Molecular Mechanisms of Inflammasome Activation and Regulation

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Vasou, A., Nightingale, K., Cetkovská, V., Scheler, J., Bamford, C. G. G., Andrejeva, J., Rowe, J. C., Swatek, K. N., Schwarz‐Linek, U., Randall, R. E., McLauchlan, J., Weekes, M. P., Bogunovic, D., & Hughes, D. J. (2025). ISG15‐Dependent Stabilisation of USP18 Is Necessary but Not Sufficient to Regulate Type I Interferon Signalling in Humans. European Journal of Immunology, 55(2). Portico. https://doi.org/10.1002/eji.202451651
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Mandel, H., Yoo, Y. J., Allen, A. J., Abedian, S., Verzani, Z., Karlson, E. W., Kleinman, L. C., Mudumbi, P. C., Oliveira, C. R., Muszynski, J. A., Gross, R. S., Carton, T. W., Kim, C., Taylor, E., Park, H., Divers, J., Kelly, J. D., Arnold, J., Geary, C. R., … Moffitt, R. A. (2025). Long-COVID incidence proportion in adults and children between 2020 and 2024. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciaf046
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Vats, K., Tian, H., Singh, K., Tyurina, Y. Y., Sparvero, L. J., Tyurin, V. A., Kruglov, O., Chang, A., Wang, J., Green, F., Samovich, S. N., Zhang, J., Chattopadhyay, A., Murray, N., Shah, V. K., Mathers, A. R., Chandran, U. R., Pilewski, J. M., Kellum, J. A., … Bunimovich, Y. L. (2024). Ferroptosis of select skin epithelial cells initiates and maintains chronic systemic immune-mediated psoriatic disease. Journal of Clinical Investigation. https://doi.org/10.1172/jci183219
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Yalcinkaya, M., Liu, W., Xiao, T., Abramowicz, S., Wang, R., Wang, N., Westerterp, M., & Tall, A. R. (2024). Cholesterol trafficking to the ER leads to the activation of CaMKII/JNK/NLRP3 and promotes atherosclerosis. Journal of Lipid Research, 65(4), 100534. https://doi.org/10.1016/j.jlr.2024.100534
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Yalcinkaya, M., Liu, W., Thomas, L.-A., Olszewska, M., Xiao, T., Abramowicz, S., Papapetrou, E. P., Westerterp, M., Wang, N., Tabas, I., & Tall, A. R. (2023). BRCC3-Mediated NLRP3 Deubiquitylation Promotes Inflammasome Activation and Atherosclerosis in Tet2 Clonal Hematopoiesis. Circulation, 148(22), 1764–1777. https://doi.org/10.1161/circulationaha.123.065344
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Yuan, H., Pian, X., Cui, J., Zhang, S., Yu, Y., Li, A., Yan, S., & Zheng, F. (2023). Exploring the effect of Mahuang Lianqiao Chixiaodou decoction on NLRP3 cell pyroptosis in an atopic dermatitis-like mouse model. Journal of Traditional Chinese Medical Sciences, 10(4), 461–469. https://doi.org/10.1016/j.jtcms.2023.09.010
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Hsu, C.-C., Fidler, T. P., Kanter, J. E., Kothari, V., Kramer, F., Tang, J., Tall, A. R., & Bornfeldt, K. E. (2023). Hematopoietic NLRP3 and AIM2 Inflammasomes Promote Diabetes-Accelerated Atherosclerosis, but Increased Necrosis Is Independent of Pyroptosis. Diabetes, 72(7), 999–1011. https://doi.org/10.2337/db22-0962
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Yalcinkaya, M., Fotakis, P., Liu, W., Endo-Umeda, K., Dou, H., Abramowicz, S., Xiao, T., Libby, P., Wang, N., Tall, A. R., & Westerterp, M. (2022). Cholesterol accumulation in macrophages drives NETosis in atherosclerotic plaques via IL-1β secretion. Cardiovascular Research, 119(4), 969–981. https://doi.org/10.1093/cvr/cvac189
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Ozdede, A., Güner, S., Ozcifci, G., Yurttas, B., Toker Dincer, Z., Atli, Z., Uygunoglu, U., Durmaz, E., Ucar, D., Ugurlu, S., Saip, S., Tabak, Ö. F., Hamuryudan, V., & Seyahi, E. (2022). POS1255 SAFETY OF THE PFIZER/BIONTECH AND SINOVAC/CORONAVAC VACCINES AMONG PATIENTS WITH BEHCET’S SYNDROME AND FAMILIAL MEDITERRANEAN FEVER. Annals of the Rheumatic Diseases, 81, 962–963. https://doi.org/10.1136/annrheumdis-2022-eular.3711
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Guo, J., Lin, W.-H. W., Zucker, J. E., Nandakumar, R., Uhlemann, A.-C., Wang, S., & Shivakoti, R. (2022). Inflammation and Mortality in COVID-19 Hospitalized Patients With and Without Type 2 Diabetes. The Journal of Clinical Endocrinology & Metabolism, 107(5), e1961–e1968. https://doi.org/10.1210/clinem/dgac003
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