Synaptic plasticity deficits in a mouse model of Timothy syndrome: LTP saturation and its pharmacological rescue by nifedipine

Lado, W., Wu, X., Choi, S., Dong, Y., Yang, G., Arancio, O., Tempia, F., Miniaci, M. C., Sulzer, D., Mosharov, E., & Tang, G. (2025). Synaptic plasticity deficits in a mouse model of Timothy syndrome: LTP saturation and its pharmacological rescue by nifedipine. Biomedicine & Pharmacotherapy, 184, 117896. https://doi.org/10.1016/j.biopha.2025.117896
Authors:
Wudu Lado
Xiaoping Wu
Sejoon Choi
Yuxin Dong
Guang Yang
Ottavio Arancio
Filippo Tempia
Maria Concetta Miniaci
David Sulzer
Eugene Mosharov
Guomei Tang
Affiliated Authors:
Wudu Lado
Xiaoping Wu
Sejoon Choi
Yuxin Dong
Guang Yang
Ottavio Arancio
David Sulzer
Eugene Mosharov
Guomei Tang
Columbia Affiliation:
Subjects:
Nifedipine (MeSH)
Long-Term Potentiation (MeSH)
Syndactyly (MeSH)
Disease Models, Animal (MeSH)
Calcium Channels, L-Type (MeSH)
Long QT Syndrome (MeSH)
Hippocampus (MeSH)
Autistic Disorder (MeSH)
Neuronal Plasticity (MeSH)
Author Keywords:
autism spectrum disorder
hippocampus, theta burst stimulation, long term potentiation
nifedipine
synaptic plasticity
timothy syndrome
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Publication Type:
Article
Unique ID:
10.1016/j.biopha.2025.117896
PMID:
39938350
DOI:
10.1016/j.biopha.2025.117896
Journal:
Biomedicine and Pharmacotherapy
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record

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