Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors

Taylor, A. M., Williams, B. R., Giordanetto, F., Kelley, E. H., Lescarbeau, A., Shortsleeves, K., Tang, Y., Walters, W. P., Arrazate, A., Bowman, C., Brophy, E., Chan, E. W., Deshmukh, G., Greisman, J. B., Hunsaker, T. L., Kipp, D. R., Saenz Lopez-Larrocha, P., Maddalo, D., Martin, I. J., … Willmore, L. (2023). Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors. Journal of Medicinal Chemistry, 66(19), 13384–13399. https://doi.org/10.1021/acs.jmedchem.3c00483
Authors:
Alexander M Taylor
Bret R Williams
Fabrizio Giordanetto
Elizabeth H Kelley
André Lescarbeau
Kelley Shortsleeves
Yong Tang
W Patrick Walters
Alfonso Arrazate
Christine Bowman
Erin Brophy
Emily W Chan
Gauri Deshmukh
Jack B Greisman
Thomas L Hunsaker
D Randal Kipp
Pablo Saenz Lopez-Larrocha
Danilo Maddalo
Iain J Martin
Paul Maragakis
Mark Merchant
Mark Murcko
Hunter Nisonoff
Vi Nguyen
Vy Nguyen
Olivia Orozco
Christopher Owen
Levi Pierce
Molly Schmidt
David E Shaw
Sherri Smith
Eric Therrien
John C Tran
Jim Watters
Nigel J Waters
Jeremy Wilbur
Lindsay Willmore
Affiliated Authors:
David E Shaw
Columbia Affiliation:
elink
Publication Type:
Article
Unique ID:
10.1021/acs.jmedchem.3c00483
PMID:
37774359
DOI:
10.1021/acs.jmedchem.3c00483
Journal:
Journal of Medicinal Chemistry
Publication Date:
Data Source:
PubMed
Source Link:
View PubMed Record

Record Created: