leukemia. Proceedings of the National Academy of Sciences, 122(14). https://doi.org/10.1073/pnas.2426742122
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Chen, H., Ferguson, C. J., Mitchell, D. C., Risch, I., Titus, A., Paulo, J. A., Hwang, A., Beck, L. K., Lin, T.-H., Gu, W., Song, S.-K., Yuede, C. M., Yano, H., Griffith, O. L., Griffith, M., Gygi, S. P., Bonni, A., & Kim, A. H. (2025). The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway. Cell Reports, 44(2), 115231. https://doi.org/10.1016/j.celrep.2025.115231
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Zhi, X., Wu, F., Qian, J., Ochiai, Y., Lian, G., Malagola, E., Zheng, B., Tu, R., Zeng, Y., Kobayashi, H., Xia, Z., Wang, R., Peng, Y., Shi, Q., Chen, D., Ryeom, S. W., & Wang, T. C. (2025). Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis. Nature. https://doi.org/10.1038/s41586-025-08591-1
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Zhao, X., Sun, Y., Zou, J., Wu, Y., Huang, M., Kong, H., Liu, G., Gerhardt, H., Gu, W., Zhang, Y., Shang, M., & Wang, X. (2025). Protein kinase A regulates ferroptosis by controlling GPX4 m6A modification through phosphorylation of ALKBH5. Cell Death & Differentiation. https://doi.org/10.1038/s41418-025-01453-3
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Fu, X., Mo, S., Buendia, A., Laurent, A. P., Shao, A., Alvarez-Torres, M. del M., Yu, T., Tan, J., Su, J., Sagatelian, R., Ferrando, A. A., Ciccia, A., Lan, Y., Owens, D. M., Palomero, T., Xing, E. P., & Rabadan, R. (2025). A foundation model of transcription across human cell types. Nature, 637(8047), 965–973. https://doi.org/10.1038/s41586-024-08391-z
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Duan, S., Nodelman, I. M., Zhou, H., Tsukiyama, T., Bowman, G. D., & Zhang, Z. (2025). H3K56 acetylation regulates chromatin maturation following DNA replication. Nature Communications, 16(1). https://doi.org/10.1038/s41467-024-55144-7
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Corinaldesi, C., Holmes, A. B., Martire, G., Tosato, A., Rizzato, D., Lovisa, F., Gallingani, I., Shen, Q., Ferrone, L., Harris, M., Davies, K., Molinaro, L., Mortara, U., Dei Tos, A. P., Ofori, K., D’Amore, E. S. G., Chiarle, R., Ngan, B., Carraro, E., … Basso, K. (2024). Single-cell transcriptomics of pediatric Burkitt lymphoma reveals intra-tumor heterogeneity and markers of therapy resistance. Leukemia, 39(1), 189–198. https://doi.org/10.1038/s41375-024-02431-3
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Kabir, M., Hu, X., Martin, T. C., Pokushalov, D., Kim, Y. J., Chen, Y., Zhong, Y., Wu, Q., Chipuk, J. E., Shi, Y., Xiong, Y., Gu, W., Parsons, R. E., & Jin, J. (2024). Harnessing the TAF1 Acetyltransferase for Targeted Acetylation of the Tumor Suppressor p53. Advanced Science. Portico. https://doi.org/10.1002/advs.202413377
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Chen, L. N., Ma, X., Herzberg, B., Henick, B. S., Biswas, A. K., Acharyya, S., & Shu, C. A. (2024). Weight loss in patients on osimertinib for metastatic EGFR-mutant non-small cell lung cancer. The Oncologist. https://doi.org/10.1093/oncolo/oyae315
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Diehl, C., Soberón, V., Baygün, S., Chu, Y., Mandelbaum, J., Kraus, L., Engleitner, T., Rudelius, M., Fangazio, M., Daniel, C., Bortoluzzi, S., Helmrath, S., Singroul, P., Gölling, V., Osorio Barrios, F., Seyhan, G., Oßwald, L., Kober-Hasslacher, M., Zeng, T., … Schmidt-Supprian, M. (2024). Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis. Immunity. https://doi.org/10.1016/j.immuni.2024.11.023
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Park, M., Nam, J. S., Kim, T., Yoon, G., Kim, S., Lee, C., Lee, C. G., Park, S., Bejoymohandas, K. S., Yang, J., Kwon, Y. H., Lee, Y. J., Seo, J. K., Min, D., Park, T., & Kwon, T. (2024). Rational Design of Biocompatible Ir(III) Photosensitizer to Overcome Drug‐Resistant Cancer via Oxidative Autophagy Inhibition. Advanced Science. Portico. https://doi.org/10.1002/advs.202407236
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Windemuth, S., Hahn, J., You, J., Wang, Z., Ding, S., Tarrab, S., Coker, C., Leong, K. W., & Danino, T. (2024). Iron-Tannin Coating Reduces Clearance and Increases Tumor Colonization of Systemically Delivered Bacteria. ACS Synthetic Biology. https://doi.org/10.1021/acssynbio.4c00333
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Yang, X., Liu, Y., Wang, Z., Jin, Y., & Gu, W. (2024). Ferroptosis as a new tool for tumor suppression through lipid peroxidation. Communications Biology, 7(1). https://doi.org/10.1038/s42003-024-07180-8
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Nam, J. S., Dixon, M. S., & Chio, I. I. C. (2024). Hydrogen sulfide: A whiff of trouble for cancer cell survival. Molecular Cell, 84(20), 3865–3867. https://doi.org/10.1016/j.molcel.2024.09.027
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Liebau, R. C., Waters, C., Ahmed, A., Soni, R. K., & Gautier, J. (2024). UVSSA facilitates transcription-coupled repair of DNA interstrand crosslinks. DNA Repair, 143, 103771. https://doi.org/10.1016/j.dnarep.2024.103771
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Lin, X., Gupta, D., Vaitsiankova, A., Bhandari, S. K., Leung, K. S. K., Menolfi, D., Lee, B. J., Russell, H. R., Gershik, S., Huang, X., Gu, W., McKinnon, P. J., Dantzer, F., Rothenberg, E., Tomkinson, A. E., & Zha, S. (2024). Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts. Molecular Cell, 84(20), 3916-3931.e7. https://doi.org/10.1016/j.molcel.2024.09.020
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Gu, J., Iyer, A., Wesley, B., Taglialatela, A., Leuzzi, G., Hangai, S., Decker, A., Gu, R., Klickstein, N., Shuai, Y., Jankovic, K., Parker-Burns, L., Jin, Y., Zhang, J. Y., Hong, J., Niu, X., Costa, J. A., Pezet, M. G., Chou, J., … Gaublomme, J. T. (2024). Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap. Nature Biotechnology. https://doi.org/10.1038/s41587-024-02386-x
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Ko, E.-J., Suh, D. S., Kim, H., Lee, J. Y., Eo, W. K., Kim, H., Kim, K. H., & Cha, H.-J. (2024). Transcriptome analysis of the effect of HERV-K env gene knockout in ovarian cancer cell lines. Genes & Genomics, 46(11), 1293–1301. https://doi.org/10.1007/s13258-024-01544-4
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Columbia Affiliation
Engreitz, J. M., Lawson, H. A., Singh, H., Starita, L. M., Hon, G. C., Carter, H., Sahni, N., Reddy, T. E., Lin, X., Li, Y., Munshi, N. V., Chahrour, M. H., Boyle, A. P., Hitz, B. C., Mortazavi, A., Craven, M., Mohlke, K. L., … Samer, E. K. (2024). Deciphering the impact of genomic variation on function. Nature, 633(8028), 47–57. https://doi.org/10.1038/s41586-024-07510-0
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Hu, X., Kabir, M., Lin, Y., Xiong, Y., Parsons, R. E., Gu, W., & Jin, J. (2024). Design, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs). Journal of Medicinal Chemistry, 67(16), 14633–14648. https://doi.org/10.1021/acs.jmedchem.4c01497
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Yu, C., Shen, Q., Holmes, A. B., Mo, T., Tosato, A., Soni, R. K., Corinaldesi, C., Koul, S., Pasqualucci, L., Hussein, S., Forouhar, F., Dalla-Favera, R., & Basso, K. (2024). MEF2B C-terminal mutations enhance transcriptional activity and stability to drive B cell lymphomagenesis. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-51644-8
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Scuoppo, C., Cai, B., Ofori, K., Scholze, H., Kumar, R., D’Alessandro, A., Basso, K., Pasqualucci, L., & Dalla-Favera, R. (2024). Repurposing NAMPT Inhibitors for Germinal Center B Cell–Like Diffuse Large B-Cell Lymphoma. Blood Cancer Discovery, 5(6), 417–427. https://doi.org/10.1158/2643-3230.bcd-24-0020
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Torres-Diz, M., Reglero, C., Falkenstein, C. D., Castro, A., Hayer, K. E., Radens, C. M., Quesnel-Vallières, M., Ang, Z., Sehgal, P., Li, M. M., Barash, Y., Tasian, S. K., Ferrando, A., & Thomas-Tikhonenko, A. (2024). An Alternatively Spliced Gain-of-Function NT5C2 Isoform Contributes to Chemoresistance in Acute Lymphoblastic Leukemia. Cancer Research. https://doi.org/10.1158/0008-5472.can-23-3804
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Yu, J., Zhang, Y., Fang, Y., Paulo, J. A., Yaghoubi, D., Hua, X., Shipkovenska, G., Toda, T., Zhang, Z., Gygi, S. P., Jia, S., Li, Q., & Moazed, D. (2024). A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance. Cell. https://doi.org/10.1016/j.cell.2024.07.006
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Toda, T., Fang, Y., Shan, C.-M., Hua, X., Kim, J.-K., Tang, L. C., Jovanovic, M., Tong, L., Qiao, F., Zhang, Z., & Jia, S. (2024). Mrc1 regulates parental histone segregation and heterochromatin inheritance. Molecular Cell. https://doi.org/10.1016/j.molcel.2024.07.002
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Singhal, A., Styers, H. C., Rub, J., Li, Z., Torborg, S. R., Kim, J. Y., Grbovic-Huezo, O., Feng, H., Tarcan, Z. Cagla., Sahin Ozkan, H., Hallin, J., Basturk, O., Yaeger, R., Christensen, J. G., Betel, D., Yan, Y., Chio, I. I. C., de Stanchina, E., & Tammela, T. (2024). A classical epithelial state drives acute resistance to KRAS inhibition in pancreas cancer. Cancer Discovery. https://doi.org/10.1158/2159-8290.cd-24-0740
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Tai, Y., Chow, A., Han, S., Coker, C., Ma, W., Gu, Y., Estrada Navarro, V., Kandpal, M., Hibshoosh, H., Kalinsky, K., Manova-Todorova, K., Safonov, A., Walsh, E. M., Robson, M., Norton, L., Baer, R., Merghoub, T., Biswas, A. K., & Acharyya, S. (2024). FLT1 activation in cancer cells promotes PARP-inhibitor resistance in breast cancer. EMBO Molecular Medicine, 16(8), 1957–1980. https://doi.org/10.1038/s44321-024-00094-2
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Ahmed, A., Kato, N., & Gautier, J. (2024). Replication-Independent ICL Repair: From Chemotherapy to Cell Homeostasis. Journal of Molecular Biology, 436(13), 168618. https://doi.org/10.1016/j.jmb.2024.168618
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Gallitto, M., De Santos, G. L., Wei, H.-J., Zhang, X., Zhang, Z., & Wu, C.-C. (2024). DIPG-41. CONVECTION ENHANCED DELIVERY-MEDIATED RADIOSENSITIZATION FOR DIFFUSE MIDLINE GLIOMA. Neuro-Oncology, 26(Supplement_4), 0–0. https://doi.org/10.1093/neuonc/noae064.094
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Liu, Y., Su, Z., Tavana, O., & Gu, W. (2024). Understanding the complexity of p53 in a new era of tumor suppression. Cancer Cell, 42(6), 946–967. https://doi.org/10.1016/j.ccell.2024.04.009
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Serra-Cardona, A., Hua, X., McNutt, S. W., Zhou, H., Toda, T., Jia, S., Chu, F., & Zhang, Z. (2024). The PCNA–Pol δ complex couples lagging strand DNA synthesis to parental histone transfer for epigenetic inheritance. Science Advances, 10(23). https://doi.org/10.1126/sciadv.adn5175
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Berndt, C., Alborzinia, H., Amen, V. S., Ayton, S., Barayeu, U., Bartelt, A., Bayir, H., Bebber, C. M., Birsoy, K., Böttcher, J. P., Brabletz, S., Brabletz, T., Brown, A. R., Brüne, B., Bulli, G., Bruneau, A., Chen, Q., DeNicola, G. M., Dick, T. P., … Conrad, M. (2024). Ferroptosis in health and disease. Redox Biology, 75, 103211. https://doi.org/10.1016/j.redox.2024.103211
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Rafic, E., Ma, C., Shih, B. B., Miller, H., Yuste, R., Palomero, T., & Etchenique, R. (2024). RuBi-Ruxolitinib: A Photoreleasable Antitumor JAK Inhibitor. Journal of the American Chemical Society, 146(19), 13317–13325. https://doi.org/10.1021/jacs.4c01720
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Lee, J., Lee, J., Sohn, E. J., Taglialatela, A., O’Sullivan, R. J., Ciccia, A., & Min, J. (2024). Extrachromosomal telomere DNA derived from excessive strand displacements. Proceedings of the National Academy of Sciences, 121(19). https://doi.org/10.1073/pnas.2318438121
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Wondisford, A. R., Lee, J., Lu, R., Schuller, M., Groslambert, J., Bhargava, R., Schamus-Haynes, S., Cespedes, L. C., Opresko, P. L., Pickett, H. A., Min, J., Ahel, I., & O’Sullivan, R. J. (2024). Deregulated DNA ADP-ribosylation impairs telomere replication. Nature Structural & Molecular Biology, 31(5), 791–800. https://doi.org/10.1038/s41594-024-01279-6
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Acharya, A., Bret, H., Huang, J.-W., Mütze, M., Göse, M., Kissling, V. M., Seidel, R., Ciccia, A., Guérois, R., & Cejka, P. (2024). Mechanism of DNA unwinding by MCM8-9 in complex with HROB. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-47936-8
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Wang, L., Wang, H., D’Angelo, F., Curtin, L., Sereduk, C. P., Leon, G. D., Singleton, K. W., Urcuyo, J., Hawkins-Daarud, A., Jackson, P. R., Krishna, C., Zimmerman, R. S., Patra, D. P., Bendok, B. R., Smith, K. A., Nakaji, P., Donev, K., Baxter, L. C., Mrugała, M. M., … Li, J. (2024). Quantifying intra-tumoral genetic heterogeneity of glioblastoma toward precision medicine using MRI and a data-inclusive machine learning algorithm. PLOS ONE, 19(4), e0299267. https://doi.org/10.1371/journal.pone.0299267
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Columbia Affiliation
He, X., Cantrell, A. C., Williams, Q. A., Gu, W., Chen, Y., Chen, J.-X., & Zeng, H. (2024). p53 Acetylation Exerts Critical Roles in Pressure Overload–Induced Coronary Microvascular Dysfunction and Heart Failure in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 44(4), 826–842. https://doi.org/10.1161/atvbaha.123.319601
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Ross, A. B., Gorhe, D., Kim, J. K., Hodapp, S., DeVine, L., Chan, K. M., Chio, I. I. C., Jovanovic, M., & Ayres Pereira, M. (2024). Systematic analysis of proteome turnover in an organoid model of pancreatic cancer by dSILO. Cell Reports Methods, 4(5), 100760. https://doi.org/10.1016/j.crmeth.2024.100760
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Tazhibi, M., McQuillan, N., Wei, H.-J., Gallitto, M., Bendau, E., Webster Carrion, A., Berg, X., Kokossis, D., Zhang, X., Zhang, Z., Jan, C.-I., Mintz, A., Gartrell, R. D., Syed, H. R., Fonseca, A., Pavisic, J., Szalontay, L., Konofagou, E. E., Zacharoulis, S., & Wu, C.-C. (2024). Focused ultrasound-mediated blood–brain barrier opening is safe and feasible with moderately hypofractionated radiotherapy for brainstem diffuse midline glioma. Journal of Translational Medicine, 22(1). https://doi.org/10.1186/s12967-024-05096-9
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