ZIAAI005022

NIH – National Institute of Allergy and Infectious Diseases

Ultrapotent Broadly Neutralizing Human-llama Bispecific Antibodies against HIV-1

Xu, J., Zhou, T., McKee, K., Zhang, B., Liu, C., Nazzari, A. F., Pegu, A., Shen, C., Becker, J. E., Bender, M. F., Chan, P., Changela, A., Chaudhary, R., Chen, X., Einav, T., Kwon, Y. D., Lin, B. C., Louder, M. K., Merriam, J. S., … Kwong, P. D. (2024). Ultrapotent Broadly Neutralizing Human‐llama Bispecific Antibodies against HIV‐1. Advanced Science, 11(26). Portico. https://doi.org/10.1002/advs.202309268
Authors:
Jianliang Xu
Tongqing Zhou
Krisha McKee
Baoshan Zhang
Cuiping Liu
Alexandra F Nazzari
Amarendra Pegu
Chen-Hsiang Shen
Jordan E Becker
Michael F Bender
Payton Chan
Anita Changela
Ridhi Chaudhary
Xuejun Chen
Tal Einav
Young Do Kwon
Bob C Lin
Mark K Louder
Jonah S Merriam
Nicholas C Morano
Sijy O'Dell
Adam S Olia
Reda Rawi
Ryan S Roark
Tyler Stephens
I-Ting Teng
Emily Tourtellott-Fogt
Shuishu Wang
Eun Sung Yang
Lawrence Shapiro
Yaroslav Tsybovsky
Nicole A Doria-Rose
Rafael Casellas
Peter D Kwong
Affiliated Authors:
Jordan E Becker
Nicholas C Morano
Ryan S Roark
Lawrence Shapiro
Peter D Kwong
Author Keywords:
bispecific antibodies
bnab
broadly neutralizing antibody
hiv-1
llama
neutralizing nanobodies
vaccination
vaccine
hiv‐1
Grants:
ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)
ZICAI005140 (NIH – National Institute of Allergy and Infectious Diseases)
ZICAI005111 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005024 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005143 (NIH – National Institute of Allergy and Infectious Diseases)
ZICAI005002 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1002/advs.202309268
PMID:
Journal:
Publication Date:
Data Source:
PubMed

Record Created:

Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody

Olia, A. S., Prabhakaran, M., Harris, D. R., Cheung, C. S.-F., Gillespie, R. A., Gorman, J., Hoover, A., Morano, N. C., Ourahmane, A., Srikanth, A., Wang, S., Wu, W., Zhou, T., Andrews, S. F., Kanekiyo, M., Shapiro, L., McDermott, A. B., & Kwong, P. D. (2024). Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1399960
Authors:
Adam S Olia
Madhu Prabhakaran
Darcy R Harris
Crystal Sao-Fong Cheung
Rebecca A Gillespie
Jason Gorman
Abigayle Hoover
Nicholas C Morano
Amine Ourahmane
Abhinaya Srikanth
Shuishu Wang
Weiwei Wu
Tongqing Zhou
Sarah F Andrews
Masaru Kanekiyo
Lawrence Shapiro
Adrian B McDermott
Peter D Kwong
Affiliated Authors:
Nicholas C Morano
Lawrence Shapiro
Peter D Kwong
Author Keywords:
anti-idiotype
broadly neutralizing antibody
cryo-em
influenza a virus
medi8852
vh6-1 class
Grants:
ZIAAI005143 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005024 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005003 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.3389/fimmu.2024.1399960
PMID:
Publication Date:
Data Source:
PubMed

Record Created:

Human neutralizing antibodies target a conserved lateral patch on H7N9 hemagglutinin head

Jia, M., Zhao, H., Morano, N. C., Lu, H., Lui, Y.-M., Du, H., Becker, J. E., Yuen, K.-Y., Ho, D. D., Kwong, P. D., Shapiro, L., To, K. K.-W., & Wu, X. (2024). Human neutralizing antibodies target a conserved lateral patch on H7N9 hemagglutinin head. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-48758-4
Authors:
Manxue Jia
Hanjun Zhao
Nicholas C Morano
Hong Lu
Yin-Ming Lui
Haijuan Du
Jordan E Becker
Kwok-Yung Yuen
David D Ho
Peter D Kwong
Lawrence Shapiro
Kelvin Kai-Wang To
Xueling Wu
Affiliated Authors:
Manxue Jia
Nicholas C Morano
Hong Lu
Jordan E Becker
David D Ho
Peter D Kwong
Lawrence Shapiro
Xueling Wu
Grants:
ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1038/s41467-024-48758-4
PMID:
Publication Date:
Data Source:
PubMed

Record Created:

Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability

Gorman, J., Cheung, C. S.-F., Duan, Z., Ou, L., Wang, M., Chen, X., Cheng, C., Biju, A., Sun, Y., Wang, P., Yang, Y., Zhang, B., Boyington, J. C., Bylund, T., Charaf, S., Chen, S. J., Du, H., Henry, A. R., Liu, T., … Kwong, P. D. (2024). Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability. Nature Communications, 15(1). https://doi.org/10.1038/s41467-023-44534-y
Authors:
Jason Gorman
Crystal Sao-Fong Cheung
Zhijian Duan
Li Ou
Maple Wang
Xuejun Chen
Cheng Cheng
Andrea Biju
Yaping Sun
Pengfei Wang
Yongping Yang
Baoshan Zhang
Jeffrey C Boyington
Tatsiana Bylund
Sam Charaf
Steven J Chen
Haijuan Du
Amy R Henry
Tracy Liu
Edward K Sarfo
Chaim A Schramm
Chen-Hsiang Shen
Tyler Stephens
I-Ting Teng
John-Paul Todd
Yaroslav Tsybovsky
Raffaello Verardi
Danyi Wang
Shuishu Wang
Zhantong Wang
Cheng-Yan Zheng
Tongqing Zhou
Daniel C Douek
John R Mascola
David D Ho
Mitchell Ho
Peter D Kwong
Affiliated Authors:
Maple Wang
Pengfei Wang
David D Ho
Subjects:
Grants:
ZICBC011891 (NIH – National Cancer Institute)
ZIAAI005024 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005023 (NIH – National Institute of Allergy and Infectious Diseases)
ZICAI005002 (NIH – National Institute of Allergy and Infectious Diseases)
ZICAI005114 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005166 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005151 (NIH – National Institute of Allergy and Infectious Diseases)
ZICAI005111 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)
P41GM103310 (NIH – National Institute of General Medical Sciences)
Publication Type:
Article
Unique ID:
10.1038/s41467-023-44534-y
PMID:
Publication Date:
Data Source:
PubMed

Record Created:

HIV-1 neutralizing antibodies elicited in humans by a prefusion-stabilized envelope trimer form a reproducible class targeting fusion peptide

Wang, S., Matassoli, F., Zhang, B., Liu, T., Shen, C.-H., Bylund, T., Johnston, T., Henry, A. R., Teng, I.-T., Tripathi, P., Becker, J. E., Changela, A., Chaudhary, R., Cheng, C., Gaudinski, M., Gorman, J., Harris, D. R., Lee, M., Morano, N. C., … Kwong, P. D. (2023). HIV-1 neutralizing antibodies elicited in humans by a prefusion-stabilized envelope trimer form a reproducible class targeting fusion peptide. Cell Reports, 42(7), 112755. https://doi.org/10.1016/j.celrep.2023.112755
Authors:
Shuishu Wang
Flavio Matassoli
Baoshan Zhang
Tracy Liu
Chen-Hsiang Shen
Tatsiana Bylund
Timothy Johnston
Amy R Henry
I-Ting Teng
Prabhanshu Tripathi
Jordan E Becker
Anita Changela
Ridhi Chaudhary
Cheng Cheng
Martin Gaudinski
Jason Gorman
Darcy R Harris
Myungjin Lee
Nicholas C Morano
Laura Novik
Sijy O'Dell
Adam S Olia
Danealle K Parchment
Reda Rawi
Jesmine Roberts-Torres
Tyler Stephens
Yaroslav Tsybovsky
Danyi Wang
David J Van Wazer
Tongqing Zhou
Nicole A Doria-Rose
Richard A Koup
Lawrence Shapiro
Daniel C Douek
Adrian B McDermott
Peter D Kwong
Affiliated Authors:
Jordan E Becker
Nicholas C Morano
Lawrence Shapiro
Peter D Kwong
Subjects:
Author Keywords:
antibody-antigen binding
cp: immunology
cryo-em structure
envelope trimer
fusion peptide
glycan hole
hiv vaccine
immunogen design
reproducible antibody class
site of vulnerability
Grants:
ZICAI005112 (NIH – National Institute of Allergy and Infectious Diseases)
ZICAI005002 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005143 (NIH – National Institute of Allergy and Infectious Diseases)
ZICAI005133 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)
ZICAI005111 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1016/j.celrep.2023.112755
PMID:
Journal:
Publication Date:
Data Source:
PubMed

Record Created:

Vaccine elicitation and structural basis for antibody protection against alphaviruses

Sutton, M. S., Pletnev, S., Callahan, V., Ko, S., Tsybovsky, Y., Bylund, T., Casner, R. G., Cerutti, G., Gardner, C. L., Guirguis, V., Verardi, R., Zhang, B., Ambrozak, D., Beddall, M., Lei, H., Yang, E. S., Liu, T., Henry, A. R., Rawi, R., … Roederer, M. (2023). Vaccine elicitation and structural basis for antibody protection against alphaviruses. Cell, 186(12), 2672-2689.e25. https://doi.org/10.1016/j.cell.2023.05.019
Authors:
Matthew S Sutton
Sergei Pletnev
Victoria Callahan
Sungyoul Ko
Yaroslav Tsybovsky
Tatsiana Bylund
Ryan G Casner
Gabriele Cerutti
Christina L Gardner
Veronica Guirguis
Raffaello Verardi
Baoshan Zhang
David Ambrozak
Margaret Beddall
Hong Lei
Eun Sung Yang
Tracy Liu
Amy R Henry
Reda Rawi
Arne Schön
Chaim A Schramm
Chen-Hsiang Shen
Wei Shi
Tyler Stephens
Yongping Yang
Maria Burgos Florez
Julie E Ledgerwood
Crystal W Burke
Lawrence Shapiro
Julie M Fox
Peter D Kwong
Mario Roederer
Affiliated Authors:
Ryan G Casner
Gabriele Cerutti
Lawrence Shapiro
Peter D Kwong
Author Keywords:
alphavirus
broadly neutralizing antibody
cryo-em
in vivo challenge
vaccine
in vivo challenge
Grants:
ZIAAI005023 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)
ZICAI005112 (NIH – National Institute of Allergy and Infectious Diseases)
ZICAI005140 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI001348 (NIH – National Institute of Allergy and Infectious Diseases)
Publication Type:
Article
Unique ID:
10.1016/j.cell.2023.05.019
PMID:
Journal:
Publication Date:
Data Source:
PubMed

Record Created:

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

Wang, P., Casner, R. G., Nair, M. S., Yu, J., Guo, Y., Wang, M., Chan, J. F.-W., Cerutti, G., Iketani, S., Liu, L., Sheng, Z., Chen, Z., Yuen, K.-Y., Kwong, P. D., Huang, Y., Shapiro, L., & Ho, D. D. (2021). A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses. Emerging Microbes & Infections, 11(1), 147–157. https://doi.org/10.1080/22221751.2021.2011623
Authors:
Pengfei Wang
Ryan G Casner
Manoj S Nair
Jian Yu
Yicheng Guo
Maple Wang
Jasper F-W Chan
Gabriele Cerutti
Sho Iketani
Lihong Liu
Zizhang Sheng
Zhiwei Chen
Kwok-Yung Yuen
Peter D Kwong
Yaoxing Huang
Lawrence Shapiro
David D Ho
Affiliated Authors:
Pengfei Wang
Ryan G Casner
Manoj S Nair
Jian Yu
Yicheng Guo
Maple Wang
Gabriele Cerutti
Sho Iketani
Lihong Liu
Zizhang Sheng
Peter D Kwong
Yaoxing Huang
Lawrence Shapiro
David D Ho
Author Keywords:
sars-cov-2
antibody
variants
sarbecovirus
sars-cov
Grants:
T32AI106711 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005149 (NIH – National Institute of Allergy and Infectious Diseases)
T32GM008224 (NIH – National Institute of General Medical Sciences)
Publication Type:
Article
Unique ID:
10.1080/22221751.2021.2011623
PMID:
Publication Date:
Data Source:
PubMed

