Taub Institute for Research on Alzheimer’s Disease and the Aging Brain

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Sarnowski, C., Huan, T., Ma, Y., Joehanes, R., Beiser, A., DeCarli, C. S., Heard-Costa, N. L., Levy, D., Lin, H., Liu, C.-T., Liu, C., Meigs, J. B., Satizabal, C. L., Florez, J. C., Hivert, M.-F., Dupuis, J., De Jager, P. L., Bennett, D. A., Seshadri, S., & Morrison, A. C. (2023). Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer’s disease at CPT1A locus. Clinical Epigenetics, 15(1). https://doi.org/10.1186/s13148-023-01589-4
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Reyes‐Dumeyer, D., Piriz, A., Soriano, B., Franco, Y., Coronado, Z. D., Recio, P., Mejia, D. R., Medrano, M., Lantigua, R. A., Vardarajan, B. N., Honig, L. S., & Mayeux, R. (2023). Challenges of recruitment and biomarkers collection in Caribbean Hispanics. Alzheimer’s & Dementia, 19(S15). Portico. https://doi.org/10.1002/alz.078371
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Nashman, Z., Runyan, A., Sydney, E., & Myeku, N. (2023). Modulation of the Immunoproteasome Affects Pathological Tau Aggregation in Alzheimer’s Disease. Alzheimer’s & Dementia, 19(S13). Portico. https://doi.org/10.1002/alz.071413
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Georgiou, E. (Eleni‐ Z., Politis, A., Yannakoulia, M., Dardiotis, E., Hadjigeorgiou, G. M., Kosmidis, M., Sakka, P., Economou, P., Scarmeas, N., & Alexopoulos, P. (2023). Prevalence of Depressive Symptoms in the Whole Spectrum of Cognitive Aging: Findings from the HELIAD Community Study. Alzheimer’s & Dementia, 19(S19). Portico. https://doi.org/10.1002/alz.074261
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Naj, A. C., Rajabli, F., Reitz, C., Jun, G. R., Benchek, P., Tosto, G., Sha, J., Zhu, C., Kushch, N. A., Lee, W., Haut, J., Hamilton‐Nelson, K. L., Wheeler, N. R., Zhao, Y., Farrell, J., Grunin, M., Leung, Y. Y., Li, D., … da Fonseca, E. L. (2023). Multi‐Ancestry Genome‐wide Association Analysis of Late‐Onset Alzheimer’s Disease (LOAD) in 60,941 Individuals Identifies Multiple Novel Cross‐Ancestry Associations and Implicates Amyloid and Complement Pathways. Alzheimer’s & Dementia, 19(S12). Portico. https://doi.org/10.1002/alz.079401
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Li, D., Farrell, J. J., Mez, J., Martin, E. R., Bush, W. S., Ruiz, A., Boada, M., de Rojas, I., Mayeux, R., Haines, J. L., Vance, M. A. P., Wang, L., Schellenberg, G. D., Lunetta, K. L., & Farrer, L. A. (2023). Novel loci for Alzheimer’s disease identified by a genome‐wide association study in Ashkenazi Jews. Alzheimer’s & Dementia, 19(12), 5550–5562. Portico. https://doi.org/10.1002/alz.13117
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Green, G. S., Yang, H., Fujita, M., Taga, M., Regev, A., Menon, V., Bennett, D. A. A., Habib, N., & De Jager, P. L. (2023). Cellular dynamics across aged human brains uncover a multicellular cascade leading to Alzheimer’s disease. Alzheimer’s & Dementia, 19(S24). Portico. https://doi.org/10.1002/alz.083212
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Barral, S., Rentería, M. A., Reyes‐Dumeyer, D., Arango, S. M., Obregon, A. M., Samper‐Ternent, R., Wong, R., Barber, R., Phillips, N., O’Bryant, S. E., Montesinos, R., Soto‐Añari, M. F., Custodio, N., & Tosto, G. (2023). Association of APOE with Alzheimer’s disease in Mexico, Caribbean‐Hispanics, Peruvian and Mexican Americans. Alzheimer’s & Dementia, 19(S12). Portico. https://doi.org/10.1002/alz.080230
