Ablating VHL in rod photoreceptors modulates RPE glycolysis and improves preclinical model of retinitis pigmentosa

Caruso, S. M., Cui, X., Robbings, B. M., Heapes, N., Demikrol, A., Lopes Da Costa, B., Hass, D. T., Quinn, P. M. J., Du, J., Hurley, J. B., & Tsang, S. H. (2025). Ablating VHL in rod photoreceptors modulates RPE glycolysis and improves preclinical model of retinitis pigmentosa. Journal of Clinical Investigation, 135(7). https://doi.org/10.1172/jci185796
Authors:
Salvatore Marco Caruso
Xuan Cui
Brian M Robbings
Noah Heapes
Aykut Demirkol
Bruna Lopes Da Costa
Daniel T Hass
Peter Mj Quinn
Jianhai Du
James B Hurley
Stephen H Tsang
Affiliated Authors:
Salvatore Marco Caruso
Xuan Cui
Noah Heapes
Aykut Demirkol
Bruna Lopes Da Costa
Peter Mj Quinn
Stephen H Tsang
Columbia Affiliation:
Subjects:
Retinitis Pigmentosa (MeSH)
Glycolysis (MeSH)
Retinal Rod Photoreceptor Cells (MeSH)
Retinal Pigment Epithelium (MeSH)
Von Hippel-Lindau Tumor Suppressor Protein (MeSH)
Disease Models, Animal (MeSH)
Hypoxia-Inducible Factor 1, alpha Subunit (MeSH)
Author Keywords:
gene therapy
glucose metabolism
metabolism
ophthalmology
retinopathy
therapeutics
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Publication Type:
Article
Unique ID:
10.1172/jci185796
PMID:
39932789
DOI:
10.1172/jci185796
Journal:
Journal of Clinical Investigation
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record

Record Created: