Inamo, J., Keegan, J., Griffith, A., Ghosh, T., Horisberger, A., Howard, K., Pulford, J. F., Murzin, E., Hancock, B., Dominguez, S. T., Gurra, M. G., Gurajala, S., Jonsson, A. H., Seifert, J. A., Feser, M. L., Norris, J. M., Cao, Y., Apruzzese, W., Bridges, S. L., … Zhang, F. (2025). Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis. Journal of Clinical Investigation, 135(6). https://doi.org/10.1172/jci185217

Yeh, Y.-S., Evans, T. D., Iwase, M., Jeong, S.-J., Zhang, X., Liu, Z., Park, A., Ghasemian, A., Dianati, B., Javaheri, A., Kratky, D., Kawarasaki, S., Goto, T., Zhang, H., Dutta, P., Schopfer, F. J., Straub, A. C., Cho, J., Lodhi, I. J., & Razani, B. (2025). Identification of lysosomal lipolysis as an essential noncanonical mediator of adipocyte fasting and cold-induced lipolysis. Journal of Clinical Investigation, 135(6). https://doi.org/10.1172/jci185340

Gauthier, T., Lim, Y.-J., Jin, W., Liu, N., Patiño, L. C., Chen, W., Warren, J., Martin, D., Morell, R. J., Dveksler, G. S., Su, G. H., & Chen, W. (2025). Activin A activation of Smad3 mitigates innate inflammation in mouse models of psoriasis and sepsis. Journal of Clinical Investigation. https://doi.org/10.1172/jci187063

Caruso, S. M., Cui, X., Robbings, B. M., Heapes, N., Demikrol, A., Lopes Da Costa, B., Hass, D. T., Quinn, P. M. J., Du, J., Hurley, J. B., & Tsang, S. H. (2025). Ablating VHL in rod photoreceptors modulates RPE glycolysis and improves preclinical model of retinitis pigmentosa. Journal of Clinical Investigation, 135(7). https://doi.org/10.1172/jci185796

Shin, A. E., Sugiura, K., Kariuki, S. W., Cohen, D. A., Flashner, S. P., Klein-Szanto, A. J., Nishiwaki, N., De, D., Vasan, N., Gabre, J. T., Lengner, C. J., Sims, P. A., & Rustgi, A. K. (2025). LIN28B-mediated PI3K/AKT pathway activation promotes metastasis in colorectal cancer models. Journal of Clinical Investigation. https://doi.org/10.1172/jci186035

Wang, B. Z., Morsink, M. A. J., Kim, S. W., Luo, L. J., Zhang, X., Soni, R. K., Lock, R. I., Rao, J., Kim, Y., Zhang, A., Neyazi, M., Gorham, J. M., Kim, Y., Brown, K., DeLaughter, D. M., Zhang, Q., McDonough, B., Watkins, J. M., Cunningham, K. M., … Vunjak-Novakovic, G. (2025). Cardiac fibroblast BAG3 regulates TGFBR2 signaling and fibrosis in dilated cardiomyopathy. Journal of Clinical Investigation, 135(1). https://doi.org/10.1172/jci181630

Williams, G. P., Freuchet, A., Michaelis, T., Frazier, A., Tran, N. K., Rodrigues Lima-Junior, J., Phillips, E. J., Mallal, S. A., Litvan, I., Goldman, J. G., Alcalay, R. N., Sidney, J., Sulzer, D., Sette, A., & Lindestam Arlehamn, C. S. (2024). PINK1 is a target of T cell responses in Parkinson’s disease. Journal of Clinical Investigation. https://doi.org/10.1172/jci180478

Vats, K., Tian, H., Singh, K., Tyurina, Y. Y., Sparvero, L. J., Tyurin, V. A., Kruglov, O., Chang, A., Wang, J., Green, F., Samovich, S. N., Zhang, J., Chattopadhyay, A., Murray, N., Shah, V. K., Mathers, A. R., Chandran, U. R., Pilewski, J. M., Kellum, J. A., … Bunimovich, Y. L. (2024). Ferroptosis of select skin epithelial cells initiates and maintains chronic systemic immune-mediated psoriatic disease. Journal of Clinical Investigation. https://doi.org/10.1172/jci183219

Liu, W., Hardaway, B. D., Kim, E., Pauli, J., Wettich, J. L., Yalcinkaya, M., Hsu, C.-C., Xiao, T., Reilly, M. P., Tabas, I., Maegdefessel, L., Schlepckow, K., Christian, H., Wang, N., & Tall, A. R. (2024). Inflammatory crosstalk impairs phagocytic receptors and aggravates atherosclerosis in clonal hematopoiesis in mice. Journal of Clinical Investigation. https://doi.org/10.1172/jci182939

Elliott, M. D., Vena, N., Marasa, M., Cocchi, E., Bheda, S., Bogyo, K., Shang, N., Zanoni, F., Verbitsky, M., Wang, C., Kolupaeva, V., Jin, G., Sofer, M., Gras Pena, R., Canetta, P. A., Bomback, A. S., Guay-Woodford, L. M., Hou, J., Gillespie, B. W., … Gharavi, A. G. (2024). Increased risk of kidney failure in patients with genetic kidney disorders. Journal of Clinical Investigation, 134(17). https://doi.org/10.1172/jci178573

Carmichael, J., Figueiredo, I., Gurel, B., Beije, N., Yuan, W., Rekowski, J., Seed, G., Carreira, S., Bertan, C., Fenor de la Maza, M. de L. D., Chandran, K., Neeb, A., Welti, J., Gallagher, L., Bogdan, D., Crespo, M., Riisnaes, R., Ferreira, A., Miranda, S., … de Bono, J. (2024). RNASEH2B loss and PARP inhibition in advanced prostate cancer. Journal of Clinical Investigation. https://doi.org/10.1172/jci178278

Cubitt, C. C., Wong, P., Dorando, H. K., Foltz, J. A., Tran, J., Marsala, L., Marin, N. D., Foster, M., Schappe, T., Fatima, H., Becker-Hapak, M., Zhou, A. Y., Hwang, K., Jacobs, M. T., Russler-Germain, D. A., Mace, E. M., Berrien-Elliott, M. M., Payton, J. E., & Fehniger, T. A. (2024). Induced CD8α identifies human NK cells with enhanced proliferative fitness and modulates NK cell activation. Journal of Clinical Investigation, 134(15). https://doi.org/10.1172/jci173602

Watanabe, J., Clutter, M. R., Gullette, M. J., Sasaki, T., Uchida, E., Kaur, S., Mo, Y., Abe, K., Ishi, Y., Takata, N., Natsumeda, M., Gadd, S., Zhang, Z., Becher, O. J., & Hashizume, R. (2024). BET bromodomain inhibition potentiates radiosensitivity in models of H3K27-altered diffuse midline glioma. Journal of Clinical Investigation, 134(13). https://doi.org/10.1172/jci174794

Ding, J., Nguyen, A. T., Lohman, K., Hensley, M. T., Parker, D., Hou, L., Taylor, J., Voora, D., Sawyer, J. K., Boudyguina, E., Bancks, M. P., Bertoni, A., Pankow, J. S., Rotter, J. I., Goodarzi, M. O., Tracy, R. P., Murdoch, D. M., Rich, S. S., Psaty, B. M., … Liu, Y. (2024). LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes. Journal of Clinical Investigation, 134(10). https://doi.org/10.1172/jci173278

Raj, J. U., Bland, R. D., Bhattacharya, J., Rabinovitch, M., & Matthay, M. A. (2024). Life-saving effect of pulmonary surfactant in premature babies. Journal of Clinical Investigation, 134(9). https://doi.org/10.1172/jci179948

Jash, A., Pridmore, T., Collins, J. B., Hay, A. M., Hudson, K. E., Luckey, C. J., & Zimring, J. C. (2024). Complement C3 and marginal zone B cells promote IgG-mediated enhancement of RBC alloimmunization in mice. Journal of Clinical Investigation, 134(8). https://doi.org/10.1172/jci167665

Steffani, M., Geng, Y., Pajvani, U. B., & Schwabe, R. F. (2024). Protective hepatocyte signals restrain liver fibrosis in metabolic dysfunction–associated steatohepatitis. Journal of Clinical Investigation, 134(7). https://doi.org/10.1172/jci179710

Tzaridis, T., & Wechsler-Reya, R. J. (2024). Just a spoonful of metformin helps the medicine go down. Journal of Clinical Investigation, 134(6). https://doi.org/10.1172/jci179144

Berry-Kravis, E., Abbeduto, L., Hagerman, R., Coffey, C. S., Cudkowicz, M., Erickson, C. A., McDuffie, A., Hessl, D., Ethridge, L., Tassone, F., Kaufmann, W. E., Friedmann, K., Bullard, L., Hoffmann, A., Veenstra-VanderWeele, J., Staley, K., Klements, D., Moshinsky, M., Harkey, B., … Pearson, B. (2023). Effects of AFQ056 on language learning in fragile X syndrome. Journal of Clinical Investigation, 134(5). https://doi.org/10.1172/jci171723

Papa, A., del Rivero Morfin, P. J., Chen, B.-X., Yang, L., Katchman, A. N., Zakharov, S. I., Liu, G., Bohnen, M. S., Zheng, V., Katz, M., Subramaniam, S., Hirsch, J. A., Weiss, S., Dascal, N., Karlin, A., Pitt, G. S., Colecraft, H. M., Ben-Johny, M., & Marx, S. O. (2024). A membrane-associated phosphoswitch in Rad controls adrenergic regulation of cardiac calcium channels. Journal of Clinical Investigation, 134(5). https://doi.org/10.1172/jci176943

Li, D., Wang, Q., Bayat, A., Battig, M. R., Zhou, Y., Bosch, D. G. M., van Haaften, G., Granger, L., Petersen, A. K., Pérez-Jurado, L. A., Aznar-Laín, G., Aneja, A., Hancarova, M., Bendova, S., Schwarz, M., Kremlikova Pourova, R., Sedlacek, Z., Keena, B. A., March, M. E., … Hakonarson, H. (2024). Spliceosome malfunction causes neurodevelopmental disorders with overlapping features. Journal of Clinical Investigation, 134(1). https://doi.org/10.1172/jci171235

Cruz-Acuña, R., Kariuki, S. W., Sugiura, K., Karaiskos, S., Plaster, E. M., Loebel, C., Efe, G., Karakasheva, T., Gabre, J. T., Hu, J., Burdick, J. A., & Rustgi, A. K. (2023). Engineered hydrogel reveals contribution of matrix mechanics to esophageal adenocarcinoma and identifies matrix-activated therapeutic targets. Journal of Clinical Investigation, 133(23). https://doi.org/10.1172/jci168146

Lee, E., O’Keefe, S., Leong, A., Park, H.-R., Varadarajan, J., Chowdhury, S., Hiner, S., Kim, S., Shiva, A., Friedman, R. A., Remotti, H., Fojo, T., Yang, H. W., Thurston, G., & Kim, M. (2023). Angiopoietin-2 blockade suppresses growth of liver metastases from pancreatic neuroendocrine tumors by promoting T cell recruitment. Journal of Clinical Investigation, 133(20). https://doi.org/10.1172/jci167994

Tang, S., De Jesus, A. C., Chavez, D., Suthakaran, S., Moore, S. K. L., Suthakaran, K., Homami, S., Rathnasinghe, R., May, A. J., Schotsaert, M., Britto, C. J., Bhattacharya, J., & Hook, J. L. (2023). Rescue of alveolar wall liquid secretion blocks fatal lung injury due to influenza-staphylococcal coinfection. Journal of Clinical Investigation, 133(19). https://doi.org/10.1172/jci163402

Yu, Z., Fidler, T. P., Ruan, Y., Vlasschaert, C., Nakao, T., Uddin, M. M., Mack, T., Niroula, A., Heimlich, J. B., Zekavat, S. M., Gibson, C. J., Griffin, G. K., Wang, Y., Peloso, G. M., Heard-Costa, N., Levy, D., Vasan, R. S., Aguet, F., Ardlie, K. G., … Natarajan, P. (2023). Genetic modification of inflammation- and clonal hematopoiesis–associated cardiovascular risk. Journal of Clinical Investigation, 133(18). https://doi.org/10.1172/jci168597

Chen, L., Shi, V., Wang, S., Sun, L., Freeman, R., Yang, J., Inkman, M. J., Ghosh, S., Ruiz, F., Jayachandran, K., Huang, Y., Luo, J., Zhang, J., Cosper, P., Luke, C. J., Spina, C. S., Grigsby, P. W., Schwarz, J. K., & Markovina, S. (2023). SCCA1/SERPINB3 suppresses antitumor immunity and blunts therapy-induced T cell responses via STAT-dependent chemokine production. Journal of Clinical Investigation, 133(15). https://doi.org/10.1172/jci163841

Gehin, C., Lone, M. A., Lee, W., Capolupo, L., Ho, S., Adeyemi, A. M., Gerkes, E. H., Stegmann, A. P. A., López-Martín, E., Bermejo-Sánchez, E., Martínez-Delgado, B., Zweier, C., Kraus, C., Popp, B., Strehlow, V., Gräfe, D., Knerr, I., Jones, E. R., Zamuner, S., … Gennarino, V. A. (2023). CERT1 mutations perturb human development by disrupting sphingolipid homeostasis. Journal of Clinical Investigation, 133(10). https://doi.org/10.1172/jci165019

Planas-Serra, L., Launay, N., Goicoechea, L., Heron, B., Jou, C., Juliá-Palacios, N., Ruiz, M., Fourcade, S., Casasnovas, C., De La Torre, C., Gelot, A., Marsal, M., Loza-Alvarez, P., García-Cazorla, À., Fatemi, A., Ferrer, I., Portero-Otin, M., Area-Gómez, E., & Pujol, A. (2023). Sphingolipid desaturase DEGS1 is essential for mitochondria-associated membrane integrity. Journal of Clinical Investigation, 133(10). https://doi.org/10.1172/jci162957

Eade, K. T., Ansell, B. R. E., Giles, S., Fallon, R., Harkins-Perry, S., Nagasaki, T., Tzaridis, S., Wallace, M., Mills, E. A., Farashi, S., Johnson, A., Sauer, L., Hart, B., Diaz-Rubio, M. E., Bahlo, M., Metallo, C., Allikmets, R., Gantner, M. L., Bernstein, P. S., & Friedlander, M. (2023). iPSC–derived retinal pigmented epithelial cells from patients with macular telangiectasia show decreased mitochondrial function. Journal of Clinical Investigation, 133(9). https://doi.org/10.1172/jci163771

Martinez-Calle, M., Courbon, G., Hunt-Tobey, B., Francis, C., Spindler, J., Wang, X., dos Reis, L. M., Martins, C. S. W., Salusky, I. B., Malluche, H., Nickolas, T. L., Moyses, R. M. A., Martin, A., & David, V. (2023). Transcription factor HNF4α2 promotes osteogenesis and prevents bone abnormalities in mice with renal osteodystrophy. Journal of Clinical Investigation, 133(11). https://doi.org/10.1172/jci159928

Grassmann, A. A., Tokarz, R., Golino, C., McLain, M. A., Groshong, A. M., Radolf, J. D., & Caimano, M. J. (2023). BosR and PlzA reciprocally regulate RpoS function to sustain Borrelia burgdorferi in ticks and mammals. Journal of Clinical Investigation, 133(5). https://doi.org/10.1172/jci166710

Lu, C., Ma, H., Song, L., Wang, H., Wang, L., Li, S., Lagana, S. M., Sepulveda, A. R., Hoebe, K., Pan, S. S., Yang, Y.-G., Lentzsch, S., & Mapara, M. Y. (2023). IFN-γR/STAT1 signaling in recipient hematopoietic antigen-presenting cells suppresses graft-versus-host disease. Journal of Clinical Investigation, 133(3). https://doi.org/10.1172/jci125986

Marks, A. R. (2023). Targeting ryanodine receptors to treat human diseases. Journal of Clinical Investigation, 133(2). https://doi.org/10.1172/jci162891

Du, W., Wang, J., Kuo, T., Wang, L., McKimpson, W. M., Son, J., Watanabe, H., Kitamoto, T., Lee, Y., Creusot, R. J., Ratner, L. E., McCune, K., Chen, Y.-W., Grubbs, B. H., Thornton, M. E., Fan, J., Sultana, N., Diaz, B. S., Balasubramanian, I., … Accili, D. (2022). Pharmacological conversion of gut epithelial cells into insulin-producing cells lowers glycemia in diabetic animals. Journal of Clinical Investigation, 132(24). https://doi.org/10.1172/jci162720

Luo, N., Mosialou, I., Capulli, M., Bisikirska, B., Lin, C.-S., Huang, Y., Shyu, P. T., Guo, X. E., Economides, A., Mann, J. J., & Kousteni, S. (2022). A neuronal action of sirtuin 1 suppresses bone mass in young and aging mice. Journal of Clinical Investigation, 132(23). https://doi.org/10.1172/jci152868

Kurokawa, K., Wang, T. C., & Hayakawa, Y. (2022). R-spondin 3 governs secretory differentiation in the gastric oxyntic glands. Journal of Clinical Investigation, 132(21). https://doi.org/10.1172/jci163380

Sobieszczyk, M. E., Maaske, J., Falsey, A. R., Sproule, S., Robb, M. L., Frenck, R. W., Tieu, H.-V., Mayer, K. H., Corey, L., Neuzil, K. M., Tong, T., Brewinski Isaacs, M., Janes, H., Bansal, H., Edwards, L. M., Green, J. A., Kelly, E. J., Shoemaker, K., Takas, T., … Hirsch, and I. (2022). Durability of protection and immunogenicity of AZD1222 (ChAdOx1 nCoV-19) COVID-19 vaccine over 6 months. Journal of Clinical Investigation, 132(18). https://doi.org/10.1172/jci160565

Pirozzolo, I., Sepulveda, M., Chen, L., Wang, Y., Lei, Y. M., Li, Z., Li, R., Sattar, H., Theriault, B., Belkaid, Y., Chong, A. S., & Alegre, M.-L. (2022). Host-versus-commensal immune responses participate in the rejection of colonized solid organ transplants. Journal of Clinical Investigation, 132(17). https://doi.org/10.1172/jci153403

Liu, W., Östberg, N., Yalcinkaya, M., Dou, H., Endo-Umeda, K., Tang, Y., Hou, X., Xiao, T., Fidler, T. P., Abramowicz, S., Yang, Y.-G., Soehnlein, O., Tall, A. R., & Wang, N. (2022). Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis. Journal of Clinical Investigation, 132(13). https://doi.org/10.1172/jci155724

Shintaku, J., Pernice, W. M., Eyaid, W., GC, J. B., Brown, Z. P., Juanola-Falgarona, M., Torres-Torronteras, J., Sommerville, E. W., Hellebrekers, D. M. E. I., Blakely, E. L., Donaldson, A., van de Laar, I., Leu, C.-S., Marti, R., Frank, J., Tanji, K., Koolen, D. A., Rodenburg, R. J., Chinnery, P. F., … Hirano, M. (2022). RRM1 variants cause a mitochondrial DNA maintenance disorder via impaired de novo nucleotide synthesis. Journal of Clinical Investigation, 132(13). https://doi.org/10.1172/jci145660

Rouanne, M., Adam, J., Radulescu, C., Letourneur, D., Bredel, D., Mouraud, S., Goubet, A.-G., Leduc, M., Chen, N., Tan, T. Z., Signolle, N., Bigorgne, A., Dussiot, M., Tselikas, L., Susini, S., Danlos, F.-X., Schneider, A. K., Chabanon, R., Vacher, S., … Marabelle, A. (2022). BCG therapy downregulates HLA-I on malignant cells to subvert antitumor immune responses in bladder cancer. Journal of Clinical Investigation, 132(12). https://doi.org/10.1172/jci145666

Caruso, S. M., Quinn, P. M. J., da Costa, B. L., & Tsang, S. H. (2022). CRISPR/Cas therapeutic strategies for autosomal dominant disorders. Journal of Clinical Investigation, 132(9). https://doi.org/10.1172/jci158287

Izquierdo, M. C., Shanmugarajah, N., Lee, S. X., Kraakman, M. J., Westerterp, M., Kitamoto, T., Harris, M., Cook, J. R., Gusarova, G. A., Zhong, K., Marbuary, E., O-Sullivan, I., Rasmus, N., Camastra, S., Unterman, T. G., Ferrannini, E., Hurwitz, B. E., & Haeusler, R. A. (2022). Hepatic FoxOs link insulin signaling with plasma lipoprotein metabolism through an apolipoprotein M/sphingosine-1-phosphate pathway. Journal of Clinical Investigation, 132(7). https://doi.org/10.1172/jci146219

Valet, C., Magnen, M., Qiu, L., Cleary, S. J., Wang, K. M., Ranucci, S., Grockowiak, E., Boudra, R., Conrad, C., Seo, Y., Calabrese, D. R., Greenland, J. R., Leavitt, A. D., Passegué, E., Méndez-Ferrer, S., Swirski, F. K., & Looney, M. R. (2022). Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression. Journal of Clinical Investigation, 132(7). https://doi.org/10.1172/jci153920

Dridi, H., Santulli, G., Gambardella, J., Jankauskas, S. S., Yuan, Q., Yang, J., Reiken, S., Wang, X., Wronska, A., Liu, X., Lacampagne, A., & Marks, A. R. (2022). IP3 receptor orchestrates maladaptive vascular responses in heart failure. Journal of Clinical Investigation, 132(4). https://doi.org/10.1172/jci152859

Bhat, N., Narayanan, A., Fathzadeh, M., Kahn, M., Zhang, D., Goedeke, L., Neogi, A., Cardone, R. L., Kibbey, R. G., Fernandez-Hernando, C., Ginsberg, H. N., Jain, D., Shulman, G. I., & Mani, A. (2022). Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice. Journal of Clinical Investigation, 132(3). https://doi.org/10.1172/jci153724

Rastelli, D., Robinson, A., Lagomarsino, V. N., Matthews, L. T., Hassan, R., Perez, K., Dan, W., Yim, P. D., Mixer, M., Prochera, A., Shepherd, A., Sun, L., Hall, K., Ballou, S., Lembo, A., Nee, J., & Rao, M. (2022). Diminished androgen levels are linked to irritable bowel syndrome and cause bowel dysfunction in mice. Journal of Clinical Investigation, 132(2). https://doi.org/10.1172/jci150789

Tall, A. R., Thomas, D. G., Gonzalez-Cabodevilla, A. G., & Goldberg, I. J. (2022). Addressing dyslipidemic risk beyond LDL-cholesterol. Journal of Clinical Investigation, 132(1). https://doi.org/10.1172/jci148559

Son, J., Ding, H., Farb, T. B., Efanov, A. M., Sun, J., Gore, J. L., Syed, S. K., Lei, Z., Wang, Q., Accili, D., & Califano, A. (2021). BACH2 inhibition reverses β cell failure in type 2 diabetes models. Journal of Clinical Investigation, 131(24). https://doi.org/10.1172/jci153876

Nakanishi, T., Pigazzini, S., Degenhardt, F., Cordioli, M., Butler-Laporte, G., Maya-Miles, D., Bujanda, L., Bouysran, Y., Niemi, M. E. K., Palom, A., Ellinghaus, D., Khan, A., Martínez-Bueno, M., Rolker, S., Amitrano, S., Roade Tato, L., Fava, F., Spinner, C. D., Prati, D., … Ganna, A. (2021). Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality. Journal of Clinical Investigation, 131(23). https://doi.org/10.1172/jci152386