Developing SHP2-based combination therapy for KRAS-amplified cancer

Li, T., Kikuchi, O., Zhou, J., Wang, Y., Pokharel, B., Bastl, K., Gokhale, P., Knott, A., Zhang, Y., Doench, J. G., Ho, Z. V., Catenacci, D. V. T., & Bass, A. J. (2023). Developing SHP2-based combination therapy for KRAS-amplified cancer. JCI Insight, 8(3). https://doi.org/10.1172/jci.insight.152714
Authors:
Tianxia Li
Osamu Kikuchi
Jin Zhou
Timothy C. Wang
Babita Pokharel
Klavdija Bastl
Prafulla C. Gokhale
Aine Knott
Yanxi Zhang
John G. Doench
Zandra V. Ho
Daniel V.T. Catenacci
Adam J. Bass
Affiliated Authors:
Babita Pokharel
Adam J. Bass
Columbia Affiliation:
Subjects:
Proto-Oncogene Proteins p21(ras) (MeSH)
Neoplasms (MeSH)
Protein Tyrosine Phosphatases in Human Health and Disease (OpenAlex Topic)
mTOR Signaling in Growth and Disease (OpenAlex Topic)
Advancements in Colorectal Cancer Research (OpenAlex Topic)
Author Keywords:
drug therapy
oncogenes
oncology
signal transduction
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Publication Type:
Article
Unique ID:
10.1172/jci.insight.152714
PMID:
36752207
DOI:
10.1172/jci.insight.152714
Journal:
JCI Insight
Publication Date:
Data Source:
OpenAlex
Source Link:
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Record Created: