R01AI169892

NIH – National Institute of Allergy and Infectious Diseases

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance

Luth, M. R., Godinez-Macias, K. P., Chen, D., Okombo, J., Thathy, V., Cheng, X., Daggupati, S., Davies, H., Dhingra, S. K., Economy, J. M., Edgar, R. C. S., Gomez-Lorenzo, M. G., Istvan, E. S., Jado, J. C., LaMonte, G. M., Melillo, B., Mok, S., Narwal, S. K., Ndiaye, T., … Winzeler, E. A. (2024). Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance. Science, 386(6725). https://doi.org/10.1126/science.adk9893

Authors:

Madeline R. Luth

Karla P. Godinez‐Macias

Daisy Chen

John Okombo

Vandana Thathy

Xiu Cheng

Sindhu Daggupati

Heledd Davies

Satish K. Dhingra

James Economy

Rebecca Edgar

Marı́a G. Gómez-Lorenzo

Eva S. Istvan

Juan Carlos Jado

Gregory LaMonte

Bruno Melillo

Sachel Mok

Sunil Kumar Narwal

Tolla Ndiaye

Sabine Ottilie

Sara Palomo Dı́az

Heekuk Park

Stella Peña

Frances Rocamora

Tomoyo Sakata‐Kato

Jennifer L. Small-Saunders

Robert L. Summers

Patrick K. Tumwebaze

Manu Vanaerschot

Guoqin Xia

Tomas Yeo

A. You

Francisco‐Javier Gamo

Daniel E. Goldberg

Lee M

Case W. McNamara

Daouda Ndiaye

Philip J. Rosenthal

Stuart L. Schreiber

Gloria Serra

Jair L. Siqueira-Neto

Tina S. Skinner‐Adams

Anne‐Catrin Uhlemann

Nobutaka Kato

Amanda K. Lukens

Dyann F. Wirth

David A. Fidock

Elizabeth A. Winzeler

Affiliated Authors:

John Okombo

Vandana Thathy

Satish K. Dhingra

Sachel Mok

Sunil Kumar Narwal

Tolla Ndiaye

Heekuk Park

Jennifer L. Small-Saunders

Manu Vanaerschot

Tomas Yeo

Anne‐Catrin Uhlemann

David A. Fidock

Columbia Affiliation:

Subjects:

Antimalarials (MeSH)

Drug Resistance (MeSH)

Drug Resistance, Multiple (MeSH)

Plasmodium falciparum (MeSH)

Protozoan Proteins (MeSH)

Directed Molecular Evolution (MeSH)

Malaria (OpenAlex Topic)

Invertebrate Immunity and Host Defense Mechanisms (OpenAlex Topic)

Aquaculture disease management and microbiota (OpenAlex Topic)

Grants:

R01AI109023 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI172066 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI103058 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI124678 (NIH – National Institute of Allergy and Infectious Diseases)

R37AI050234 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI185559 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI169892 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI154777 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI152533 (NIH – National Institute of Allergy and Infectious Diseases)

T32GM008666 (NIH – National Institute of General Medical Sciences)

T32GM139790 (NIH – National Institute of General Medical Sciences)

Publication Type:

Article

Unique ID:

10.1126/science.adk9893

PMID:

39607932

DOI:

10.1126/science.adk9893

Journal:

Science

Publication Date:

2024-11-28

Data Source:

OpenAlex

Source Link:

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Record Created:

Tuesday, December 17, 2024 - 14:36

Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase

Xie, S. C., Wang, Y., Morton, C. J., Metcalfe, R. D., Dogovski, C., Pasaje, C. F. A., Dunn, E., Luth, M. R., Kumpornsin, K., Istvan, E. S., Park, J. S., Fairhurst, K. J., Ketprasit, N., Yeo, T., Yildirim, O., Bhebhe, M. N., Klug, D. M., Rutledge, P. J., Godoy, L. C., … Tilley, L. (2024). Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-45224-z

Authors:

Stanley C. Xie

Wang Yi-nuo

Craig J. Morton

Riley D. Metcalfe

Con Dogovski

Charisse Flerida A. Pasaje

Elyse Dunn

Madeline R. Luth

Krittikorn Kümpornsin

Eva S. Istvan

Joon Sung Park

Kate J. Fairhurst

Nutpakal Ketprasit

Tomas Yeo

Okan Yıldırım

Mathamsanqa N. Bhebhe

Dana M. Klug

Peter J. Rutledge

Luiz C. Godoy

Sumanta Dey

Mariana Laureano de Souza

Jair L. Siqueira-Neto

Yawei Du

Tanya Puhalovich

Mona Amini

Gerald J. Shami

Duangkamon Loesbanluechai

Shuai Nie

Nicholas A. Williamson

Gouranga P. Jana

Bikash C. Maity

Patrick Thomson

Thomas P. Foley

Derek S. Tan

Jacquin C. Niles

Byung Woo Han

Daniel E. Goldberg

Jeremy N. Burrows

David A. Fidock

Lee M

Elizabeth A. Winzeler

Michael D. W. Griffin

Matthew H. Todd

Leann Tilley

Affiliated Authors:

Kate J. Fairhurst

Tomas Yeo

David A. Fidock

Columbia Affiliation:

Subjects:

Aspartate-tRNA Ligase (MeSH)

Antimalarials (MeSH)

Ribosome Structure and Translation Mechanisms (OpenAlex Topic)

Efficacy and Safety of Antiretroviral Therapy for HIV (OpenAlex Topic)

Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (OpenAlex Topic)

Grants:

P30CA008748 (NIH – National Cancer Institute)

R01AI152533 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI141543 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI169892 (NIH – National Institute of Allergy and Infectious Diseases)

T32GM008666 (NIH – National Institute of General Medical Sciences)

Publication Type:

Article

Unique ID:

10.1038/s41467-024-45224-z

PMID:

38297033

DOI:

10.1038/s41467-024-45224-z

Journal:

Nature Communications

Publication Date:

2024-01-31

Data Source:

OpenAlex

Source Link:

View OpenAlex Record

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Record Created:

Friday, July 26, 2024 - 09:28

Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases

Wang, L., Bohmer, M. J., Wang, J., Nardella, F., Calla, J., Laureano De Souza, M., Schindler, K. A., Montejo, L., Mittal, N., Rocamora, F., Treat, M., Charlton, J. T., Tumwebaze, P. K., Rosenthal, P. J., Cooper, R. A., Chakrabarti, R., Winzeler, E. A., Chakrabarti, D., & Gray, N. S. (2024). Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases. Journal of Medicinal Chemistry, 67(2), 1460–1480. https://doi.org/10.1021/acs.jmedchem.3c02046

Authors:

Lushun Wang

Monica J Bohmer

Jinhua Wang

Flore Nardella

Jaeson Calla

Mariana Laureano De Souza

Kyra A Schindler

Lukas Montejo

Nimisha Mittal

Frances Rocamora

Mayland Treat

Jordan T Charlton

Patrick K Tumwebaze

Philip J Rosenthal

Roland A Cooper

Ratna Chakrabarti

Elizabeth A Winzeler

Debopam Chakrabarti

Nathanael S Gray

Affiliated Authors:

Kyra A Schindler

Columbia Affiliation:

Vagelos College of Physicians and Surgeons
- Department of Microbiology and Immunology

Subjects:

Antimalarials (MeSH)

Malaria (MeSH)

Receptor, EphA2 (MeSH)

Grants:

R01AI152533 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI172066 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI169892 (NIH – National Institute of Allergy and Infectious Diseases)

Publication Type:

Article

Unique ID:

10.1021/acs.jmedchem.3c02046

PMID:

38214254

DOI:

10.1021/acs.jmedchem.3c02046

Journal:

Journal of Medicinal Chemistry

Publication Date:

2024-01-12

Data Source:

PubMed

Source Link:

View PubMed Record

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Record Created:

Friday, July 26, 2024 - 10:08

Antimalarial drug discovery: progress and approaches

Siqueira-Neto, J. L., Wicht, K. J., Chibale, K., Burrows, J. N., Fidock, D. A., & Winzeler, E. A. (2023). Antimalarial drug discovery: progress and approaches. Nature Reviews Drug Discovery, 22(10), 807–826. https://doi.org/10.1038/s41573-023-00772-9

Authors:

Jair L Siqueira-Neto

Kathryn J Wicht

Kelly Chibale

Jeremy N Burrows

David A Fidock

Elizabeth A Winzeler

Affiliated Authors:

David A Fidock

Columbia Affiliation:

Subjects:

Antimalarials (MeSH)

Plasmodium (MeSH)

Grants:

R01AI152092 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI152533 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI169892 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI109023 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI143521 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI124678 (NIH – National Institute of Allergy and Infectious Diseases)

R01AI151639 (NIH – National Institute of Allergy and Infectious Diseases)

R37AI050234 (NIH – National Institute of Allergy and Infectious Diseases)

Publication Type:

Article

Unique ID:

10.1038/s41573-023-00772-9

PMID:

37652975

DOI:

10.1038/s41573-023-00772-9

Journal:

Nature Reviews Drug Discovery

Publication Date:

2023-10-01

Data Source:

PubMed

Source Link:

View PubMed Record

Record Created:

Monday, August 5, 2024 - 11:45