Taub Institute for Research on Alzheimer’s Disease and the Aging Brain

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Wang, T., Archer, D. B., Ali, M., Wu, Y., Mormino, E., Buckley, R. F., Lee, A. J., Saykin, A. J., De Jager, P. L., Schneider, J. A., Bennett, D. A., Barnes, L. L., Vardarajan, B. N., Mayeux, R., Kunkle, B. W., Bush, W. S., Keene, C. D., Seshadri, S., … Sperling, R. A. (2024). Multimodal Genetic Analysis of Brain Amyloidosis. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.090566
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Noble, J. M., Minchala, S. G., Hedmann, M. G., Teresi, J., Ocepek‐Welikson, K., Silver, S. A., Eimicke, J. P., Ramirez, M., Harris, A., Lloyd, A., Chhea, K., Arango, C. A., Lee, Y., Sawyer, V., & Williams, O. (2024). Development of the 7‐item ASK‐AD Assess Symptoms and Knowledge of Alzheimer’s Disease tool for multigenerational community dementia awareness: Findings from Old SCHOOL Hip Hop. Alzheimer’s & Dementia, 20(S7). Portico. https://doi.org/10.1002/alz.089722
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McIntire, L. B., Mares, J., Costa, A. P., Lazarian, A., Wartchow, K. M., Dartora, W., Nuriel, T., & Menon, V. (2024). Commonalities in the lipid profile shift in ApoE ε4 risk variant and mild cognitive impairment highlight acyl chain remodeling. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.087508
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Scambray, K. A., Nelson, M. E., Morris, E. P., Palms, J. D., Taylor, L., Sol, K., Schupf, N., Brickman, A. M., Manly, J. J., & Zahodne, L. B. (2024). Subjective Social Status, Brain Health, and Cognitive Reserve Across Race/Ethnicity and Sex/Gender. Alzheimer’s & Dementia, 20(S7). Portico. https://doi.org/10.1002/alz.087985
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Siemers, E. R., Evans, E. E., Fisher, T. L., Boise, M., Foster, A., Leonard, J. E., Mishra, V., Mallow, C. L., Porsteinsson, A. P., Turner, R. S., Bond, W., Huffaker, J., Farlow, M. R., Honig, L. S., Sheldon, E., Townley, R. A., Winner, P., Norton, J., Holub, R., … Zauderer, M. (2024). Results of SIGNAL‐AD, a randomized, phase 1b/2 trial to evaluate safety and efficacy of targeting reactive astrocytes with pepinemab, SEMA4D blocking antibody, in people with mild Alzheimer’s dementia. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.092538
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Bahl, A., Honig, L. S., Kang, M. S., Sanchez, D., Reyes‐Dumeyer, D., Manly, J. J., Lantigua, R. A., Dage, J. L., Brickman, A. M., Vardarajan, B. N., Mayeux, R., & Gu, Y. (2024). Blood‐Based Biomarkers to Aid in Alzheimer’s Disease Prediction or Diagnosis: Analysis in a Multi‐Ethnic Cohort Study. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.091795
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Fan, K., Aslam, M. M., Dang, L. T., Gorijala, P., Shi, R., Feingold, E., Kamboh, M. I., Lee, J. H., Xicota, L., Cohen, A. D., Handen, B. L., Christian, B. T., Head, E., Mapstone, M., & Cruchaga, C. (2024). Genome‐wide association of Tau imaging and plasma biomarkers in adults with Down Syndrome. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.092615
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Charisis, S., Ntanasi, E., Mamalaki, E., Skaperda, Z., de la Colina, A. N., Kouretas, D., & Scarmeas, N. (2024). Association of Blood Redox Markers with Alzheimer Disease Biomarkers and Cognitive Performance. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.085708
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Cieza, B., Yang, Z., Reyes‐Dumeyer, D., Lee, A. J., Dugger, B. N., Jin, L., Murray, M. E., Dickson, D. W., Pericak‐Vance, M. A., Vance, J. M., Foroud, T. M., Mayeux, R., & Tosto, G. (2024). Polytranscriptomic risk score for Alzheimer Disease in a large diverse multi‐center brain bank study. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.092971
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Lippert, R. V., Edwards, N. C., Tosto, G., Pyne, J. D., Lao, P. J., & Brickman, A. M. (2024). Cumulative Incidence Rate Score for Alzheimer’s Disease Risk is Associated with White Matter Hyperintensity Volume in Older Adults Without Dementia. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.092734
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Durant, A., Mukherjee, S., Lee, M. L., Choi, S., Scollard, P., Trittschuh, E. H., Mez, J., Bush, W. S., Kunkle, B. W., Naj, A. C., Gifford, K. A., Cuccaro, M. L., Cruchaga, C., Hassenstab, J. J., Pericak‐Vance, M. A., Farrer, L. A., Wang, L., Haines, J. L., … Jefferson, A. L. (2024). Evaluating the association between APOE genotypes and cognitive resilience in SuperAgers. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.093260
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Gao, S., Bassil, D. T., Wagner, R. G., du Toit, J., Huber, H., Ashton, N. J., Cotton‐Samuel, D., Farrell, M. T., Mngomezulu, V., Manly, J. J., Tollman, S., Berkman, L. F., Zetterberg, H., & Brickman, A. M. (2024). Assessing the feasibility of dried blood spot (DBS) collection for blood‐based biomarkers of Alzheimer’s Disease in rural South Africa. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.092596
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Honig, L. S., Kang, M. S., Reyes‐Dumeyer, D., Franco, Y., Medrano, M., Piriz, A., Recio, P., Mejia, D. R., Soriano, B., Lantigua, R. A., & Mayeux, R. (2024). Biomarkers, clinical status, and cognitive performance in a Caribbean Hispanic cohort. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.093556
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de la Colina, A. N., Charisis, S., Ntanasi, E., Mamalaki, E., Skaperda, Z., Kouretas, D., & Scarmeas, N. (2024). Comparison of cerebrospinal fluid and plasma oxidative stress biomarkers. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.085482
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McLachlan, M., Rouanet, J. P., Garimella, A., Price, J. C., Tudorascu, D., Laymon, C. M., Keator, D. B., Betthauser, T. J., Kreisl, W. C., Lao, P. J., Minhas, D. S., Klunk, W. E., Cohen, A., Handen, B. L., Fryer, T. D., Zaman, S., Koeppe, R. A., Head, E., Mapstone, M., … Christian, B. T. (2024). Comparison of reference region stability for longitudinal amyloid PET in Down syndrome. Alzheimer’s & Dementia, 20(S9). Portico. https://doi.org/10.1002/alz.094104
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Neumann, D. L., Tozlu, C., Razlighi, Q. R., Luchsinger, J. A., Stern, Y., Devanand, D., & Kuceyeski, A. (2024). Decreased entropy of functional MRI signals in individuals with mild cognitive impairment compared to cognitively normal controls. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.087627
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Cornejo‐Olivas, M., Griswold, A. J., Saldarriaga‐Mayo, A., Mena, P. R., Rodriguez, R. S., Adams, L. D., Whitehead, P. L., Isasi, R., Illanes‐Manrique, M., Sarapura‐Castro, E., Rajabli, F., McInerney, K. F., Milla‐Neyra, K., Manrique‐Enciso, C., Beecham, G. W., Castro‐Suarez, S., George‐Hyslop, P. S., Araujo‐Aliaga, I., Cuccaro, M. L., … Pericak‐Vance, M. A. (2024). A novel stop‐gain SORL1 mutation from Amerindian background in a Peruvian family with Alzheimer’s Disease of the PeADI Study. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.090818
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Lee, H., Tzuang, M., Chow, T. W., Kang, Y., Tee, B. L., Li, C., Ho, P., Gu, Y., Lu, A. T., Choi, Y., Jun, G. R., Wang, L., Yu, H. (Ho), & Park, V. T. (2024). Translation and Cultural Adaptation of Tools to Assess Diverse Asian American and Asian Canadian Populations: The Asian Cohort for Alzheimer’s Disease Study. Alzheimer’s & Dementia, 20(S7). Portico. https://doi.org/10.1002/alz.092279
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Hofmann, A., Häsler, L. M., Lambert, M., Kaeser, S. A., Gräber-Sultan, S., Obermüller, U., Kuder-Buletta, E., la Fougere, C., Laske, C., Vöglein, J., Levin, J., Fox, N. C., Ryan, N. S., Zetterberg, H., Llibre-Guerra, J. J., Perrin, R. J., Ibanez, L., Schofield, P. R., Brooks, W. S., … Xu, J. (2024). Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-52937-8
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Taga, M., Fujita, M., Parghi, N., & De Jager, P. L. (2024). Automated image segmentation uncovers the association of a microglial subtype defined by High CD74 Expression with cognitive decline. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.092664
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Custodio, N., Montesinos, R., Malaga, M., Custodio, B., Chambergo‐Michilot, D., Bustamante‐Paytan, D., Yauri, Z., Aguero, K., Verastegui, G., Lanata, S., Butler, C., & Tosto, G. (2024). The modified Rowland Universal Dementia Assessment Scale for dementia screening in Peruvian population. Alzheimer’s & Dementia, 20(S3). Portico. https://doi.org/10.1002/alz.090904
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Guzmán, D. S., Rentería, M. A., Avila, J. F., Turney, I. C., Johnson, A. S., Smith, A. C., Okafor, A., Houlihan, H. M., Heuer, L. B., Alshikho, M. J., Morales, C., Mazen, J., Gu, Y., Manly, J. J., Brickman, A. M., & Lao, P. J. (2024). Differential association of moderate alcohol use with neurodegeneration, cerebrovascular disease, and cognition by racial, ethnic and sex/gender groups in middle age. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.091479
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Grodstein, F., Lemos, B., Yang, J., de Paiva Lopes, K., Vialle, R. A., Seyfried, N., Wang, Y., Shireby, G., Hannon, E., Thomas, A., Brookes, K., Mill, J., De Jager, P. L., & Bennett, D. A. (2024). Genetic architecture of epigenetic cortical clock age in brain tissue from older individuals: alterations in CD46 and other loci. Epigenetics, 19(1). https://doi.org/10.1080/15592294.2024.2392050
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Logue, M. W., Labadorf, A. T., O’Neill, N. K., Dickson, D. W., Flanagan, M. E., Franklin, E. E., Frosch, M. P., Gearing, M., Jin, L., Kofler, J., Lee, E. B., Mayeux, R., McKee, A. C., Miller, C. A., Murray, M. E., Nelson, P. T., Perrin, R. J., Schneider, J. A., Stein, T. D., … Farrer, L. A. (2024). Identification of differentially expressed genes in post‐mortem tissue from African American Alzheimer disease cases and controls. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.091575
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Akinyemi, R. O., Griswold, A. J., Coker, M., Whitehead, P. L., Rajabli, F., Akinwande, K. S., Diala, S., Ogunronbi, M., Scott, K., Obiako, R., Adams, L. D., Hamilton‐Nelson, K. L., Wahab, K., Mena, P. R., Akpalu, A. K., Kunkle, B. W., Sarfo, F. S., Vance, J. M., Okubadejo, N. U., … Consortium, A. D. (2024). Genetic architecture of Alzheimer’s disease in a West African Cohort: Insights from the READD ‐ ADSP. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.093308
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Goldberg, T. E., Lee, S., Devanand, D., & Schneider, L. S. S. (2024). Comparison of Relative Change with Effect Size Metrics in Alzheimer’s Disease Anti‐amyloid Clinical Trials. Alzheimer’s & Dementia, 20(S8). Portico. https://doi.org/10.1002/alz.094862
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Zaman, A. F., Mena, P. R., McInerney, K. F., Celis, K., Adams, L. D., Duke, T., Sanchez, J. J., Chavez, J., Cespedes, J., Starks, T. D., Laux, R. A., Hamilton‐Nelson, K. L., Rajabli, F., Byrd, G. S., Reitz, C., Tosto, G., Ogrocki, P. K., Caban‐Holt, A. M., Haines, J. L., … Cuccaro, M. L. (2024). Assessing the Utility of a Knowledge Based Algorithm for Classifying Alzheimer disease and Mild Cognitive Impairment in the Recruitment and Retention for Alzheimer’s Disease Diversity Cohorts in the ADSP (READD‐ADSP) Project. Alzheimer’s & Dementia, 20(S3). Portico. https://doi.org/10.1002/alz.091433
