Discovery of WEE1 Kinase Inhibitors with Potent Activity against Patient-Derived, Metastatic Colorectal Cancer Organoids

Syphers, J. L., Wright, J. A., Liu, S., Gee, Y. S., Gao, F., Mudududdla, R., Che, D. Q., Chang, A., Sloan, E. K., Narasimhan, V., Heriot, A., Ramsay, R. G., de Nys, R., Silva, T. N., Vrbanac, L., Sammour, T., Lawrence, M. J., Tin, T., Maddern, G. J., … Baell, J. B. (2025). Discovery of WEE1 Kinase Inhibitors with Potent Activity against Patient-Derived, Metastatic Colorectal Cancer Organoids. Journal of Medicinal Chemistry, 68(8), 8065–8090. https://doi.org/10.1021/acs.jmedchem.4c02541
Authors:
Joel L Syphers
Josephine A Wright
Shen Liu
Yi Sing Gee
Fan Gao
Ramesh Mudududdla
Da Qing Che
Aeson Chang
Erica K Sloan
Vignesh Narasimhan
Alexander Heriot
Robert G Ramsay
Rebekah de Nys
Tharindie N Silva
Laura Vrbanac
Tarik Sammour
Matthew J Lawrence
Teresa Tin
Guy J Maddern
Kevin Fenix
Harleen Kaur
Kate Barratt
Gerhard Kelter
Armin Maier
Markus Posch
Hongfu Lu
Xiaomin Wang
Alex Zhavoronkov
Heping Wei
Fei Huang
Daniel L Worthley
Daniel L Priebbenow
Siddhartha Mukherjee
Susan L Woods
Jonathan B Baell
Affiliated Authors:
Siddhartha Mukherjee
Columbia Affiliation:
Subjects:
Protein-Tyrosine Kinases (MeSH)
Organoids (MeSH)
Colorectal Neoplasms (MeSH)
Protein Kinase Inhibitors (MeSH)
Cell Cycle Proteins (MeSH)
Antineoplastic Agents (MeSH)
Drug Discovery (MeSH)
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Publication Type:
Article
Unique ID:
10.1021/acs.jmedchem.4c02541
PMID:
40207690
DOI:
10.1021/acs.jmedchem.4c02541
Journal:
Journal of Medicinal Chemistry
Publication Date:
Data Source:
PubMed
Source Link:
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Record Created: