ZICAI005114

NIH – National Institute of Allergy and Infectious Diseases

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Cholesterol reduction by immunization with a PCSK9 mimic

Zhang, B., Chuang, G.-Y., Biju, A., Biner, D., Cheng, J., Wang, Y., Bao, S., Chao, C. W., Lei, H., Liu, T., Nazzari, A. F., Yang, Y., Zhou, T., Chen, S. J., Chen, X., Kong, W.-P., Ou, L., Parchment, D. K., Sarfo, E. K., … Kwong, P. D. (2024). Cholesterol reduction by immunization with a PCSK9 mimic. Cell Reports, 43(6), 114285. https://doi.org/10.1016/j.celrep.2024.114285
Authors:
Baoshan Zhang
Gwo-Yu Chuang
Andrea Biju
Daniel Biner
Jiaxuan Cheng
Yiran Wang
Saran Bao
Cara W Chao
Haotian Lei
Tracy Liu
Alexandra F Nazzari
Yongping Yang
Tongqing Zhou
Steven J Chen
Xuejun Chen
Wing-Pui Kong
Li Ou
Danealle K Parchment
Edward K Sarfo
HaoMin SiMa
John-Paul Todd
Shuishu Wang
Ruth A Woodward
Cheng Cheng
Reda Rawi
John R Mascola
Peter D Kwong
Affiliated Authors:
Peter D Kwong
Columbia Affiliation:
Subjects:
Proprotein Convertase 9 (MeSH)
Cholesterol (MeSH)
Immunization (MeSH)
Macaca fascicularis (MeSH)
Author Keywords:
cholesterol
cp: immunology
cp: metabolism
half-life
immunogen design
low-density lipoprotein
pcsk9
proprotein convertase subtilisin/kexin type 9
vaccine
Grants:
ZICAI005114 (NIH – National Institute of Allergy and Infectious Diseases)
P41GM103310 (NIH – National Institute of General Medical Sciences)
Publication Type:
Article
Unique ID:
10.1016/j.celrep.2024.114285
PMID:
38819987
DOI:
10.1016/j.celrep.2024.114285
Journal:
Cell Reports
Publication Date:
Data Source:
PubMed
Source Link:
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Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability

Gorman, J., Cheung, C. S.-F., Duan, Z., Ou, L., Wang, M., Chen, X., Cheng, C., Biju, A., Sun, Y., Wang, P., Yang, Y., Zhang, B., Boyington, J. C., Bylund, T., Charaf, S., Chen, S. J., Du, H., Henry, A. R., Liu, T., … Kwong, P. D. (2024). Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability. Nature Communications, 15(1). https://doi.org/10.1038/s41467-023-44534-y
Authors:
Jason Gorman
Crystal Sao-Fong Cheung
Zhijian Duan
Li Ou
Maple Wang
Xuejun Chen
Cheng Cheng
Andrea Biju
Yaping Sun
Pengfei Wang
Yongping Yang
Baoshan Zhang
Jeffrey C Boyington
Tatsiana Bylund
Sam Charaf
Steven J Chen
Haijuan Du
Amy R Henry
Tracy Liu
Edward K Sarfo
Chaim A Schramm
Chen-Hsiang Shen
Tyler Stephens
I-Ting Teng
John-Paul Todd
Yaroslav Tsybovsky
Raffaello Verardi
Danyi Wang
Shuishu Wang
Zhantong Wang
Cheng-Yan Zheng
Tongqing Zhou
Daniel C Douek
John R Mascola
David D Ho
Mitchell Ho
Peter D Kwong
Affiliated Authors:
Maple Wang
Pengfei Wang
David D Ho
Columbia Affiliation:
Subjects:
Single-Domain Antibodies (MeSH)
Lassa Fever (MeSH)
Grants:
ZICBC011891 (NIH – National Cancer Institute)
ZIAAI005024 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005023 (NIH – National Institute of Allergy and Infectious Diseases)
ZICAI005002 (NIH – National Institute of Allergy and Infectious Diseases)
ZICAI005114 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005166 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005151 (NIH – National Institute of Allergy and Infectious Diseases)
ZICAI005111 (NIH – National Institute of Allergy and Infectious Diseases)
ZIAAI005022 (NIH – National Institute of Allergy and Infectious Diseases)
P41GM103310 (NIH – National Institute of General Medical Sciences)
Publication Type:
Article
Unique ID:
10.1038/s41467-023-44534-y
PMID:
38177144
DOI:
10.1038/s41467-023-44534-y
Journal:
Nature Communications
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
View Web of Science Record
View Scopus Record

Record Created:

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