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Biber, S. A., Prado, M. G., Culhane, J. E., Phuong, J., Keller, B., Lerch, M., Wang, S., Noble, J. M., Moulder, K. L., Saykin, A. J., Gao, S., Lai, A., Natarajan, K., Kukull, W. A., Mooney, S., & Stephens, K. (2024). Advancing Alzheimer’s disease and related dementias (ADRD) and COVID‐19 research by linking real‐world data with a standardized longitudinal ADRD data platform. Alzheimer’s & Dementia, 20(S8). Portico. https://doi.org/10.1002/alz.094785
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Ciesielski, T. H., Tosto, G., Durodoye, R. O., Rajabli, F., Akinyemi, R. O., Pericak‐Vance, M. A., Haines, J. L., & Williams, S. M. (2024). Evidence of recent evolutionary selection at eQTLs for APOE. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.092921
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Houlihan, H. M., Johnson, A. S., Smith, A. C., Guzmán, D. S., Okafor, A., Heuer, L. B., Talmasov, D., Chikwem, N., Dass, D. S., Noble, J. M., Kreisl, W. C., Small, S. A., & Lao, P. J. (2024). Microglia density measured by TSPO PET across amyloid positivity and clinical variants. Alzheimer’s & Dementia, 20(S8). Portico. https://doi.org/10.1002/alz.095057
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Lao, P. J., Edwards, N. C., Flores‐Aguilar, L., Rizvi, B., Smith, A. C., Tudorascu, D., Rosas, H. D., Yassa, M. A., Handen, B. L., Christian, B. T., Gutierrez, J., Wilcock, D. M., Head, E., & Brickman, A. M. (2024). Longitudinal changes in neuroimaging markers of small vessel disease: Implications for clinical trials. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.092029
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Chapman, S., Cosentino, S., Nosheny, R. L., Herman, M., Brickman, A. M., & Simoes, S. (2024). Subjective Cognitive Decline is associated with blood‐plasma Neurofilament Light in cognitively normal older adults. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.087052
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Contreras, A. G., Walters, S., Eissman, J. M., Archer, D. B., Regelson, A. N., Durant, A., Mukherjee, S., Lee, M. L., Choi, S., Scollard, P., Trittschuh, E. H., Mez, J., Bush, W. S., Kunkle, B. W., Naj, A. C., Gifford, K. A., Bilgel, M., Kuzma, A. B., Cuccaro, M. L., … Hohman, T. J. (2024). Cross‐Ancestry Meta‐Analysis of APOE‐ε4 Stratified GWAS of Longitudinal Cognitive Decline in Older Adults. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.090846
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Castellano, T., Wang, T. C., Nolan, E., Archer, D. B., Cody, K., Harrison, T. M., Wu, Y., Durant, A., Janve, V. A., Engelman, C. D., Jagust, W. J., Albert, M. S., Johnson, S. C., Resnick, S. M., Sperling, R. A., Bilgel, M., Saykin, A. J., Vardarajan, B. N., Mayeux, R., … Koran, M. E. I. (2024). Genetic and Sex Associations with Earlier Estimated Onset of Amyloid Positivity from over 4000 Harmonized Positron Emission Tomography Images. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.092852
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Lao, P. J., Edwards, N. C., Flores‐Aguilar, L., Rizvi, B., Smith, A. C., Tudorascu, D., Rosas, H. D., Yassa, M. A., Handen, B. L., Christian, B. T., Gutierrez, J., Wilcock, D. M., Head, E., & Brickman, A. M. (2024). Longitudinal changes in neuroimaging markers of small vessel disease: Implications for clinical trials. Alzheimer’s & Dementia, 20(S9). Portico. https://doi.org/10.1002/alz.094386
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Joyce, J. L., Cosentino, S., Rizer, S., Dargie, S. A., Chapman, S., Mora, L., Libon, D. J., Tom, S. E., Marder, K., & Rosser, M. (2024). Preliminary Findings from EMPOWER: Evaluating Memory as Part of Women’s Routine Care. Alzheimer’s & Dementia, 20(S3). Portico. https://doi.org/10.1002/alz.092824
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Mielke, M. M., Kurzman, H. R., Hu, Y. H., Cho, M., Liss, J., Burns, J. M., Obisesan, T. O., Hornbecker, M., Pallay, A., Smith, S. R., Honig, L. S., Parker, M. W., Bell, J., & Hampel, H. (2024). Advancing Early Detection of Alzheimer’s Disease in the Primary Care Setting in the United States. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.086582
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Edwards, N. C., Lao, P. J., Alshikho, M. J., Rizvi, B., Aguilar, L. F., Petersen, M., O’Bryant, S. E., Tudorascu, D., Handen, B. L., Gutierrez, J., Wilcock, D. M., Head, E., & Brickman, A. M. (2024). Independent and interactive contributions of cerebrovascular disease, neuroinflammation, and tau pathophysiology to Alzheimer’s disease‐related diagnostic conversion in adults with Down syndrome. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.087570
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Goldberg, D., Wadhwani, A. R., Wolk, D. A., Lee, E. B., Bennett, D. A., De Jager, P. L., Schneider, J. A., Zhou, W., & McMillan, C. T. (2024). DNA methylation associates with regional tau pathology beyond age and APOE. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.092539
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Goldberg, T. E., Kim, H., Devanand, D., & Lee, S. (2024). Effects of APOE e4 and Neuropathological Diagnoses on Neuropsychiatric Symptoms: Mediation Analyses and Likely Causation in an Integrated NACC Database. Alzheimer’s & Dementia, 20(S8). Portico. https://doi.org/10.1002/alz.094887
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Mares, J., Sharma, A., Guo, J., & Nuriel, T. (2024). Investigating the APOE4‐associated heterogeneity of imaging biomarkers across AD diagnostic stages. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.087489
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Caro, D. D., Rodriguez, S., Wetmore, J. B., Godinez, J. D., Camarillo, I. A., Goldman, J., Uhlmann, W. R., McCain, S., Caban, M., Leu, C., Abraido‐Lanza, A. F., Lantigua, R. A., Chung, W. K., Roberts, J. S., Siegel, K., & Ottman, R. (2024). Exploring the Immediate Impact of APOE ε4ε4 Genotype Disclosure among Latinos. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.086185
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Libon, D. J., Swenson, R., Tobyne, S. E., Price, C. C., Lamar, M., Cosentino, S., Banks, R., Jannati, A., Showalter, J., Bates, D., & Pascual‐Leone, A. (2024). A Brief Digital Neuropsychological Protocol – II: Using Artificial Intelligence to Assess Verbal Serial List Learning Recognition Latency. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.091489
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Libon, D. J., Swenson, R., Tobyne, S., Price, C. C., Lamar, M., Cosentino, S., Banks, R., Jannati, A., Showalter, J., Bates, D., & Pascual‐Leone, A. (2024). A Brief Digital Neuropsychological Protocol – I: Using Artificial Intelligence Assisted Technology to Assess Process and Errors. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.091441
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Arain, H. A., Idiarte, J. F., Lama, T. D., Figueroa, H. Y., Guo, J., Duff, K. E., & Nuriel, T. (2024). APOE4 Alters Tau Propagation in Regions Associated with Early Alzheimer’s Disease in a Humanized Mouse Model of Tau Spread. Alzheimer’s & Dementia, 20(S1). Portico. https://doi.org/10.1002/alz.089837
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Honig, L. S., Kim, J. M., Gonzalez, W. P., DiMuro, V., Jagannathan, R., Marder, K., Noble, J. M., Bell, K. L., & Mayeux, R. (2024). Clinical Use of Lecanemab at an Academic Medical Center. Alzheimer’s & Dementia, 20(S8). Portico. https://doi.org/10.1002/alz.095181
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Argiris, G., Stern, Y., & Habeck, C. G. (2024). Brain Resilience to Targeted Attack of Resting BOLD Networks as a Measure of Cognitive Reserve. Alzheimer’s & Dementia, 20(S2). Portico. https://doi.org/10.1002/alz.087406
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