Mechanisms and Implications of Ferroptosis in Cancer

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Jeong, M.-S., Baek, S.-W., Yang, G.-E., Mun, J.-Y., Kim, J. A., Kim, T.-N., Nam, J.-K., Choi, Y.-H., Lee, J.-S., Chu, I.-S., & Leem, S.-H. (2025). Chemoresistance-motility signature of molecular evolution to chemotherapy in non-muscle-invasive bladder cancer and its clinical implications. Cancer Letters, 610, 217339. https://doi.org/10.1016/j.canlet.2024.217339
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Banu, M. A., Dovas, A., Argenziano, M. G., Zhao, W., Sperring, C. P., Cuervo Grajal, H., Liu, Z., Higgins, D. M., Amini, M., Pereira, B., Ye, L. F., Mahajan, A., Humala, N., Furnari, J. L., Upadhyayula, P. S., Zandkarimi, F., Nguyen, T. T., Teasley, D., Wu, P. B., … Canoll, P. (2024). A cell state-specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma. The EMBO Journal. https://doi.org/10.1038/s44318-024-00176-4
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Hassan, N., Yi, H., Malik, B., Gaspard-Boulinc, L., Samaraweera, S. E., Casolari, D. A., Seneviratne, J., Balachandran, A., Chew, T., Duly, A., Carter, D. R., Cheung, B. B., Norris, M., Haber, M., Kavallaris, M., Marshall, G. M., Zhang, X. D., Liu, T., Wang, J., … Wang, J. Y. (2024). Loss of the stress sensor GADD45A promotes stem cell activity and ferroptosis resistance in LGR4/HOXA9-dependent AML. Blood, 144(1), 84–98. https://doi.org/10.1182/blood.2024024072
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Qiu, B., Zandkarimi, F., Saqi, A., Castagna, C., Tan, H., Sekulic, M., Miorin, L., Hibshoosh, H., Toyokuni, S., Uchida, K., & Stockwell, B. R. (2024). Fatal COVID-19 pulmonary disease involves ferroptosis. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-48055-0
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Ko, K.-P., Zhang, S., Huang, Y., Kim, B., Zou, G., Jun, S., Zhang, J., Zhao, Y., Martin, C., Dunbar, K. J., Efe, G., Rustgi, A. K., Nakagawa, H., Zhang, H., Liu, Z., & Park, J.-I. (2024). Tumor niche network-defined subtypes predict immunotherapy response of esophageal squamous cell cancer. IScience, 27(5), 109795. https://doi.org/10.1016/j.isci.2024.109795
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Upadhyayula, P. S., Higgins, D. M., Mela, A., Banu, M., Dovas, A., Zandkarimi, F., Patel, P., Mahajan, A., Humala, N., Nguyen, T. T. T., Chaudhary, K. R., Liao, L., Argenziano, M., Sudhakar, T., Sperring, C. P., Shapiro, B. L., Ahmed, E. R., Kinslow, C., Ye, L. F., … Canoll, P. (2023). Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-36630-w
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Chatila, W. K., Walch, H., Hechtman, J. F., Moyer, S. M., Sgambati, V., Faleck, D. M., Srivastava, A., Tang, L., Benhamida, J., Ismailgeci, D., Campos, C., Wu, F., Chang, Q., Vakiani, E., de Stanchina, E., Weiser, M. R., Widmar, M., Yantiss, R. K., Shah, M. A., … Yaeger, R. (2023). Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers. Nature Communications, 14(1). https://doi.org/10.1038/s41467-022-35592-9
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Arakawa, Y., Goldlust, S. A., Colman, H., Reardon, D. A., Welch, M. R., Yamaguchi, S., Butowski, N. A., Li, J., Iino, S., Song, G., Jackman, A., Xie, Y., Wagle, M.-C., Lebedinsky, C., & Narita, Y. (2023). 10007-ACT-2 FIRST IN HUMAN STUDY OF DSP-0390, AN ORAL EMOPAMIL BINDING PROTEIN (EBP) INHIBITOR, IN RECURRENT HIGH-GRADE GLIOMA (HGG): PRELIMINARY RESULTS. Neuro-Oncology Advances, 5(Supplement_5), v2–v2. https://doi.org/10.1093/noajnl/vdad141.006
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In, G. K., Ribeiro, J. R., Yin, J., Xiu, J., Bustos, M. A., Ito, F., Chow, F., Zada, G., Hwang, L., Salama, A. K. S., Park, S. J., Moser, J. C., Darabi, S., Domingo-Musibay, E., Ascierto, M. L., Margolin, K., Lutzky, J., Gibney, G. T., Atkins, M. B., … VanderWalde, A. M. (2023). Multi-omic profiling reveals discrepant immunogenic properties and a unique tumor microenvironment among melanoma brain metastases. Npj Precision Oncology, 7(1). https://doi.org/10.1038/s41698-023-00471-z
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Minns, H., Padilla, O., Wei, H.-J., Gartrell, R. D., Webster-Carrion, A., Tazhibi, M., McQuillan, N., Zhang, X., Gallitto, M., Yeh, R., Zhang, Z., Hei, T., Szalontay, L., Pavisic, J., Garty, G., Garvin, J., Canoll, P., Vanpouille-Box, C., Menon, V., … Wu, C.-C. (2023). 53 Inducing immune response with FLASH and conventional radiation in diffuse midline glioma (DMG). Regular and Young Investigator Award Abstracts. https://doi.org/10.1136/jitc-2023-sitc2023.0053
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Saini, S., & Owusu-Ansah, E. (2023). Dissecting the mechanism of regulation of a ferroptosis-like form of cell death in Drosophila melanogaster. Frontiers in Cell Death, 2. https://doi.org/10.3389/fceld.2023.1209641
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Liang, D., Feng, Y., Zandkarimi, F., Wang, H., Zhang, Z., Kim, J., Cai, Y., Gu, W., Stockwell, B. R., & Jiang, X. (2023). Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones. Cell, 186(13), 2748-2764.e22. https://doi.org/10.1016/j.cell.2023.05.003
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Liu, Y., Liu, Y., Ye, S., Feng, H., & Ma, L. (2023). A new ferroptosis-related signature model including messenger RNAs and long non-coding RNAs predicts the prognosis of gastric cancer patients. Journal of Translational Internal Medicine, 11(2), 145–155. https://doi.org/10.2478/jtim-2023-0089
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Migliozzi, S., Oh, Y. T., Hasanain, M., Garofano, L., D’Angelo, F., Najac, R. D., Picca, A., Bielle, F., Di Stefano, A. L., Lerond, J., Sarkaria, J. N., Ceccarelli, M., Sanson, M., Lasorella, A., & Iavarone, A. (2023). Integrative multi-omics networks identify PKCδ and DNA-PK as master kinases of glioblastoma subtypes and guide targeted cancer therapy. Nature Cancer, 4(2), 181–202. https://doi.org/10.1038/s43018-022-00510-x
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Columbia Affiliation
Tanagala, K. K. K., Morin-Baxter, J., Carvajal, R., Cheema, M., Dubey, S., Nakagawa, H., Yoon, A., Cheng, Y.-S. L., Taylor, A., Nickerson, J., Mintz, A., & Momen-Heravi, F. (2022). SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response. Journal for ImmunoTherapy of Cancer, 10(12), e005088. https://doi.org/10.1136/jitc-2022-005088
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Gupta, P., Dang, M., Hao, D., Bojja, K., Tran, T., Shehwana, H., Kamiya-Matsuoka, C., Li, J., Audia, A., Kassab, C., Ott, M., Gumin, J., Alenazy, S., Goldman, A., Seth, S., Maheshwari, A., Balasubramaniyan, V., Vaillant, B., Groot, J. de, … Bhat, K. (2022). 1001 Immunophenotyping of brain tumors identifies interferon enriched phagocytes in human gliomas. Regular and Young Investigator Award Abstracts, A1043–A1043. https://doi.org/10.1136/jitc-2022-sitc2022.1001
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Liu, Y., Liu, Y., Ye, S., Feng, H., & Ma, L. (2022). Development and validation of cuproptosis-related gene signature in the prognostic prediction of liver cancer. Frontiers in Oncology, 12. https://doi.org/10.3389/fonc.2022.985484
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Tourigny, D. S., Zucker, M., Kim, M., Russo, P., Coleman, J., Lee, C.-H., Carlo, M. I., Chen, Y.-B., Hakimi, A. A., Kotecha, R. R., & Reznik, E. (2022). Molecular Characterization of the Tumor Microenvironment in Renal Medullary Carcinoma. Frontiers in Oncology, 12. https://doi.org/10.3389/fonc.2022.910147
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Myer, P. A., Kim, H., Blümel, A. M., Finnegan, E., Kel, A., Thompson, T. V., Greally, J. M., Prehn, J. HM., O’Connor, D. P., Friedman, R. A., Floratos, A., & Das, S. (2022). Master Transcription Regulators and Transcription Factors Regulate Immune-Associated Differences Between Patients of African and European Ancestry With Colorectal Cancer. Gastro Hep Advances, 1(3), 328–341. https://doi.org/10.1016/j.gastha.2022.01.004
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Fernández, E. C., Wang, J., Griffin, A., Minns, H., Wei, H.-J., Zhang, X., Szalontay, L., Mundi, P., Wu, C.-C., Gartrell, R., Zacharoulis, S., Califano, A., & Pavisic, J. (2022). DIPG-57. A systems biology approach to defining and targeting master regulator dependencies from bulk and single-Cell RNA-seq in diffuse midline glioma (DMG). Neuro-Oncology, 24(Supplement_1), i31–i32. https://doi.org/10.1093/neuonc/noac079.114
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Biswas, A. K., Han, S., Tai, Y., Ma, W., Coker, C., Quinn, S. A., Shakri, A. R., Zhong, T. J., Scholze, H., Lagos, G. G., Mela, A., Manova-Todorova, K., de Stanchina, E., Ferrando, A. A., Mendelsohn, C., Canoll, P., Yu, H. A., Paik, P. K., Saqi, A., … Acharyya, S. (2022). Targeting S100A9–ALDH1A1–Retinoic Acid Signaling to Suppress Brain Relapse inEGFR-Mutant Lung Cancer. Cancer Discovery, 12(4), 1002–1021. https://doi.org/10.1158/2159-8290.cd-21-0910
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Jin, J., Schorpp, K., Samaga, D., Unger, K., Hadian, K., & Stockwell, B. R. (2022). Machine Learning Classifies Ferroptosis and Apoptosis Cell Death Modalities with TfR1 Immunostaining. ACS Chemical Biology, 17(3), 654–660. https://doi.org/10.1021/acschembio.1c00953
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