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Zhao, Q., Hu, J., Kong, L., Jiang, S., Tian, X., Wang, J., Hashizume, R., Jia, Z., Fowlkes, N. W., Yan, J., Xia, X., Yi, S. F., Dao, L. H., Masopust, D., Heimberger, A. B., & Li, S. (2023). FGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-36430-2
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Yang, H., Mukherjee, S., Latimer, C. S., Teng, L., White, C. C., Yu, L., Sperling, R. A., Larson, E. B., Crane, P. K., Keene, C. D., Bennett, D. A. A., Schneider, J. A., & De Jager, P. L. (2023). A genome‐wide association study of LATE‐NC (limbic‐predominant age‐related TDP‐43 encephalopathy neuropathologic change) reveals a distinct genetic architecture. Alzheimer’s & Dementia, 19(S12). Portico. https://doi.org/10.1002/alz.079393
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Libby, J. B., Roshani, R., Seto, M., Wang, T., Nudelman, K. N. H., Buckley, R. F., Saykin, A. J., Mormino, E. C., Sperling, R. A., Mayeux, R., Dumitrescu, L. C., & Hohman, T. J. (2023). Genetically Regulated Telomere Length Relates to Brain Amyloidosis. Alzheimer’s & Dementia, 19(S12). Portico. https://doi.org/10.1002/alz.079903
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Gomes, P. A., Bodo, C., Nogueras-Ortiz, C., Samiotaki, M., Chen, M., Soares-Cunha, C., Silva, J. M., Coimbra, B., Stamatakis, G., Santos, L., Panayotou, G., Tzouanou, F., Waites, C. L., Gatsogiannis, C., Sousa, N., Kapogiannis, D., Costa-Silva, B., & Sotiropoulos, I. (2023). A novel isolation method for spontaneously released extracellular vesicles from brain tissue and its implications for stress-driven brain pathology. Cell Communication and Signaling, 21(1). https://doi.org/10.1186/s12964-023-01045-z
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Adkins‐Jackson, P. A., Gobaud, A. N., Kim, B., Higgins, C., Bailey, Z. D., Hardeman, R. R., Ford, T. N., Matz, M. B., Uzzi, M., Gee, G., Szanton, S. L., Avila, J. F., & Manly, J. J. (2023). “The place where danger waits”: Ten years of the 1994 Crime Bill incarceration on cognitive function in older adults racialized as Black. Alzheimer’s & Dementia, 19(S23). Portico. https://doi.org/10.1002/alz.079398
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Ma, Y., Chen, K. W., Fujita, M., Yu, L., Menon, V., Schneider, J. A., Bennett, D. A. A., & De Jager, P. L. (2023). Cataloging the role of brain cell types on suppressing the effect of APOE ε4 on Alzheimer’s disease risk. Alzheimer’s & Dementia, 19(S12). Portico. https://doi.org/10.1002/alz.077046
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Pyne, J., Morales, C., Alshikho, M. J., Lao, P. J., Turney, I. C., Gutierrez, J., Manly, J. J., Mayeux, R., & Brickman, A. M. (2023). Total and posterior cerebral blood flow is associated with white matter hyperintensity volume and Alzheimer’s‐like patterns of brain atrophy in older adults. Alzheimer’s & Dementia, 19(S17). Portico. https://doi.org/10.1002/alz.077345
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Smith, A. C., Hartley, S., Plante, D. T., Johnson, A. S., Guzmán, D. S., Okafor, A., Rossano, S., Tudorascu, D., Brickman, A. M., Christian, B. T., Okonkwo, O., Ances, B., Cohen, A., Handen, B. L., & Lao, P. J. (2023). Association of tau burden with sleep disordered breathing in adults with Down syndrome. Alzheimer’s & Dementia, 19(S24). Portico. https://doi.org/10.1002/alz.083005
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Wu, Y., Dumitrescu, L. C., De Jager, P. L., Menon, V., Schneider, J. A., Bennett, D. A. A., Petyuk, V. A., & Hohman, T. J. (2023). Single‐cell Transcriptomes Reveal Cell‐type Specific Roles of VEGF Family Genes in the Pathogenesis of Alzheimer’s Disease. Alzheimer’s & Dementia, 19(S12). Portico. https://doi.org/10.1002/alz.078447
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Johnson, A. S., Zou, J., Smith, A. C., Okafor, A., Guzmán, D. S., Kreisl, W. C., Brickman, A. M., Luchsinger, J. A., & Lao, P. J. (2023). Discovering correlates of off‐target 18F‐MK6240 signal in community‐dwelling adults. Alzheimer’s & Dementia, 19(S10). Portico. https://doi.org/10.1002/alz.081866
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Lao, P. J., Sedaghat, A., Edwards, N. C., Lippert, R. V., Rizvi, B., Smith, A. C., Tudorascu, D., Rosas, H. D., Yassa, M. A., Handen, B. L., Christian, B. T., Gutierrez, J., Wilcock, D. M., Head, E., & Brickman, A. M. (2023). Pseudo‐longitudinal trajectories of cerebrovascular disease biomarkers in adults with Down syndrome across the lifespan. Alzheimer’s & Dementia, 19(S10). Portico. https://doi.org/10.1002/alz.081900
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Munkombwe, C., Misiura, M., Igwe, K. C., Likos, K. D. S., Verble, D. D., Zetterberg, H., Brickman, A. M., Hu, W. T., Dotson, V. M., & Wharton, W. (2023). Neuroimaging Correlates of Alzheimer’s Disease biomarkers in a mid‐life, racially diverse high‐risk cohort. Alzheimer’s & Dementia, 19(S16). Portico. https://doi.org/10.1002/alz.080380
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Wang, L., Ho, P., Tee, B. L., Li, C., Gu, Y., Yokoyama, J. S., Reyes‐Dumeyer, D., Faber, K. M., Lee, W., Song, Y. E., Tzuang, M., Vardarajan, B. N., Yang, H., Choi, Y., Feldman, H. H., Henderson, V., Hsiung, G. R., Mayeux, R., … Rosen, H. J. (2023). Asian Cohort for Alzheimer’s Disease Pilot Study on Genetic and Non‐Genetic Risk Factors for Alzheimer’s Disease among Asian Americans and Canadians. Alzheimer’s & Dementia, 19(S22). Portico. https://doi.org/10.1002/alz.076993
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Walters, S., Eissman, J. M., Mukherjee, S., Lee, M. L., Choi, S., Scollard, P., Trittschuh, E. H., Mez, J. B., Bush, W. S., Kunkle, B. W., Naj, A. C., Gifford, K. A., Cuccaro, M. L., Cruchaga, C., Pericak‐Vance, M. A., Farrer, L. A., Wang, L., Haines, J. L., … Jefferson, A. L. (2023). Genetic predictors of multiple cognitive domains within ancestry groups in older adults. Alzheimer’s & Dementia, 19(S12). Portico. https://doi.org/10.1002/alz.079076
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Janve, V. A., Archer, D. B., Eissman, J. M., Durant, A., Mukherjee, S., Lee, M. L., Choi, S., Scollard, P., Trittschuh, E. H., Mez, J. B., Bush, W. S., Engelman, C. D., Lu, Q., Fardo, D. W., Buckley, R. F., Mormino, E. C., Kunkle, B. W., Naj, A. C., … Gifford, K. A. (2023). Predicted gene expression identifies novel tissue‐specific gene predictors of memory performance in older adults. Alzheimer’s & Dementia, 19(S12). Portico. https://doi.org/10.1002/alz.073327
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Rossano, S., Talmasov, D., Johnson, A. S., Smith, A. C., Guzmán, D. S., Okafor, A., Kreisl, W. C., De Jager, P. L., & Lao, P. J. (2023). Validating noninvasive techniques for 11C‐ER176 PET quantification in controls and Alzheimer’s disease patients. Alzheimer’s & Dementia, 19(S17). Portico. https://doi.org/10.1002/alz.078290
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Miller, G. W., Kalia, V., Lai, Y., Honig, L. S., Mayeux, R., Vardarajan, B. N., Lantigua, R. A., Lee, A. J., Manly, J. J., & Nandakumar, R. (2023). Exposomics for Characterization of Environmental Drivers of AD. Alzheimer’s & Dementia, 19(S23). Portico. https://doi.org/10.1002/alz.077827
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Naderi, E., Aguado-Barrera, M. E., Schack, L. M. H., Dorling, L., Rattay, T., Fachal, L., Summersgill, H., Martínez-Calvo, L., Welsh, C., Dudding, T., Odding, Y., Varela-Pazos, A., Jena, R., Thomson, D. J., Steenbakkers, R. J. H. M., Dennis, J., Lobato-Busto, R., Alsner, J., … Ness, A. (2023). Large-scale meta–genome-wide association study reveals common genetic factors linked to radiation-induced acute toxicities across cancer types. JNCI Cancer Spectrum, 7(6). https://doi.org/10.1093/jncics/pkad088
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Hoost, S. S., Honig, L. S., Kang, M. S., Sanchez, D., Reyes‐Dumeyer, D., Lantigua, R. A., Dage, J. L., Brickman, A. M., Manly, J. J., Mayeux, R., & Gu, Y. (2023). Nutrient intake in relation to longitudinal change of blood‐based biomarkers of Alzheimer’s disease. Alzheimer’s & Dementia, 19(S15). Portico. https://doi.org/10.1002/alz.079125
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Johnson, A. S., Ziaggi, G., Smith, A. C., Guzmán, D. S., Okafor, A., Huey, E. D., Kreisl, W. C., Talmasov, D., & Lao, P. J. (2023). Elevated Tau burden in Amygdala and Hippocampus amongst older participants with psychosis. Alzheimer’s & Dementia, 19(S10). Portico. https://doi.org/10.1002/alz.081869
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Sawyer, R. P., Bennett, A., Blair, J., Molano, J., Timmerman, E., Foster, F., Karkoska, K., Hyacinth, H. I., Manly, J. J., Howard, V. J., Petrov, M. E., Hoffmann, C. M., Yu, F., Demel, S. L., Aziz, Y., Hooper, D., Hill, E. J., Johnson, J., Pounders, J., & Shatz, R. (2023). History of obstructive sleep apnea associated with incident cognitive impairment in white but not black individuals in a US national cohort study. Sleep Medicine, 112, 1–8. https://doi.org/10.1016/j.sleep.2023.09.021
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Renteria, M. A., Petrosyan, S., Saenz, J., Arango, S. M., Aguila, E., Barral, S., Tosto, G., Reyes‐Dumeyer, D., Samper‐Ternent, R., Obregon, A. M., & Wong, R. (2023). The association of English‐Spanish and Indigenous‐Spanish bilingualism with cognition among older adults in the Mexican Health and Aging Study (MHAS). Alzheimer’s & Dementia, 19(S14). Portico. https://doi.org/10.1002/alz.078663
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Bhattarai, P., Cosacak, M. I., Lee, A. J., Yilmaz, E., Is, O., Wang, X., Vardarajan, B. N., Ertekin‐Taner, N., Mayeux, R., & Kizil, C. (2023). Functional investigation of the gliovascular niche‐related genes and their relevance to Alzheimer’s disease pathomechanisms in zebrafish. Alzheimer’s & Dementia, 19(S13). Portico. https://doi.org/10.1002/alz.073812
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Byfield, G., Starks, T. D., Luther, R., Edwards, C. L., Lloyd, S. L., Caban‐Holt, A., Adams, L. D., Vance, J. M., Cuccaro, M., Haines, J. L., Reitz, C., Pericak‐Vance, M. A., & Byrd, G. S. (2023). Leveraging African American family connectors for Alzheimer’s disease genomic studies. Alzheimer’s & Dementia, 19(12), 5437–5446. Portico. https://doi.org/10.1002/alz.13106
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Song, S., Sun, Y., Zhang, Y., Ye, K., Shen, Y., & Gu, Y. (2023). Physical activity reduces the socioeconomic disparity in dementia risk: A UK Biobank cohort study. Alzheimer’s & Dementia, 19(S23). Portico. https://doi.org/10.1002/alz.080195
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Reyes‐Dumeyer, D., Piriz, A., Soriano, B., Franco, Y., Coronado, Z. D., Recio, P., Mejia, D. R., Medrano, M., Lantigua, R. A., Vardarajan, B. N., Honig, L. S., & Mayeux, R. (2023). Biomarker collection from the Caribbean Hispanic families from Dominican Republic and New York. Alzheimer’s & Dementia, 19(S22). Portico. https://doi.org/10.1002/alz.074856
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Siddiqui, T., Cosacak, M. I., Popova, S., Bhattarai, P., Yilmaz, E., Lee, A. J., Min, Y., Wang, X., Allen, M., İş, Ö., Atasavum, Z. T., Rodriguez-Muela, N., Vardarajan, B. N., Flaherty, D., Teich, A. F., Santa-Maria, I., Freudenberg, U., Werner, C., Tosto, G., … Kizil, C. (2023). Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer’s disease. Npj Regenerative Medicine, 8(1). https://doi.org/10.1038/s41536-023-00311-5
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Kalia, V., Reyes‐Dumeyer, D., Dubey, S., Nandakumar, R., Lee, A. J., Lantigua, R. A., Medrano, M., Mejia, D. R., Recio, P., Honig, L. S., Mayeux, R., Miller, G. W., & Vardarajan, B. N. (2023). Metabolites correlate with plasma biomarkers and clinical diagnosis of Alzheimer’s Disease. Alzheimer’s & Dementia, 19(S15). Portico. https://doi.org/10.1002/alz.078516
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Joyce, J., Chapman, S., Gifford, K. A., Shagalow, S., Waltrip, L. H., Zeiger, P., Kann, M., Ravichander, A., Rizer, S., Marder, K., Jefferson, A. L., & Cosentino, S. (2023). Sex/gender differences in subjective cognitive decline’s association to cognition and depression. Alzheimer’s & Dementia, 19(S22). Portico. https://doi.org/10.1002/alz.073811
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Chen, J., Cazenave-Gassiot, A., Xu, Y., Piroli, P., Hwang, R., DeFreitas, L., Chan, R. B., Di Paolo, G., Nandakumar, R., Wenk, M. R., & Marquer, C. (2023). Lysosomal phospholipase A2 contributes to the biosynthesis of the atypical late endosome lipid bis(monoacylglycero)phosphate. Communications Biology, 6(1). https://doi.org/10.1038/s42003-023-04573-z
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Middleton, J., MacLeod, K. R., Bozoki, A., Galvin, J. E., Irwin, D. J., Lippa, C., Litvan, I., Lopez, O. L., Berman, S., Tsuang, D. W., Zabetian, C. P., Honig, L. S., Marder, K., Fleisher, J. E., Sabbagh, M., Wint, D., Taylor, A., Bekris, L. M., Leverenz, J. B., & Galasko, D. R. (2023). Use of α‐synuclein seed amplification assays to assess how clinical features relate to the diagnosis of Dementia with Lewy Bodies. Alzheimer’s & Dementia, 19(S14). Portico. https://doi.org/10.1002/alz.078103
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Melgarejo, J. D., Vatcheva, K. P., Mena, L. J., Chavez, C. A., Silva, E., Calmon, G., Mavarez, R. P., Lee, J. H., Terwilliger, J. D., & Maestre, G. E. (2023). Cognitive Decline Associated with Longitudinal Changes in 24‐h Ambulatory Blood Pressure Variability. Alzheimer’s & Dementia, 19(S22). Portico. https://doi.org/10.1002/alz.077628
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Eissman, J. M., Walters, S., Mukherjee, S., Lee, M. L., Choi, S., Scollard, P., Trittschuh, E. H., Mez, J. B., Bush, W. S., Kunkle, B. W., Naj, A. C., Gifford, K. A., Cuccaro, M. L., Cruchaga, C., Pericak‐Vance, M. A., Farrer, L. A., Wang, L., Haines, J. L., … Jefferson, A. L. (2023). Sex‐specific genetic architecture of multiple domains of cognition among older adults. Alzheimer’s & Dementia, 19(S12). Portico. https://doi.org/10.1002/alz.077007
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Rossano, S., Talmasov, D., Johnson, A. S., Smith, A. C., Guzmán, D. S., Okafor, A., Kreisl, W. C., De Jager, P. L., & Lao, P. J. (2023). Validating noninvasive techniques for 11C‐ER176 PET quantification in controls and Alzheimer’s disease patients. Alzheimer’s & Dementia, 19(S10). Portico. https://doi.org/10.1002/alz.081801
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Wisch, J. K., Gordon, B. A., Boerwinkle, A. H., Flores, S., McKay, N. S., Henson, R. L., Thippabhotla, S., Kennedy, J. T., Butt, O. H., Chen, C. D., Handen, B. L., Christian, B. T., Head, E., Mapstone, M., Tudorascu, D., Zammit, M. D., Cohen, A., Johnson, S. C., … Fagan, A. M. (2023). Cross‐sectional comparison of the role of tau burden among Down Syndrome Alzheimer disease and autosomal‐dominant Alzheimer disease. Alzheimer’s & Dementia, 19(S14). Portico. https://doi.org/10.1002/alz.079102
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Alshikho, M. J., Pyne, J., Lao, P. J., Turney, I. C., Berroa, J., Gutierrez, J., Manly, J. J., & Brickman, A. M. (2023). Regional White Matter Hyperintensities are Associated with Diminished Blood Flow and Microstructure in Middle Age. Alzheimer’s & Dementia, 19(S17). Portico. https://doi.org/10.1002/alz.077380
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Browne, L. Y., Cedeno, J. A., White, P. G., Cesar, O., Azad, D. Z., Tosto, G., Osorio, R. S., & Bubu, O. M. M. (2023). The Black Experience of COVID‐19. What is next for Clinical Psychologists in Alzheimer’s Disease research post‐pandemic? Alzheimer’s & Dementia, 19(S19). Portico. https://doi.org/10.1002/alz.073473
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Brickman, A. M., Grodsky, E., Manly, J. J., Muller, C., & Warren, J. R. (2023). High School and Beyond: Cohort Data for Studying the Effects of Education on Midlife Cognition. Alzheimer’s & Dementia, 19(S22). Portico. https://doi.org/10.1002/alz.075607
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Hojjati, S. H., Feiz, F., Nayak, S., Shteingart, J., Ozoria, S., Picha, S. G., Fernández, A., Devanand, D. P., Luchsinger, J. A., Stern, Y., & Razlighi, Q. R. (2023). Hub brain regions for the remote spatial association between tau and Amyloid‐β proteins. Alzheimer’s & Dementia, 19(S16). Portico. https://doi.org/10.1002/alz.076456
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Sasse, A., Ng, B., Spiro, A. E., Tasaki, S., Bennett, D. A., Gaiteri, C., De Jager, P. L., Chikina, M., & Mostafavi, S. (2023). Benchmarking of deep neural networks for predicting personal gene expression from DNA sequence highlights shortcomings. Nature Genetics, 55(12), 2060–2064. https://doi.org/10.1038/s41588-023-01524-6
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Membreno, R., Thomas, K. R., Calcetas, A. T., Edwards, L., Bordyug, M., Showell, M., Stanfill, M., Brenner, E. K., Walker, K. S., Rotblatt, L. J., Brickman, A. M., Edmonds, E. C., & Bangen, K. J. (2023). Regional White Matter Hyperintensities Relate to Specific Cognitive Abilities in Older Adults Without Dementia. Alzheimer Disease & Associated Disorders, 37(4), 303–309. https://doi.org/10.1097/wad.0000000000000585
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