Journal of Medicinal Chemistry
Displaying 1 - 10 of 10
Knaab, T. C., Moritz, A., Pessanha de Carvalho, L., Klein, S., Lungerich, B., Lohse, K., Kruse, L., Mombo-Ngoma, G., Orta, L., Thibaud, J. L., de Villiers, K. A., Fidock, D. A., Burckhardt, B. B., Held, J., Wittlin, S., & Kurz, T. (2024). TKK130 is a 3-Hydroxy-Propanamidine (HPA) with Potent Antimalarial In Vivo Activity and a High Barrier to Resistance. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.4c01465
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Columbia Affiliation
Brettell, S. B., Janha, O., Begen, A., Cann, G., Sharma, S., Olaniyan, N., Yelland, T., Hole, A. J., Alam, B., Mayville, E., Gillespie, R., Capper, M., Fidock, D. A., Milligan, G., Clarke, D. J., Tobin, A. B., & Jamieson, A. G. (2024). Targeting PfCLK3 with Covalent Inhibitors: A Novel Strategy for Malaria Treatment. Journal of Medicinal Chemistry, 67(21), 18895–18910. https://doi.org/10.1021/acs.jmedchem.4c01300
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Columbia Affiliation
Hu, X., Kabir, M., Lin, Y., Xiong, Y., Parsons, R. E., Gu, W., & Jin, J. (2024). Design, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs). Journal of Medicinal Chemistry, 67(16), 14633–14648. https://doi.org/10.1021/acs.jmedchem.4c01497
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Columbia Affiliation
Wang, L., Bohmer, M. J., Wang, J., Nardella, F., Calla, J., Laureano De Souza, M., Schindler, K. A., Montejo, L., Mittal, N., Rocamora, F., Treat, M., Charlton, J. T., Tumwebaze, P. K., Rosenthal, P. J., Cooper, R. A., Chakrabarti, R., Winzeler, E. A., Chakrabarti, D., & Gray, N. S. (2024). Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases. Journal of Medicinal Chemistry, 67(2), 1460–1480. https://doi.org/10.1021/acs.jmedchem.3c02046
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Columbia Affiliation
Boutin, R., Lee, H.-F., Guan, T. L., Nguyen, T. T., Huang, X. F., Waller, D. D., Lu, J., Christine Chio, I. I., Michel, R. P., Sebag, M., & Tsantrizos, Y. S. (2023). Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor Efficacy in Multiple Myeloma, Pancreatic Ductal Adenocarcinoma, and Colorectal Cancer. Journal of Medicinal Chemistry, 66(23), 15776–15800. https://doi.org/10.1021/acs.jmedchem.3c01271
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Columbia Affiliation
Taylor, A. M., Williams, B. R., Giordanetto, F., Kelley, E. H., Lescarbeau, A., Shortsleeves, K., Tang, Y., Walters, W. P., Arrazate, A., Bowman, C., Brophy, E., Chan, E. W., Deshmukh, G., Greisman, J. B., Hunsaker, T. L., Kipp, D. R., Saenz Lopez-Larrocha, P., Maddalo, D., Martin, I. J., … Willmore, L. (2023). Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors. Journal of Medicinal Chemistry, 66(19), 13384–13399. https://doi.org/10.1021/acs.jmedchem.3c00483
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Webb, D. A., Meyer, M. J., Medubi, K. M., Tylek, A. S., Yocum, G. T., Roni, M. S. R., Zahn, N. M., Swartwout, S. A., Masoud, A. K., Emala, C. W., Stafford, D. C., & Arnold, L. A. (2023). Design, Synthesis, and Biological Evaluation of Novel Spiro Imidazobenzodiazepines to Identify Improved Inhaled Bronchodilators. Journal of Medicinal Chemistry, 66(14), 9853–9865. https://doi.org/10.1021/acs.jmedchem.3c00647
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Ashton, T. D., Dans, M. G., Favuzza, P., Ngo, A., Lehane, A. M., Zhang, X., Qiu, D., Chandra Maity, B., De, N., Schindler, K. A., Yeo, T., Park, H., Uhlemann, A.-C., Churchyard, A., Baum, J., Fidock, D. A., Jarman, K. E., Lowes, K. N., Baud, D., … Sleebs, B. E. (2023). Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4. Journal of Medicinal Chemistry, 66(5), 3540–3565. https://doi.org/10.1021/acs.jmedchem.2c02092
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Columbia Affiliation
Lowe, M. A., Cardenas, A., Valentin, J.-P., Zhu, Z., Abendroth, J., Castro, J. L., Class, R., Delaunois, A., Fleurance, R., Gerets, H., Gryshkova, V., King, L., Lorimer, D. D., MacCoss, M., Rowley, J. H., Rosseels, M.-L., Royer, L., Taylor, R. D., Wong, M., … de Haro, T. (2022). Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362. Journal of Medicinal Chemistry, 65(20), 14121–14143. https://doi.org/10.1021/acs.jmedchem.2c01336
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Columbia Affiliation
Turgutalp, B., Bhattarai, P., Ercetin, T., Luise, C., Reis, R., Gurdal, E. E., Isaak, A., Biriken, D., Dinter, E., Sipahi, H., Schepmann, D., Junker, A., Wünsch, B., Sippl, W., Gulcan, H. O., Kizil, C., & Yarim, M. (2022). Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer’s Disease. Journal of Medicinal Chemistry, 65(18), 12292–12318. https://doi.org/10.1021/acs.jmedchem.2c01003
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Columbia Affiliation