Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4

Awalt, J. K., Ooi, Z. K., Ashton, T. D., Mansouri, M., Calic, P. P. S., Zhou, Q., Vasanthan, S., Lee, S., Loi, K., Jarman, K. E., Penington, J. S., Qiu, D., Zhang, X., Lehane, A. M., Mao, E. Y., Gancheva, M. R., Wilson, D. W., Giannangelo, C., MacRaild, C. A., … Sleebs, B. E. (2025). Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4. Journal of Medicinal Chemistry, 68(8), 8933–8966. https://doi.org/10.1021/acs.jmedchem.5c00614
Authors:
Jon Kyle Awalt
Zi Kang Ooi
Trent D Ashton
Mahta Mansouri
Petar P S Calic
Qingmiao Zhou
Santhya Vasanthan
Serena Lee
Katie Loi
Kate E Jarman
Jocelyn S Penington
Deyun Qiu
Xinxin Zhang
Adele M Lehane
Emma Y Mao
Maria R Gancheva
Danny W Wilson
Carlo Giannangelo
Christopher A MacRaild
Darren J Creek
Tomas Yeo
Tanaya Sheth
David A Fidock
Alisje Churchyard
Jake Baum
Mufuliat T Famodimu
Michael J Delves
Mojca Kristan
Lindsay Stewart
Colin J Sutherland
Rachael Coyle
Hannah Jagoe
Marcus C S Lee
Mrittika Chowdury
Tania F de Koning-Ward
Delphine Baud
Stephen Brand
Paul F Jackson
Alan F Cowman
Madeline G Dans
Brad E Sleebs
Affiliated Authors:
Tomas Yeo
Tanaya Sheth
David A Fidock
Columbia Affiliation:
Subjects:
Malaria (OpenAlex Topic)
Computational Methods in Drug Discovery (OpenAlex Topic)
Catalytic C-H Amination Reactions (OpenAlex Topic)
Indoles (MeSH)
Plasmodium falciparum (MeSH)
Antimalarials (MeSH)
Acetamides (MeSH)
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Publication Type:
Article
Unique ID:
10.1021/acs.jmedchem.5c00614
PMID:
40228810
DOI:
10.1021/acs.jmedchem.5c00614
Journal:
Journal of Medicinal Chemistry
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record
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Record Created: