S10RR025686

NIH – National Center for Research Resources

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Cholesterol trafficking to the ER leads to the activation of CaMKII/JNK/NLRP3 and promotes atherosclerosis

Yalcinkaya, M., Liu, W., Xiao, T., Abramowicz, S., Wang, R., Wang, N., Westerterp, M., & Tall, A. R. (2024). Cholesterol trafficking to the ER leads to the activation of CaMKII/JNK/NLRP3 and promotes atherosclerosis. Journal of Lipid Research, 65(4), 100534. https://doi.org/10.1016/j.jlr.2024.100534
Authors:
Mustafa Yalcinkaya
Wenli Liu
Tong Xiao
Sandra Abramowicz
Ranran Wang
Nan Wang
Marit Westerterp
Alan R Tall
Affiliated Authors:
Mustafa Yalcinkaya
Wenli Liu
Tong Xiao
Sandra Abramowicz
Ranran Wang
Nan Wang
Marit Westerterp
Alan R Tall
Columbia Affiliation:
Subjects:
Molecular Mechanisms of Inflammasome Activation and Regulation (OpenAlex Topic)
Cholesterol Metabolism and Atherosclerosis (OpenAlex Topic)
Immunological Mechanisms in Atherosclerosis Development (OpenAlex Topic)
NLR Family, Pyrin Domain-Containing 3 Protein (MeSH)
Atherosclerosis (MeSH)
Cholesterol (MeSH)
Calcium-Calmodulin-Dependent Protein Kinase Type 2 (MeSH)
Endoplasmic Reticulum (MeSH)
Author Keywords:
cholesterol
nlrp3 inflammasome
er
camkii
jnk
Grants:
P30CA013696 (NIH – National Cancer Institute)
S10RR025686 (NIH – National Center for Research Resources)
R01HL155431 (NIH – National Heart, Lung, and Blood Institute)
Publication Type:
Article
Unique ID:
10.1016/j.jlr.2024.100534
PMID:
38522750
DOI:
10.1016/j.jlr.2024.100534
Journal:
Journal of Lipid Research
Publication Date:
Data Source:
PubMed
Source Link:
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Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Upadhyayula, P. S., Higgins, D. M., Mela, A., Banu, M., Dovas, A., Zandkarimi, F., Patel, P., Mahajan, A., Humala, N., Nguyen, T. T. T., Chaudhary, K. R., Liao, L., Argenziano, M., Sudhakar, T., Sperring, C. P., Shapiro, B. L., Ahmed, E. R., Kinslow, C., Ye, L. F., … Canoll, P. (2023). Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-36630-w
Authors:
Pavan S. Upadhyayula
Dominique M. Higgins
Angeliki Mela
Matei Banu
Athanassios Dovas
Fereshteh Zandkarimi
Purvi Patel
Aayushi Mahajan
Nelson Humala
Trang T. T. Nguyen
Kunal R. Chaudhary
Lillian Liao
Michael Argenziano
Tejaswi Sudhakar
Colin P. Sperring
Benjamin L. Shapiro
Eman R. Ahmed
Connor Kinslow
Ling F. Ye
Markus D. Siegelin
Simon Cheng
Rajesh Soni
Jeffrey N. Bruce
Brent R. Stockwell
Peter Canoll
Affiliated Authors:
Pavan S. Upadhyayula
Dominique M. Higgins
Angeliki Mela
Matei Banu
Athanassios Dovas
Purvi Patel
Aayushi Mahajan
Nelson Humala
Trang T. T. Nguyen
Kunal R. Chaudhary
Lillian Liao
Michael Argenziano
Tejaswi Sudhakar
Colin P. Sperring
Benjamin L. Shapiro
Eman R. Ahmed
Ling F. Ye
Markus D. Siegelin
Rajesh Soni
Jeffrey N. Bruce
Brent R. Stockwell
Peter Canoll
Columbia Affiliation:
Subjects:
Ferroptosis (MeSH)
Glioma (MeSH)
Mechanisms and Implications of Ferroptosis in Cancer (OpenAlex Topic)
Lipid Metabolism in Cancer Pathogenesis (OpenAlex Topic)
Epigenetic Modifications and Their Functional Implications (OpenAlex Topic)
Grants:
P30CA013696 (NIH – National Cancer Institute)
R35CA209896 (NIH – National Cancer Institute)
P01CA087497 (NIH – National Cancer Institute)
UL1TR001873 (NIH – National Center for Advancing Translational Sciences)
S10RR025686 (NIH – National Center for Research Resources)
R01NS103473 (NIH – National Institute of Neurological Disorders and Stroke)
R61NS109407 (NIH – National Institute of Neurological Disorders and Stroke)
T35AG044303 (NIH – National Institute On Aging)
Publication Type:
Article
Unique ID:
10.1038/s41467-023-36630-w
PMID:
36864031
DOI:
10.1038/s41467-023-36630-w
Journal:
Nature Communications
Publication Date:
Data Source:
Scopus
Source Link:
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CD47-SIRPα axis blockade in NASH promotes necroptotic hepatocyte clearance by liver macrophages and decreases hepatic fibrosis

Shi, H., Wang, X., Li, F., Gerlach, B. D., Yurdagul, A., Moore, M. P., Zeldin, S., Zhang, H., Cai, B., Zheng, Z., Valenti, L., & Tabas, I. (2022). CD47-SIRPα axis blockade in NASH promotes necroptotic hepatocyte clearance by liver macrophages and decreases hepatic fibrosis. Science Translational Medicine, 14(672). https://doi.org/10.1126/scitranslmed.abp8309
Authors:
Hongxue Shi
Xiaobo Wang
Fang Li
Brennan D Gerlach
Arif Yurdagul
Mary P Moore
Sharon Zeldin
Hanrui Zhang
Bishuang Cai
Ze Zheng
Luca Valenti
Ira Tabas
Affiliated Authors:
Hongxue Shi
Xiaobo Wang
Fang Li
Brennan D Gerlach
Arif Yurdagul
Mary P Moore
Sharon Zeldin
Hanrui Zhang
Bishuang Cai
Ze Zheng
Ira Tabas
Columbia Affiliation:
Subjects:
Non-alcoholic Fatty Liver Disease (MeSH)
Grants:
P30CA013696 (NIH – National Cancer Institute)
S10RR025686 (NIH – National Center for Research Resources)
R00HL145131 (NIH – National Heart, Lung, and Blood Institute)
R00HL130574 (NIH – National Heart, Lung, and Blood Institute)
R00DK115778 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
R01DK116620 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
P30DK132710 (NIH – National Institute of Diabetes and Digestive and Kidney Diseases)
Publication Type:
Article
Unique ID:
10.1126/scitranslmed.abp8309
PMID:
36417485
DOI:
10.1126/scitranslmed.abp8309
Journal:
Science Translational Medicine
Publication Date:
Data Source:
PubMed
Source Link:
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Efferocytosis induces macrophage proliferation to help resolve tissue injury

Gerlach, B. D., Ampomah, P. B., Yurdagul, A., Liu, C., Lauring, M. C., Wang, X., Kasikara, C., Kong, N., Shi, J., Tao, W., & Tabas, I. (2021). Efferocytosis induces macrophage proliferation to help resolve tissue injury. Cell Metabolism, 33(12), 2445-2463.e8. https://doi.org/10.1016/j.cmet.2021.10.015
Authors:
Brennan D. Gerlach
Patrick B. Ampomah
Arif Yurdagul
Chuang Liu
Max C. Lauring
Xiaobo Wang
Canan Kasikara
Na Kong
Jinjun Shi
Wei Tao
Ira Tabas
Affiliated Authors:
Brennan D. Gerlach
Patrick B. Ampomah
Arif Yurdagul
Max C. Lauring
Xiaobo Wang
Canan Kasikara
Ira Tabas
Columbia Affiliation:
Subjects:
Macrophages (MeSH)
Phagocytosis (MeSH)
Mechanisms of Apoptotic Cell Clearance and Immune Regulation (OpenAlex Topic)
Macrophage Activation and Polarization (OpenAlex Topic)
Mechanosensitive Ion Channels in Physiology and Disease (OpenAlex Topic)
Author Keywords:
dnase2a
erk1/2 signaling
mertk
myc
atherosclerosis
efferocytosis
inflammation resolution
mtorc2/rictor
macrophage
macrophage proliferation
Grants:
P30CA013696 (NIH – National Cancer Institute)
S10RR027050 (NIH – National Center for Research Resources)
S10RR025686 (NIH – National Center for Research Resources)
R35HL145228 (NIH – National Heart, Lung, and Blood Institute)
R01HL127464 (NIH – National Heart, Lung, and Blood Institute)
P01HL087123 (NIH – National Heart, Lung, and Blood Institute)
K99HL145131 (NIH – National Heart, Lung, and Blood Institute)
T32HL007343 (NIH – National Heart, Lung, and Blood Institute)
P20GM121307 (NIH – National Institute of General Medical Sciences)
S10OD020056 (NIH – Office of the Director, National Institutes of Health)
Publication Type:
Article
Unique ID:
10.1016/j.cmet.2021.10.015
PMID:
34784501
DOI:
10.1016/j.cmet.2021.10.015
Journal:
Cell Metabolism
Publication Date:
Data Source:
Scopus
Source Link:
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Membrane curvature and connective fiber alignment in guinea pig round window membrane

Arriaga, M., Arteaga, D. N., Fafalis, D., Yu, M., Wang, X., Kasza, K. E., Lalwani, A. K., & Kysar, J. W. (2021). Membrane curvature and connective fiber alignment in guinea pig round window membrane. Acta Biomaterialia, 136, 343–362. https://doi.org/10.1016/j.actbio.2021.09.036
Authors:
Miguel Arriaga
Daniel N. Arteaga
Dimitrios Fafalis
Michelle Yu
Xun Wang
Karen E. Kasza
Anil K. Lalwani
Jeffrey W. Kysar
Affiliated Authors:
Daniel N. Arteaga
Michelle Yu
Anil K. Lalwani
Jeffrey W. Kysar
Columbia Affiliation:
Subjects:
Perilymph (MeSH)
Round Window, Ear (MeSH)
Author Keywords:
collagen fibers
confocal microscopy
elastic fibers
hyperbolic paraboloid
round window membrane
Grants:
P30CA013696 (NIH – National Cancer Institute)
S10RR025686 (NIH – National Center for Research Resources)
R01DC014547 (NIH – National Institute On Deafness and Other Communication Disorders)
Publication Type:
Article
Unique ID:
10.1016/j.actbio.2021.09.036
PMID:
34563725
DOI:
10.1016/j.actbio.2021.09.036
Journal:
Acta Biomaterialia
Publication Date:
Data Source:
Scopus
Source Link:
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Impact of Systemic versus Intratympanic Dexamethasone Administration on the Perilymph Proteome

Szeto, B., Valentini, C., Aksit, A., Werth, E. G., Goeta, S., Brown, L. M., Olson, E. S., Kysar, J. W., & Lalwani, A. K. (2021). Impact of Systemic versus Intratympanic Dexamethasone Administration on the Perilymph Proteome. Journal of Proteome Research, 20(8), 4001–4009. https://doi.org/10.1021/acs.jproteome.1c00322
Authors:
Betsy Szeto
Chris Valentini
Aykut Aksit
Emily G. Werth
Shahar Goeta
Lewis M. Brown
Elizabeth S. Olson
Jeffrey W. Kysar
Anil K. Lalwani
Affiliated Authors:
Betsy Szeto
Chris Valentini
Emily G. Werth
Shahar Goeta
Lewis M. Brown
Elizabeth S. Olson
Jeffrey W. Kysar
Anil K. Lalwani
Columbia Affiliation:
Subjects:
Dexamethasone (MeSH)
Glucocorticoids (MeSH)
Perilymph (MeSH)
Proteome (MeSH)
Author Keywords:
3d printing
dexamethasone
inner ear diagnostics
microneedle
perilymph sampling
proteomics
round window membrane
steroids
3d printing steroids
Grants:
P30CA013696 (NIH – National Cancer Institute)
S10RR025686 (NIH – National Center for Research Resources)
R01DC014547 (NIH – National Institute On Deafness and Other Communication Disorders)
Publication Type:
Article
Unique ID:
10.1021/acs.jproteome.1c00322
PMID:
34291951
DOI:
10.1021/acs.jproteome.1c00322
Journal:
Journal of Proteome Research
Publication Date:
Data Source:
Scopus
Source Link:
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Record Created:

Novel 3D-printed hollow microneedles facilitate safe, reliable, and informative sampling of perilymph from guinea pigs

Szeto, B., Aksit, A., Valentini, C., Yu, M., Werth, E. G., Goeta, S., Tang, C., Brown, L. M., Olson, E. S., Kysar, J. W., & Lalwani, A. K. (2021). Novel 3D-printed hollow microneedles facilitate safe, reliable, and informative sampling of perilymph from guinea pigs. Hearing Research, 400, 108141. https://doi.org/10.1016/j.heares.2020.108141
Authors:
Betsy Szeto
Aykut Aksit
Chris Valentini
Michelle Yu
Emily G. Werth
Shahar Goeta
Chuanning Tang
Lewis M. Brown
Elizabeth S. Olson
Jeffrey W. Kysar
Anil K. Lalwani
Affiliated Authors:
Betsy Szeto
Chris Valentini
Michelle Yu
Emily G. Werth
Shahar Goeta
Chuanning Tang
Lewis M. Brown
Elizabeth S. Olson
Jeffrey W. Kysar
Anil K. Lalwani
Columbia Affiliation:
Subjects:
Perilymph (MeSH)
Author Keywords:
3d printing
inner ear diagnostics
microneedle
perilymph sampling
proteomics
round window membrane
Grants:
P30CA013696 (NIH – National Cancer Institute)
S10RR025686 (NIH – National Center for Research Resources)
R01DC014547 (NIH – National Institute On Deafness and Other Communication Disorders)
Publication Type:
Article
Unique ID:
10.1016/j.heares.2020.108141
PMID:
33307286
DOI:
10.1016/j.heares.2020.108141
Journal:
Hearing Research
Publication Date:
Data Source:
Scopus
Source Link:
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Record Created:

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