Gene Therapy Techniques and Applications

Displaying 1 - 17 of 17CSV
Shahid, S., Prockop, S. E., Flynn, G. C., Mauguen, A., White, C., Bieler, J., McAvoy, D., Hosszu, K., Cancio, M. I., Jakubowski, A. A., Scaradavou, A., Boelens, J. J., Sauter, C. S., Perales, M.-A., Giralt, S. A., Taylor, C., Chaudhari, J., Wang, X., Rivière, I., … Curran, K. J. (2025). Allogeneic Off-the-Shelf CAR T-Cell Therapy for Relapsed or Refractory B-Cell Malignancies. Blood Advances. https://doi.org/10.1182/bloodadvances.2024015157
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Keller, M. D., Hanley, P. J., Chi, Y.-Y., Aguayo-Hiraldo, P., Dvorak, C. C., Verneris, M. R., Kohn, D. B., Pai, S.-Y., Dávila Saldaña, B. J., Hanisch, B., Quigg, T. C., Adams, R. H., Dahlberg, A., Chandrakasan, S., Hasan, H., Malvar, J., Jensen-Wachspress, M. A., Lazarski, C. A., Sani, G., … Pulsipher, M. A. (2024). Antiviral cellular therapy for enhancing T-cell reconstitution before or after hematopoietic stem cell transplantation (ACES): a two-arm, open label phase II interventional trial of pediatric patients with risk factor assessment. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-47057-2
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Migden, M. R., Chai-Ho, W., Daniels, G. A., Wise-Draper, T. M., Kheterpal, M., Tang, J. C., Bolotin, D., Verschraegen, C., Poklepovic, A. S., Khan, S. A., Ibrahim, S. F., Zeitouni, N. C., Medina, T., Tsai, K. K., Tucci, C., Navia, S., Donthireddy, L., Bommareddy, P. K., Hou, J. W., & Davar, D. (2023). 777 Initial results from an open-label phase 1b/2 study of RP1 oncolytic immunotherapy in solid organ and hematopoietic cell transplant recipients with advanced cutaneous malignancies (ARTACUS). Regular and Young Investigator Award Abstracts. https://doi.org/10.1136/jitc-2023-sitc2023.0777
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Barsan, V., Li, Y., Prabhu, S., Baggott, C., Nguyen, K., Pacenta, H., Phillips, C. L., Rossoff, J., Stefanski, H., Talano, J.-A., Moskop, A., Baumeister, S., Verneris, M. R., Myers, G. D., Karras, N. A., Cooper, S., Qayed, M., Hermiston, M., Satwani, P., … Schultz, L. M. (2023). Tisagenlecleucel utilisation and outcomes across refractory, first relapse and multiply relapsed B-cell acute lymphoblastic leukemia: a retrospective analysis of real-world patterns. EClinicalMedicine, 65, 102268. https://doi.org/10.1016/j.eclinm.2023.102268
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Kehrer, T., Cupic, A., Ye, C., Yildiz, S., Bouhaddou, M., Crossland, N. A., Barrall, E. A., Cohen, P., Tseng, A., Çağatay, T., Rathnasinghe, R., Flores, D., Jangra, S., Alam, F., Mena, I., Aslam, S., Saqi, A., Rutkowska, M., Ummadi, M. R., … Miorin, L. (2023). Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis. Cell Host & Microbe, 31(10), 1668-1684.e12. https://doi.org/10.1016/j.chom.2023.08.003
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Lao, Y.-H., Ji, R., Zhou, J. K., Snow, K. J., Kwon, N., Saville, E., He, S., Chauhan, S., Chi, C.-W., Datta, M. S., Zhang, H., Quek, C. H., Cai, S. S., Li, M., Gaitan, Y., Bechtel, L., Wu, S.-Y., Lutz, C. M., Tomer, R., … Leong, K. W. (2023). Focused ultrasound–mediated brain genome editing. Proceedings of the National Academy of Sciences, 120(34). https://doi.org/10.1073/pnas.2302910120
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Boboila, S., Okochi, S., Banerjee, D., Barton, S., Street, C., Zenilman, A. L., Wang, Q., Gartrell, R. D., Saenger, Y. M., Welch, D., Wu, C.-C., Kadenhe-Chiweshe, A., Yamashiro, D. J., & Connolly, E. P. (2023). Combining immunotherapy with high-dose radiation therapy (HDRT) significantly inhibits tumor growth in a syngeneic mouse model of high-risk neuroblastoma. Heliyon, 9(6), e17399. https://doi.org/10.1016/j.heliyon.2023.e17399
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Savage, T. M., Vincent, R. L., Rae, S. S., Huang, L. H., Ahn, A., Pu, K., Li, F., de los Santos-Alexis, K., Coker, C., Danino, T., & Arpaia, N. (2023). Chemokines expressed by engineered bacteria recruit and orchestrate antitumor immunity. Science Advances, 9(10). https://doi.org/10.1126/sciadv.adc9436
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Stefanski, H. E., Eaton, A., Baggott, C., Rossoff, J., Verneris, M. R., Prabhu, S., Pacenta, H. L., Phillips, C. L., Talano, J.-A., Moskop, A., Margossian, S. P., Myers, G. D., Karras, N. A., Brown, P. A., Qayed, M., Hermiston, M., Satwani, P., Krupski, M. C., Keating, A. K., … Schultz, L. M. (2023). Higher doses of tisagenlecleucel are associated with improved outcomes: a report from the pediatric real-world CAR consortium. Blood Advances, 7(4), 541–548. https://doi.org/10.1182/bloodadvances.2022007246
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Fine, R. L., Mao, Y., Garcia-Carracedo, D., Su, G. H., Qiu, W., Hochfeld, U., Nichols, G., Li, Y.-L., Dinnen, R. D., Raffo, A., & Brandt-Rauf, P. W. (2023). Gene Therapy with p14/tBID Induces Selective and Synergistic Apoptosis in Mutant Ras and Mutant p53 Cancer Cells In Vitro and In Vivo. Biomedicines, 11(2), 258. https://doi.org/10.3390/biomedicines11020258
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Deb, D., Wu, Y., Coker, C., Harimoto, T., Huang, R., & Danino, T. (2022). Design of combination therapy for engineered bacterial therapeutics in non-small cell lung cancer. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-26105-1
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Walters, M. C., Thompson, A. A., Kwiatkowski, J. L., Parikh, S., Mapara, M. Y., Rifkin-Zenenberg, S., Aygun, B., Kasow, K. A., Miller, A., Zhang, L., Chawla, A., Macari, E. R., Pierciey, F. J., Tisdale, J. F., & Kanter, J. (2022). Lovo-cel (bb1111) Gene Therapy for Sickle Cell Disease: Updated Clinical Results and Investigations into Two Cases of Anemia from Group C of the Phase 1/2 HGB-206 Study. Blood, 140(Supplement 1), 26–28. https://doi.org/10.1182/blood-2022-162288
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Tanaka, J., Senpuku, H., Ogawa, M., Yasuhara, R., Ohnuma, S., Takamatsu, K., Watanabe, T., Mabuchi, Y., Nakamura, S., Ishida, S., Sadaoka, T., Takaki, T., Shirota, T., Shimane, T., Inoue, T., Sakai, T., Mori, M., Tsuji, T., Saito, I., & Mishima, K. (2022). Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication. Nature Cell Biology, 24(11), 1595–1605. https://doi.org/10.1038/s41556-022-01007-6
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Li, T.-W., Kenney, A. D., Park, J.-G., Fiches, G. N., Liu, H., Zhou, D., Biswas, A., Zhao, W., Que, J., Santoso, N., Martinez-Sobrido, L., Yount, J. S., & Zhu, J. (2022). SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.1007089
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Liu, L., Iketani, S., Guo, Y., Reddem, E. R., Casner, R. G., Nair, M. S., Yu, J., Chan, J. F.-W., Wang, M., Cerutti, G., Li, Z., Morano, N. C., Castagna, C. D., Corredor, L., Chu, H., Yuan, S., Poon, V. K.-M., Chan, C. C.-S., Chen, Z., … Ho, D. D. (2022). An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses. Science Translational Medicine, 14(646). https://doi.org/10.1126/scitranslmed.abn6859
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