Record Created:

An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses

Liu, L., Iketani, S., Guo, Y., Reddem, E. R., Casner, R. G., Nair, M. S., Yu, J., Chan, J. F.-W., Wang, M., Cerutti, G., Li, Z., Morano, N. C., Castagna, C. D., Corredor, L., Chu, H., Yuan, S., Poon, V. K.-M., Chan, C. C.-S., Chen, Z., … Ho, D. D. (2022). An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses. Science Translational Medicine, 14(646). https://doi.org/10.1126/scitranslmed.abn6859
Authors:
Lihong Liu
Sho Iketani
Yicheng Guo
Eswar R. Reddem
Ryan G. Casner
Manoj S. Nair
Jian Yu
Jasper F.-W. Chan
Maple Wang
Gabriele Cerutti
Zhiteng Li
Nicholas C. Morano
Candace D. Castagna
Laura Corredor
Hin Chu
Shuofeng Yuan
Vincent Kwok-Man Poon
Chris Chun-Sing Chan
Zhiwei Chen
Yang Luo
Marcus Cunningham
Alejandro Chavez
Michael T. Yin
David S. Perlin
Moriya Tsuji
Kwok-Yung Yuen
Peter D. Kwong
Zizhang Sheng
Yaoxing Huang
Lawrence Shapiro
David D. Ho
Affiliated Authors:
Lihong Liu
Sho Iketani
Yicheng Guo
Eswar R. Reddem
Ryan G. Casner
Manoj S. Nair
Jian Yu
Maple Wang
Gabriele Cerutti
Zhiteng Li
Nicholas C. Morano
Candace D. Castagna
Laura Corredor
Yang Luo
Alejandro Chavez
Michael T. Yin
Moriya Tsuji
Kwok-Yung Yuen
Peter D. Kwong
Zizhang Sheng
Yaoxing Huang
Lawrence Shapiro
David D. Ho
Grants:
ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005149 (NIH – National Institute of Allergy and Infectious Diseases)
P41GM103403 (NIH – National Institute of General Medical Sciences)
S10OD020056 (NIH – Office of the Director, National Institutes of Health)
Publication Type:
Article
Unique ID:
10.1126/scitranslmed.abn6859
PMID:
Publication Date:
Data Source:
Scopus

Record Created:

Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants

Xu, J., Xu, K., Jung, S., Conte, A., Lieberman, J., Muecksch, F., Lorenzi, J. C. C., Park, S., Schmidt, F., Wang, Z., Huang, Y., Luo, Y., Nair, M. S., Wang, P., Schulz, J. E., Tessarollo, L., Bylund, T., Chuang, G.-Y., Olia, A. S., … Casellas, R. (2021). Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants. Nature, 595(7866), 278–282. https://doi.org/10.1038/s41586-021-03676-z
Authors:
Jianliang Xu
Kai Xu
Seolkyoung Jung
Andrea Conte
Jenna Lieberman
Frauke Muecksch
Julio Cesar Cetrulo Lorenzi
Solji Park
Fabian Schmidt
Zijun Wang
Yaoxing Huang
Yang Luo
Manoj S. Nair
Pengfei Wang
Jonathan E. Schulz
Lino Tessarollo
Tatsiana Bylund
Gwo-Yu Chuang
Adam S. Olia
Tyler Stephens
I-Ting Teng
Yaroslav Tsybovsky
Tongqing Zhou
Vincent Munster
David D. Ho
Theodora Hatziioannou
Paul D. Bieniasz
Michel C. Nussenzweig
Peter D. Kwong
Rafael Casellas
Affiliated Authors:
Yaoxing Huang
Yang Luo
Manoj S. Nair
Pengfei Wang
David D. Ho
Grants:
ZICBC011265 (NIH – National Cancer Institute)
ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005147 (NIH – National Institute of Allergy and Infectious Diseases)
ZICAI005112 (NIH – National Institute of Allergy and Infectious Diseases)
ZICAI005111 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAR041211 (NIH – National Institute of Arthritis and Musculoskeletal and Skin Diseases)
Publication Type:
Article
Unique ID:
10.1038/s41586-021-03676-z
PMID:
Journal:
Publication Date:
Data Source:
Scopus

Record Created:

Structural basis for accommodation of emerging B.1.351 and B.1.1.7 variants by two potent SARS-CoV-2 neutralizing antibodies

Cerutti, G., Rapp, M., Guo, Y., Bahna, F., Bimela, J., Reddem, E. R., Yu, J., Wang, P., Liu, L., Huang, Y., Ho, D. D., Kwong, P. D., Sheng, Z., & Shapiro, L. (2021). Structural basis for accommodation of emerging B.1.351 and B.1.1.7 variants by two potent SARS-CoV-2 neutralizing antibodies. Structure, 29(7), 655-663.e4. https://doi.org/10.1016/j.str.2021.05.014
Authors:
Gabriele Cerutti
Micah Rapp
Yicheng Guo
Fabiana Bahna
Jude Bimela
Eswar R. Reddem
Jian Yu
Pengfei Wang
Lihong Liu
Yaoxing Huang
David D. Ho
Peter D. Kwong
Zizhang Sheng
Lawrence Shapiro
Affiliated Authors:
Gabriele Cerutti
Micah Rapp
Yicheng Guo
Fabiana Bahna
Jude Bimela
Eswar R. Reddem
Jian Yu
Pengfei Wang
Lihong Liu
Yaoxing Huang
David D. Ho
Peter D. Kwong
Zizhang Sheng
Lawrence Shapiro
Author Keywords:
b.1.351 and b.1.1.7 variants
covid-19
sars-cov-2
cryo-em
low-frequency immune response
neutralizing antibody
receptor-binding domain
Grants:
R21AI143407 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)
R21AI144408 (NIH – National Institute of Allergy and Infectious Diseases)
U24GM129539 (NIH – National Institute of General Medical Sciences)
DP5OD023118 (NIH – Office of the Director, National Institutes of Health)
Publication Type:
Article
Unique ID:
10.1016/j.str.2021.05.014
PMID:
Journal:
Publication Date:
Data Source:
Scopus

Record Created:

Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class

Rapp, M., Guo, Y., Reddem, E. R., Yu, J., Liu, L., Wang, P., Cerutti, G., Katsamba, P., Bimela, J. S., Bahna, F. A., Mannepalli, S. M., Zhang, B., Kwong, P. D., Huang, Y., Ho, D. D., Shapiro, L., & Sheng, Z. (2021). Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class. Cell Reports, 35(1), 108950. https://doi.org/10.1016/j.celrep.2021.108950
Authors:
Micah Rapp
Yicheng Guo
Eswar R Reddem
Jian Yu
Lihong Liu
Pengfei Wang
Gabriele Cerutti
Phinikoula Katsamba
Jude S Bimela
Fabiana A Bahna
Seetha M Mannepalli
Baoshan Zhang
Peter D Kwong
Yaoxing Huang
David D Ho
Lawrence Shapiro
Zizhang Sheng
Affiliated Authors:
Micah Rapp
Yicheng Guo
Eswar R Reddem
Jian Yu
Lihong Liu
Pengfei Wang
Gabriele Cerutti
Phinikoula Katsamba
Jude S Bimela
Fabiana A Bahna
Seetha M Mannepalli
Peter D Kwong
Yaoxing Huang
David D Ho
Lawrence Shapiro
Zizhang Sheng
Author Keywords:
covid-19
multi-donor antibody class
neutralizing antibody
quaternary recognition
rbd
sars-cov-2
spike
Grants:
ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)
U24GM129539 (NIH – National Institute of General Medical Sciences)
P30GM124165 (NIH – National Institute of General Medical Sciences)
P41GM103310 (NIH – National Institute of General Medical Sciences)
Publication Type:
Article
Unique ID:
10.1016/j.celrep.2021.108950
PMID:
Journal:
Publication Date:
Data Source:
PubMed

Record Created:

Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite

Cerutti, G., Guo, Y., Zhou, T., Gorman, J., Lee, M., Rapp, M., Reddem, E. R., Yu, J., Bahna, F., Bimela, J., Huang, Y., Katsamba, P. S., Liu, L., Nair, M. S., Rawi, R., Olia, A. S., Wang, P., Zhang, B., Chuang, G.-Y., … Shapiro, L. (2021). Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite. Cell Host & Microbe, 29(5), 819-833.e7. https://doi.org/10.1016/j.chom.2021.03.005
Authors:
Gabriele Cerutti
Yicheng Guo
Tongqing Zhou
Jason Gorman
Myungjin Lee
Micah Rapp
Eswar R Reddem
Jian Yu
Fabiana Bahna
Jude Bimela
Yaoxing Huang
Phinikoula S Katsamba
Lihong Liu
Manoj S Nair
Reda Rawi
Adam S Olia
Pengfei Wang
Baoshan Zhang
Gwo-Yu Chuang
David D Ho
Zizhang Sheng
Peter D Kwong
Lawrence Shapiro
Affiliated Authors:
Gabriele Cerutti
Yicheng Guo
Micah Rapp
Eswar R Reddem
Jian Yu
Fabiana Bahna
Jude Bimela
Yaoxing Huang
Phinikoula S Katsamba
Lihong Liu
Manoj S Nair
Pengfei Wang
David D Ho
Zizhang Sheng
Peter D Kwong
Lawrence Shapiro
Author Keywords:
antibody class
antigenic supersite
covid-19
multi-donor antibody
n-terminal domain
neutralizing antibody
sars-cov-2
Grants:
R21AI143407 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005147 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)
R21AI144408 (NIH – National Institute of Allergy and Infectious Diseases)
ZICAI005112 (NIH – National Institute of Allergy and Infectious Diseases)
P41GM103310 (NIH – National Institute of General Medical Sciences)
U24GM129539 (NIH – National Institute of General Medical Sciences)
P30GM124165 (NIH – National Institute of General Medical Sciences)
DP5OD023118 (NIH – Office of the Director, National Institutes of Health)
Publication Type:
Article
Unique ID:
10.1016/j.chom.2021.03.005
PMID:
Publication Date:
Data Source:
PubMed

Record Created:

Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody

Madan, B., Zhang, B., Xu, K., Chao, C. W., O’Dell, S., Wolfe, J. R., Chuang, G.-Y., Fahad, A. S., Geng, H., Kong, R., Louder, M. K., Nguyen, T. D., Rawi, R., Schön, A., Sheng, Z., Nimrania, R., Wang, Y., Zhou, T., Lin, B. C., … DeKosky, B. J. (2021). Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody. Proceedings of the National Academy of Sciences, 118(10). https://doi.org/10.1073/pnas.2011653118
Authors:
Bharat Madan
Baoshan Zhang
Kai Xu
Cara W Chao
Sijy O'Dell
Jacy R Wolfe
Gwo-Yu Chuang
Ahmed S Fahad
Hui Geng
Rui Kong
Mark K Louder
Thuy Duong Nguyen
Reda Rawi
Arne Schön
Zizhang Sheng
Rajani Nimrania
Yiran Wang
Tongqing Zhou
Bob C Lin
Nicole A Doria-Rose
Lawrence Shapiro
Peter D Kwong
Brandon J DeKosky
Affiliated Authors:
Zizhang Sheng
Lawrence Shapiro
Peter D Kwong
Author Keywords:
broadly neutralizing antibodies
fusion peptide
hiv-1 vaccines
somatic hypermutation
yeast display
Grants:
ZICAI005140 (NIH – National Institute of Allergy and Infectious Diseases)
R01AI141452 (NIH – National Institute of Allergy and Infectious Diseases)
R21AI143407 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)
P20GM103638 (NIH – National Institute of General Medical Sciences)
P20GM113117 (NIH – National Institute of General Medical Sciences)
DP5OD023118 (NIH – Office of the Director, National Institutes of Health)
Publication Type:
Article
Unique ID:
10.1073/pnas.2011653118
PMID:
Publication Date:
Data Source:
PubMed

Record Created: