OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma

Nguyen, T. T. T., Torrini, C., Shang, E., Shu, C., Mun, J.-Y., Gao, Q., Humala, N., Akman, H. O., Zhang, G., Westhoff, M.-A., Karpel-Massler, G., Bruce, J. N., Canoll, P., & Siegelin, M. D. (2024). OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma. JCI Insight. https://doi.org/10.1172/jci.insight.172565
Authors:
Trang Nguyen
Consuelo Torrini
Enyuan Shang
Chang Shu
Jeong-Yeon Mun
Qiuqiang Gao
Nelson Humala
Hasan O. Akman
Guoan Zhang
Mike‐Andrew Westhoff
Georg Karpel‐Massler
Jeffrey N. Bruce
Peter Canoll
Markus D. Siegelin
Affiliated Authors:
Trang Nguyen
Consuelo Torrini
Chang Shu
Jeong-Yeon Mun
Qiuqiang Gao
Nelson Humala
Hasan O. Akman
Jeffrey N. Bruce
Peter Canoll
Markus D. Siegelin
Columbia Affiliation:
Subjects:
Aniline Compounds (MeSH)
bcl-X Protein (MeSH)
Caprylates (MeSH)
Glioblastoma (MeSH)
Ketoglutarate Dehydrogenase Complex (MeSH)
Sulfides (MeSH)
Sulfonamides (MeSH)
Synthetic Lethal Mutations (MeSH)
Xenograft Model Antitumor Assays (MeSH)
Metabolic Reprogramming in Cancer Biology (OpenAlex Topic)
ATP Synthase Function and Regulation (OpenAlex Topic)
Mitochondrial Dynamics and Reactive Oxygen Species Regulation (OpenAlex Topic)
Author Keywords:
apoptosis pathways
oncology
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Publication Type:
Article
Unique ID:
10.1172/jci.insight.172565
PMID:
38483541
DOI:
10.1172/jci.insight.172565
Journal:
JCI Insight
Publication Date:
Data Source:
OpenAlex
Source Link:
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Record Created: