Chronic Opioid Treatment Arrests Neurodevelopment and Alters Synaptic Activity in Human Midbrain Organoids

Kim, H. S., Xiao, Y., Chen, X., He, S., Im, J., Willner, M. J., Finlayson, M. O., Xu, C., Zhu, H., Choi, S. J., Mosharov, E. V., Kim, H., Xu, B., & Leong, K. W. (2024). Chronic Opioid Treatment Arrests Neurodevelopment and Alters Synaptic Activity in Human Midbrain Organoids. Advanced Science, 11(21). Portico. https://doi.org/10.1002/advs.202400847
Authors:
Hye Sung Kim
Yang Xiao
Xuejing Chen
Siyu He
Jongwon Im
Moshe J. Willner
Michael O. Finlayson
Cong Xu
Huixiang Zhu
Se Joon Choi
Eugene V. Mosharov
Hae‐Won Kim
Bin Xu
Kam W. Leong
Affiliated Authors:
Hye Sung Kim
Yang Xiao
Xuejing Chen
Siyu He
Jongwon Im
Moshe J. Willner
Michael O. Finlayson
Cong Xu
Huixiang Zhu
Se Joon Choi
Eugene V. Mosharov
Bin Xu
Kam W. Leong
Columbia Affiliation:
Subjects:
Mesencephalon (MeSH)
Organoids (MeSH)
Analgesics, Opioid (MeSH)
Developmental Origins of Adult Health and Disease (OpenAlex Topic)
Neurotoxic Effects of Anesthetic Agents on Brain Development (OpenAlex Topic)
Brown Adipose Tissue Function and Physiology (OpenAlex Topic)
Author Keywords:
brain organoid
fentanyl
neurodevelopment
opioid
single-cell rna sequencing
single‐cell rna sequencing
elink
Publication Type:
Article
Unique ID:
10.1002/advs.202400847
PMID:
38549185
DOI:
10.1002/advs.202400847
Journal:
Advanced Science
Publication Date:
Data Source:
OpenAlex
Source Link:
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