Taub Institute for Research on Alzheimer’s Disease and the Aging Brain

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Oka, T., Matsuzawa, Y., Tsuneyoshi, M., Nakamura, Y., Aoshima, K., Tsugawa, H., Weiner, M., Aisen, P., Petersen, R., Jack, C. R., Jagust, W., Trojanowki, J. Q., Toga, A. W., Beckett, L., Green, R. C., Saykin, A. J., Morris, J., Shaw, L. M., … Liu, E. (2024). Multiomics analysis to explore blood metabolite biomarkers in an Alzheimer’s Disease Neuroimaging Initiative cohort. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-56837-1
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Zambon, A., Rico, L. C., Herman, M., Gundacker, A., Telalovic, A., Hartenberger, L.-M., Kuehn, R., Romanov, R. A., Hussaini, S. A., Harkany, T., & Pollak, D. D. (2022). Gestational immune activation disrupts hypothalamic neurocircuits of maternal care behavior. Molecular Psychiatry, 29(4), 859–873. https://doi.org/10.1038/s41380-022-01602-x
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Gaynor, A. M., Ahsan, A., Jung, D., Schofield, E., Li, Y., Ryan, E., Ahles, T. A., & Root, J. C. (2022). Novel computerized neurocognitive test battery is sensitive to cancer-related cognitive deficits in survivors. Journal of Cancer Survivorship, 18(2), 466–478. https://doi.org/10.1007/s11764-022-01232-w
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Liampas, I., Siokas, V., Kyrozis, A., Sakoutis, G., Yannakoulia, M., Kosmidis, M. H., Sakka, P., Scarmeas, N., Hadjigeorgiou, G. M., & Dardiotis, E. (2024). Longitudinal Cognitive Trajectories in Older Adults with Restless Legs Syndrome or Willis–Ekbom Disease. Life, 14(4), 430. https://doi.org/10.3390/life14040430
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Ryvicker, M., Barrón, Y., Song, J., Zolnoori, M., Shah, S., Burgdorf, J. G., Noble, J. M., & Topaz, M. (2024). Using Natural Language Processing to Identify Home Health Care Patients at Risk for Diagnosis of Alzheimer’s Disease and Related Dementias. Journal of Applied Gerontology. https://doi.org/10.1177/07334648241242321
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Anastasi, J. K., Capili, B., Norton, M., McMahon, D. J., & Marder, K. (2024). Recruitment and retention of clinical trial participants: understanding motivations of patients with chronic pain and other populations. Frontiers in Pain Research, 4. https://doi.org/10.3389/fpain.2023.1330937
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Nguyen, S. T., Guo, J., Song, S., Reyes-Dumeyer, D., Sanchez, D., Brickman, A. M., Manly, J. J., Schupf, N., Lantigua, R. A., Mayeux, R. P., & Gu, Y. (2024). Physical Activity Moderates the Relationship between Cardiovascular Disease Risk Burden and Cognition in Older Adults. Neuroepidemiology, 1–11. Portico. https://doi.org/10.1159/000536354
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Dressman, D., Tasaki, S., Yu, L., Schneider, J., Bennett, D. A., Elyaman, W., & Vardarajan, B. (2024). Polygenic risk associated with Alzheimer’s disease and other traits influences genes involved in T cell signaling and activation. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1337831
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Wang, Y., Sarnowski, C., Lin, H., Pitsillides, A. N., Heard‐Costa, N. L., Choi, S. H., Wang, D., Bis, J. C., Blue, E. E., Boerwinkle, E., De Jager, P. L., Fornage, M., Wijsman, E. M., Seshadri, S., Dupuis, J., Peloso, G. M., & DeStefano, A. L. (2024). Key variants via the Alzheimer’s Disease Sequencing Project whole genome sequence data. Alzheimer’s & Dementia, 20(5), 3290–3304. Portico. https://doi.org/10.1002/alz.13705
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Fujita, M., Gao, Z., Zeng, L., McCabe, C., White, C. C., Ng, B., Green, G. S., Rozenblatt-Rosen, O., Phillips, D., Amir-Zilberstein, L., Lee, H., Pearse, R. V., Khan, A., Vardarajan, B. N., Kiryluk, K., Ye, C. J., Klein, H.-U., Wang, G., Regev, A., … De Jager, P. L. (2024). Cell subtype-specific effects of genetic variation in the Alzheimer’s disease brain. Nature Genetics, 56(4), 605–614. https://doi.org/10.1038/s41588-024-01685-y
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Hsieh, Y., Augur, Z. M., Arbery, M., Ashour, N., Barrett, K., Pearse, R. V., Tio, E. S., Duong, D. M., Felsky, D., De Jager, P. L., Bennett, D. A., Seyfried, N. T., & Young‐Pearse, T. L. (2024). Person‐specific differences in ubiquitin‐proteasome mediated proteostasis in human neurons. Alzheimer’s & Dementia, 20(4), 2952–2967. Portico. https://doi.org/10.1002/alz.13680
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Listwan, T. A., Krinsky‐McHale, S. J., Kovacs, C. M., Lee, J. H., Pang, D. I., Schupf, N., Tycko, B., Zigman, W. B., & Silverman, W. (2024). Prodromal Alzheimer’s disease can affect activities of daily living for adults with Down syndrome. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 16(1). Portico. https://doi.org/10.1002/dad2.12562
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Ma, D. J., Yang, Y., Harguindeguy, N., Tian, Y., Small, S. A., Liu, F., Rothman, D. L., & Guo, J. (2023). Magnetic Resonance Spectroscopy Spectral Registration Using Deep Learning. Journal of Magnetic Resonance Imaging, 59(3), 964–975. Portico. https://doi.org/10.1002/jmri.28868
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Makepeace, K. A. T., Rookyard, A. W., Das, L., Vardarajan, B. N., Chakrabarty, J. K., Jain, A., Kang, M. S., Werth, E. G., Reyes‐Dumeyer, D., Zerlin‐Esteves, M., Honig, L. S., Mayeux, R., & Brown, L. M. (2024). Data‐Independent Acquisition and Label‐Free Quantification for Quantitative Proteomics Analysis of Human Cerebrospinal Fluid. Current Protocols, 4(3). Portico. https://doi.org/10.1002/cpz1.1014
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Hayes-Larson, E., Ackley, S. F., Turney, I. C., La Joie, R., Mayeda, E. R., & Glymour, M. M. (2023). Considerations for Use of Blood-Based Biomarkers in Epidemiologic Dementia Research. American Journal of Epidemiology, 193(3), 527–535. https://doi.org/10.1093/aje/kwad197
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Malamon, J. S., Farrell, J. J., Xia, L. C., Dombroski, B. A., Das, R. G., Way, J., Kuzma, A. B., Valladares, O., Leung, Y. Y., Scanlon, A. J., Lopez, I. A. B., Brehony, J., Worley, K. C., Zhang, N. R., Wang, L.-S., Farrer, L. A., Schellenberg, G. D., Lee, W.-P., & Vardarajan, B. N. (2024). A comparative study of structural variant calling in WGS from Alzheimer’s disease families. Life Science Alliance, 7(5), e202302181. https://doi.org/10.26508/lsa.202302181
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Silverman, W., Krinsky‐McHale, S. J., Kovacs, C., Lee, J. H., Listwan, T., Pang, D. I., Zigman, W. B., & Schupf, N. (2023). Individualized estimated years from onset of Alzheimer’s disease– related decline for adults with Down syndrome. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 15(2). Portico. https://doi.org/10.1002/dad2.12444
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Thomas, A., Ryan, C. P., Caspi, A., Liu, Z., Moffitt, T. E., Sugden, K., Zhou, J., Belsky, D. W., & Gu, Y. (2024). Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study. Annals of Neurology, 95(6), 1069–1079. Portico. https://doi.org/10.1002/ana.26900
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Wang, G., Li, Y., Xiong, C., Benzinger, T. L. S., Gordon, B. A., Hassenstab, J., Aschenbrenner, A. J., McDade, E., Clifford, D. B., Libre‐Guerra, J. J., Shi, X., Mummery, C. J., van Dyck, C. H., Lah, J. J., Honig, L. S., Day, G., Ringman, J. M., Brooks, W. S., … Fox, N. C. (2024). Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer’s disease. Alzheimer’s & Dementia, 20(4), 2698–2706. Portico. https://doi.org/10.1002/alz.13735
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Xicota, L., Cosentino, S., Vardarajan, B., Mayeux, R., Perls, T. T., Andersen, S. L., Zmuda, J. M., Thyagarajan, B., Yashin, A., Wojczynski, M. K., Krinsky‐McHale, S., Handen, B. L., Christian, B. T., Head, E., Mapstone, M. E., Schupf, N., Lee, J. H., & Barral, S. (2024). Whole genome‐wide sequence analysis of long‐lived families (Long‐Life Family Study) identifies MTUS2 gene associated with late‐onset Alzheimer’s disease. Alzheimer’s & Dementia, 20(4), 2670–2679. Portico. https://doi.org/10.1002/alz.13718
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Herman, M., Randall, G. W., Spiegel, J. L., Maldonado, D. J., & Simoes, S. (2024). Endo-lysosomal dysfunction in neurodegenerative diseases: opinion on current progress and future direction in the use of exosomes as biomarkers. Philosophical Transactions of the Royal Society B: Biological Sciences, 379(1899). https://doi.org/10.1098/rstb.2022.0387
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Cullen, P. J., Holstege, H., Small, S. A., & St George-Hyslop, P. (2024). Understanding the endo-lysosomal network in neurodegeneration. Philosophical Transactions of the Royal Society B: Biological Sciences, 379(1899). https://doi.org/10.1098/rstb.2022.0372
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Alessi, D. R., Cullen, P. J., Cookson, M., Merchant, K. M., & Small, S. A. (2024). Retromer-dependent lysosomal stress in Parkinson’s disease. Philosophical Transactions of the Royal Society B: Biological Sciences, 379(1899). https://doi.org/10.1098/rstb.2022.0376
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Tsapanou, A., Ghanem, A., Chapman, S., Stern, Y., Huey, E. D., Cosentino, S., & Louis, E. D. (2024). Sleep problems as predictors of cognitive decline in essential tremor: A prospective longitudinal cohort study. Sleep Medicine, 116, 13–18. https://doi.org/10.1016/j.sleep.2024.02.016
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Caban-Holt, A., Cuccaro, M. L., Lloyd, S. L., Starks, T. D., Adams, L. D., Ford, T., Haines, J. L., Beecham, G., Reitz, C., Vance, J. M., Pericak-Vance, M. A., & Byrd, G. S. (2024). Attitudes and Perceptions about Brain Donation Among African Americans: Implications for Recruitment into Alzheimer’s Disease Research. Journal of Alzheimer’s Disease, 97(4), 1621–1627. https://doi.org/10.3233/jad-230461
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DiProspero, N., Sathishkumar, M., Janecek, J., Smith, A., McMillan, L., Petersen, M., Tustison, N., Keator, D. B., Doran, E., Hom, C. L., Nguyen, D., Andrews, H., Krinsky‐McHale, S., Brickman, A. M., Rosas, H. D., Lai, F., Head, E., Mapstone, M., Silverman, W., … Yassa, M. A. (2024). Neurofilament light chain concentration mediates the association between regional medial temporal lobe structure and memory in adults with Down syndrome. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 16(1). Portico. https://doi.org/10.1002/dad2.12542
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Rybnicek, J., Chen, Y., Milic, M., Tio, E. S., McLaurin, J., Hohman, T. J., De Jager, P. L., Schneider, J. A., Wang, Y., Bennett, D. A., Tripathy, S., Felsky, D., & Lambe, E. K. (2024). CHRNA5 links chandelier cells to severity of amyloid pathology in aging and Alzheimer’s disease. Translational Psychiatry, 14(1). https://doi.org/10.1038/s41398-024-02785-3
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Morales, C. D., Cotton-Samuel, D., Lao, P. J., Chang, J. F., Pyne, J. D., Alshikho, M. J., Lippert, R. V., Bista, K., Hale, C., Edwards, N. C., Igwe, K. C., Deters, K., Zimmerman, M. E., & Brickman, A. M. (2024). Small vessel cerebrovascular disease is associated with cognition in prospective Alzheimer’s clinical trial participants. Alzheimer’s Research & Therapy, 16(1). https://doi.org/10.1186/s13195-024-01395-x
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Patel, R., Cosentino, S., Zheng, E. Z., Schupf, N., Barral, S., Feitosa, M., Andersen, S. L., Sebastiani, P., Ukraintseva, S., Christensen, K., Zmuda, J., Thyagarajan, B., & Gu, Y. (2024). Systemic inflammation in relation to exceptional memory in the Long Life Family Study (LLFS). Brain, Behavior, & Immunity - Health, 37, 100746. https://doi.org/10.1016/j.bbih.2024.100746
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Kraal, A. Z., Zaheed, A. B., Krasnova, A., Vadari, H., Byrd, D. R., & Zahodne, L. B. (2023). Time-lagged associations between two adverse childhood experiences and later-life cognitive function through educational attainment and stroke. Journal of the International Neuropsychological Society, 30(2), 107–116. https://doi.org/10.1017/s135561772300036x
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Adkins-Jackson, P. B., Taikeff, N., Akingbulu, J., Avila-Rieger, J. F., & Corona-Long, C. A. (2024). Parkinson’s Disease Inequities in Daily Cognitive Activities: An Intersectional Approach. Ethnicity & Disease, 34(2), 113–122. https://doi.org/10.18865/ed.34.2.113
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Rossano, S. M., Johnson, A. S., Smith, A., Ziaggi, G., Roetman, A., Guzman, D., Okafor, A., Klein, J., Tomljanovic, Z., Stern, Y., Brickman, A. M., Lee, S., Kreisl, W. C., & Lao, P. (2024). Microglia measured by TSPO PET are associated with Alzheimer’s disease pathology and mediate key steps in a disease progression model. Alzheimer’s & Dementia, 20(4), 2397–2407. Portico. https://doi.org/10.1002/alz.13699
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Falcicchia, C., Tozzi, F., Gabrielli, M., Amoretti, S., Masini, G., Nardi, G., Guglielmo, S., Ratto, G. M., Arancio, O., Verderio, C., & Origlia, N. (2023). Microglial extracellular vesicles induce Alzheimer’s disease-related cortico-hippocampal network dysfunction. Brain Communications, 5(3). https://doi.org/10.1093/braincomms/fcad170
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Kobayashi, L. C., Jones, R. N., Briceño, E. M., Rentería, M. A., Zhang, Y., Meijer, E., Langa, K. M., Lee, J., & Gross, A. L. (2024). Cross‐national comparisons of later‐life cognitive function using data from the Harmonized Cognitive Assessment Protocol (HCAP): Considerations and recommended best practices. Alzheimer’s & Dementia, 20(3), 2273–2281. Portico. https://doi.org/10.1002/alz.13694
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Lu, J., Toro, C., Adams, D. R., Acosta, M. T., Adam, M., Alvarez, R. L., Alvey, J., Amendola, L., Andrews, A., Ashley, E. A., Bacino, C. A., Bademci, G., Balasubramanyam, A., Baldridge, D., Bale, J., Bamshad, M., Barbouth, D., Bayrak-Toydemir, P., … Beck, A. (2024). LUSTR: a new customizable tool for calling genome-wide germline and somatic short tandem repeat variants. BMC Genomics, 25(1). https://doi.org/10.1186/s12864-023-09935-9
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Rayamajhi, D., Ege, M., Ukhanov, K., Ringers, C., Zhang, Y., Jung, I., D’Gama, P. P., Li, S. S., Cosacak, M. I., Kizil, C., Park, H.-C., Yaksi, E., Martens, J. R., Brody, S. L., Jurisch-Yaksi, N., & Roy, S. (2024). The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation. PLOS Biology, 22(1), e3002468. https://doi.org/10.1371/journal.pbio.3002468
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Leung, Y. Y., Naj, A. C., Chou, Y.-F., Valladares, O., Schmidt, M., Hamilton-Nelson, K., Wheeler, N., Lin, H., Gangadharan, P., Qu, L., Clark, K., Kuzma, A. B., Lee, W.-P., Cantwell, L., Nicaretta, H., van der Lee, S., English, A., Kalra, D., … Muzny, D. (2024). Human whole-exome genotype data for Alzheimer’s disease. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-44781-7
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McInvale, J. J., Canoll, P., & Hargus, G. (2024). Induced pluripotent stem cell models as a tool to investigate and test fluid biomarkers in Alzheimer’s disease and frontotemporal dementia. Brain Pathology, 34(4). Portico. https://doi.org/10.1111/bpa.13231
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Vyas, C. M., Manson, J. E., Sesso, H. D., Cook, N. R., Rist, P. M., Weinberg, A., Moorthy, M. V., Baker, L. D., Espeland, M. A., Yeung, L.-K., Brickman, A. M., & Okereke, O. I. (2024). Effect of multivitamin-mineral supplementation versus placebo on cognitive function: results from the clinic subcohort of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial and meta-analysis of 3 cognitive studies within COSMOS. The American Journal of Clinical Nutrition, 119(3), 692–701. https://doi.org/10.1016/j.ajcnut.2023.12.011
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Honig, L. S., Barakos, J., Dhadda, S., Kanekiyo, M., Reyderman, L., Irizarry, M., Kramer, L. D., Swanson, C. J., & Sabbagh, M. (2023). ARIA in patients treated with lecanemab (BAN2401) in a phase 2 study in early Alzheimer’s disease. Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 9(1). Portico. https://doi.org/10.1002/trc2.12377
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Yu, Q., Du, F., Belli, I., Gomes, P. A., Sotiropoulos, I., & Waites, C. L. (2024). Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain. Cell Death & Disease, 15(1). https://doi.org/10.1038/s41419-024-06458-3
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Bartosch, A. M. W., Youth, E. H. H., Hansen, S., Wu, Y., Buchanan, H. M., Kaufman, M. E., Xiao, H., Koo, S. Y., Ashok, A., Sivakumar, S., Soni, R. K., Dumitrescu, L. C., Lam, T. G., Ropri, A. S., Lee, A. J., Klein, H.-U., Vardarajan, B. N., Bennett, D. A., Young-Pearse, T. L., … Teich, A. F. (2023). ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer’s disease. The Journal of Neuroscience, JN-RM-2324-22. https://doi.org/10.1523/jneurosci.2324-22.2023
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Ho, P., Yu, W. H., Tee, B. L., Lee, W., Li, C., Gu, Y., Yokoyama, J. S., Reyes‐Dumeyer, D., Choi, Y., Yang, H., Vardarajan, B. N., Tzuang, M., Lieu, K., Lu, A., Faber, K. M., Potter, Z. D., Revta, C., Kirsch, M., McCallum, J., … Wang, L. (2024). Asian Cohort for Alzheimer’s Disease (ACAD) pilot study on genetic and non‐genetic risk factors for Alzheimer’s disease among Asian Americans and Canadians. Alzheimer’s & Dementia, 20(3), 2058–2071. Portico. https://doi.org/10.1002/alz.13611
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Aoun, A., Shetler, O., Raghuraman, R., Rodriguez, G. A., & Hussaini, S. A. (2024). Beyond correlation: optimal transport metrics for characterizing representational stability and remapping in neurons encoding spatial memory. Frontiers in Cellular Neuroscience, 17. https://doi.org/10.3389/fncel.2023.1273283
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