Endoplasmic Reticulum

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Sassano, M. L., Tyurina, Y. Y., Diometzidou, A., Vervoort, E., Tyurin, V. A., More, S., La Rovere, R., Giordano, F., Bultynck, G., Pavie, B., Swinnen, J. V., Bayir, H., Kagan, V. E., Scorrano, L., & Agostinis, P. (2025). Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis. Nature Cell Biology, 27(6), 902–917. https://doi.org/10.1038/s41556-025-01668-z
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Nakamura, K., Aoyama-Ishiwatari, S., Nagao, T., Paaran, M., Obara, C. J., Sakurai-Saito, Y., Johnston, J., Du, Y., Suga, S., Tsuboi, M., Nakakido, M., Tsumoto, K., Kishi, Y., Gotoh, Y., Kwak, C., Rhee, H.-W., Seo, J. K., Kosako, H., Potter, C., … Hirabayashi, Y. (2025). Mitochondrial complexity is regulated at ER-mitochondria contact sites via PDZD8-FKBP8 tethering. Nature Communications, 16(1). https://doi.org/10.1038/s41467-025-58538-3
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Larrea, D., Tamucci, K. A., Kabra, K., Velasco, K. R., Yun, T. D., Pera, M., Montesinos, J., Agrawal, R. R., Paradas, C., Smerdon, J. W., Lowry, E. R., Stepanova, A., Yoval-Sanchez, B., Galkin, A., Wichterle, H., & Area-Gomez, E. (2025). Altered mitochondria-associated ER membrane (MAM) function shifts mitochondrial metabolism in amyotrophic lateral sclerosis (ALS). Nature Communications, 16(1). https://doi.org/10.1038/s41467-024-51578-1
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Gong, B., Johnston, J. D., Thiemicke, A., de Marco, A., & Meyer, T. (2024). Endoplasmic reticulum–plasma membrane contact gradients direct cell migration. Nature, 631(8020), 415–423. https://doi.org/10.1038/s41586-024-07527-5
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Morcillo, P., Kabra, K., Velasco, K., Cordero, H., Jennings, S., Yun, T. D., Larrea, D., Akman, H. O., & Schon, E. A. (2024). Aberrant ER-mitochondria communication is a common pathomechanism in mitochondrial disease. Cell Death & Disease, 15(6). https://doi.org/10.1038/s41419-024-06781-9
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Yalcinkaya, M., Liu, W., Xiao, T., Abramowicz, S., Wang, R., Wang, N., Westerterp, M., & Tall, A. R. (2024). Cholesterol trafficking to the ER leads to the activation of CaMKII/JNK/NLRP3 and promotes atherosclerosis. Journal of Lipid Research, 65(4), 100534. https://doi.org/10.1016/j.jlr.2024.100534
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Hewitt, V. L., Miller-Fleming, L., Twyning, M. J., Andreazza, S., Mattedi, F., Prudent, J., Polleux, F., Vagnoni, A., & Whitworth, A. J. (2022). Decreasing pdzd8-mediated mito–ER contacts improves organismal fitness and mitigates Aβ42toxicity. Life Science Alliance, 5(11), e202201531. https://doi.org/10.26508/lsa.202201531
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Ibáñez, F., Montesinos, J., Area-Gomez, E., Guerri, C., & Pascual, M. (2021). Ethanol Induces Extracellular Vesicle Secretion by Altering Lipid Metabolism through the Mitochondria-Associated ER Membranes and Sphingomyelinases. International Journal of Molecular Sciences, 22(16), 8438. https://doi.org/10.3390/ijms22168438
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