Department of Molecular Pharmacology and Therapeutics

Displaying 51 - 100 of 168CSV
Lampe, G. D., King, R. T., Halpin-Healy, T. S., Klompe, S. E., Hogan, M. I., Vo, P. L. H., Tang, S., Chavez, A., & Sternberg, S. H. (2023). Targeted DNA integration in human cells without double-strand breaks using CRISPR-associated transposases. Nature Biotechnology, 42(1), 87–98. https://doi.org/10.1038/s41587-023-01748-1
Publication Date
Stokes, M. E., Vasciaveo, A., Small, J. C., Zask, A., Reznik, E., Smith, N., Wang, Q., Daniels, J., Forouhar, F., Rajbhandari, P., Califano, A., & Stockwell, B. R. (2024). Subtype-selective prenylated isoflavonoids disrupt regulatory drivers of MYCN-amplified cancers. Cell Chemical Biology, 31(4), 805-819.e9. https://doi.org/10.1016/j.chembiol.2023.11.007
Publication Date
Blomquist, V. G., Niu, J., Choudhury, P., Al Saneh, A., Colecraft, H. M., & Ahern, C. A. (2023). Transfer RNA-mediated restoration of potassium current and electrical correction in premature termination long-QT syndrome hERG mutants. Molecular Therapy - Nucleic Acids, 34, 102032. https://doi.org/10.1016/j.omtn.2023.102032
Publication Date
Hill, R., Sanchez, J., Lemel, L., Antonijevic, M., Hosking, Y., Mistry, S. N., Kruegel, A. C., Javitch, J. A., Lane, J. R., & Canals, M. (2023). Assessment of the potential of novel and classical opioids to induce respiratory depression in mice. British Journal of Pharmacology, 180(24), 3160–3174. Portico. https://doi.org/10.1111/bph.16199
Publication Date
Ribault, A., Benadjaoud, M. A., Squiban, C., Arnaud, L., Judicone, C., Leroyer, A. S., Rousseau, A., Huet, C., Guha, C., Benderitter, M., Lacroix, R., Flamant, S., Chen, E. I., Simon, J.-M., & Tamarat, R. (2023). Circulating microvesicles correlate with radiation proctitis complication after radiotherapy. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-022-21726-y
Publication Date
Labouesse, M. A., Torres-Herraez, A., Chohan, M. O., Villarin, J. M., Greenwald, J., Sun, X., Zahran, M., Tang, A., Lam, S., Veenstra-VanderWeele, J., Lacefield, C. O., Bonaventura, J., Michaelides, M., Chan, C. S., Yizhar, O., & Kellendonk, C. (2023). A non-canonical striatopallidal Go pathway that supports motor control. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-42288-1
Publication Date
Ramalingam, N., Jin, S.-X., Moors, T. E., Fonseca-Ornelas, L., Shimanaka, K., Lei, S., Cam, H. P., Watson, A. H., Brontesi, L., Ding, L., Hacibaloglu, D. Y., Jiang, H., Choi, S. J., Kanter, E., Liu, L., Bartels, T., Nuber, S., Sulzer, D., Mosharov, E. V., … Dettmer, U. (2023). Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity. Npj Parkinson’s Disease, 9(1). https://doi.org/10.1038/s41531-023-00444-w
Publication Date
Li, P., Zhen, Y., Kim, C., Liu, Z., Hao, J., Deng, H., Deng, H., Zhou, M., Wang, X.-D., Qin, T., & Yu, Y. (2023). Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA -mutated cancer. Science Advances, 9(43). https://doi.org/10.1126/sciadv.adg7752
Publication Date
Whitebirch, A. C., Santoro, B., Barnett, A., Lisgaras, C. P., Scharfman, H. E., & Siegelbaum, S. A. (2023). Reduced Cholecystokinin-Expressing Interneuron Input Contributes to Disinhibition of the Hippocampal CA2 Region in a Mouse Model of Temporal Lobe Epilepsy. The Journal of Neuroscience, 43(41), 6930–6949. https://doi.org/10.1523/jneurosci.2091-22.2023
Publication Date
Serafini, R. A., Estill, M., Pekarskaya, E. A., Sakloth, F., Shen, L., Javitch, J. A., & Zachariou, V. (2023). Tianeptine promotes lasting antiallodynic effects in a mouse model of neuropathic pain. Neuropsychopharmacology, 48(11), 1680–1689. https://doi.org/10.1038/s41386-023-01645-w
Publication Date
Moriya, Y., Kasahara, Y., Ishihara, K., Hall, F. S., Hagino, Y., Hen, R., Ikeda, K., Uhl, G. R., & Sora, I. (2023). Heterozygous and homozygous gene knockout of the 5-HT1B receptor have different effects on methamphetamine-induced behavioral sensitization. Behavioural Pharmacology, 34(7), 393–403. https://doi.org/10.1097/fbp.0000000000000745
Publication Date
Meszaros, J., Geggier, P., Manning, J. J., Asher, W. B., & Javitch, J. A. (2023). Methods for automating the analysis of live-cell single-molecule FRET data. Frontiers in Cell and Developmental Biology, 11. https://doi.org/10.3389/fcell.2023.1184077
Publication Date
Ager, C. R., Zhang, M., Chaimowitz, M., Bansal, S., Tagore, S., Obradovic, A., Jugler, C., Rogava, M., Melms, J. C., McCann, P., Spina, C., Drake, C. G., Dallos, M. C., & Izar, B. (2023). KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response. Journal for ImmunoTherapy of Cancer, 11(9), e006782. https://doi.org/10.1136/jitc-2023-006782
Publication Date
Pei, J., Zhang, J., Wang, X., Kim, C., Yu, Y., & Cong, Q. (2022). Impact of Asp/Glu‐ADP‐ribosylation on protein‐protein interaction and protein function. PROTEOMICS, 23(17). Portico. https://doi.org/10.1002/pmic.202200083
Publication Date
Zou, X., Shanmugam, S. K., Kanner, S. A., Sampson, K. J., Kass, R. S., & Colecraft, H. M. (2023). Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.83466
Publication Date
Lee, K. H., Manning, J. J., Javitch, J., & Shi, L. (2023). A Novel “Activation Switch” Motif Common to All Aminergic Receptors. Journal of Chemical Information and Modeling, 63(16), 5001–5017. https://doi.org/10.1021/acs.jcim.3c00732
Publication Date
Gavin, A. C., & Colecraft, H. M. (2023). Design and Applications of Genetically-Encoded Voltage-Dependent Calcium Channel Inhibitors. Voltage-Gated Ca2+ Channels: Pharmacology, Modulation and Their Role in Human Disease, 139–155. https://doi.org/10.1007/164_2023_656
Publication Date
Petersen, J. E., Pedersen, M. H., Dmytriyeva, O., Nellemose, E., Arora, T., Engelstoft, M. S., Asher, W. B., Javitch, J. A., Schwartz, T. W., & Trauelsen, M. (2023). Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2. Molecular Metabolism, 74, 101757. https://doi.org/10.1016/j.molmet.2023.101757
Publication Date
Kohler, C. G., Wolf, D. H., Abi-Dargham, A., Anticevic, A., Cho, Y. T., Fonteneau, C., Gil, R., Girgis, R. R., Gray, D. L., Grinband, J., Javitch, J. A., Kantrowitz, J. T., Krystal, J. H., Lieberman, J. A., Murray, J. D., Ranganathan, M., Santamauro, N., Van Snellenberg, J. X., Tamayo, Z., … Hohing, T. (2023). Illness Phase as a Key Assessment and Intervention Window for Psychosis. Biological Psychiatry Global Open Science, 3(3), 340–350. https://doi.org/10.1016/j.bpsgos.2022.05.009
Publication Date
Hobson, B. D., Stanley, A. T., De Los Santos, M. B., Culbertson, B., Mosharov, E. V., Sims, P. A., & Sulzer, D. (2023). Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrain. Brain, Behavior, and Immunity, 111, 277–291. https://doi.org/10.1016/j.bbi.2023.04.008
Publication Date
Menale, C., Trinchese, G., Aiello, I., Scalia, G., Dentice, M., Mollica, M. P., Yoon, N. A., & Diano, S. (2023). Nutrient-Dependent Mitochondrial Fission Enhances Osteoblast Function. Nutrients, 15(9), 2222. https://doi.org/10.3390/nu15092222
Publication Date
Cambre, E., Christenfeld, E., Torres, A. H., & Canetta, S. (2023). Measuring Motivation Using the Progressive Ratio Task in Adolescent Mice. Current Protocols, 3(5). Portico. https://doi.org/10.1002/cpz1.776
Publication Date
Jobin, M.-L., De Smedt-Peyrusse, V., Ducrocq, F., Baccouch, R., Oummadi, A., Pedersen, M. H., Medel-Lacruz, B., Angelo, M.-F., Villette, S., Van Delft, P., Fouillen, L., Mongrand, S., Selent, J., Tolentino-Cortez, T., Barreda-Gómez, G., Grégoire, S., Masson, E., Durroux, T., Javitch, J. A., … Trifilieff, P. (2023). Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling. Molecular Psychiatry, 28(5), 1960–1969. https://doi.org/10.1038/s41380-022-01928-6
Publication Date
Poggio, E., Vallese, F., Hartel, A. J. W., Morgenstern, T. J., Kanner, S. A., Rauh, O., Giamogante, F., Barazzuol, L., Shepard, K. L., Colecraft, H. M., Clarke, O. B., Brini, M., & Calì, T. (2023). Perturbation of the host cell Ca2+ homeostasis and ER-mitochondria contact sites by the SARS-CoV-2 structural proteins E and M. Cell Death & Disease, 14(4). https://doi.org/10.1038/s41419-023-05817-w
Publication Date
Vidyadhara, D. J., Somayaji, M., Wade, N., Yücel, B., Zhao, H., Shashaank, N., Ribaudo, J., Gupta, J., Lam, T. T., Sames, D., Greene, L. E., Sulzer, D. L., & Chandra, S. S. (2023). Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease. Cell Reports, 42(3), 112231. https://doi.org/10.1016/j.celrep.2023.112231
Publication Date
Pederick, D. T., Perry-Hauser, N. A., Meng, H., He, Z., Javitch, J. A., & Luo, L. (2023). Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons. ELife, 12. CLOCKSS. https://doi.org/10.7554/elife.83529
Publication Date
Shashaank, N., Somayaji, M., Miotto, M., Mosharov, E. V., Makowicz, E. A., Knowles, D. A., Ruocco, G., & Sulzer, D. L. (2023). Computational models of dopamine release measured by fast scan cyclic voltammetry in vivo. PNAS Nexus, 2(3). https://doi.org/10.1093/pnasnexus/pgad044
Publication Date
Kim, C., Wang, X.-D., Jang, S., & Yu, Y. (2023). PARP1 inhibitors induce pyroptosis via caspase 3-mediated gasdermin E cleavage. Biochemical and Biophysical Research Communications, 646, 78–85. https://doi.org/10.1016/j.bbrc.2023.01.055
Publication Date
Zou, X., Wu, X., Sampson, K. J., Colecraft, H. M., Larsson, H. P., & Kass, R. S. (2022). Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels. Frontiers in Physiology, 13. https://doi.org/10.3389/fphys.2022.902224
Publication Date
Vasciaveo, A., Arriaga, J. M., de Almeida, F. N., Zou, M., Douglass, E. F., Picech, F., Shibata, M., Rodriguez-Calero, A., de Brot, S., Mitrofanova, A., Chua, C. W., Karan, C., Realubit, R., Pampou, S., Kim, J. Y., Afari, S. N., Mukhammadov, T., Zanella, L., Corey, E., … Abate-Shen, C. (2022). OncoLoop: A Network-Based Precision Cancer Medicine Framework. Cancer Discovery, 13(2), 386–409. https://doi.org/10.1158/2159-8290.cd-22-0342
Publication Date
Qian, J., Guan, X., Xie, B., Xu, C., Niu, J., Tang, X., Li, C. H., Colecraft, H. M., Jaenisch, R., & Liu, X. S. (2023). Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons. Science Translational Medicine, 15(679). https://doi.org/10.1126/scitranslmed.add4666
Publication Date
Slavi, N., Balasubramanian, R., Lee, M. A., Liapin, M., Oaks-Leaf, R., Peregrin, J., Potenski, A., Troy, C. M., Ross, M. E., Herrera, E., Kosmidis, S., John, S. W. M., & Mason, C. A. (2023). CyclinD2-mediated regulation of neurogenic output from the retinal ciliary margin is perturbed in albinism. Neuron, 111(1), 49-64.e5. https://doi.org/10.1016/j.neuron.2022.10.025
Publication Date
Burke, A., Borot, F., Du, X., Churchill, M., Ding, J., Grass, A. M., DeSouza, P., Ali, A. M., & Mukherjee, S. (2022). A novel therapeutic bispecific format based on synthetic orthogonal heterodimers enables T cell activity against Acute myeloid leukemia. Oncogene, 42(1), 26–34. https://doi.org/10.1038/s41388-022-02532-2
Publication Date
Zahr, T., Liu, L., Chan, M., Zhou, Q., Cai, B., He, Y., Aaron, N., Accili, D., Sun, L., & Qiang, L. (2023). PPARγ (Peroxisome Proliferator-Activated Receptor γ) Deacetylation Suppresses Aging-Associated Atherosclerosis and Hypercholesterolemia. Arteriosclerosis, Thrombosis, and Vascular Biology, 43(1), 30–44. https://doi.org/10.1161/atvbaha.122.318061
Publication Date
Chernoff, M. B., Delgado, D., Tong, L., Chen, L., Oliva, M., Tamayo, L. I., Best, L. G., Cole, S., Jasmine, F., Kibriya, M. G., Nelson, H., Huang, L., Haack, K., Kent, J., Umans, J. G., Graziano, J., Navas-Acien, A., Karagas, M. R., Ahsan, H., & Pierce, B. L. (2023). Sequencing-based fine-mapping and in silico functional characterization of the 10q24.32 arsenic metabolism efficiency locus across multiple arsenic-exposed populations. PLOS Genetics, 19(1), e1010588. https://doi.org/10.1371/journal.pgen.1010588
Publication Date
He, Y., B’nai Taub, A., Yu, L., Yao, Y., Zhang, R., Zahr, T., Aaron, N., LeSauter, J., Fan, L., Liu, L., Tazebay, R., Que, J., Pajvani, U., Wang, L., Silver, R., & Qiang, L. (2022). PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms. Advanced Science, 10(2). Portico. https://doi.org/10.1002/advs.202204190
Publication Date
Carazo-Arias, E., Nguyen, P. T., Kass, M., Jee, H. J., Nautiyal, K. M., Magalong, V., Coie, L., Andreu, V., Gergues, M. M., Khalil, H., Akil, H., Arcego, D. M., Meaney, M., Anacker, C., Samuels, B. A., Pintar, J. E., Morozova, I., Kalachikov, S., & Hen, R. (2022). Contribution of the Opioid System to the Antidepressant Effects of Fluoxetine. Biological Psychiatry, 92(12), 952–963. https://doi.org/10.1016/j.biopsych.2022.05.030
Publication Date
Morgenstern, T. J., Nirwan, N., Hernández-Ochoa, E. O., Bibollet, H., Choudhury, P., Laloudakis, Y. D., Ben Johny, M., Bannister, R. A., Schneider, M. F., Minor, D. L., & Colecraft, H. M. (2022). Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-35025-7
Publication Date
Comollo, T. W., Zou, X., Zhang, C., Kesters, D., Hof, T., Sampson, K. J., & Kass, R. S. (2022). Exploring mutation specific beta blocker pharmacology of the pathogenic late sodium channel current from patient-specific pluripotent stem cell myocytes derived from long QT syndrome mutation carriers. Channels, 16(1), 173–184. https://doi.org/10.1080/19336950.2022.2106025
Publication Date
Liu, H., Iketani, S., Zask, A., Khanizeman, N., Bednarova, E., Forouhar, F., Fowler, B., Hong, S. J., Mohri, H., Nair, M. S., Huang, Y., Tay, N. E. S., Lee, S., Karan, C., Resnick, S. J., Quinn, C., Li, W., Shion, H., Xia, X., … Stockwell, B. R. (2022). Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-29413-2
Publication Date